• 동의생리병리학회지
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• 제22권6호
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• pp.1557-1561
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• 2008

Red ginseng possibly has new ingredients converted during steaming and dry process from fresh ginseng. Kujeungkupo method which means 9 repetitive steamings and dryings process was used for the production of red ginseng from 6-year old ginseng roots. Saponin was extracted from each red ginseng produced at the 1st, 3rd, 5th, 7th, and 9th during the steaming and drying treatment, and we analyzed saponin content with TLC. Minor saponins, such as ginsenoside-Rg3, -Rh2, compound K, and F2, increased as the process time of steaming and drying, but major saponins (ginsenoside-Rb1, -Rb2, -Rc, -Rd, -Re, -Rf, -Rg1) were decreased. Major saponins were yet observed almost at the 1st process, then degraded as the increasing time of steaming and drying process. Especially, ginsenoside-Re and -Rg were observed as considerable amount after the 1st treatment, but there were no trace of them after the 9th treatment. Ginsenoside-Rg1, -Rb2, and -Rb1 were also reduced remarkedly by 96.6%, 96%, and 92.3%, respectively. Minor saponins were increased significantly, especially for ginsenoside-Rg3 and ginsenoside-F2. These results suggest that Kujeungkupo method is the very useful method for the production of minor ginsenoside-Rg3 and -Rh2.

• 대한수의사회지
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• 제29권11호
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• pp.669-676
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• 1993

• Smart Structures and Systems
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• 제14권4호
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• pp.595-615
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• 2014

This study aims to investigate the relationship between structural damage and sensitivity indices using the Hilbert-Huang transform (HHT) method. Two damage detection indices are proposed: the ratio of bandwidth (RB), and the ratio of effective stiffness (RES). The nonlinear four bays multiple degree of freedom models with various predominant frequencies are constructed using the SAP2000 program. Adjusted PGA earthquake data (Japan 311, Chi-Chi 921) are used as the excitations. Next the damage detection indices obtained using the HHT and the fast Fourier transform (FFT) methods are evaluated based on the acceleration responses of the structures to earthquakes. Simulation results indicate that, the column of the 1 st floor is the first yielding position and the RB value is changed when the RES<90% in all cases. Moreover, the RB value of the 1 st floor changes more sensitive than those from the top floor. In addition, when the structural response is nonlinear (i.e., RES<100%), the RB and the RES curves indicate the incremental change in the HHT spectra. However, the same phenomenon can be found from FFT spectra only when the stiffness reduction is large enough. Therefore, the RB estimated from the smoothed HHT spectra is an effective and sensitive index for detecting structural damage.

• 한국지진공학회논문집
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• 제6권4호
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• pp.39-49
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• 2002

본 연구에서는 저경도 고무받침 시험체의 다양한 특성실험을 통하여 저경도 고무받침의 특성을 파악하였다. 고무받침의 파악하고자 하는 특성은 변위 의존성, 반복재하특성, 진동수 의존성, 면압 의존성, 온도 의존성, 극한전단특성, 수직강성 및 전단변형능력 등이다. 특성실험결과, 저경도 고무받침의 특성치는 변위와 면압의 영향을 크게 받는 것으로 나타났으며, 진동수가 증가할수록 유효강성과 등가감쇠비가 조금 증가하며, 반복재하의 영향을 거의 받지 않았다. 그리고 대변형에 의해 변형경화 영역을 경험한 고무받침은 전단탄성계수가 저하되나, 시간이 경과하면서 일부 회복됨을 확인하였다. 끝으로, 전단파괴실험을 수행하였으며, 축소 시험체의 경우에 전단파괴가 전단변형률 490% 근처에서 진행되었고 실물의 경우에는 430%에서 진행되었다

• Journal of Ginseng Research
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• 제46권1호
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• pp.104-114
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• 2022

Background: Abnormalities of myelin, which increases the efficiency of action potential conduction, are found in neurological disorders. Korean Red Ginseng (KRG) demonstrates therapeutic efficacy against some of these conditions, however effects on oligodendrocyte (OL)s are not well known. Here, we examined the effects of KRG-derived components on development and protection of OL-lineage cells. Methods: Primary OL precursor cell (OPC) cultures were prepared from neonatal mouse cortex. The protective efficacies of the KRG components were examined against inhibitors of mitochondrial respiratory chain activity. For in vivo function of Rb1 on myelination, after 10 days of oral gavage into adult male mice, forebrains were collected. OPC proliferation were assessed by BrdU incorporation, and differentiation and myelination were examined by qPCR, western blot and immunocytochemistry. Results: The non-saponin promoted OPC proliferation, while the saponin promoted differentiation. Both processes were mediated by AKT and extracellular regulated kinase (ERK) signaling. KRG extract, the saponin and non-saponin protected OPCs against oxidative stress, and both KRG extract and the saponin significantly increased the expression of the antioxidant enzyme. Among 11 major ginsenosides tested, Rb1 significantly increased OL membrane size in vitro. Moreover, Rb1 significantly increased myelin formation in adult mouse brain. Conclusion: All KRG components prevented OPC deaths under oxidative stress. While non-saponin promoted proliferation, saponin fraction increased differentiation and OL membrane size. Furthermore, among all the tested ginsenosides, Rb1 showed the biggest increase in the membrane size and significantly enhanced myelination in vivo. These results imply therapeutic potentials of KRG and Rb1 for myelin-related disorders.

