• 문화기술의 융합
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• 제5권4호
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• pp.413-420
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• 2019

본 연구의 목적은 기존의 body fat mass 변수와 고콜레스테롤혈증의 연관성연구를 벗어나, 머신러닝기법을 기반으로 body fat mass 변수들의 조합을 이용하여 고콜레스테롤혈증 예측 모델을 개발하는 것이다. 이러한 연구를 위하여 국민건강영양조사 데이터를 기반으로 두 가지 variable selection 메소드와 머신러닝 알고리즘을 이용하여 총 6개의 모델을 생성하였고 질병 예측력을 비교분석하였다. 여러 body fat mass 관련 변수들 중에서 몸통지방량 변수가 고콜레스테롤혈증 예측력이 가장 우수한 변수인 것을 밝혀내었고, 머신러닝 기반 예측모델들 중에서 correlation-based feature subset selection 기반 naive Bayes 알고리즘을 이용한 모델이 0.739의 the area under the receiver operating characteristic curve 값과 0.36의 Matthews correlation coefficient 값을 얻었다. 이러한 연구의 결과는 향후 국내외 대규모 스크리닝 및 대중보건 연구에서 질병예측분야의 중요정보로 활용될 것으로 예상한다.

• Safety and Health at Work
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• 제1권1호
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• pp.69-79
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• 2010

Objectives: Various cytokines induced by inhalation of coal dust may mediate inflammation and lead to tissue damage or fibrosis, such as coal workers' pneumoconiosis (CWP). Methods: To investigate the relevance of serum cytokines in CWP, the levels of serum interleukin-8 (IL-8) and tumor necrosis factor-alpha (TNF-${\alpha}$) as CWP biomarkers in 110 retired coal miners (22 controls and 88 CWP subjects) were related to cross sectional findings and 1-year progressive changes of the pneumoconiosis. Progressive changes of CWP were evaluated by paired comparison of chest radiographs. Analysis by a receiver operating characteristic curve assessed the biomarker potential of each cytokine. Results: The mean serum IL-8 level was significantly higher in CWP compared to controls and IL-8 levels correlated with the degree of CWP. The median serum TNF-${\alpha}$ level was significantly higher in subjects with progressive CWP compared to subjects without CWP progression. The area under the ROC curve for IL-8 (0.70) and TNF-${\alpha}$ (0.72) for CWP identification and progression, respectively, indicated the biomarker potential of the two cytokines. Serum cutoff values of IL-8 and TNF-${\alpha}$ were 11.63 pg/mL(sensitivity, 69%; specificity, 64%) and 4.52 pg/mL (sensitivity, 67%; specificity, 79%), respectively. Conclusion: The results suggest that high levels of serum IL-8 are associated with the presence of CWP and those of serum TNF-${\alpha}$ are associated with the progression of CWP.

• Korean Journal of Radiology
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• 제22권3호
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• pp.435-441
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• 2021

Objective: To evaluate the usefulness of the ventricular volume percentage quantified using three-dimensional (3D) brain computed tomography (CT) data for interpreting serial changes in hydrocephalus. Materials and Methods: Intracranial and ventricular volumes were quantified using the semiautomatic 3D threshold-based segmentation approach for 113 brain CT examinations (age at brain CT examination ≤ 18 years) in 38 patients with hydrocephalus. Changes in ventricular volume percentage were calculated using 75 serial brain CT pairs (time interval 173.6 ± 234.9 days) and compared with the conventional assessment of changes in hydrocephalus (increased, unchanged, or decreased). A cut-off value for the diagnosis of no change in hydrocephalus was calculated using receiver operating characteristic curve analysis. The reproducibility of the volumetric measurements was assessed using the intraclass correlation coefficient on a subset of 20 brain CT examinations. Results: Mean intracranial volume, ventricular volume, and ventricular volume percentage were 1284.6 ± 297.1 cm³, 249.0 ± 150.8 cm³, and 19.9 ± 12.8%, respectively. The volumetric measurements were highly reproducible (intraclass correlation coefficient = 1.0). Serial changes (0.8 ± 0.6%) in ventricular volume percentage in the unchanged group (n = 28) were significantly smaller than those in the increased and decreased groups (6.8 ± 4.3% and 5.6 ± 4.2%, respectively; p = 0.001 and p < 0.001, respectively; n = 11 and n = 36, respectively). The ventricular volume percentage was an excellent parameter for evaluating the degree of hydrocephalus (area under the receiver operating characteristic curve = 0.975; 95% confidence interval, 0.948-1.000; p < 0.001). With a cut-off value of 2.4%, the diagnosis of unchanged hydrocephalus could be made with 83.0% sensitivity and 100.0% specificity. Conclusion: The ventricular volume percentage quantified using 3D brain CT data is useful for interpreting serial changes in hydrocephalus.

