• 한국환경보건학회지
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• 제43권1호
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• pp.1-22
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• 2017

'The worstest environment disaster', 'World's first biocide massacre', 'Home-based Sewol ferry disaster' are all phrases attached to the recent humidifier disinfectant disaster. In the spring of 2011, four of 8 pregnant women including 1 adult man passed away at a university hospital in Seoul due to breathing failure. Epidemiologic investigation conducted by the Korean CDC soon revealed the inhalation of humidifier disinfectant, which had been widely used in Korea during the winter, to be responsible for the disease. As well as lung fibrosis hardening of the lungs, other diseases including asthma, rhinitis, skin disease, liver disease, fetal disease or cancers have been researched for their relation with exposure to the products. By February 9, 2017, 5,342 cases had registered for health problems and 1,131 of them were already dead (20.8% mortality rate). Based on studies by government agencies and a telephone survey of the general population by Seoul National University and civic groups, around 20% of the general public of Korea has used these products. Since the market release of the first product by SK Chemical in 1994, over 7.1 million items from around 20 brands were sold up to 2011. Most of the products were manufactured by well-known large conglomerates such as SK, Lotte, Samsung, Shinsegye, LG, and GS, as well as some European companies including UK-based Reckitt Benckiser and TESCO, the German firm Henkel, the Danish firm KeTox, and an Irish company. Even though this disaster was unveiled in 2011 by the Korean government, the issue of the victims was neglected for over five years. In 2016, an unexpected but intensive investigation by prosecutors found that Reckitt Benckiser manipulated and concealed animal tests for its own brand and brought several university experts and company employees to court. The matter was an intense social issue in Korea from May to June with a surge in media coverage. The prosecutor's investigation and a nationwide boycott campaign organized by victims and environmental groups against Reckitt Benckiser, whose product had been used by more than 70% of victims, led to the producer's official apology and a compensation scheme. A legislative investigation organized after the April 2016 national election revealed the producers' faults and the government's responsibility, but failed to meet expectations. A special law for the victims passed the National Assembly in January 2017 and a punitive system together with a massive environmental epidemiology investigation are expected to be the only solutions for this tragedy. Sciences of medicine, toxicology and environmental health have provided decisive evidence so far, but for the remaining problems the perspectives of social sciences such as sociology and jurisprudence are highly necessary, similar to with the Minamata disease and Wonjin Rayon events. It may not be easy to follow this issue using unfamiliar terminology from medical and chemical science and the long, complicated history of the event. For these reasons the author has attempted to write this article in a question and answer format to render it easier to follow. The 17 questions are: Q1 What is humidifier disinfectant? Q2 What kind of health problems are caused by humidifier disinfectant? Q3 How many victims are there? Q4 What is the analysis of the 1,112 cases of death? Q5 What is the problem with the government's diagnostic criteria and the solution? Q6 Who made what brands? Q7 Has there been a recall? What is still on sale? Q8 Was safety not checked by any producers? Q9 What are the government's responsibilities? Q10 Is it true that these products were sold only in Korea? Q11 Why and how was it unveiled only in 2011 after 17 years of sales? Q12 What delayed the resolution of the victim issue? Q13 What is the background of the prosecutor's investigation in early 2016? Q14 Is it possible to report new victim cases without evidence of product purchase? Q15 What is happening with the victim issue? Q16 How does it compare with the cases of Minamata disease and Wonjin Rayon? Q17 Are there prevention measures and lessons?