• Journal of Animal Science and Technology
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• 제46권1호
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• pp.115-122
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• 2004

한우 어미소(24개월령)와 송아지(1 개월령)를 대상으로 6일 동안 07:00시부터 18:00시까지 42가지의 세부 행동을 관찰 분석하였다. 42가지의 세부 행동 중에서 서 있는 자세(ST), 걸어다니는 동작(WA), 가슴을 대고 누워 있는 자세(LD), 옆으로 누워있는 자세(LF), 놓여있는 여물 또는 사료를 먹는 동작(EA), 냄새를 맡는 동작(SF), 서서 자신을 핥는 동작(EA), 냄새를 맡는 동작(SF), 서서 자신을 핥는 동작(SG), 새끼나 상대방을 핥아주는 동작(PG), 몸을 비비는 동작(RB), 물을 마시는 동작(DR), 서서 반추행동을 하고 있는 동작(SR), 가슴을 대고 누어서 반추 행동을 하고 있는 동작(LR), 서서 꼬리를 흔드는 동작(STW), 서서 반추 행동을 하며 동시에 꼬리를 흔드는 동작(SRW), 젖을 빠는 동작(SUK), 그리고 새끼나 다른 소에 볼을 대는 동작(CR)과 같은 16가지의 행동을 주로 나타내었다. 즉, 유지행동, 사회행동, 섭식행동을 주로 나타내었다. 어미소는 LD가 25%로 가장 높은 빈도를 보였고, 다음으로 ST가 23%, EA가 13%, LR이 10%, SR이 7%, SG와 RB가 4%, 그리고 PG와 SF가 3%의 빈도를 보였다. 송아지는 LD가 52%로 가장 높은 빈도를 보였다. 송아지는 LD가 52%로 가장 높은 빈도를 보였고, 다음으로 ST가 28%, LF가 4%, EA와 WA가 3%, 그리고 SF와 SUK가 2%의 빈도를 보였으며, 그 외의 행동들은 1% 미만이었다. 그리고 주요 시간대인 07:00시, 12:00시, 18:00시에 어미소와 송아지의 행동 양상을 살펴보았는데, 어미소와 송아지 모두가 시간대별로 다른 행동 양상을 나타내었다. 향후 계절 및 우사 등에 따른 행동 양식 차이에 대한 심도 깊은 연구가 이루어져야 할 것으로 판단된다.

• 한국약용작물학회지
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• 제18권4호
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• pp.255-265
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• 2010

The extent of growth L. plantarum (LP), L. delbrueckii subsp. bulgaricus (LD), L. fermentum (LF), S. thermophilus (ST), B. longum (BI) and S. cerevisiae (SA) was generally good with the lower concentration of the ginseng extract. Total sapogenin content was slightly different with kinds of a fermentation microorganism and the time of fermentation process, and generally reduced compare to before fermentation. The content of ginsenoside Rb1, Rb2, Rb3, Re and Rf were decreased with the fermentation but ginsenoside Rd was increased by the E, LF and SA fermented extract. The content of compound K increased in the order of not-fermented extrac < enzyme fermented extract < enzyme and microorganism fermented extract, and as the fermented time get longer, the content of compound K was sightly increased. Especially, the content of compound K of the SA fermented extract was the most increased, also it of the BI, LD and LF fermented extract was increased, so these extract were considered a high valuable. Polyphenol content of the BI, LD, LP and ST fermented extract indicated $9.18{\pm}0.39{\sim}15.68{\pm}0.54$ mg/10 g which was lower than it of a not-fermented extract ($11.92{\pm}0.26{\sim}28.41{\pm}0.39$ mg/10 g). Flavonoid content of a ginseng fermented extract indicated $26.93{\pm}0.17{\sim}156.45{\pm}1.29$ mg/10 g, it was higher than a not-fermented extract ($18.06{\pm}0.90$ mg/10 g). As the fermented time get longer, the flavonoid content tendency to increase. DPPH radical scavenging activity of a fermented ginseng extract was $24.11{\pm}1.41{\sim}55.62{\pm}0.33%$, it was slightly lower compared to a natural antioxidant, vitamin C. But it of the LF and ST fermented extract was similar to a natural antioxidant, vitamin C. It has not a concerned in a fermentation. Nitrite scavenging ability of a 24 hr fermented extract was above 80% at pH 2.5 and 4.2, it was similar to an artificial antioxidant, BHT ($84.76{\pm}0.13%$; pH2.5, $84.98{\pm}0.11%$; pH 4.2). It has not a concerned in a fermentation. SOD-like activity of a fermented extract was lower than that of a not-fermented extract ($19.22{\pm}0.51%$), but it of the E and LP-fermented extract was a very highly notable value. As the fermented time get longer, the SOD-like activity tendency to increase.

