• Journal of The Korean Society of Agricultural Engineers
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• v.62 no.4
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• pp.33-43
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• 2020

In order to reduce damage from farmland inundation caused by recent climate change, it is necessary to predict the risk of farmland inundation accurately. Inundation modeling should be performed by considering multiple time distributions of possible rainfalls, as digital forecasts of Korea Meteorological Administration is provided on a six-hour basis. As building multiple inputs and creating inundation models take a lot of time, it is necessary to shorten the forecast time by building a data base (DB) of farmland inundation probability. Therefore, the objective of this study is to establish a DB of farmland inundation probability in accordance with forecasted rainfalls. In this study, historical data of the digital forecasts was collected and used for time division. Inundation modeling was performed 100 times for each rainfall event. Time disaggregation of forecasted rainfall was performed by applying the Multiplicative Random Cascade (MRC) model, which uses consistency of fractal characteristics to six-hour rainfall data. To analyze the inundation of farmland, the river level was simulated using the Hydrologic Engineering Center - River Analysis System (HEC-RAS). The level of farmland was calculated by applying a simulation technique based on the water balance equation. The inundation probability was calculated by extracting the number of inundation occurrences out of the total number of simulations, and the results were stored in the DB of farmland inundation probability. The results of this study can be used to quickly predict the risk of farmland inundation, and to prepare measures to reduce damage from inundation.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.33 no.2
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• pp.549-557
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• 2013

An flood inundation map is able to convey spatial distribution of inundation to a decision maker for flood risk management. A roughness coefficient with unclear values and a discharge obtained from the stage-discharge rating equation are key sources of uncertainty in flood inundation mapping by using a hydraulic model. Also, the uncertainty analysis needs an observation for the flood inundation, and satellite images is useful to obtain spatial distribution of flood. Accordingly, the objective of this study is to quantify uncertainty arising roughness and discharge in flood inundation mapping by using a hydraulic model and a satellite image. To perform this, flood inundations were simulated by HEC-RAS and terrain analysis, and ISODATA (Iterative Self-Organizing Data Analysis) was used to classify waterbody from Landsat 5TM imagery. The classified waterbody was used as an observation to calculate F-statistic (likelihood measure) in GLUE (Generalized Likelihood Uncertainty Estimation). The results from GLUE show that flood inundation areas are 74.59 $km^2$ for lower 5 % uncertainty bound and 151.95 $km^2$ for upper 95% uncertainty bound, respectively. The quantification of uncertainty in flood inundation mapping will play a significant role in realizing the efficient flood risk management.

• Maxillofacial Plastic and Reconstructive Surgery
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• v.40
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• pp.44.1-44.17
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• 2018

Background: Coffee extract has been investigated by many authors, and many minor components of coffee are known, such as polyphenols, diterpenes (kahweol and cafestol), melanoidins, and trigonelline, to have anti-inflammatory, anti-oxidant, anti-angiogenic, anticancer, chemoprotective, and hepatoprotective effects. Therefore, it is necessary to know its pharmacological effect on hepatocytes which show the most active cellular regeneration in body. Methods: In order to determine whether coffee extract has a beneficial effect on the liver, 20 C57BL/6J mice were intraperitoneally injected once with dialyzed coffee extract (DCE)-2.5 (equivalent to 2.5 cups of coffee a day in man), DCE-5, or DCE-10, or normal saline (control), and then followed by histological observation and IP-HPLC (immunoprecipitation high performance liquid chromatography) over 24 h. Results: Mice treated with DCE-2.5 or DCE-5 showed markedly hypertrophic hepatocytes with eosinophilic cytoplasms, while those treated with DCE-10 showed slightly hypertrophic hepatocytes, which were well aligned in hepatic cords with increased sinusoidal spaces. DCE induced the upregulations of cellular proliferation, growth factor/RAS signaling, cellular protection, p53-mediated apoptosis, angiogenesis, and antioxidant and protection-related proteins, and the downregulations of NFkB signaling proteins, inflammatory proteins, and oncogenic proteins in mouse livers. These protein expression changes induced by DCE were usually limited to the range ± 10%, suggesting murine hepatocytes were safely reactive to DCE within the threshold of physiological homeostasis. DCE-2.5 and DCE-5 induced relatively mild dose-dependent changes in protein expressions for cellular regeneration and de novo angiogenesis as compared with non-treated controls, whereas DCE-10 induced fluctuations in protein expressions. Conclusion: These observations suggested that DCE-2.5 and DCE-5 were safer and more beneficial to murine hepatocytes than DCE-10. It was also found that murine hepatocytes treated with DCE showed mild p53-mediated apoptosis, followed by cellular proliferation and growth devoid of fibrosis signaling (as determined by IP-HPLC), and subsequently progressed to rapid cellular regeneration and wound healing in the absence of any inflammatory reaction based on histologic observations.

