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Comparison of the Effects of Intratympanic Steroid Injection at Different Intervals in Sudden Sensorineural Hearing Loss

  • Sung, Han Kyung;Kang, Ju Chang;Shin, Kyu Ha;An, Yun Suk
    • Korean Journal of Audiology
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    • v.24 no.1
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    • pp.24-28
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    • 2020
  • Background and Objectives: Systemic steroid therapy (SST) and intratympanic steroid injection (ISI) have been the treatment of choice for sudden sensorineural hearing loss (SSNHL). We studied the effect of ISI administered at different intervals on hearing outcomes in patients with SSNHL. Subjects and Methods: We performed a retrospective study of 427 patients diagnosed with SSNHL at Bundang Jesaeng Hospital, of whom 51 patients with SSNHL who received SST and four ISIs were included in this study. Patients were treated with four ISIs either every day for 4 days (group 1) or at intervals (mean duration of interval: 2.21 days) (group 2). Hearing outcomes were evaluated using the pure-tone test before the injection and 14 days, 1 month, and 3 months after the final injection. Recovery rates were classified based on Siegel's criteria. Results: The amount of improvement was 27.67 dB (±20.45) in group 1 and 32.79 dB (±21.42) in group 2. However, there were no significant differences between the two groups (p= 0.714). The recovery rates based on Siegel's criteria were 18/27 (66.7%) and 16/24 (66.7%) in groups 1 and 2, respectively, with no significant difference (p=1.000). Considering only complete recoveries in hearing recovery, the recovery rates were 15/27 (55.6%) and 14/24 (58.3%) in groups 1 and 2, respectively, with no significant difference (p=0.842). Conclusions: There were no significant differences in hearing outcomes or recovery rates after ISI administration every day or at intervals of 2-3 days.

Comparison of the Effects of Intratympanic Steroid Injection at Different Intervals in Sudden Sensorineural Hearing Loss

  • Sung, Han Kyung;Kang, Ju Chang;Shin, Kyu Ha;An, Yun Suk
    • Journal of Audiology & Otology
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    • v.24 no.1
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    • pp.24-28
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    • 2020
  • Background and Objectives: Systemic steroid therapy (SST) and intratympanic steroid injection (ISI) have been the treatment of choice for sudden sensorineural hearing loss (SSNHL). We studied the effect of ISI administered at different intervals on hearing outcomes in patients with SSNHL. Subjects and Methods: We performed a retrospective study of 427 patients diagnosed with SSNHL at Bundang Jesaeng Hospital, of whom 51 patients with SSNHL who received SST and four ISIs were included in this study. Patients were treated with four ISIs either every day for 4 days (group 1) or at intervals (mean duration of interval: 2.21 days) (group 2). Hearing outcomes were evaluated using the pure-tone test before the injection and 14 days, 1 month, and 3 months after the final injection. Recovery rates were classified based on Siegel's criteria. Results: The amount of improvement was 27.67 dB (±20.45) in group 1 and 32.79 dB (±21.42) in group 2. However, there were no significant differences between the two groups (p= 0.714). The recovery rates based on Siegel's criteria were 18/27 (66.7%) and 16/24 (66.7%) in groups 1 and 2, respectively, with no significant difference (p=1.000). Considering only complete recoveries in hearing recovery, the recovery rates were 15/27 (55.6%) and 14/24 (58.3%) in groups 1 and 2, respectively, with no significant difference (p=0.842). Conclusions: There were no significant differences in hearing outcomes or recovery rates after ISI administration every day or at intervals of 2-3 days.

A Study on the Engineering Design for 20kW-Grade Waste Gas Heat Recovery (20kW급 폐열회수 시스템 공정 설계에 관한 연구)

  • Kim, Kyoung Su;Bang, Se Kyoung;Jeong, Eun Ik;Yi, Chung Seob
    • Journal of the Korean Society of Manufacturing Process Engineers
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    • v.17 no.4
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    • pp.91-96
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    • 2018
  • This study is collects design data through the process design of the organic Rankine cycle, which can produce 20kW of electric power through the recovery of waste heat. In this study, the simulation was conducted by using APSEN HYSYS in order to make the model for the process design of the 20kW class waste heat recovery system. For the thermodynamic model, the test was conducted with hot water as the heat source, with the water steam used as the cooling water for the cooler and the refrigerant R245fa in the cycle. In Case 1 and Case 2, it was expected and found that the cycle efficiency was 10.6% and that 36.86kw was produced, considering the margin of 84% of 20kW. In Case 3 and Case 4, it was expected and found from the simulation that the cycle efficiency was 12% and that 30.0kw was produced, considering the margin of 84% of 20kW.