• Asian Pacific Journal of Cancer Prevention
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• 제14권2호
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• pp.811-816
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• 2013

Background: Pervious studies suggested occupational workers exposure to pentachlorophenol (PCP) might contribute to increased risk of cancer. However, few studies have focused on associations between PCP and cancer risk at the community level. Objective: The present study was to explore the cancer risk for the community population living long-term in a PCP contaminated area. Methods: All the cancer cases diagnosed in 2009-2011 in Tongling City were collected. The cancer patients' residencies were geo-referenced in each district. The historical PCP usage for each district of Tongling was calculated as the PCP pollution index, which was further used to divide into PCP exposure categories. Standardized rate ratios (SRRs) of cancer incidence were applied to detect the cancer risk as exposure grade elevated. Correlation analysis was performed to analyze the relationship between PCP pollution and cancer incidence. Results: A total of 5,288 cancer cases (3,451 male and 1,837 female) were identified. PCP usage was correlated with the incidence of leukemia (r=0.88, P=0.002) for males, and with cancer of the esophagus for males (r=0.83, P=0.008) and females (r=0.71, P=0.020). Compared with the low exposure category, significant SRRs for total cancer sites was obtained for high PCP exposure category (SRR=1.61, 95%CI=1.59-1.62). Most SRR values of the cancer sites were significantly increased as exposure grade elevated and exposure time extended. Conclusion: The present study found that community residents living in the PCP contaminated area had increased risk of cancers. Leukemias, lymphomas and nasopharyngeal and esophageal cancers are most possibly associated with PCP exposure.

• 문화기술의 융합
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• 제7권3호
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• pp.155-161
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• 2021

27개 사업장, 1897 근로자를 대상으로 근골격계질환 증상조사표를 받아 근골격계증상과 근로자 개인적 특성과의 상관관계를 분석하였다. 근로자의 근골격계질환 증상 유무는 한국산업안전보건공단의 근골격계부담작업 유해요인조사 지침에 따라 관리대상자 이상을 기준으로 했으며 개인적 특성으로는 작업자의 연령, 업무부담, 가사부담, 직장경력, 여가종류, 성별, 결혼유무로 구분하였다. 조사는 업무부담, 가사부담, 직장경력의 서열변수는 이분형 로지스틱 회귀분석을 통해 상관관계를 조사하였으며 그 외 명목변수는 교차분석과 카이제곱분석으로 해당 결과의 유의성을 확인하였다. 그 결과 작업자의 연령이 낮을수록, 업무부하와 가사부담이 높을수록, 여성일 경우, 여가활동을 가지지 않을 경우 근골격계질환 증상발현율이 높아진다는 것을 확인하였다. 그러나 본 연구의 결과를 다른 연구결과와 비교한 결과 조금씩 결과가 다른 점을 미루어볼 때 본 연구의 자료를 근골격계질환 예방의 개략적인 지표로써 활용할 수는 있지만 정량적 지표로써 활용하가 전 추가적인 연구가 필요할 것으로 사료된다.

• 대한예방한의학회지
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• 제3권2호
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• pp.55-77
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• 1999

Oriental Medical Service established foundation that Oriental medical clinic can take part in industrial health service by being specified industrial calamity medical treatment organ, but research which develope program that Oriental Medical Service approach on the occupational disease and industrial health only dealt in the Western Medical System was insufficient. So we studied on theoretical foundation and basic bearing about .program of oriental medical health examination in the workplace, it is based on explanation and assessment reformed by western medicine. We reached the conclusion as follows, 1. We must reconsider the concept that mind of Oriental medicine is preventive medicine, and assess positively result of social medicine. 2. Importance of industrial health is being enlarged in the category of health care. 3. Western medical health in including industrial health have faced much problems at this time, we can search by alternative proposal grafting on Oriental Medicine. 4. Oriental medical participation in the industrial health have various benefits at side satisfaction of workers, effect of prevention, efficiency of cost, and increasing rate of medical treatment and return to workplace of workers with industrial calamity. 5. We must consider Oriental Medical Health Examination as one way of health management program of workers, not as formality. 6. The advantage of Oriental Medical Health Examination can increase ability of individual health management in preventive medicine and the production in workers' health management.