• Korean Journal of Medicinal Crop Science
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• v.11 no.1
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• pp.31-39
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• 2003

The antioxidative activities and biological properties in the EtOAc extracts and purified extracts of Orostachys japonicus were measured by assay of DPPH, xanthine/xanthine oxidase and mammalian cells(2-12). Scavenging of DPPH radical and inhibition of xanthine/xanthine oxidase of EtOAc extracts were showed the highest activity in the arable land and in September. The S-4 fraction showed the highest activity among the silica-gel column chromatography fractions. LH-4 fraction showed higher activity than the other fractionsins in assay of DPPH and xanthine/xanthine oxidase. Fatty acids and phenolic compounds were identified by GC/MS and main compounds were 1,2,3-benzenetriol, alpha-androsta-7,14-diene in LH-4 fraction. The activities of POD and SOD in samples havested on different habitats were high such as arable land> intermountain> seashore. That of POD and SOD in crude extracts of late stage were higher than early stage. Isozyme bands of crude extracts samplinged in all habitats and all growing stages showed two bands and the signal intensity showed strongly according to passage of growing stage. The purified extracts of LH-4 fraction showed excellent inhibition effect in proliferation of HL-60 cells and markedly suppressed colony formation in mouse fibroblast cells. Dose response between partially purified extracts(400ppm) and negative control did not produced statistically significant reduction in colony formation.

• Environmental Mutagens and Carcinogens
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• v.26 no.4
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• pp.125-132
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• 2006

Previous studies showed that epigallocatechin gallate(EGCG) have substantial effects of suppressing the N-methyl-N'-nitro-N-nitrosoguanidine(MNNG)-initiated cell transformation process on the bases of foci formation frequency and loss of anchorage dependency. In this study we tried to clarify the molecular mechanism of suppressing the cell transformation process. Mouse cell line balb/c 3T3 A31-1-1 was exposed 2 days to MNNG followed by 15 days 12-O-tetradecanoylphorbol-13-acetate(TPA) treatment for our transformation process. EGCG was added after the time point of 24 hours exposure to TPA and incubated for 19 days. 2029 genes were selected in our transformation process that showed fold change value of 1.5 or more in the microarray gene expression analysis covering the mouse full genome. These genes were found to be involved mainly in the cell cycle pathway, focal adhesion, adherens junction, TGE-$\beta$ signaling, apoptosis, lysine degradation, insulin signaling, ECM-receptor interaction. Among the genes, we focused on the 631 genes(FC>0.5) reciprocally affected by EGCG treatment. Our study suggest that EGCG down-regulate the gene expressions of up stream signaling factors such as nemo like kinase with MAPK activity and PI3-Kinase, Ras GTPase and down stream factors such as cyclin D1, D2, H, T2, cdk6.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.36 no.7B
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• pp.795-805
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• 2011