Recovery Techniques for Deleted Email Items in Email Client (이메일 클라이언트 내의 삭제된 이메일 복원에 관한 연구)

  • Jeong, Cho-Rong;Lee, Keun-Gi;Lee, Sang-Jin
    • Journal of the Korea Institute of Information Security & Cryptology
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    • v.21 no.6
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    • pp.45-54
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    • 2011
  • Corporations use e-mail as their primary method for internal communication and business processes. By their nature, the e-mails are in general used for major business processes that contain large amounts of business information. When there is a critical event, such as Technology leakage, an e-mail message can become important evidence. However, as there is a high likelihood that a suspect will intentionally erase an e-mail message, the ability to recover deleted e-mail is very important. This pater analyzes the deleted e-mail item structure in files of various e-mail clients, and explains the possibility and methods of recovery.

Comparative Efficacy of 5 Anesthetic Agents in the Glass Catfish Kryptopterus vitreolus (유리메기(Kryptopterus vitreolus)에 대한 최적 마취제 선정을 위한 연구)

  • Lee, Hyo Bin;Jung, Hyo Sun;Ko, Min Gyun;Kim, Dong Soo
    • Korean Journal of Fisheries and Aquatic Sciences
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    • v.50 no.6
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    • pp.824-828
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    • 2017
  • We investigated the anesthetic effects of MS-222 (tricaine methanesulfonate), clove oil, 2-phenoxyethanol, $NaHCO_3$, lidocaine-HCl and lidocaine-$HCl/NaHCO_3$ in the glass catfish Kryptopterus vitreolus. Based on the efficacy criteria of complete anesthetic induction from 60 s to 120 s, recovery within 300 s, the lowest effective concentrations at $24^{\circ}C$ were determined to be 60 ppm (induction $82.8{\pm}17.6s$, recovery $80.2{\pm}34.7s$) for MS-222, 40 ppm (induction $70.5{\pm}8.2s$, recovery $83.4{\pm}17.7s$) for clove oil, 250 ppm (induction $64.3{\pm}24.0s$, recovery $62.8{\pm}15.6s$) for 2-phenoxyethanol, 300 ppm (induction $127.3{\pm}13.3s$, recovery $107.5{\pm}4.8s$) for lidocaine-HCl and 200/100 ppm (induction $81.2{\pm}17.2s$, recovery $98.3{\pm}19.7s$) for lidocaine-$HCl/NaHCO_3$. Thus, 200/100 ppm of lidocaine-$HCl/NaHCO_3$ was found to be an effective anesthetic agent.

Pharmacokinetics and gastric adhesion of aceglutamide aluminum complex on the combination of antacid in rats

  • Nam, Kweon-Ho;Cho, Jae-Youl;Yoo, Eun-Sook;Han, Sang-Bum;Yu, Young-Hyo;Park, Myung-Hwan;Park, Jeong-Hill
    • Proceedings of the Korean Society of Applied Pharmacology
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    • 1995.04a
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    • pp.97-97
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    • 1995
  • On the combination of antacid, the pharmacokinetics and gastric adhesion of $\^$14/C-aceglutamide aluminum complex($\^$14/C-AGA) were examined in rats. Specially, This study was focused on the drug interaction that the coadministration of antacid may affect the oral absorption and gastric adhesion of aceglutamide aluminum complex(AGA). After the oral administration of $\^$14/C-AGA and antacid to rats, the radioactivity of plasma and urinary recovery was lower than that of $\^$14/C-AGA administered group. Relatively, the cumulative recovery of radioactivity in feces was increased significantly. The comparative bioavailability of $\^$14/C-AGA from the plasma concentration-time curve and urinary recovery was about 60%. in vitro, the effect of antacid in the gastric adhesion of AGA was not significantly different between AGA and AGA/antacid treatment. And it accorded well with the result of in vivo experiment. In conclusion, on the combination of antacid, the oral absorption of AGA was decreased but the gastric adhesion was not affected in respect of drug interaction.

