• Smart Structures and Systems
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• v.16 no.1
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• pp.101-139
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• 2015

In this paper, it is aimed to investigate the restoration effect on the structural behavior of masonry arch bridges. Dandalaz masonry arch bridge located on the 4km east of Karacasu town of Aydin, Turkey is selected as a numerical example. The construction year of the bridge is not fully known, but the bridge is dated back to 15th century. Considering the current situation, it can be easily seen that the structural elements such as arch, side walls and timber blocks are heavily damaged and the bridge is unserviceable. Firstly finite element model of the bridge is constituted to reflect the current situation (before restoration) using building survey drawings. After, restoration project is explained and finite element model is reconstituted (after restoration). The structural responses of the bridge are obtained before and after restoration under dead load, live load and dynamic earthquake loads. For both conditions, maximum displacements, maximum-minimum principal stresses and maximum-minimum elastic strains are given with detail using contours diagrams and compared with each other to determine the restoration effect. From the study, it can be seen that the maximum internal forces are consisted under dynamic loads before and after restoration. Also, the restoration projects and studies have important and positive effects on the structural response of the bridge to transfer these structures to future.

• Geomechanics and Engineering
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• v.18 no.3
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• pp.299-313
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• 2019

This research investigated the nonlinear compressibility, permeability, the yielding due to structural degradation and their effects on consolidation behavior of structured soft soils. Based on oedometer and hydraulic conductivity test results of natural and reconstituted soft clays, linear log (1+e) ~ $log\;{\sigma}^{\prime}$ and log (1+e) ~ $log\;k_v$ relationships were developed to capture the variations in compressibility and permeability, and the yield stress ratio (YSR) was introduced to characterize the soil structure of natural soft clay. Semi-analytical solutions for one-dimensional consolidation of soft clay under time-dependent loading incorporating the effects of soil nonlinearity and soil structure were proposed. The semi-analytical solutions were verified against field measurements of a well-documented test embankment and they can give better accuracy in prediction of excess pore pressure compared to the predictions using the existing analytical solutions. Additionally, parametric studies were conducted to analyze the effects of YSR, compression index (${\lambda}_r$ and ${\lambda}_c$), and permeability index (${\eta}_k$) on the consolidation behavior of structured soft clays. The magnitude of the difference between degree of consolidation based on excess pore pressure ($U_p$) and that based on strain ($U_s$) depends on YSR. The parameter ${\lambda}_c/{\eta}_k$ plays a significant role in predicting consolidation behavior.

• International journal of thyroidology
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• v.11 no.2
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• pp.160-166
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• 2018

Background and objectives: Salivary hypofunction is one of the common side effects after radioiodine therapy, and its pathophysiology is salivary ductal stenosis resulting from ductal cell injury. This study aimed to develop the functional culture environment of human parotid gland ductal cells in in vitro three-dimensional perfusion culture system. Materials and Methods: We compared plastic dish culture method and three-dimensional culture system containing Matrigel and nanofiber. Morphogenesis of reconstituted salivary structures was assessed by histomorphometry. Functional characteristics were assessed by immunohistochemistry and reverse transcription polymerase chain reaction (aquaporin 5, CK7, CK18, connexin 43, and p21). In addition, we designed the media perfusion culture system and identified higher rate of cell proliferation and expression of connexin 43 in perfusion system comparing to dish. Results: Human parotid ductal cells were well proliferated with the ductal cell characters under environment with Matrigel. In the presence of Matrigel, aquaporin 5, CK18 and connexin 43 were more expressed than 2D dish and 3D nanofiber setting. In the media perfusion culture system, ductal cells in 3D culture media showed higher cells count and connexin 43 expression compared to 2D dish. Conclusion: This in vitro ductal cell perfusion culture system using Matrigel could be used to study for radioiodine induced sialadenitis model in vivo.

• Journal of Apiculture
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• v.33 no.4
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• pp.277-282
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• 2018

Ethanol extracted propolis (EEP) was mixed with honey (honeypolis) to dissolve well in water and in vitro skin irritation test was conducted. In vitro method is designed to predict and classify the skin irritation potential of a chemical by assessment of its effect on $EpiDerm^{TM}$, a reconstituted three-dimensional human epidermis model. Cytotoxicity is expressed as the reduction of mitochondrial dehydrogenase activity measured by formazan production from MTT after a 60 min exposure period. In this study under the given conditions honeypolis showed no irritant effects. Honeypolis meets acceptance criteria if: mean absolute OD 570 nm of the three negative control tissues is ${\geq}0.8$ and ${\leq}2.8$, mean relative tissue viability of the three positive control tissues is ${\leq}20%$, standard deviation of relative tissue viability obtained from each three concurrently tested tissues is ${\leq}18%$. Honeypolis is therefore classified as "non-irritant" in accordance with UN GHS "No Category".

• Journal of English Language & Literature
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• v.64 no.3
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• pp.483-530
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• 2018

Unpacking and dispersing rights of various kinds formerly enjoyed by a selected few has been the constant motivation behind the democratization and modernization of human society. Human rights and later civil rights have continuously been constituted and reconstituted in response to the demands of the laboring class, slaves, women, subalterns, animals, and things, expanding beyond the boundaries of class, race, nation, sexuality, gender, species and organism. Calling attention to the ways in which literary and cultural texts have narrated rights so as to inscribe these human, nonhuman, and inhuman demands. Narrating rights offer opportunities to interrogate the lasting contributions of English language and literature to questioning, reforming, and practicing rights. The interrogation is particularly pertinent in this age in which revised and dispersed rights are creating new conflicts, requiring them to be narrated differently and imaginatively so as to allow all the parties in conflict to participate in working out the conflicts. With the 2017 theme of "Literature and Human Rights," JELL editorial collective hope to explore the relationship between literature and human rights in its multiple simultaneous, and plural manifestations in an open platform. "Narrating Rights" is a double-edged task that, on one hand, reflects the singular life conditions or contexts of a human, inhuman or nonhuman being and, on the other hand, aspires to the perpetual process of rights' universal application. Eleven out of all the keynote speakers at the 2017 ELLAK Convention were invited to this roundtable on Literature and Human Rights. The following transcription includes the dialogues of the eleven discussants.