The research on the immersive media technology is actively being done with the emergence of immersive services using immersive media, especially in the broadcasting industry and with the increased market demand for it. The industry which produces, transmits, processes and services the immersive contents is commonly called Immersive Media Industry. Immersive Media Industry has recently received attention as next-generation strategic industry with its high marketability and its high possibility of market expansion through convergence with other industry such as education, health, advertisement, travel and public service industry. As other advanccd country such as the U.S., Japan and Europe buckle down to take the innitiative in the immersive media industry, Korea government also begins to make plan to promote the immersive media industry. As above, immersive media industry is a cutting-edge convergence industry which embraces broadcasting, telecommunication and contents industry and it is rising as core growth engine industry. This article analyses the economic effects of immersive media industry through quantatitive method and evaluates the relations between the immersive media industry and the other related industries. As a result, the effect on production inducement of immersive media industry is 610.9 billion Korean Won; the effect on value-added inducement is 468.7 billion Korean Won; and it is measured that 3,258 job will be created by the immersive media industry.

• Ecology and Resilient Infrastructure
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• v.2 no.2
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• pp.128-136
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• 2015

River areas include channels, floodplains and all the areas affected by physical and ecological processes in river systems. It is noticeably different from present riparian zone which is bounded by dykes. In this study, two methods for delineation of a floodplain are proposed, which are used for evaluation of the function of a river. One of them is a geomorphology-based technique and the other is hydrology-based inundation analysis. For the Mankyung River, these two methods are applied to delineate the floodplain area. Areas delineated with both methods are mutually compared. The results show that the geomorphology-based method is suitable for the delineation of a valley bottom, including the floodplain in a broader sense, which is unlike an inundated area reflecting contemporary hydrologic conditions. Compared with other flood frequency areas, a 100-year flood inundation area was found reasonable to represent the spatial extent of a floodplain without regard to the longitudinal location along a river. However, it is necessary in certain rivers reach where the division of a channel exists to compare a geomorphological analysis on a valley bottom with an inundation area of different frequencies.

• Journal of the Korean Geographical Society
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• v.39 no.2
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• pp.229-240
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• 2004

This article aimed to suggest a program for environmental protection and sustainable development in southwest Primorskii Krai of the Russian federation by analysis of Natural conditions, natural resources and current economic activities. Issues relating to protecting unique biodiversity toward economic development are examined. Special attention is given to functional zoning of the Russian part of lower Tumen River drainage. Functional zoning is key to protecting the unique biodiversity found in wet and marshlands of the lower Tumen River. Recommendations for acceptable economic activity are provided. The major components for a Sustainable Development Program in this area are: to define economically effective and ecologically acceptable types of regional activity (aquaculture; deer farming; recreation) and effective forms of territorial organization; to determine the restrictions on regional industrial and economic development; to organize rational regional land use by carrying out functional zoning and by coordinating this activity with all land users, including restructuring existing protected territories into a single system and include it into an international biospheric network.

• Proceedings of the Korea Water Resources Association Conference
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• 2012.05a
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• pp.535-535
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• 2012

