• Asian Pacific Journal of Cancer Prevention
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• v.17 no.3
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• pp.1309-1312
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• 2016

Inflammation can play an important role in cancer progression and the prognostic importance of neutrophil to lymphocyte ratio (NLR), a marker of inflammation, in cancer is a current investigation topic. In the present study, we aimed to determine whether there is a prognostic link between NLR and metastatic gastric cancer (mGC). A total of 143 patients from the Akdeniz University and Antalya Training and Research Hospital database were retrospectively analyzed. The median NLR value was 3.34. The median overall survival (OS) and median progression-free survival (PFS) were 11.6 and 7.9 months, respectively, in patients with NLR<3.34 while these values were 8.3 and 6.2 months respectively in patients with NLR>3.34 (p<0.001 and p=0.011, respectively). Our study showed that increased NLR is an independent prognostic factor associated with short survival in patients with mGC.

• Archives of Pharmacal Research
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• v.27 no.7
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• pp.797-805
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• 2004

LPD vectors are non-viral vehicles for gene delivery comprised of polycation-condensed plasmid DNA and liposomes. Here, we described a novel anionic LPD formulation containing protamine-DNA complexes and pH sensitive liposomes composed of DOPE and cholesteryl hemisuccinate (Chems). Central composite design (CCD) was employed to optimize stable LPD formulation with small particle size. A three factor, five-level CCD design was used for the optimization procedure, with the weight ratio of protamine/DNA ($X_1$), the weight ratio of Chems/DNA ($X_2$) and the molar ratio of Chems/DOPE in the anionic liposomes ($X_3$) as the independent variables. LPD size ($Y_1$) and LPD protection efficiency against nuclease ($Y_2$) were response variables. Zeta potential determination was utilized to define the experimental design region. Based on experimental design, responses for the 15 formulations were obtained. Mathematical equations and response surface plots were used to relate the dependent and independent variables. The mathematical model predicted optimized $X_1-X_3$ levels that achieve the desired particle size and the protection efficiency against nuclease. According to these levels, an optimized LPD formulation was prepared, resulting in a particle size of 185.3 nm and protection efficiency of 80.22％.

• Journal of Families and Better Life
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• v.29 no.5
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• pp.121-140
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• 2011

The purpose of this study is to understand how the economic conditions and needs of single-parent families are different between single-mother and single-father families, and also how they are dependent on household composition. The data for this study were drawn from the 1st Korea Welfare Panel Study and analyzed by frequencies, means, ${\chi}^2$, t-test, F-test, and logistic regression with the STATA 9.1 program. The major findings are as follows: (1) Single-parent families are more likely to live in a three-generation household than married couple families. (2) The composition of a three-generation household of single-parent families is affected by sex, age, education, type of marital disruption, the type of employment of single parents and the age of the last-born child. (3) The income-to-needs ratio is not significantly different depending on the sex of the single parents and their household composition. However, material hardship is significantly low in three-generation household single-parent families. (4) There are differences between three-generation single-parent families and independent single-parent families in income sources: The ratio of public transfer to total incomes is higher in three-generation households than independent households, while the ratio of private transfer to total incomes is higher in independent households.

• International Journal of Highway Engineering
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• v.11 no.2
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• pp.151-158
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• 2009

This study deals with the rear-end collisions in the rural aiea. The objectives of this study are 1) to analyze the characteristics of rear-end accidents of signalized intersections, and 2) to develop the accident models for Cheongju-Cheongwon. In pursing the above, this study gives the particular attentions to comparing the characters of urban and rural area. In this study, the dependent variables are the number of accidents and value of EPDO(equivalent property damage only), and independent variables are the traffic volumes and geometric elements. The main results analyzed are the followings. First, the statistical analyses show that the Poisson accident model using the number of accident as a dependant variable are statistically significant and the negative binomial accident model using the value of EPDO are statistically significant. Second, the independent variables of Poisson model are analyzed to be the ratio of high-occupancy vehicles, total traffic volume and the sum of exit/entry, and those of negative binomial regression are the main road width, total traffic volume and the ratio of high-occupancy vehicles. Finally, the specific independent variables to the rural area are the main road width, the ratio of high occupancy vehicle, and the sum exit/entry.

• Journal of Gastric Cancer
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• v.12 no.3
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• pp.164-172
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• 2012

Purpose: The purpose of this study is to investigate the prognostic significance of tumor size for 5-year survival rate in patients with gastric cancer. Materials and Methods: A total of 1,697 patients with gastric cancer, who underwent potentially curative gastrectomy, were evaluated. Patients were divided into 4 groups as follows, according to the median size of early and advanced gastric cancer, respectively: small early gastric cancer (tumor size ${\leq}3$ cm), large early gastric cancer (tumor size >3 cm), small advanced gastric cancer (tumor size ${\leq}$ 6 cm), and large advanced gastric cancer (tumor size >6 cm). The prognostic value of tumor size for 5-year survival rate was investigated. Results: In a univariate analysis, tumor size is a significant prognostic factor in advanced gastric cancer, but not in early gastric cancer. Multivariate analysis showed that tumor size is an independent prognostic factor for 5-year survival rate in advanced gastric cancer (P=0.003, hazard ratio=1.372, 95% confidence interval=1.115~1.690). When advanced gastric cancer is subdivided into 2 groups, according to serosa invasion: Group 1; serosa negative (T2 and T3, 7th AJCC), and Group 2; serosa positive (T4a and T4b, 7th AJCC), tumor size is an independent prognostic factor in Group 1 (P=0.011, hazard ratio=1.810, 95% confidence interval=1.149~2.852) and in Group 2 (P=0.033, hazard ratio=1.288, 95% confidence interval=1.020~1.627), respectively. Conclusions: Tumor size is an independent prognostic factor in advanced gastric cancer irrespective of the serosa invasion, but not in early gastric cancer.