• BMB Reports
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• v.54 no.3
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• pp.157-163
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• 2021

The transient interactions between cellular components, particularly on membrane surfaces, are critical in the proper function of many biochemical reactions. For example, many signaling pathways involve dimerization, oligomerization, or other types of clustering of signaling proteins as a key step in the signaling cascade. However, it is often experimentally challenging to directly observe and characterize the molecular mechanisms such interactions-the greatest difficulty lies in the fact that living cells have an unknown number of background processes that may or may not participate in the molecular process of interest, and as a consequence, it is usually impossible to definitively correlate an observation to a well-defined cellular mechanism. One of the experimental methods that can quantitatively capture these interactions is through membrane reconstitution, whereby a lipid bilayer is fabricated to mimic the membrane environment, and the biological components of interest are systematically introduced, without unknown background processes. This configuration allows the extensive use of fluorescence techniques, particularly fluorescence fluctuation spectroscopy and single-molecule fluorescence microscopy. In this review, we describe how the equilibrium diffusion of two proteins, K-Ras4B and the PH domain of Bruton's tyrosine kinase (Btk), on fluid lipid membranes can be used to determine the kinetics of homodimerization reactions.

• Geotechnical Engineering
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• v.10 no.4
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• pp.167-180
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• 1994

A series of long term consolidation tests were conducted under loading -unloading and loading(pc) -unloading(p.) -reloading(p,) conditions using reconstituted clay in order to investigate the effect of stress history on secondary consolidation characteristics and the applicability of the secondary consolidation model suggested by Bjerrum to overconsolidated clays. According to the test results, the secondary compression settlement affected by the stress history in the first half of experimental period and the coefficient of secondary compression, C‥‥ is dependent on overconsolidation ratio, OCR(p,1 p.), maBium OCR (p./p.), and unloading duration time. Moreover the coefficient of secondary consolidation in the latter half of experimental period Cn is mainly affected by OCR and it gradually reduces with OCR increment. Finally the comparison of the experimental results with the Bjerrum model indicates that the Bjerrum model can be applied beyond certain range of stress history in the overconsolidated clay.

• Asian-Australasian Journal of Animal Sciences
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• v.14 no.3
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• pp.351-357
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• 2001

The rapid formation of a cream line cannot be observed in raw goat's milk standing at a low temperature. Although the poor creaming ability of goat's milk has been considered to be due to the small size of milk fat globules and the lack of euglobulin capable of being adsorbed on milk fat globules, there is much left to study. The present work attempted to elucidate a factor for poor creaming ability of goat's milk. The creaming ability of the experimental milks reconstituted from creams and skim milks separated from cow's milk or goat's milk was measured by the volume of the cream layer and the fat content of bottom layer. The polypeptides composition of the P1 the fraction (i.e., the high molecular weight fraction eluted near the void volume obtained by the gel filtration of whey) and milk fat globule membrane prepared from both milks were compared. It was found that the promotion of creaming originated from goat's skim milk was lower than that from cow's skim milk. The P1 fraction in goat's skim milk was less than that in cow's skim milk. The polypeptide (M.W. $4.3{\times}10^4$), found in the P1 fraction of cow's milk was not found in the P1 fraction of goat's milk. It is suggested that the poor creaming ability of goat milk is caused mainly by the difference from cow milk in the amount and the composition of the P1 fraction.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.13 no.11
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• pp.5033-5043
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• 2012

The purpose of this study is to complement the problem of lecture evaluation items and to improve the lecture evaluation items to fit to original purpose of lecture evaluation to enhance the lecture's quality. For this, meanings of good teaching, lecture evaluation domains and elements of preceding study, the contents and problems of lecture evaluation tools in A college were searched, and in this foundation, an improved lecture evaluation tool was suggested. As the result of this study, important features of the improved tool are followed: First, the compositions of evaluation domains, evaluation elements, and evaluation items were reconstituted. Second, to acquire the important information for the better lecture, the items were devised according to the features of good teaching in colleges. Third, the items concerned of evaluation elements which is commonly suggested by the lecture evaluation tools of preceding study were developed. Forth, if there is the information which is required for the enhancement of the lecture quality, the items were developed though the result could not be presented in the arithmetical means. Fifth, evaluation items to improve the problems of lecture evaluation tools which had been carried out in A college were developed.

• Journal of the Korean Geotechnical Society
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• v.31 no.9
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• pp.17-27
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• 2015

We perform a series of experimental tests to evaluate whether the shear strength of clean sands can be reliably predicted from shear wave velocity. Isotropic drained triaxial tests on clean sands reconstituted at different relative densities are performed to measure the shear strength and bender elements are used to measure the shear wave velocity. Laboratory tests reveal that a correlation between shear wave velocity, void ratio, and confining pressure can be made. The correlation can be used to determine the void ratio from measured shear wave velocity, from which the shear strength is predicted. We also show that a unique relationship exists between maximum shear modulus and effective axial stress at failure. The accuracy of the equation can be enhanced by including the normalized confining pressure in the equation. Comparisons between measured and predicted effective friction angle demonstrate that the proposed equation can accurately predict the internal friction angle of granular soils, accounting for the effect of the relative density, from shear wave velocity.