• 지역사회간호학회지
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• 제4권1호
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• pp.14-24
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• 1993

The Purpose of this study was to explore the condition of periodic medical examination and the health care services of industries in order to offer some basic data on developing industrial nursing care. To achieve this goal a self - administered questionnaire (developed by the academic affairs of community health nursing) was provieded to the nurses in 56 industries from Dec. 10, 1992 to Jan. 20, 1993. The statistical computer package, SPSS, was used to manipulate the data along with T-test and ANOVA. The results were as follows : 1. General characteristics: The greater part of the industries were manufacturing company, and below 300 employees of industry were 55.4%. The shift system was mostly one shift(66.1%) and three shift(23.2%), and 50.0% them organized the Industrial Safety and Health Commitee. Average a number of employees was 631 person. 2. Periodic Medical Examination: Most of the workers were receiving periodic medical examination from the designated hospital (95.71%). From the about 12.89% were gone through a colse medical examination. In colse medical examination 58.41% were decided 'C' and 36.73% were decided 'D'. About 6.23% off those who had any clinical findings were work-time shortening(7.84%), work-transition(8.12%), recoverating at home. The majority of the workers receive the result of the periodic medical examination individually (78.5%). 3. Special medical examination: The rate of those who are receiving special medical examination were 76.82% and about 8.24% were decided 'C' and 1.23% were decided 'D' Those who had any health problems were receiving follow-up checking (9.10%) and medical treatment while working (15.04%). The health managers in the company can consult (85.7%) those who had any suspicious sign and symptoms of occupational disease. 4. Health care services: The average score of health care services were 17.57 point out of 28 point, and the score was lower in health assessment and environmental hygiene than medical diagnosis and health education. There were significant differences in environmental hygine (F=3.72, P=0.017), health care services(F=3.94, P=0.013) according to the size of the size of the industries The other's significancy is not shown by any type of industrial nurse. The level of health care services were higher in the wokers who had better health and showed no singificant differences(T=-0.73, P=0.470).

• 치위생과학회지
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• 제17권4호
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• pp.333-340
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• 2017

본 연구는 중소사업장에 종사하는 생산직 근로자를 대상으로 치석제거 경험 관련요인을 알아보기 위해 수행되었다. 조사대상은 광주광역시 188개 중소기업 중 편의추출법으로 5개 사업장을 선정하여 사업장에 근무하는 근로자 455명을 대상으로 자가 보고형 설문조사를 통해 일반적 특성과 근무관련특성, 치석제거 경험 등을 조사하였다. 빈도분석, t-검정, 교차분석, 다중로지스틱 회귀분석을 이용하여 분석하였다. 대상자의 최근 1년 이내 치석제거 경험은 47.0%였으며, 근로자의 연령이 낮은 경우(aOR, 3.09; 95% CI, 1.60~5.96), 직위가 높은 경우(aOR, 2.68; 95% CI, 1.55~4.63), 구강건강에 대한 관심도가 높은 경우(aOR, 2.15; 95% CI, 1.02~4.52), 최근 1년간 정기적인 구강 검진 경험이 있는 경우(aOR, 2.76; 95% CI, 1.50~5.11), 치석제거 건강보험급여화를 인지하고 있는 경우(aOR, 2.91; 95% CI, 1.80~4.72)가 치석제거 경험의 가능성이 높았다. 결론적으로 치석제거 경험은 47.0%로 비교적 낮았으며, 치석제거 경험에 관련된 요인들은 연령, 직위, 사용 중인 구강관리보조용품, 정기적인 구강검진, 구강질환으로 인한 조퇴 경험, 치석제거 급여화 인지여부였다. 이러한 요인들을 고려하여 근로자의 근무환경 개선 및 치석제거의 인식도 향상을 통해 치석제거 경험률을 높인다면 향후 근로자들의 치주관리에 긍정적인 영향을 미칠 것으로 판단된다.

