• 한국지반공학회논문집
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• 제36권9호
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• pp.21-32
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• 2020

본 연구에서는 포항 액상화 현상 발생 현장에서 채취한 모래를 사용하여 진동삼축시험 및 전단파 속도 측정을 수행하였으며, 시험결과를 기반으로 액상화 저항곡선을 도출하여 액상화 저항강도(CRR)를 산정하였다. 전단파 속도는 지진 발생 전 현장상태를 모사하고자 압밀 단계 종료 시점에서 측정한 값을 활용하였다. 시험을 통해 액상화 저항강도에 대한 두 가지 인자(입도분포, 상대밀도)의 영향을 확인하였으며 기존 문헌에서 제시된 타 사질토의 액상화 저항강도와의 비교를 통해 포항 모래의 액상화 저항강도를 정량적으로 평가하였다. 또한, 측정한 전단파 속도를 활용하여 실제 현장에서 사용되는 액상화 평가 곡선과의 비교를 통해 시험 결과의 신뢰성을 확인하였다.

• 한국임상약학회지
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• 제9권1호
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• pp.71-76
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• 1999

The stability of penicillin G potassium injection after reconstitution was evaluated in two different diluents of sodium chloride $0.9\%$ and dextrose $5\%$ in water stored at room temperature or refrigerated condition. The concentrations of penicillin G, stored for 24 hours at room temperature or for 10 days at refrigerated condition, were determined by HPLC. Also the pHs of the reconstituted solutions were monitored. The concentrations and pHs of penicillin G potassium 500,000 U/ml injection after reconstitution gradually decreased in all conditions. Stored at room temperature after reconstitution, a new peak which suspected as degradation products of penicillin G was detected in 5 hours in sodium chloride $0.9\%$, 4 hours in dextrose $5\%$ in water. At refrigerated condition, the new peak was detected in 4 days in both sodium chloride $0.9\%$ and dextrose $5\%$ in water. The degradation products of penicillin G allergy have been thought to be one of the substances responsible for evoking allergic reactions. In conclusion, the penicillin G potassium 500,000 U/ml injection after reconstitution was stable for 4 hours in sodium chloride $0.9\%$ 3 hours in dextrose $5\%$ in water solution at room temperature. At refrigerated condition, both solutions were stable for 3 days after reconstitution.

• Membrane and Water Treatment
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• 제8권4호
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• pp.381-393
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• 2017

The inorganic components in tobacco sheet extract have significant influence on the sensory taste of the cigars and the harmful component delivery in cigarette smoke. To identify the contributions of the divalent inorganic components on harmful components delivery in cigarette smoke, a self-made selective electrodialysis was assembled with monovalent ion-selective ion exchange membranes. The influences of current density and extract content on the desalination performance were investigated. Result indicates that the majorities chloride, nitrate, and sulfate ions were removed, comparing with 50-60% of potassium and only less than 10% of magnesium and calcium ions removed in the investigated current density. The permselectivity of the tested cations across the Selemion CSO cation exchange membranes follows the order: $K^+>Ca^{2+}>Mg^{2+}$. A current density of $15mA/cm^2$ is an optional choice by considering both the energy consumption and separation efficiency. When the extract contents are in the range of 7%-20%, the removal ratios the potassium ions are kept around 60%, while the removal ratios of the calcium and magnesium ions fluctuate in the range of 16-27% and 8-14%, respectively. The tobacco smoke experiments indicated that the divalent metal ions have dual roles for the harmful component delivery in cigarette smoke. The divalent potassium and calcium ions were unfavorable for the total particulate matter emission but beneficial to decrease the HCN delivery in the mainstream cigarette smoke. The selective electrodialysis is a robust technology to decrease the harmful component delivery in cigarette smoke.

• Archives of Pharmacal Research
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• 제29권4호
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• pp.339-342
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• 2006

