• Journal of IKEEE
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• v.21 no.3
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• pp.320-330
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• 2017

Porous nanosilica (PNS) has been identified as a potential candidate for controlled drug delivery. However, unmodified PNS-based carriers exhibited an initial release of loaded bioactive agents, which may limit their potential clinical applications. In this study, the surface of PNS was functionalized with adamantylamine (ADA) via disulfide bonds (-S-S-), PNS-S-S-ADA, which was then modified with cyclodextrin (CD)-heparin (Hep) (CD-Hep), PNS-S-S-CDH, for redox triggered rhodamine B (RhB) delivery. The obtained samples were then characterized by proton nuclear magnetic resonance ($^{1}H\;NMR$), Fourier transform infrared (FTIR), and transmission electron microscope (TEM). These results showed that PNS-S-S-CDH was successfully formed with spherical shape and average diameter of $45.64{\pm}2.33nm$. In addition, RhB was relatively encapsulated in the PNS-S-S-CDH (RhB@PNS-S-S-CDH) and slowly released up to 3 days. The release of RhB, in particular, was triggered due to the cleavage of -S-S- in the presence of dithiothreitol (DTT). It might be anticipated that the modified PNS can be used as redox-responsive drug delivery system in cancer therapy.

• Bulletin of the Korean Chemical Society
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• v.16 no.10
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• pp.968-971
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• 1995

The heme assignment of the 1H NMR spectrum of cytochrome c3 of Desulfovibrio vulgaris Hildenborough within the X-ray structure were fully cross established according to their redox potential. The major reduction of the heme turned out to take place in the order of hemes Ⅳ,Ⅰ,Ⅱ and Ⅲ(the heme numbers indicating the order of bonding to the primary sequence). This assignment can provide the physicochemical basis for the elucidation of electron transfer of this protein.

• Textile Coloration and Finishing
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• v.18 no.5 s.90
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• pp.53-60
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• 2006

The 1,3-bis(4-aminoaryl)squaraines showed color, change behavior, they were found to undergo reduction with sodium borohydride in solution to give colorless leuco compounds, which oxidized readily in air back to the colored squaraine dye. We have shown that initial observations indicated that the derivatives synthesized gave new donor-acceptor chromophores. It is also interesting to note than the oxidation of the leuco squaraines did initially produce a species absorbing about 630-680 wavelengths. The 1,3-squaraines have found many uses as near-infrared absorbers, laser dyes and photoconductive materials. Furthermore their color-change redox behavior has potential in the area of peroxidase-based bioassaysas oxidation sensitive indicator systems were investigated.

• Biomolecules & Therapeutics
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• v.26 no.1
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• pp.19-28
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• 2018

Rapidly proliferating cancer cells require energy and cellular building blocks for their growth and ability to maintain redox balance. Many studies have focused on understanding how cancer cells adapt their nutrient metabolism to meet the high demand of anabolism required for proliferation and maintaining redox balance. Glutamine, the most abundant amino acid in plasma, is a well-known nutrient used by cancer cells to increase proliferation as well as survival under metabolic stress conditions. In this review, we provide an overview of the role of glutamine metabolism in cancer cell survival and growth and highlight the mechanisms by which glutamine metabolism affects cancer cell signaling. Furthermore, we summarize the potential therapeutic approaches of targeting glutamine metabolism for the treatment of numerous types of cancer.

• Journal of Environmental Health Sciences
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• v.23 no.4
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• pp.97-103
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• 1997

Carbofuran was incubated for four weeks in three differenf types of paddy soil samples at 25$\circ$C. The soil samples prepared in the present study were as follows: control soil, 3% cellulose added soil and 10% cellulose added soil. The degradation rate of carbofuran significantly decreased by the addition of cellulose to soil(p<0.05). The initial pH of soils was 5.0. After incubation for four weeks, the pH of 10% cellulose added soil sample was lower than those of control soil and 3% cellulose added soil. According to increased organic carbon content of the soil, redox potentials of soils decreased. The decreased degradation rate of carbofuran in 10% cellulose added soil was related to the highly negative redox potentials in contrast with the oxidised conditions of control soil and 3% cellulose added soil.