하천 환경의 변화는 자연적으로 일어나기도 하지만, 우리나라 경우 대부분 하천 정비, 골재 채취, 수중보와 하구둑 등 하천시설물의 건설, 그리고 댐 및 교량건설 등 인위적인 요인에 의한 변화가 지배적이다 이렇게 환경이 변화하면 하천의 평형 상태는 파괴되며 하천의 평형 상태를 복원하는 과정에서 하천의 침식 또는 퇴적이 일어나며 이러한 과정의 총체적인 결과로서 하상변동이 일어나게 된다. 하상변동은 단기적인 면에서는 하천에서의 취수, 배수, 주운동 하천관리에 직접적인 영향을 주며, 장기적인 면에서는 하천시설물의 안정, 홍수위 및 지하수위 변화, 홍수터와 같은 하천부지의 변화 등 하천 및 유역 관리에 광범위한 영향을 주고 있다 하천의 유황 및 하상재료의 인위적인 변화에 의한 장기적인 하상변동 효과를 예측하고 분석하는 것은 하천계획 및 관리 면에서 매우 중요하다. 또한 하천 정비사업 등에 의한 영향을 제대로 평가하기 위해서는 비교적 단기간의 홍수 또는 호우 사상에 대한 단기적인 하상변동 효과를 정확하게 예측하는 것은 필수적이다. 외국에서는 하상변동 예측의 필요성을 일찍이 인식하여 다수의 하상변동 예측모형이 개발되어 하천 실무에 사용되고 있으며, 국내에서도 하천 흐름의 등수 역학적 해석을 위해 여러 가지 수치 기법들에 대한 연구가 진행되고 발전되어져 왔다. 현재 국내에서는 측량 자료이용과 모형적용의 용이성을 이유로 1차원 점변 부정류 해석프로그램인 HEC-RAS 모형을 많이 사용하고 있으며 대부분의 하천 정비 기본계획 수립에 있어서도 1차원 해석 모형을 적용하고 있는 실정이다. 국내에 서 수행된 하상변동 예측에 관한 연구들은 대부분 1차원 모형이므로 하천의 사행의 진행이나 유사의 횡방향 분포 등은 고려할 수 없다. 또한 하상변동 계산 시 이동상 부분의 전체가 균일하게 상승 또는 하향하는 것으로 가정하기 때문에 흐름이 급변하는 데 적용하는 것은 적합하지 않다. 따라서 본 연구에서는 4대강살리기 사업이 진행중인 낙동강유역 구미보지점을 대상으로 2차원 흐름 및 하상변동 수치모형인 CCHE2D 모형을 적용하여 50년, 100년, 200년 빈도별로 모의를 실시, 보설치 전 후의 하상변동을 비교 분석 하였다. 모의 결과 보설치 후의 경우 보 상류단은 전반적으로 퇴적의 양상을 보였으며, 보 하류단의 만곡부의 경우 홍수량이 증가함에 따라 유속 및 소류력이 비슷한 패턴으로 증가하여 침식이 관찰되었다. 특히 보 직하류의 경우 수문을 기준으로 다량의 침식이 있음을 보였으며, 침식이 계속 진행된다면 보유실과 같은 심각한 결과를 초래할 수 있기 때문에 침식을 방지 할 수 있는 다양한 장치가 마련되어야 할 것으로 판단된다.

• Journal of Biomedical and Translational Research
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• v.19 no.4
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• pp.116-124
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• 2018

Korean Native Pig (KNP) has a uniform black coat color, excellent meat quality, white colored fat, solid fat structure and good marbling. However, its growth performance is low, while the western origin Yorkshire pig has high growth performance. To take advantage of the unique performance of the two pig breeds, we raised crossbreeds (KNP ${\times}$ Yorkshire to make use of the heterotic effect. We then analyzed the liver transcriptome as it plays an important role in fat metabolism. We sampled at two stages: 10 weeks and at 26 weeks. The stages were chosen to correspond to the change in feeding system. A total of 16 pigs (8 from each stage) were sampled and RNA sequencing was performed. The reads were mapped to the reference genome and differential expression analysis was performed with edgeR package. A total of 324 genes were found to be significantly differentially expressed (${\left|log2FC\right|}$ > 1 & q < 0.01), out of which 180 genes were up-regulated and 144 genes were down-regulated. Principal Component Analysis (PCA) showed that the samples clustered according to stages. Functional annotation of significant DEGs (differentially expressed genes) showed that GO terms such as DNA replication, cell division, protein phosphorylation, regulation of signal transduction by p53 class mediator, ribosome, focal adhesion, DNA helicase activity, protein kinase activity etc. were enriched. KEGG pathway analysis showed that the DEGs functioned in cell cycle, Ras signaling pathway, p53 signaling pathway, MAPK signaling pathway etc. Twenty-nine transcripts were also part of the DEGs, these were predominantly Cys2His2-like fold group (C2H2) family of zinc fingers. A protein-protein interaction (PPI) network analysis showed that there were three highly interconnected clusters, suggesting an enrichment of genes with similar biological function. This study presents the first report of liver tissue specific gene regulation in a cross-bred Korean pig.