A simple high performance liquid chromatographic (HPLC) method was developed for the determination of tolperisone in human plasma. Tolperisone and internal standard (chlorphenesin) were isolated from 1 mL of plasma using 8 mL of dichlormethane. The organic phase was collected and evaporated under nitrogen gas. The residue was then reconstituted with 300 mL aliquot of mobile phase and a 100 mL aliquot was injected onto the $C_{18}$ reverse-phased column. The mobile phase, $45\%$ methanol containing $1\%$ glacial acetic acid and $0.05\%$ 1-hexanesulfonic acid was run at a flow rate of 1 mL/min. The column effluent was monitored using UV detector at 260 nm. The retention times for tolperisone and the internal standard were approximately 7.1 and 8.4 min, respectively. The standard curve was linear with minimal intra-day and inter-day variability. The quantification limit of tolperisone in human plasma was 10 ng/ mL. The proposed method has been applied to the determination of pharmacokinetic profile of tolperisone in Koreans. The T max of tolperisone in Koreans $(0.94{\pm}0.42\;h)$ was not significantly differ from that reported in Europeans (0.5-1 h), but the mean half-life in Koreans $(1.14{\pm}0.27\;h)$ was shorter than that in Europeans $(2.56{\pm}0.2\;h)$. The proposed HPLC method is simple, accurate, reproducible and suitable for pharmacokinetic study of tolperisone.

• Molecules and Cells
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• 제44권9호
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• pp.647-657
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• 2021

As a pancreatic inflammatory marker, regenerating islet-derived protein 3A (Reg3A) plays a key role in inflammation-associated pancreatic carcinogenesis by promoting cell proliferation, inhibiting apoptosis, and regulating cancer cell migration and invasion. This study aimed to reveal a novel immuno-regulatory mechanism by which Reg3A modulates tumour-promoting responses during pancreatic cancer (PC) progression. In an in vitro Transwell system that allowed the direct co-culture of human peripheral blood-derived dendritic cells (DCs) and Reg3A-overexpressing/ silenced human PC cells, PC cell-derived Reg3A was found to downregulate CD80, CD83 and CD86 expression on educated DCs, increase DC endocytic function, inhibit DC-induced T lymphocyte proliferation, reduce IL-12p70 production, and enhance IL-23 production by DCs. The positive effect of tumour-derived Reg3A-educated human DCs on PC progression was demonstrated in vivo by intraperitoneally transferring them into PC-implanted severe combined immunodeficiency (SCID) mice reconstituted with human T cells. A Reg3A-JAK2/STAT3 positive feedback loop was identified in DCs educated with Reg3A. In conclusion, as a tumour-derived factor, Reg3A acted to block the differentiation and maturation of the most important antigen-presenting cells, DCs, causing them to limit their potential anti-tumour responses, thus facilitating PC escape and progression.

• 복식문화연구
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• 제29권4호
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• pp.572-584
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• 2021

The emergence of environmental and social issues has led to global discussions for the realization of sustainable development. The purpose of this study is to propose a method of sustainable fashion design using waste Hanbok, focusing on men's Hanbok with cultural values. The study utilizes literature research and fashion design development. From the literature study, reform was judged to be a higher concept encompassing reduction, recycling, and upcycling. Reduction is a design method through removal, and recycling design transforms from its original form into a completely different product. Upcycling design focuses on improvement and change in functionality. Accordingly, nine redesigns using men's Hanbok were developed from which three were produced. Consequently, the reduction design demonstrated a small range of variation without changing the item, and cultural sustainability was confirmed through the design that removed the components and recombined the Hanbok. Second, recycling redesign can be reconstituted into a different item. Third, upcycling enables various designs through module assembly, which prolongs the lifespan of the product and confirms its value as a raw material for waste Hanbok. This study is meaningful in realizing sustainable fashion and suggesting practical measures for the sustainability of Korean traditional culture and creative fashion design planning.

• 동양고전연구
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• 제63호
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• pp.221-252
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• 2016

본고에서는 유성기 음반과 관련하여 20세기 초 고전소설의 장르적 전환과 변모의 양상에 대하여 살펴보고자 하였다. 이를 위하여 먼저 유성기 음반에 수용된 고전소설의 현황을 파악하는 한편, 고전소설이 유성기 음반에 수용되면서 발생한 장르적 전환과 변모의 양상, 그리고 그것의 지향에 대하여 살펴보았다. 본고에서 살펴본 결과를 간단히 정리하면 다음과 같다. 첫째, 본고에서는 고전소설을 주 소재로 하여 녹음된 유성기 음반을 대상으로 하였다. 그리고 본 연구에서는 <숙영낭자전>, <심청전>, <장화홍련전>, <춘향전> 등을 비롯한 10종의 고전소설이 31종의 음반이 대상이 되었다. 둘째, 고전소설은 유성기 음반에 수용되면서 가요, 가요극, 극, 아동극, 영화설명, 판소리, 희극 등의 다양한 장르로 전환되었다. 그리고 그 과정에서 서사 전개가 인물 간의 대화를 중심으로 새롭게 구성되었다. 셋째, 고전소설이 유성기 음반으로 수용되면서 영화설명이나 근대극 등으로 재생산된 작품들은 고전소설이 본래 가지고 있던 문제의식과 가치 등을 유지함으로써 전통을 고수하고 있다. 반면 희극으로 재생산된 작품들은 본래의 문제의식과 가치를 고수하기보다는 당대 사회현상과 맞물려 가벼운 웃음을 추구하고 있다.

