• 제목/요약/키워드: rearrangement

검색결과 816건 처리시간 0.026초

Fluorescence in situ hybridization (FISH)를 이용하여 분석한 Bleomycin에 의한 사람 림프구의 염색체 재배열 (Chromosome Rearrangements Detected by Fluorescence in situ Hybridization in Human Lymphocyte Exposed to Bleomycin)

  • 손은희;정경인;정해원
    • 한국환경성돌연변이발암원학회지
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    • 제17권1호
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    • pp.12-16
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    • 1997
  • Chromosome rearrangement induced by bleomycin were identified by fluorescence in situ hybridization with probe for chromosome 4. The frequency of color junctions, translocations, dicentric and acenttic fragments increased with bleomycin dose. Different types of balanced translocation and dicentric were scored and compared. The frequency of cells exhibiting multiple aberration was higher compared to that of cells exposed to Gamma radiation suggesting that effect of bleomycin might be similar to that of high LET radiation.

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A Sub-field Rearrangement Driving Method for Reducing Dynamic False Contour in Plasma Display Panels

  • Lee, Seung-Yong;Choi, Byong-Deok
    • Journal of Information Display
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    • 제7권1호
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    • pp.30-34
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    • 2006
  • A sub-field rearrangement driving method has been proposed to reduce a DFC (Dynamic False Contour) phenomenon in plasma display panels. The proposed driving method expresses 256 gray levels with 16 sub-fields, while conventional one uses only 8 sub-fields. Notwithstanding the increase in the number of sub-fields, the display time is similar to the conventional 8 sub-fields driving method by appropriate choosing selective writing and selective erasing for sub-fields.

The First Synthesis of Dually Modified Southern-Mimicking Nucleoside: 4'-Methyl Branched and Bicyclo [3.1.0] Hexane Locked Nucleoside

  • Kim, Kwan-Woo;Hong, Joon-Hee
    • Bulletin of the Korean Chemical Society
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    • 제25권5호
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    • pp.668-672
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    • 2004
  • This paper reports the stereoselective synthesis of a novel nucleoside, 4'-methyl branched and bicyclo [3.1.0] hexane locked-nucleoside 12, using a sequential [3,3]-sigmatropic rearrangement/carbene cycloaddition reaction/Curtius reaction strategy with a high stereoselectivity.

Practical Hofmann Rearrangement

  • Jew, Sang-Sup;Park, Hyeung-Geun;Kang, Myoung-hee;Lee, Tae-hee;Cho, Youn-sang
    • Archives of Pharmacal Research
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    • 제15권4호
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    • pp.333-335
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    • 1992
  • Hofmann rearrangement of a series of primary aliphatic and aromatic carboxamides 1a-1m with HgO-NBS (or dibromantin)R'OH-DMF gives corresponding carbamates 2a-2m in excellent yields.

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옥시인돌과 이사틴 유도체들의 합성 (Synthesis of Oxindole and Isatin Derivatives)

  • 김병소
    • 한국산업융합학회 논문집
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    • 제6권2호
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    • pp.123-129
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    • 2003
  • Oxindoles(6a-g) are obtained by rhodium(II)-catalyzed Wolff rearrangement of diazoquinolinediones in moderate yields. Treatment of 6a-g oxindole derivatives reacted with CAN in acetonitrile at room temperature to gave 7a-g isatins in good yields. The structures of these compound were identified by MP, IR and NMR-spectra.

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Synthesis and Antiviral Activity of Novel Anomeric Branched Carbocyclic Nucleosides

  • Kim, Ai-Hong;Hong, Joon-Hee
    • Archives of Pharmacal Research
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    • 제28권10호
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    • pp.1105-1110
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    • 2005
  • Novel anomeric branched carbocyclic nucleosides were synthesized from 1,3-dihydroxy acetone. 4'-Hydroxymethyl was installed by [3,3]-sigmatropic rearrangement reaction and 1'-methyl group was introduced by carbonyl addition of methylmagnesium bromide. The coupling of nucleosidic bases and desilylation afforded a series of novel nucleosides. The synthesized compounds $16{\~}19$ were evaluated for their antiviral activity against HIV-1, HSV-1, HSV-2, and EMCV. Compounds 16 and 19 exhibit toxicity non-related to any anti-HIV-1 activity.

Synthsis and Antiviral Evaluation of Novel 3'-and 4 -Doubly Branched Carbocyclic Nucleosides as Potential Antiviral Agents

  • Hong, Joon-Hee
    • Archives of Pharmacal Research
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    • 제26권12호
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    • pp.1109-1116
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    • 2003
  • A series of 3'- and 4'-branched carbocyclic nucleosides 25, 26, 27, 28, 29 and 30 were synthesized starting from simple acyclic ketone derivatives. The construction of the required quaternary carbon was made using a [3,3]-sigmatropic rearrangement. In addition, the installation of a methyl group in the 3'-position was accomplished using a Horner-Wadsworth-Emmons (HWE) reaction with triethyl 2-phosphonopropionate. Bis-vinyl was successfully cyclized using a Grubbs' catalyst (Ⅱ). Natural bases (adenine, cytosine, uracil) were efficiently coupled with the use of a Pd(0) catalyst.