• 한국콘텐츠학회논문지
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• 제18권3호
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• pp.256-264
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• 2018

본 연구는 구강건강행위와 구강병 발생요인검사결과와의 관련성을 확인하고자 경기도와 충청남도에 소재한 대학의 치위생과 학생을 대상으로 진행되었다. 자기기입식 설문지 작성과 구강병 발생요인검사로 진행되었으며 다음과 같은 결론을 얻었다. 칫솔질 횟수는 1일 3회가 60.2%, 1일 간식 횟수는 1회 이하가 49.7%, 간식의 종류는 점착성이 없는 가당 간식이 66.5%, 음료수의 종류는 유가당 음료수가 49.7%로 가장 높게 나타났다. 자극성 타액 분비율은 평균 9.41ml, 타액 완충능력은 평균 9.52점, 포도당 잔류시간은 평균 12.02분으로 조사되었다. Streptococcus mutans colony count 검사에서 저위험군인 <$10^5$은 80.1%, Lactobacillus는 저위험군인 <$10^5$은 82.6%로 조사되었다. 자극성 타액 분비율과 비자극성 타액 및 타액 완충능은 양의 상관관계를 보였으며, 불소도포 경험이 있는 경우 포도당 잔류시간이 10.66분, 불소도포 경험이 없는 경우 13.33분으로 나타나 통계적으로 유의한 차이를 보였다(p=.008). 전신건강과 직결되어 있는 구강건강을 위해서는 대중들이 쉽게 접할 수 있는 구강보건교육의 기회를 마련하고, 평생구강건강관리 프로그램을 지속적으로 개발 및 제공해야 할 것으로 사료된다.

• 한국환경보건학회:학술대회논문집
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• 한국환경보건학회 2003년도 Challenges and Achievements in Environmental Health
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• pp.24-25
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• 2003

Lead is ubiquitous in the human environment as a result of industrialization. China's rapid industrialization and traffic growth have increased the potential for lead emissions. Lead poisoning in children is one of the most common public health problems today, and it is entirely preventable. Children are more vulnerable to lead pollution and lead in their bodies can affect their nervous, circulatory, and digestive systems. Children are exposed to lead from different sources (such as paint, gasoline, and solder) and through different pathways (such as air, food, water, dust, and soil). Although all children are exposed to some lead from food, air, dust, and soil, some children are exposed to high dose sources of lead. Significant sources of lead for China's children include industrial emissions (often close to housing and schools), leaded gasoline, and occupational exposure that occurs when parents wear lead-contaminated clothing home from work, burning of coal for home heat and cooking, contaminated food, and some traditional medicines. To assess the blood lead level in children in China, a large-scale study was conducted in 19 cities among 9 provinces during 1997 to 2000. There were 6502 children, aged 3-5 years, were recruited in the study The result indicates that the mean blood lead level was 8.83ug/dl 3-5 year old living in city area. The mean blood lead level of boys was higher than that of girls (9.1l ug/dl vs 8.73ug/dl). Almost 30 percent childrens blood lead level exceeded 10ug/dl. The average blood lead level was higher than that of in 1985 (8.83ug/dl vs 8.lug/dl). An epidemiological study was carried on the children living around the cottage industries recycling the lead from battery. Nine hundreds fifty nine children, aged 5-12 years, living in lead polluted villages where the lead smelters located near the residential area and 207 control children live in unpolluted area were recruited in the study. The lead levels in air, soil, drinking water and crops were measured. The blood lead and ZnPP level were tested for all subjects. The results show that the local environment was polluted. The lead levels both in the air and crops were much higher than that of in control area. In the polluted area, the average blood level was 49.6ug/dl (rang 19.5-89.3ug/dl). Whereas, in the unpolluted area, the average blood level was 12.4ug/dl (rang 4.6-24.8ug/dl). This study indicates that in some countryside area, some cottage industries induce seriously lead pollution and cause children health problem. For the introducing of unleaded gasoline in some large cities, such as Beijing and Shanghai, the blood lead level showed a declined trend since 1997. By 2000, the use of leaded gasoline in motor vehicles has been prohibited in China. The most recent data available show that levels of lead in blood among children in Shanghai decreased from 8.3ug/dl in 1997 to 7.6ug/dl in 1999. The prevalence rate of children lead poisoning (blood lead >10ug/dl) was also decreased from 37.8% to 24.8%. In children living in downtown area, the blood lead level reduced dramatically. To explore the relationship between gene polymorphisms and individual susceptibility of lead poisoning, a molecular epidemiological study was conducted among children living in lead polluted environment. The result showed that the subjects with ALAD2 allele has higher ZPP level, and the subjects with VDR B allele has larger head circumference than only with b allele. In the present study, we demonstrated that ALAD genotypes modify lead effects on heme metabolism and VDR gene variants influence the skull development in highly exposed children. The polymorphism of ALAD and VDR genes might be the molecular inherited factor modifying the susceptibility of lead poisoning. Recently, Chinese government pays more attention to lead pollution and lead poisoning in children problem. The leaded gasoline was prohibited used in motor vehicles since 2000. The government has decided to have a clampdown on the high-polluted lead smelters for recycling the lead from battery in countryside. It is hopeful that the risk of lead poisoning in children will be decreased in the further

