• 대한치과보철학회지
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• 제42권2호
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• pp.226-237
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• 2004

Purpose: Four finite element models were constructed in the mandible having a single implant fixture connected to the first premolar-shaped superstructure, in order to evaluate how the shape of the fixture and the implant-abutment connection would influence the stress level of the supporting tissues fixtures, and prosthethic components. Material and methods : The superstructures were constructed using UCLA type abutment, ADA type III gold alloy was used to fabricate a crown and then connected to the fixture with an abutment screw. The models BRA, END , FRI, ITI were constructed from the mandible implanted with Branemark, Endopore, Frialit-2, I.T.I. systems respectively. In each model, 150 N of vertical load was placed on the central pit of an occlusal plane and 150 N of $40^{\circ}$ oblique load was placed on the buccal cusp. The displacement and stress distribution in the supporting tissues and the other components were analysed using a 2-dimensional finite element analysis . The maximum stress in each reference area was compared. Results : 1. Under $40^{\circ}$ oblique loading, the maximum stress was larger in the implant, superstructure and supporting tissue, compared to the stress pattern under vertical loading. 2. In the implant, prosthesis and supporting tissue, the maximum stress was smaller with the internal connection type (FRI) and the morse taper type (ITI) when compared to that of the external connection type (BRA & END). 3. In the superstructure and implant/abutment interface, the maximum stress was smaller with the internal connection type (FRI) and the morse taper type (ITI) when compared to that of the external connection type (BRA & END). 4. In the implant fixture, the maximum stress was smaller with the internal connection type (FRI) and the morse taper type (ITI) when compared to that of the external connection type (BRA & END). 5 The stress was more evenly distributed in the bone/implant interface through the FRI of trapezoidal step design. Especially Under $40^{\circ}$ oblique loading, The maximum stress was smallest in the bone/implant interface. 6. In the implant and superstructure and supporting tissue, the maximum stress occured at the crown loading point through the ITI. Conclusion: The stress distribution of the supporting tissue was affected by shape of a fixture and implant-abutment connection. The magnitude of maximum stress was reduced with the internal connection type (FRI) and the morse taper type (ITI) in the implant, prosthesis and supporting tissue. Trapezoidal step design of FRI showed evenly distributed the stress at the bone/implant interface.

• 한국지반환경공학회 논문집
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• 제14권11호
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• pp.5-12
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• 2013

본 연구의 목적은 토석류 발생 가능성이 높은 산지에 소단을 설치하였을 경우 산지 하류에서의 토석류의 거동과 메카니즘을 측정하는 것이다. 수치모델은 질량보존 및 운동량 보존에 관한 방정식에 기초하여 유한차분법을 이용하여 수행되었다. 토석류 거동을 측정하기 위하여 3가지 형태의 소단을 갖는 사면과 직선 사면에서의 토석류 변화를 비교하였다. 우선 하류단에서 소단폭의 길이 변화에 따른 직선 사면과 소단을 갖는 사면에 대한 유량과 토사체적 농도를 조사하였고, 공급유량 변화에 따른 소단을 갖는 사면에서의 유량과 토사체적 농도를 조사하였다. 소단을 갖는 수로에서는 소단폭의 길이가 길어질수록 소단으로 인해 토석류가 저유량 형태로 나타났으며, 고유량의 요동분포의 지속시간이 줄어들었다. 이는 소단이 토석류를 지연시키는 데 효과적인 것을 발견하였다. RMS비 비교 결과 소단을 갖는 사면이 직선 사면보다 유량이 적게 나타난 것을 확인하였다. 토사체적농도의 경우 소단폭의 길이가 길어질수록 변곡점이 나타나지 않고 완만한 형태의 그래프를 나타냈으다. 또한, 저농도의 토사와 물이 혼합되어 하류부로 유하하기 때문에 하류부에서의 토석류에 의한 피해를 저감시키는 데 효과가 있었다. 본 연구의 결과는 토석류 재해 예측 및 다양한 대책을 세우는 데 좋은 정보를 제공할 것이다.