• Korean Journal of Materials Research
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• v.21 no.7
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• pp.396-402
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• 2011

In this study, by using tin chloride solution as a raw material, a nano-sized tin oxide powder with an average particle size below 50 nm is generated by a spray pyrolysis process. The properties of the generated tin oxide powder depending on the inflow speed of the raw material solution are examined. When the inflow speed of the raw material solution is 2 ml/min, the majority of generated particles appear in the shape of independent polygons with average size above 80-100 nm, while droplet-shaped particles show an average size of approximately 30 nm. When the inflow speed is increased to 5 ml/min, the ratio of independent particles decreases, and the average particle size is approximately 80-100 nm. When the inflow speed is increased to 20 ml/min, the ratio of droplet-shaped particles increases, whereas the ratio of independent particles with average size of 80-100 nm decreases. When the inflow speed is increased to 100 ml/min, the average size of the generated particles is around 30-40 nm, and most of them maintain a droplet shape. With a rise of inflow speed from 2 ml/min to 5 ml/min, a slight increase of the XRD peak intensity and a minor decrease of specific surface area are observed. When the inflow speed is increased to 20 ml/min, the XRD peak intensity falls dramatically, although a significant rise of specific surface area is observed. When the inflow speed is increased to 100 ml/min, the XRD peak intensity further decreases, while the specific surface area increases.

• Journal of the Korean Geotechnical Society
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• v.40 no.4
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• pp.137-144
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• 2024

The purpose of this paper is to analyze the significance of independent variables in estimating crack density using machine learning algorithms. The algorithms used were random forest and SHAP, with the independent variables being compressional wave velocity, shear wave velocity, porosity, and Poisson's ratio. Rock samples were collected from construction sites and processed into cylindrical forms to facilitate the acquisition of each input property. Artificial weathering was conducted twelve times to obtain values for both independent and dependent variables with multiple features. The application of the two algorithms revealed that porosity is a crucial independent variable in estimating crack density, whereas shear wave velocity has a relatively low impact. These results suggested that the four physical properties set as independent variables were sufficient for estimating crack density. Additionally, they presented a methodology for verifying the appropriateness of the independent variables using algorithms such as random forest and SHAP.

• Journal of the Society of Naval Architects of Korea
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• v.60 no.4
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• pp.213-221
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• 2023

The demand for Liquefied Natural Gas (LNG) carriers and LNG-fueled ships has significantly increased in recent years due to the sulfur-oxide emission regulations by the International Maritime Organization (IMO). The main goal of this paper is to introduce the process for the Engineering Critical Assessment (ECA) of IMO independent type-B cargo tanks made from 9% nickel alloy. A methodology proposed by the British Standard was used to conduct ECA for any structure with initial flaws. Based on this standard, a Matlab code was developed to perform ECA. Coarse mesh Finite Element Analysis (FEA) was performed on an independent type-B LNG cargo tank with a capacity of 15,000 m³. The location with the highest development of maximum principal stress was identified at the bottom of the cargo tank. Fine mesh FEA was performed to obtain the stress range required for ECA. The dynamic cargo tank loads used for FEA were determined using some ship rules presented by Det Norske Veritas. As a result of performing a 20-year long-term crack propagation analysis with a semi-elliptical surface crack, the fracture-to-yield ratio exceeded the Fracture Assessment Line (FAL) and some structural reinforcement was necessary. Performing a 15-day short-term crack propagation analysis, the fracture-to-yield ratio remained within the FAL, and no significant LNG leaks were expected. This paper is believed to provide a guide for performing ECA of LNG cargo tanks in the future by providing the basic theory and application sample necessary to perform ECA.

• Health Policy and Management
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• v.13 no.3
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• pp.129-147
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• 2003

This study is to grasp a trend of profitability classified by characteristics of hospitals and to analyze related factors. Subjects are 145 hospitals which have gotten the standardization audit by Korean Hospital Association during 1998-200l. Profitability was measured in the aspect of operation profit rate with operating margin to gross revenue as proxy variables. Independent variables were classified by general factors (ownership, number of beds, period of establishment, competition), financial factors (liabilities to total assets, current ratio, fixed ratio, total asset turnover, inventories turnover), and factors related to patient treatment (average length of stay, bed occupancy rate, new outpatient ratio, admission ratio of outpatients, number of patients per specialist, personnel costs per adjusted inpatient, administrative costs per adjusted inpatient). Hierarchical multiple regression analysis model was used in this study. As a result of hierarchical multiple regression analyzation of operating margin to gross revenue, adjustive $R^2$ of general factors was relatively more powerful. The factors had significant effect on operating margin to gross revenue were ownership(+), number of beds(+), competition(+), current ratio(+), fixed ratio(+), total asset turnover(+), personnel costs per adjusted inpatient(-).

• Magazine of the Korean Society of Agricultural Engineers
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• v.28 no.1
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• pp.75-82
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• 1986

In this paper. the characteristics of mechanical behaviour due to various edge-ratio of uniformly loaded clamped skew-~plates has been described. In this study, the skew-plate was discretized using 8-noded isoparametric element and Mindlin's plate theory was adapted in finite element formulation. The edge-ratio 0.5,0.8,1.0,1.2,1.5,2.0 and 2.5 were considered. Hence, five cond- itions of the skew-angle, the seven levels of edge ratio were tried. When the edge-ratio was 2.5 or the edge-ratio was 2.0 and the skew-angle was less than 45 degree, the behaviour of the uniformly loaded the skew-plate with all edges clamped was independent of the skew-angle.