• 한국가금학회지
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• 제27권1호
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• pp.51-61
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• 2000

This study was conducted to estimate the general production performance, heritabilities, and genetic phenotypic correlations on several economic traits by multiple trait animal model in Korean native chicken. The data were collected from the records of 5,192 pullets produced from 2,029 dams and 250 sires in Daejon Branch, National Livestock Research Institute from April 10. 1994 to February 10. 1997. Body weights of Red Brown (RB), Yellow Brown (YB), Grey Brown (GB) and Black (B) strains were 1,649.9, 1,439.6, 1,455.6 and 1,575.3g at age of 150 days and 1,923.5, 1,689.6, 1,812.4 and 1,924.0g at age of 270 days, respectively. The ranges of coefficient of variation for body weight were 11.52 to 14.02 at age of 150 days and 12.82 to 14.59% at age of 270 days, respectively. The first eggs of RB, YB, GB and B strains were produced at 147.4, 146.5, 151.1 and 152.1 days, respectively and the coefficients of variation were 7.80 to 8.41%. Egg weight at 270 days were 49.7, 47.6, 48.8 and 48.7 g for RB, YB, GB nd B strains, and coefficients of variation were 6.99 to 7.94% . The number of eggs at age of 270days were 75.8, 78.0, 76.7 and 68.8 for RB, YB, GB and B strains, respectively, and coefficient of variations were 23.87 to 29.89%. On heritability estimates in RB, YB, GB and strains body weight were 0.40, 0.10, 0.09 and 0.57 for RB, YB, GB and B strains at age of 150 days, and 0.23, 0.09, 0.38 and 0.24 at age of 270 days were 0.39, 0.47, 0.60 and 0.62, and egg weights at 270 days and age at 1st egg were 0.36, 0.12, 0.38 and 0.26, number of egg production at 270 days were 0.44, 0.36, 0.58 and 0.49, respectively. The genetic correlation coefficients of body weight with the age of first egg, egg weight and number of egg production at 270days were -0.07∼0.67, -0.24∼0.70 and 0.12∼0.41, respectively ; age of first egg with number of egg production at 270days and egg weight were -0.75∼0.91 and 0.34∼0.97 ; and egg weight with number of egg production at 270days were 0.18∼0.68. The phenotypic correlation coefficients of body weight with at age of first egg, egg weight and number of egg production at 270days were -0.01∼0.74, -0.04∼0.72 and 0.25∼0.57 ; age of first egg with number of egg production at 270days and egg weight were 0.26∼0.52 and 0.52∼0.92, respectively ; and egg weight with number of egg production at 270days were 0.34∼0.91.

• 대한가정학회지
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• 제30권1호
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• pp.35-47
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• 1992

The objective of this research was to determine whether the pressure on the cylinder by stretch fabric could be related by the size of cylinder, the amount of extension, and the properties of the fabric. The results were as follows : 1. There were linear relationships between the pressure of the fabric exerts on the cylinder and percentage of extension of the fabric, the radius of the cylinder, the tensile stress of the fabric, and the bending and shearing properties of the fabric. 2. From the results above, 4 regression equations from which the pressure could be estimated were derived by regression analysis. The equations were as follows : 1) P=a/Rb 2) P=c＋ds 3) P=e＋fSt 4) P=g＋hB P : Pressure, R : Radius of cylinder, S : Percentage of Stretch, St : Tensile stress, B : Bending property.

• 한국식생활문화학회지
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• 제16권5호
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• pp.478-482
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• 2001

This study was conducted to investigate the difference of general feature and ginsenoside content of 6 years old ginseng root among different grade of roots. Total weight of a 1st grade-6 years old ginseng root was 115.1g and weight, length, diameter and specific gravity of main root were 64.68g, 8.39cm, 3.31cm and 0.96, respectively. Main root of 1st grade ginseng root was larger in size and specific gravity and more heavy than that of End or 3rd grade of the roots. Though crude saponin contents were not so different among the different grade of roots, but ginsenoside Rb1, Rg1 and Re content were higher in 1st grade of root than that of 2nd or 3rd grade of root. Those ginsenosides were located mainly in periderm and cortex.