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Clinical Assessment of Pain and Sensory Function in Peripheral Nerve Injury and Recovery: A Systematic Review of Literature

  • John, Albin A.;Rossettie, Stephen;Rafael, John;Cox, Cameron T.;Ducic, Ivica;Mackay, Brendan J.
    • Archives of Plastic Surgery
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    • v.49 no.3
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    • pp.427-439
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    • 2022
  • Peripheral nerve injuries (PNIs) often present with variable symptoms, making them difficult to diagnose, treat, and monitor. When neurologic compromise is inadequately assessed, suboptimal treatment decisions can result in lasting functional deficits. There are many available tools for evaluating pain and functional status of peripheral nerves. However, the literature lacks a detailed, comprehensive view of the data comparing the clinical utility of these modalities, and there is no consensus on the optimal algorithm for sensory and pain assessment in PNIs. We performed a systematic review of the literature focused on clinical data, evaluating pain and sensory assessment methods in peripheral nerves. We searched through multiple databases, including PubMed/Medline, Embase, and Google Scholar, to identify studies that assessed assessment tools and explored their advantages and disadvantages. A total of 66 studies were selected that assessed various tools used to assess patient's pain and sensory recovery after a PNI. This review may serve as a guide to select the most appropriate assessment tools for monitoring nerve pain and/or sensory function both pre- and postoperatively. As the surgeons work to improve treatments for PNI and dysfunction, identifying the most appropriate existing measures of success and future directions for improved algorithms could lead to improved patient outcomes.

Design and Implementation of Open-Loop Clock Recovery Circuit for 39.8 Gb/s and 42.8 Gb/s Dual-Mode Operation

  • Lim, Sang-Kyu;Cho, Hyun-Woo;Shin, Jong-Yoon;Ko, Je-Soo
    • ETRI Journal
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    • v.30 no.2
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    • pp.268-274
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    • 2008
  • This paper proposes an open-loop clock recovery circuit (CRC) using two high-Q dielectric resonator (DR) filters for 39.8 Gb/s and 42.8 Gb/s dual-mode operation. The DR filters are fabricated to obtain high Q-values of approximately 950 at the 40 GHz band and to suppress spurious resonant modes up to 45 GHz. The CRC is implemented in a compact module by integrating the DR filters with other circuits in the CRC. The peak-to-peak and RMS jitter values of the clock signals recovered from 39.8 Gb/s and 42.8 Gb/s pseudo-random binary sequence (PRBS) data with a word length of $2^{31}-1$ are less than 2.0 ps and 0.3 ps, respectively. The peak-to-peak amplitudes of the recovered clocks are quite stable and within the range of 2.5 V to 2.7 V, even when the input data signals vary from 150 mV to 500 mV. Error-free operation of the 40 Gb/s-class optical receiver with the dual-mode CRC is confirmed at both 39.8 Gb/s and 42.8 Gb/s data rates.

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Effects of Warm-up Performance on SI Engine with Exhaust Heat Recovery System (배기열 회수장치 적용에 따른 SI 엔진의 웜업 성능에 미치는 영향)

  • Park, Kyoun-Suk;Suh, Ho-Cheol;Park, Sun-Hong;Kim, In-Tae;Jang, Sung-Wook
    • Transactions of the Korean Society of Automotive Engineers
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    • v.19 no.6
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    • pp.53-60
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    • 2011
  • The effect of exhaust heat recovery system can be evaluated by two well known method. First method is to measure the time duration from engine start under cold coolant temperature till coolant get warmed. By this methodology coolant warming duration can be index of warm-up effect. Second method is to analyze heat balance of the engine during warm-up phase under steady engine operation so that wasted energy by losses such as cooling and exhaust can be index of warm-up effect. This study focused on evaluation of warming-up effect by both methodology above mentioned using 2L SI engine under from idle to 2000rpm steady condition. Results, idle operation showed low heat recovery efficiency but under higher engine speed condition, remarkable heat recovery efficiency improvement was observed. In 2000rpm steady condition, warm-up duration of engine is decreased by exhaust heat recovery system.

Vapor Detection of ssDNA Decorated Graphene Transistor (ssDNA를 이용한 그래핀 가스 센서)

  • Jung, Youngmo;Kim, Young Jun;Moon, Hi Gue;Kim, Soo Min;Shin, Beomju;Lee, Joo Song;Seo, Minah;Lee, Taikjin;Kim, Jae Hun;Jun, Seong Chan;Lee, Seok;Kim, Chulki
    • Journal of Sensor Science and Technology
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    • v.23 no.5
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    • pp.310-313
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    • 2014
  • We report a way to improve the ability of graphene to operate as a gas sensor by applying single stranded deoxyribonucleic acid (DNA). The sensitivity and recovery of the DNA-graphene sensor depending on the different DNA sequences are analyzed. The different sensor responses to reactive chemical vapors are demonstrated in the time domain. Because of the chemical gating effect of the deposited DNA, the resulting devices show complete and rapid recovery to baseline unlike the bare graphene at room temperature. The application of the pattern recognition technique can increase the potential of DNA-graphene sensors as a chemical vapor classifier.