• 천문학회보
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• 제40권2호
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• pp.39.3-40
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• 2015

The NISS (Near-infrared Imaging Spectrometer for Star formation history) onboard NEXTSat-1 is the near-infrared instrument optimized to the first small satellite of NEXTSat series. The capability of both imaging and low spectral resolution spectroscopy in the near-infrared range is a unique function of the NISS. The major scientific mission is to study the cosmic star formation history in local and distant universe. For those purposes, the main targets are nearby galaxies, galaxy clusters, star-forming regions and low background regions. The off-axis optical design of the NISS with two linear variable filters is optimized to have a wide field of view ($2deg.{\times}2deg.$) as well as the wide wavelength range from 0.95 to $3.8{\mu}m$. The mechanical structure is considered to endure the launching condition as well as the space environment. The dewar inside the telescope is designed to operate the infrared detector at 80K stage. From the thermal analysis, we confirmed that the telescope and the dewar can be cooled down to around 200K and 80K, respectively in order to reduce the large amount of thermal noise. The stray light analysis is shown that a light outside a field of view can be reduced below 1%. After the fabrications of the parts of engineering qualification model (EQM), the NSS EQM was successfully assembled and integrated into the satellite. To verify operations of the satellite in space, the space environment tests such as the vibration, shock and thermal-vacuum test were performed. Here, we report the results of the critical design review for the NISS.

• 대한토목학회논문집
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• 제37권2호
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• pp.311-324
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• 2017

과부하 맨홀에서의 에너지 손실은 도심지의 침수피해를 가중시키는 요인이 된다. 그러므로 과부하 4방향 합류맨홀에서 에너지 손실의 저감을 위한 흐름특성 분석이 필요하다. 본 연구에서는 현황조사 결과를 고려하여 수리실험 장치를 제작하였으며, 사각형 맨홀 및 연결관은 하수도시설 기준을 준용하여 1/5로 축소 제작하였다. 또한 과부하 4방향 사각형 합류맨홀에서 에너지 손실을 저감 시킬 수 있는 인버트 형상 조건을 도출하기 위하여 Fluent 6.3모형으로 수치모의를 실시하였다. 선정된 수리실험 조건인 유출유량($Q_{out}$)에 대한 측면 유입유량($Q_{lar}$)의 비($Q_{lat}/Q_{out}$)와 유출유량(2.0, 3.0, 4.0, 4.8 l/sec) 및 인버트 형상 변화 조건(십자형, 개선형)을 변화시키며 수리실험을 실시하였다. 십자형 인버트는 과부하 4방향 합류 맨홀의 배수능력 향상에 영향이 미미한 것으로 분석되었다. 그러나 개선된 직사각 개거형 인버트와 정사각 개거형 인버트는 각각 평균적으로 약 7%, 28%의 손실계수가 감소하여 배수능력을 개선하는 것으로 분석되었다. 따라서 도시 관거 시설의 배수능력을 증대시키기 위하여 본 연구에서 제시된 개선형 인버트의 설치 및 활용이 가능할 것으로 판단된다.

• 대한원격탐사학회지
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• 제33권5_1호
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• pp.455-467
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• 2017

초분광 영상을 이용한 표적 탐지를 수행할 때에는 인접한 분광 밴드의 중복성의 문제 및 고차원 데이터로 인해 발생하는 방대한 계산량의 문제점을 해결하기 위한 특징 추출 과정이 필수적이다. 본 연구는 기계 학습 분야의 특징 선택 기법을 초분광 밴드 선택에 적용하기 위해 $L_{2,1}$-norm regression 모델을 이용한 새로운 밴드 선택 기법을 제안하였으며, 제안한 밴드 선택 기법의 성능 분석을 위해 표적이 존재하는 초분광영상을 직접 촬영하고 이를 바탕으로 표적 탐지를 수행한 결과를 분석하였다. 350 nm~2500 nm 파장 대역에서 밴드 수를 164개에서 약 30~40개로 감소시켰을 때 Adaptive Cosine Estimator(ACE) 탐지 성능이 유지되거나 향상되는 결과를 보였다. 실험 결과를 통해 제안한 밴드 선택 기법이 초분광 영상에서 탐지에 효율적인 밴드를 추출해 내며, 이를 통해 성능의 감소 없이 데이터의 차원 감소를 수행할 수 있어 향후 실시간 표적 탐지 시스템의 처리 속도 향상에 도움을 줄 수 있을 것으로 보인다.