• Bulletin of the Korean Chemical Society
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• v.17 no.8
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• pp.688-693
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• 1996

Tetradentate Schiff base ligands derived from 2-hydroxy-1-naphthaldehyde and aliphatic diamine have been synthesized. Cu(Ⅱ) complexes of Schiff base ligands have been synthesized from the free ligands and copper acetate. The mole ratio of ligand to copper was identified to be 1:1 by the result of elemental analysis and Cu(Ⅱ) complexes were in a four-coordinated configuration. The electrochemical redox process of Cu(Ⅱ) complexes in a DMF solution has been investigated by cyclic voltammetry, chronoamperometry, differential pulse voltammetry, and controlled potential coulometry. The redox process of Cu(Ⅱ) complexes is one electron transfer process in quasi-reversible and diffusion-controlled reaction. The electrochemical redox potentials and the kinetic parameters of Cu(Ⅱ) complexes are affected by the chelate ring of Schiff base ligands.

• KSBB Journal
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• v.6 no.3
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• pp.299-307
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• 1991

In this paper the effect of light on non-aerated Baker's Yeast(Saccharomyces cereuisiae) production and the protein excretion to the extracellular fluid is studied. Previous results in our laboratory indicate that at pH=5 and T-32$^{\circ}C$ yeast may be affected by light, but those differences seem to be within statistical variation of the data. In this paper, cell and extracellular protein concentrations along with redox potential are monitored for batch fermentations in the presence and absence of light at pH levels of 3 and 5 and at 31$^{\circ}C$, in order to explore whether possible light effects can be more readily discerned at lower pH values. Yeast particle size distributions are also determined over the course of fermentation using a particle counter in order to add one more measuring tool to our usual cell and total protein measurements. An apparently noticeable difference in the redox potential is observed between the light and the dark runs for early times for the pH=3 runs. The particle size distributions show differences in the particle diameters between light and dark runs at pH=3, but those differences fall within one standard deviation of the mean particle diameters.

• Textile Coloration and Finishing
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• v.21 no.5
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• pp.35-40
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• 2009

Computational calculations of molecular orbital and electrochemical redox/oxidation potentials are of very importance to determine the compound properties. The energy levels of molecular orbital were calculated by the density function theory (DFT) with exchange correction functional of local density approximation (LSA) based on the Perdew-Wang (PWC) setting and cyclic voltammetry.

• 한국생물공학회:학술대회논문집
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• 2000.11a
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• pp.665-668
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• 2000

Recombinant Escherichia coli NZN111 ($F-{\Delta}pfl::Cam$ ldhA::Kan) harboring pTrcML, a plasmid containing the E. coli malic enzyme gene, produced considerable amount of malic acid along with the desired product succinic acid. This seemed to be due to the unmatched redox states between glucose and succinic acid. Therefore, a more reduced carbon substrate sorbitol was examined for the possibility of matching the potential during succinic acid production. When NZN111 (pTrcML) was cultured in LB medium containing 20 g/L sorbitol under $CO_2$ atmosphere, 10 g/L of succinic acid was produced. The apparent yield of succinic acid was 1.1 g succinic acid per g sorbitol, which is 85% of the maximum theoretical yield.

• BMB Reports
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• v.31 no.5
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• pp.444-452
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• 1998

The visible spectra of soybean ferric leghemoglobin reductase exhibited a charge transfer band at 530 nm under aerobic condition. Spectra of the oxidized enzyme show a flavin peak at 454 nm and the enzyme has three redox states associated with the active site of the enzyme. The enzyme has an active disulfide bridge and two-electron transfer may dominate in the ferric state of leghemoglobin reduction. The midpoint potentials of the enzyme were determined by spectrotitration to be -0.294 V for disulfide/dithiol and -0.318 V for FAD/$FADH_2$. Since the midpoint potentials for $NAD^+$/NADH and the ferrous/ferric states of leghemoglobin are -0.32 V and +0.22 V, respectively, it is proposed that two electrons are transferred sequentially from NADH to FAD, to the disulfide group, and then to the ferric state of leghemoglobin in the enzyme reaction.