• 한국한의학연구원논문집
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• 제17권2호
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• pp.107-113
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• 2011

Objectives : Sasang typology is extensively studied for the Sasang constitution diagnosis objectification with various data, for example, questionaires, reference materials, etc and analyzed with the several statistical methods. In this study, we used ROC-curve (Receiver Operating Characteristic curve) analysis to diagnose Sasang constitution, which is a kind of epidemiologic research methods and is away from traditional statistical methods. Methods : We collected personality questionnaire which consists of 15 items, from 24 oriental medical clinics. We analyzed the sensitivity and specificity using ROC curve method based on the score of personality questionnaire and also investigated classification accuracy and cut-off value of Sasang constitution. Results : The AUC (area under the ROC curve) value was 0.508 (p=.5511) for Taeeumin, 0.629 (p<.0001) for Soeumin and 0.604(p<.0001) for Soyangin, respectively. so the classification accuracy for Soeumin was highest Soeumin for over 30 points and Soyangin for below 28 points respectively. Conclusions : We suggest that Taeeumin is not classified easily in the ROC-curve analysis. We may classify Soeumin and Soyangin but the accuracy of Sasang constitutional diagnosis is still low.

• 한국전문물리치료학회지
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• 제23권4호
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• pp.63-70
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• 2016

Background: The Pediatric Balance Scale (PBS) and the Fullerton Advanced Balance (FAB) scale were used to assess balance function in patients with balance problem. These multidimensional clinical balance scales provide information about potential risk factors for falls. Objects: The purpose of this study was to investigate and compare the predictive properties of the PBS and FAB scales relative to fall risk in children with cerebral palsy (CP) using a receiver operating characteristic analysis. Methods: In total, 49 children with CP (boy=21, girl=28) who were diagnosed with level 1 or 2 according to the Gross Motor Function Classification System participated in this study. The PBS and FAB were performed, and verified cut-off score, sensitivity, specificity, and the area of under the curve (AUC). Results: In this study, the PBS scale was as a predictive measure of fall risk, but the FAB was not significant in children with CP. A cut-off score of 45.5 points provided optimal sensitivity of .90 and specificity of .69 on the PBS, and a cut-off score of 21.5 points provided optimal sensitivity of .90 and specificity of .62 on the FAB. Both scales showed moderately accurate of AUC with .79 and .76, respectively. Conclusion: The PBS is a useful screening tool for predicting fall risk in children with cerebral palsy, and those who score 45.5 or lower indicate a high risk for falls and are in need of balance intervention.

• Asian Pacific Journal of Cancer Prevention
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• 제14권3호
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• pp.1803-1806
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• 2013

Purpose: Carbohydrate antigen (CA) 242 is inversely related to prognosis in many cancers. However, few data regarding CA 242 in esophageal cancer (EC) are available. The aim of this study was to determine the prognostic value of CA 242 and propose an optimum cut-off point in predicting survival difference in patients with esophageal squamous cell carcinoma (ESCC). Methods: A retrospective analysis was conducted of 192 cases. A receiver operating characteristic (ROC) curve for survival prediction was plotted to verify the optimum cuf-off point. Univariate and multivariate analyses were performed to evaluate prognostic parameters for survival. Results: The positive rate for CA 242 was 7.3% (14/192). The ROC curve for survival prediction gave an optimum cut-off of 2.15 (U/ml). Patients with CA 242 ${\leq}$ 2.15 U/ml had significantly better 5-year survival than patients with CA 242 >2.15 U/ml (45.4% versus 22.6%; P=0.003). Multivariate analysis showed that differentiation (P=0.033), CA 242 (P=0.017), T grade (P=0.004) and N staging (P<0.001) were independent prognostic factors. Conclusions: Preoperative CA 242 is a predictive factor for long-term survival in ESCC, especially in nodal-negative patients. We conclude that 2.15 U/ml may be the optimum cuf-off point for CA 242 in predicting survival in ESCC.

• 한국보건간호학회지
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• 제32권2호
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• pp.304-318
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• 2018

Purpose: This study examined the characteristic of the Injury Severity Score (ISS) of Korean geriatric patients with a traumatic injury in a nationally representative sample to determine the optimal cutoff of ISS of mortality according to age. Methods: The subjects were 3,018 non-elderly patients and 1,584 elderly patients with an ISS and Korean Triage and Acuity Scale (KTAS) in 2016 from the data of the Health Insurance Review and Assessment Service. The traumatic characteristics of the elderly and non-elderly were compared by stratifying the ISS. Receiver Operating Characteristic (ROC) curve analysis was used to find the optimal cutoff of ISS of mortality according to age. Results: The elderly were more prone to severe trauma than the non-elderly were. The distribution of KTAS grades was lower, even though the severity of ISS was as high as that of the non-elderly. The optimal cutoff score of the ISS for mortality in the ROC curve was lower in elderly over 65 years than in the other age group. Conclusion: The elderly are more prone to severe trauma and death than non-elderly, even though their ISS is low. Therefore, a strategy to prevent elderly from experiencing serious trauma and managing their geriatric trauma actively is needed.