• 대한한의학회지
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• 제20권2호
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• pp.108-120
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• 1999

In this study, body weight levels of glucose, insulin and triglyceride in blood and glucosidase activity of the small intestine were investigated to determine the effect of Sangbaegpitang and Supungsungiwhan on the glucose metabolism of db/db mice. The GLUT4 mRNA of muscle tissue and the Acetyl CoA Carboxylase and the activation rate of GLUT2 mRNA of liver tissue were measured by the reverse transcription-polymerase chain reaction method and by the vitro transcription. The results were obtained as follows: 1. In the Sangbaegpitang administration group, (1) The level of triglyceride was decreased significantly and the glucosidase activity of the small intestine was inhibited remarkably, (2) The amounts of the GLUT4 mRNA in muscle tissue and Acetyl CoA Carboxylase mRNA in liver tissue were increased significantly. (3) Though glucose level in both fasting and non-fasting, were decreased and the insulin level in blood was increased, the results showed no statistical significance. 2. In the Supungsungiwhan administration group, (1) The levels of glucose and triglyceride were decreased significantly in the blood of non-fasting animals. (2) The glucosidase activity of small intestine was inhibited markedly and the amounts of GLUT4 mRNA of muscle tissue and GLUT2 mRNA of liver tissue were increased significantly. (3) The glucose levels in the fasting group were reduced, while insulin level was increased but showed no statistical significance, Based on the above results, our conclusions are as follows: Sangbaegpitang & Supungsungiwhan are thought to be capable of inhibiting the activity glucosidase, the enzyme which influences carbohydrate metabolism in the small intestine of db/db mice(the experimental diabetic model) and delaying the absorption of carbohydrate, thus proving effective on inhibiting the increase of non-fasting glucose level effectively. Futhermore Sangbaegpitang and Supungsungiwhan are though: to be capable of preventing the composition of free fatty acids by restoring the production of GLUT4 mRNA of muscle tissues and GLUT2 mRNA of liver tissues. Those results suggests that above prescriptions can be applied to non-insulin dependent diabetes mellitus in order to improve insulin resistance.

• 한국지하수토양환경학회지:지하수토양환경
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• 제8권4호
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• pp.1-11
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• 2003

압축력의 변화에 따른 균열 간극변화 양상을 측정하고 간극변화와 수리전도도와의 관계를 파악하기 위해 이 연구에서는 다섯 단계의 수직 일축압축력을 균열면에 연속적으로 가하면서 고해상도의 공초점 레이저 스캔 현미경 (confocal laser scanning microscope; CLSM)을 이용하여 간극의 크기를 측정하고 디지털 이미지를 획득하였다. 기존의 연구들과는 달리 이 연구의 측정방법은 압력변화에 대한 동일시료 간극의 반응을 연속적으로 파악할 수 있는 점이 특징이다. 측정결과는 간극크기가 일정하지 않은 불평탄한 균열형태를 매우 잘 나타내었다. 균열 조도(roughness)로 인해 압력에 따른 간극 변화량은 일정하지 않고 부분마다 다름을 보였다. 각 압력단계에서 간극변화에 따른 투수성 변화양상을 파악하고자 실내투수시험을 병행하여 실시한 결과, 각 압력단계에서의 투수성 변화도 일정한 감소율을 나타내지 않고 간극 변화율이 크더라도 투수율은 오히려 작은 경우도 관찰되었다. 현미경을 통해 측정한 물리적 간극과 실제 유체유동 경로가 되는 수리간극의 크기 차이를 파악하기 위해 계산을 한 결과, 미미한 갈이지만 물리적 간극보다 작은 크기의 수리간극이 구해졌다. 또한, 실내투수시험 결과를 이용하여 구한 투수계수는 삼승법칙을 따르지 않는 것으로 드러났으며, 이러한 사실들은 균열 양쪽이 서로 평행하지 않고 불평탄한 양상을 가짐을 의미하는 것으로서, 현미경을 통해 직접 관찰한 간극양상과 잘 일치하는 것이다.