• 한국축산식품학회지
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• 제42권1호
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• pp.46-60
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• 2022

In this study, angiotensin-I-converting enzyme inhibitory (ACEI) activity was evaluated in fermented goat milk fermented by lactic acid bacteria (LAB) from fermented foods and breast milk. Furthermore, the potential for ACEI peptides was identified in fermented goat milk with the highest ACEI activity. The proteolytic specificity of LAB was also evaluated. The 2% isolate was inoculated into reconstituted goat milk (11%, w/v), then incubated at 37℃ until pH 4.6 was reached. The supernatant produced by centrifugation was analyzed for ACEI activity and total peptide. Viable cell counts of LAB and titratable acidity were also evaluated after fermentation. Peptide identification was carried out using nano liquid chromatography mass spectrometry (LC-MS/MS), and potential as an ACEI peptide was carried out based on a literature review. The result revealed that ACEI activity was produced in all samples (20.44%-60.33%). Fermented goat milk of Lc. lactis ssp. lactis BD17 produced the highest ACEI activity (60.33%; IC₅₀ 0.297±0.10 mg/mL) after 48 h incubation, viable cell counts >8 Log CFU/mL, and peptide content of 4.037±0.27/mL. A total of 261 peptides were released, predominantly derived from casein (93%). The proteolytic specificity of Lc. lactis ssp. lactis BD17 through cleavage on the amino acid tyrosine, leucine, glutamic acid, and proline. A total of 21 peptides were identified as ACEI peptides. This study showed that one of the isolates from fermented food, namely Lc. lactis ssp. lactis BD17, has the potential as a starter culture for the production of fermented goat milk which has functional properties as a source of antihypertensive peptides.

• 디지털융복합연구
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• 제20권2호
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• pp.361-366
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• 2022

최근 융합 미디어의 발전에 따라 디지털 애니메이션 산업은 Intellectual Property(지식 재산) 캐릭터를 중심으로 다양한 산업분야에서 많은 콘텐츠를 개발하였다. 광고 및 홍보물 뿐 아니라 Intellectual Property 디지털 애니메이션도 마니아층의 지지와 사랑을 받았다. 우수한 Intellectual Property 캐릭터 이미지가 상업적으로 큰 경제 수익을 창출한다는 통계도 있다. 본 연구는 일본, 미국, 중국의 세 개 대표적인 Intellectual Property 애니메이션 사례를 선택하여 각각 Intellectual Property 애니메이션 캐릭터 이미지 재활용 및 시대적 기술과 문화예술 스타일을 결합해 전통문화 IP 캐릭터를 현대적 캐릭터 디자인으로 재구성하는 두 측면에서 분석하였다. 본 논문 연구를 통해 캐릭터 이미지 활용 방식에 따라 IP 애니메이션의 확장 가능성을 알 수 있었다. 디지털 애니메이션 제작 시 Intellectual Property에 대한 중요성을 인지하고 캐릭터 개발 시 참고 자료가 되기를 기대한다.

• 한국지반공학회논문집
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• 제22권12호
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• pp.57-65
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• 2006

낙동강 하구지역에는 부산점토라고 불리는 연약점토가 두텁게 분포하고 있다. 과거 10년 동안에 대단위 지반개량 사업이 수행되어 왔지만, 주로 시료교란 때문에 압밀침하량과 시간을 아주 과소평가하여 왔었다. 이를 극복하기 위하여 부산점토에 대한 체계적인 지반조사에 의하여 압축특성을 규명할 필요가 요구되었다. 따라서 본 연구에서는 해안지역의 두 현장에서 개선된 시료채취기술을 적용하여 얻어진 시료에 대하여 지질조사, 불교란 및 교란 시료에 대한 압밀실험이 수행되었다. 이 결과를 이용하여 각종 압축정수의 산정과 그들의 상관성을 규명하였으며, 특히 퇴적환경에 따라 물리적 특성, 구조수준, 교란도 및 압축정수의 변화를 분석하였다.