• 한국발생생물학회지:발생과생식
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• 제11권3호
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• pp.235-243
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• 2007

인간 제대혈 세포는 조혈모세포, 중간엽 줄기세포와내피전구세포를 풍부하게 포함하고 있다. 인간 제대혈 속의 중간엽 줄기세포는 조혈모세포와는 달리 다능성 줄기세포이며 신경세포로 분화할 수 있는 잠재성을 가지고 있다. 본 연구에서는 세포배양을 통해 제대혈의 중간엽 줄기세포를 신경세포와 콜린성 신경세포로 분화를 유도하였다. 중간엽 줄기세포를 신경세포로 분화시키기 위해 배양액에 dimethyl sulphoxide(DMSO)와 butylated hydroxyanisole(BHA)를 첨가하여 유도하였으며 basic fibroblast growth factor(bFGF), retinoic acid(RA), sonic hedgehog(Shh)를 처리하여 콜린성 신경세포로 분화시켰다. DMSO와 BHA에 처리된 중간엽 줄기세포가 빠르게 신경세포 모양으로 분화하는 것을 관찰하였으며, 이것은 면역조직학적 염색에서 신경세포 특이 표지인 $\beta$-tubulin III, 별아교세포에 대한 특이 표지인 GFAP, 희돌기아교세포에 대한 특이 표지인 Gal-C에 대해 양성반응을 나타내었고, 그 비율은 각각 $32.3{\pm}2.9%$, $11.0{\pm}0.9%,\;9.4{\pm}1.0%$였다. RT-PCR 분석에서 배양 단계에 따라 신경세포에 특이적인 표지 인자가 발현됨을 통해, 중간엽 줄기세포가 신경세포로 분화됨을 확인하였다. 또한, 중간엽 줄기세포에 bFGF, RA, Shh를 처리하여 콜린성 신경세포로 분화시켰을 때, 전체 중간엽 세포 중 $31.3{\pm}3.2%$가 신경세포 특이 표지인 $\beta$-tubulin III에 양성반응을 보였으며 이들 세포 중 $70.0{\pm}7.8%$가 콜린성 신경 특이 표지인 ChAT에 양성반응을 보였고, 이것은 Woodbury 방법에 의한 신경분화의 경우보다 3배 가량 높은 비율로 콜린성 신경의 분화를 유도한 것이다. 이러한 실험 결과들은 인간 제대혈의 중간엽 줄기세포가 콜린성 신경세포로 분화가 가능하고 이러한 잠재성을 가진 제대혈 중간엽 줄기세포는 퇴행성 신경질환에 대한 세포 치료제로서 가능성을 제시한다.