• 한국작물학회지
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• 제50권4호
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• pp.238-246
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• 2005

Rice yield and protein content have been shown to be highly variable across paddy fields. In order to characterize this spatial variability of rice within a field, two-year experiments were conducted in 2002 and 2003 in a large-scale rice field of $6,600m^2$ In year 2004, an experiment was conducted to know if variable rate treatment (VRT) of N fertilizer, that was prescribed for site-specific management at panicle initiation stage, could reduce spatial variation in yield and protein content of rice while increasing yield compared to conventional uniform N topdressing (UN, 33kg N/ha at PIS) method. VRT nitrogen prescription for each grid was calculated based on the nitrogen (N) uptake (from panicle initiation to harvest) required for target rice protein content of $6.8\%$, natural soil N supply, and recovery of top-dressed N fertilizer. The required N uptake for target rice protein content was calculated from the equations to predict rice yield and protein content from plant growth parameters at panicle initiation stage (PIS) and N uptake from PIS to harvest. This model· equations were developed from the data obtained from the previous two-year experiments. The plant growth parameters for the calculation of the required N were predicted non-destructively by canopy reflectance measurement. Soil N supply for each grid was obtained from the experiment of year 2003, and N recovery was assumed to be $60\%$ according to the previous reports. The prescribed VRT N ranged from 0 to 110kg N/ha with an average of 57kg/ha that was higher than 33 kg/ha of UN. The results showed that VRT application successfully worked not only to reduce spatial variability of rice yield and protein content but also to increase rough rice yield by 960kg/ha. The coefficient of variation (CV) for rice yield and protein content was reduced significantly to $8.1\%$ and $7.1\%$ in VRT from $14.6\%$ and $13.0\%$ in UN, respectively. And also the average protein content of milled rice in VRT showed very similar value of target protein content of $6.8\%$. In conclusion the procedure used in this paper was believed to be reliable and promising method for reducing within-field spatial variability of rice yield and protein content. However, inexpensive, reliable, and fast estimation methods of natural N supply and plant growth and nutrition status should be prepared before this method could be practically used for site-specific crop management in large-scale rice field.

• 한국산학기술학회논문지
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• 제13권3호
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• pp.1255-1262
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• 2012

현재 가동 중인 월성 원자력 발전의 핵연료 교체로봇 시스템을 살펴보면 핵연료 교환에 필요한 구동압력 제어를 위해 PI제어기를 사용한다. PI제어는 구조가 간단하고 이득 설정을 통해 시스템 요구조건에 만족하는 제어 성능을 낼 수 있지만 밸브와 관로 등의 파라미터 변화로부터 적절한 이득 변경 없이 안정한 제어가 힘들다. 이러한 문제를 해결하기 위해 PI제어기 이득을 동적으로 변경 하거나 PI제어기 출력을 보상하도록 제어기를 구성하는 것이 바람직하다. 본 연구개발의 목적은 파라미터 변화에도 안정한 제어가 가능하도록 제어기를 설계하여 오차와 진동현상을 줄이는데 있다. 제안한 PI/NN제어 기법은 PI제어기와 신경회로망 제어기를 병렬 결합한 구조로 신경회로망 제어기가 PI제어기 출력을 보상하여 파라미터 변화에 강인하도록 설계 하였다. 제어기의 성능평가를 위해 직접 실 공정에 테스트하기가 힘들기 때문에 공정의 특성을 반영하여 모델링한 시뮬레이터를 개발하였고, 시뮬레이션 결과를 실 공정데이터와 비교하여 공정 특성을 모사함을 보였으며, 파라미터 변화에 PI/NN제어기가 오차 및 진동현상을 줄이는 것을 확인 하였다. 또한, 실 공정에서 사용 중인 PI제어기를 주 제어기로 사용하면서 파라미터 변화에 대한 비선형성을 보상하는 제어기 역할을 하기 때문에 신경회로망을 단독으로 사용하였을 때 보다 더 신뢰성 있고 안정적인 제어가 가능하다.

