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http://dx.doi.org/10.7314/APJCP.2016.17.3.1309

The Neutrophil to Lymphocyte Ratio is an Independent Prognostic Factor in Patients with Metastatic Gastric Cancer  

Musri, Fatma Yalcin (Department of Medical Oncology, Akdeniz University School of Medicine)
Mutlu, Hasan (Department of Medical Oncology, Akdeniz University School of Medicine)
Eryilmaz, Melek Karakurt (Department of Medical Oncology, Akdeniz University School of Medicine)
Salim, Derya Kivrak (Department of Medical Oncology, Akdeniz University School of Medicine)
Gunduz, Seyda (Department of Medical Oncology, Antalya Training and Research Hospital)
Coskun, Hasan Senol (Department of Medical Oncology, Akdeniz University School of Medicine)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.17, no.3, 2016 , pp. 1309-1312 More about this Journal
Abstract
Inflammation can play an important role in cancer progression and the prognostic importance of neutrophil to lymphocyte ratio (NLR), a marker of inflammation, in cancer is a current investigation topic. In the present study, we aimed to determine whether there is a prognostic link between NLR and metastatic gastric cancer (mGC). A total of 143 patients from the Akdeniz University and Antalya Training and Research Hospital database were retrospectively analyzed. The median NLR value was 3.34. The median overall survival (OS) and median progression-free survival (PFS) were 11.6 and 7.9 months, respectively, in patients with NLR<3.34 while these values were 8.3 and 6.2 months respectively in patients with NLR>3.34 (p<0.001 and p=0.011, respectively). Our study showed that increased NLR is an independent prognostic factor associated with short survival in patients with mGC.
Keywords
Gastric cancer; neutrophil-to-lymphocyte ratio; progression-free survival; overall survival;
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