• Journal of Preventive Medicine and Public Health
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• 제32권1호
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• pp.30-39
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• 1999

이 연구는 특수건강진단기관의 소음성 난청 진단결과의 유소견자$(D_1)$와 요관찰자(C)를 하나의 평가 지표로 설정하여, 첫째 소음 특수건강진단 결과 소음성 난청의 실태 파악, 둘째 소음성 난청 요관찰 자의 청력장애 평가, 셋째 정력장애 정도 에 따른 각 주파수 영역별 기도순음청력 검사 결과를 통해 청력손실의 정도를 파악하고 이의 판정기준에 따른 진단의 적정성을 검토하고자 하였다. 1. 1994년 l월부터 12월까지의 73개 특수건강진단기관의 특수건강진단 실시 사업장은 27,347개이며 이중 소음 특수 건강진단 설시 사업장은 16,388개(59.9%)이었으며, 전체 특수건강진단 수진 근로자는 731,029명이며 이중 소음 특수 건강진단 수진 근로자는 343,457명 (47.0%)이었다. 소음성 난청 요관찰자는 38,058명, 소음성 난청 유소견자는 1,358 명으로 소음성 난청 요관찰률은 11.1%, 유소견율은 0.44%이었다. 지역에 따라 소음성 난청 요관찰률의 차이를 보여주며 판정기준의 적용에 따른 기도순음 청력평균손실치가 일부 적정하게 판단되지 못하였음을 보여 주었다. 2. ISO 기준의 3분법에 의한 청력 평가시 97%가 경도난청 이하였으며, 회화음 역에서의 4분법에 비해 거의 비슷하였으나 약간 정상역이 많았고, 고음역을 포함하여 평가하는 4분법과 6분법의 적용시 정상자의 경도난청으로의 가능성이 높다고 볼 수 있어 청력평가시 평가방법의 적용에 따라 내재적인 판별능의 차이를 보여준다고 볼 수 있다. 3. 우측귀의 청력역치를 ISO 기준에 의해 평가한 후 양귀의 청력역치의 분포 및 차이를 보면, 우측귀의 평균역치(표준편차)가 20.54(9.56) dB, 좌측귀의 평균역치가 20.54(9.57) dB로 좌측귀의 평균역치가 우측보다 높았다. 양귀의 청력이 75.4%에서 정상역이었으며, 21,562명 (90.6%)의 양귀 청력역치 차이의 범위가 10dB이내였다. 4. 소음성 난청 요관찰자의 회화음역에 속하는 500, 1,000 및 2,000 Hz에서의 기도청력역치를 산술평균으로 하여 구하는 3분법의 청력손실도(표준편차)를 주파수 별로 보면, 우측귀에서 500 Hz 21.08(10.23), 1,000 Hz 18.44(10.01), 2,000 Hz 22.09(13.46), 4,000 Hz 52.36(16.38) dB이었다. 평균청력손실도를 10 dB 간격으로 구분한 후 각각의 주파수별 청력역치를 살펴보면, 정상역인 20 dB미만에서 고음역인 4,000 Hz에서 회화음역인 500, 1,000 및 2,000 Hz에서 보다 평균 30-40 dB 이상의 역치를 보이는 $C_5-dip$ 현상을 특징적으로 보였다. 평균정력손질이 증가함에 따라 4,000 Hz에서의 역치 증가 현상이 점차적으로 감소하다 평균청력손실이 50 dB 이상에서는 10dB 내외의 차이만을 나타내었다. 이상과 같이 소음성 난청 요관찰자에 대한 분석에서 소음성 난청의 평가방법 에 따른 실태와 의미, 소음에 의한 조기청력손실의 특정과 소음성 난청의 판정기준에 따른 진단의 적정성을 확인할 수 있었으며, 소음성 난청 요관찰자에 대한 관리의 필요성을 제언할 수 있겠다.