• Journal of Pharmaceutical Investigation
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• 제25권3호spc1호
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• pp.7-20
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• 1995

Taurine, a ${\beta}-amino$ acid, plays an important role as a neuromodulator and is necessary for the normal development of the brain. Since de novo synthesis of taurine in the brain is minimal and in vivo studies suggest that taurine dose not cross the blood-brain barrier, we examined whether the choroid plexus, the blood-cerebrospinal fluid (CSF) barrier, plays a role in taurine transport in the central nervous system. The uptake of $[^3H]-taurine$ into ATP depleted choroid plexus from rabbit was substantially greater in the presence of an inwardly directed $Na^+$ gradient taurine accumulation was negligible. A transient in side-negative potential gradient enhanced the $Na^+-driven$ uptake of taurine into the tissue slices, suggesting that the transport process is electrogenic, $Na^+-driven$ taurine uptake was saturable with an estimated $V_{max}$ of $111\;{\pm}\;20.2\;nmole/g/15\;min$ and a $K_M\;of\;99.8{\pm}29.9\;{\mu}M$. The estimated coupling ratio of $Na^+$ and taurine was $1.80\;{\pm}\;0.122.$ $Na^+-dependent$ taurine uptake was significantly inhibited by ${\beta}-amino$ acids, but not by ${\alpha}-amino$ acids, indicating that the transporter is selective for ${\beta}-amino$ acids. Since it is known that the physiological concentration of taurine in the CSF is lower than that in the plasma, the active transport system we characterized may face the brush border (i.e., CSF facing) side of the choroid plexus and actively transport taurine out of the CSF. Therefore, we examined in vivo elimination of taurine from the CSF in the rat to determine whether elimination kinetics of taurine from the CSF is consistent with the in vitro study. Using a stereotaxic device, cannulaes were placed into the lateral ventricle and the cisterna magna of the rat. Radio-labelled taurine and inulin (a marker of CSF flow) were injected into the lateral ventricle, and the concentrations of the labelled compounds in the CSF were monitored for upto 3 hrs in the cisterna magna. The apparent clearance of taurine from CSF was greater than the estimated CSF flow (p<0.005) indicating that there is a clearance process in addition to the CSF flow. Taurine distribution into the choroid plexus was at least 10 fold higher than that found in other brain areas (e. g., cerebellum, olfactory bulb and cortex). When unlabelled taurine was co-administered with radio-labelled taurine, the apparent clearance of taurine was reduced (p<0.0l), suggesting a saturable disposition of taurine from CSF. Distribution of taurine into the choroid plexus, cerebellum, olfactory bulb and cortex was similarly diminished, indicating that the saturable uptake of taurine into these tissues is responsible for the non-linear disposition. A pharmacokinetic model involving first order elimination and saturable distribution described these data adequately. The Michaelis-Menten rate constant estimated from in vivo elimination study is similar to that obtained in the in vitro uptake experiment. Collectively, our results demonstrate that taurine is transported in the choroid plexus via a $Na^+-dependent,saturable$ and apparently ${\beta}-amino$ acid selective mechanism. This process may be functionally relevant to taurine homeostasis in the brain.