• 기본간호학회지
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• 제12권3호
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• pp.347-353
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• 2005

Purpose: The purpose of this study was to identify whether neck circumference might be correlated with other obesity indices and to determine the neck circumference cutoff level for obesity in female college students. Method: The data were obtained by measuring other anthropometric indices including BMI and neck circumference from 325 female college students in J city, Chungbuk Province. Receiver Operating Characteristic curve(ROC curve) analysis was used to find the optimal neck circumference cutoff level against BMI $25kg/m^2$. Results: The mean BMI was $21.4kg/m^2$, and the prevalence of obesity was 12.6%. Neck circumference was significantly correlated with body weight, BMI, waist circumference, hip circumference, waist to hip ratio, % body fat, triceps skinfold thickness, systolic and diastolic blood pressure. Neck circumference of 31.95cm was the best cutoff level for determining female students with a BMI over $25kg/m^2$, and the characteristic was acceptable with 97.6% sensitivity and 85.6% specificity. Conclusions: Neck circumference was strongly correlated with the other conventional obesity indices. Female college students with neck circumference over 31.95cm require an additional evaluation of obesity.

• 한국측량학회지
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• 제36권2호
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• pp.51-58
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• 2018

최근, 다양한 위성센서가 개발되면서 다시기 위성영상의 취득이 용이해지고 있다. 이에 따라, 재난/재해, 국토모니터링 등과 같은 활용분야에 다시기 위성영상을 적용하기 위한 변화탐지 기법에 대한 연구들이 수행되고 있다. 특히, 빠른 시간 내에 변화지역의 추출이 가능한 무감독 변화탐지 기법의 개발과 관련된 연구들이 수행되고 있지만, 계절적 변화 등과 같은 방사적 차이로 인해 오탐지가 발생하는 단점이 있다. 따라서, 본 연구에서는 무감독 변화탐지 기법 중의 하나인 $S^2CVA$ 기법을 적용하여 생성한 변화방향 벡터를 이용하여 계절적 영향으로 인한 오탐지를 감소시키고자 하였다. 이를 위하여, 동일한 계절을 가지는 RapidEye 위성영상과 다른 계절에 촬영된 RapidEye 위성 영상에 $S^2CVA$ 기법을 적용하였으며, $S^2CVA$의 변화방향벡터가 계절적 영향에 따른 오탐지를 제거할 수 있는지를 분석하였다. 정량적 평가를 위해 변화탐지 결과의 ROC 곡선과 AUC 분석을 통해 기존의 방법에 비해 변화탐지 성능이 향상된 것을 확인하였다.

• 대한영상의학회지
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• 제81권5호
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• pp.1164-1174
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• 2020

목적 수술 전 초음파 검사에서 갑상선 종양의 재발을 예측할 수 있는 심층 학습 모델을 개발하고자 한다. 대상과 방법 수술 전 초음파에서 병리학적으로 확진된 갑상선 수술을 받은 229명의 환자(남성:여성 = 42:187, 평균 연령, 49.6세)의 대표적인 초음파 이미지를 포함시켰다. 각각 대표적인 횡축 또는 종축 초음파 이미지가 선택되었다. 신경 네트워크용 Python 2.7.6 및 Keras 2.1.5, convolutional neural network을 사용한 심층 학습이 사용되었다. 재발한 환자와 재발이 없는 환자의 임상 및 조직학적 특징을 비교하였다. 그룹 간의 심층 학습 모델의 receiver operating characteristic curve 곡선 아래의 영역은 재발 갑상선암을 예측하기 위한 심층 학습 모델의 예측에 사용되었다. 결과 전체 환자 229명 중 49명이 종양 재발(21.4%)을 보였다. 종양의 크기, 다원성은 재발이 없는 군과 재발 군에서 유의한 차이가 있었다(p < 0.05). 재발성 갑상선암 예측을 위한 심층 학습 모델의 전반적인 평균 area under the curve (이하 AUC) 값은 0.9 ± 0.06이었다. 평균 AUC는 macrocarcinoma에서 0.87 ± 0.03, microcarcinoma에서 0.79 ± 0.16이었다. 결론 갑상선암의 초음파 이미지를 이용한 심층 학습 모델로 갑상선암 재발의 예측 모델 구축의 가능성을 보여주었다.