• Current Optics and Photonics
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• 제6권6호
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• pp.619-626
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• 2022

In this study, we develop a three-dimensional (3D) terahertz time-of-flight (THz-TOF) imaging technique with a large depth range, based on asynchronous optical sampling (ASOPS) methods. THz-TOF imaging with the ASOPS technique enables rapid scanning with a time-delay span of 10 ns. This means that a depth range of 1.5 m is possible in principle, whereas in practice it is limited by the focus depth determined by the optical geometry, such as the focal length of the scan lens. We characterize the spatial resolution of objects at different vertical positions with a focal length of 5 cm. The lateral resolution varies from 0.8-1.8 mm within the vertical range of 50 mm. We obtain THz-TOF images for samples with multiple reflection layers; the horizontal and vertical locations of the objects are successfully determined from the 2D cross-sectional images, or from reconstructed 3D images. For instance, we can identify metallic objects embedded in insulating enclosures having a vertical depth range greater than 30 mm. For feasible practical use, we employ the proposed technique to locate a metallic object within a thick chocolate bar, which is not accessible via conventional transmission geometry.

• 세라미스트
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• 제21권3호
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• pp.204-215
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• 2018

Proteases are one of the most abundant classes of enzymes in living organisms and have been considered major targets for drug development. However, despite the ability to specifically cleave their substrates, many attempts to assay protease activity have generally relied upon the use of gel zymography or fluorophore-labeled peptide substrates, which is limited in rapid and multiplex analysis. Here we review the recent advances in nanoparticle (NP)-utilized assays of protease activity focused on in vitro and cell imaging-based approaches. Owing to large surface area and unprecedented physical properties of NPs, these approaches are anticipated to facilitate many applications related to protease activity-based disease diagnosis and drug discovery.

• International Journal of Safety
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• 제7권2호
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• pp.17-22
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• 2008

Recent developments in contactless, air-coupled sensing of seismic and ultrasonic waves in concrete structures are presented. Contactless sensing allows for rapid, efficient and consistent data collection over a large volume of material. Two inspection applications are discussed: air-coupled impact-echo scanning of concrete structures using seismically generated waves, and air-coupled imaging of internal damages in concrete using ultrasonic tomography. The first application aims to locate and characterize shallow delamination defects within concrete bridge decks. Impact-echo method is applied to scan defected concrete slabs using air coupled sensors. Next, efforts to apply air-coupled ultrasonic tomography to concrete damage imaging are discussed. Preliminary results are presented for air-coupled ultrasonic tomography applied to solid elements to locate internal defects. The results demonstrate that, with continued development, air-coupled ultrasonic tomography may provide improved evaluation of unseen material defects within structures.

• 대한방사성의약품학회지
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• 제6권1호
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• pp.39-45
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• 2020

Recently, single-domain antibodies (sdAb) are bioengineered for molecular imaging applications. Single-domain antibody, obtained from naturally occurring antibodies in camelid species and cartilaginous fish is the smallest fully functional antigen-binding antibody fragments of heavy-chain. Since their discovery, they have been investigated extensively in clinical therapeutics, monitoring and diagnostics. Their small size is important advantage for high solubility, high stability, fast blood clearance and rapid targeting. This review article summarizes the recent status of this new antibody to visualize, diagnose or inhibit specific targets of cancer.

• Imaging Science in Dentistry
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• 제36권2호
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• pp.111-116
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• 2006

PET/CT is a new imaging technology that combines high-quality Positron Emission Tomography (PET) and Computed Tomography (CT). This imaging provides simultaneous anatomical and metabolic information. Therefore PET/CT is useful diagnostic modality for early detection of malignant tumor, accurate staging, decision on therapeutic plan, monitoring response to therapy and rapid detection of recurrence. We report oral and maxillofacial cancers diagnosed by using PET/CT and the usefulness of PET/CT in the evaluation of postoperative recurrence.

• Nuclear Engineering and Technology
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• 제52권11호
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• pp.2572-2580
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• 2020

Emerging gamma ray detection applications that utilize neutron-based interrogation result in the prompt emission of high-energy (>2 MeV) gamma-rays. Rapid imaging is enabled by scintillators that possess high density, high atomic number, and excellent energy resolution. In this paper, we evaluate the bright (50,000 photons/MeV) oxide scintillator, cerium-doped Gd₂Al₂Ga₃O₁₂ (GAGG(Ce)). A silicon photomultiplier (SiPM) array is coupled to a GAGG(Ce) scintillator array (12 × 12 pixels) and integrated into a coded-aperture based gamma-ray imaging system. A resistor-based symmetric charge division circuit was used reduce the multiplicity of the analog outputs from 144 to 4. The developed system exhibits 9.1%, 8.3%, and 8.0% FWHM energy resolutions at 511 keV, 662 keV, and 1173.2 keV, respectively. In addition, a pixel-identification resolution of 602 ㎛ FWHM was obtained from the GAGG(Ce) scintillator array.

• Journal of the Optical Society of Korea
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• 제19권5호
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• pp.456-466
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• 2015

We investigated an anti-aliasing (AA) filter for digital camera photography by which the excessively high-frequency components of the image signal are suppressed to avoid the aliasing effect. Our optomechanical AA filter was implemented by applying rapid relative motions to the imaging sensor. By the engineered motion blur of the mechanical dithers, the effective point-spread function (PSF) of the imaging system could be tailored to reject the unwanted high-frequency components of the image. For optimal operations, we developed a spiral filter motion protocol that could produce a Gaussian-like PSF. We experimentally demonstrated that our AA filter provides an improved filtering characteristic with a better compromise of the rejection performance and the signal loss. We also found that the pass band characteristic can be enhanced further by a color-differential acquisition mode. Our filter scheme provides a useful method of digital photography for low-error image measurements as well as for ordinary photographic applications where annoying $moir{\acute{e}}$ patterns must be suppressed efficiently.

• 한국의학물리학회지:의학물리
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• 제2권1호
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• pp.3-16
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• 1991

Abstract. An area of particularly rapid technological growth in the last 15 years has been medical imaging (conventional X-ray, ultrasound, X-ray computed tomography (CT), magnetic resonance imaging (MRI). As the number and complexity of imaging studies rises, it becomes ever more important to distribute these images and the associated diagnoses in a timely and cost-effective fashion. The purpose of this paper is to describe the requirements for a future digital radiology system which will efficiently handle the large volume of images that generated, add new functionality to improve productivity of physicians, technologists, and other health care providers, and provide enough flexibility to allow the system to grow as medical image technology grows.

• 대한약학회:학술대회논문집
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• 대한약학회 2004년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
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• pp.109-110
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• 2004

• Imaging Science in Dentistry
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• 제34권1호
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• pp.13-18
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• 2004

Purpose : This study was to evaluate the influence of slice thickness of computed tomography (CT) and rapid protyping (RP) type on the accuracy of 3-dimensional medical model. Materials and Methods: Transaxial CT data of human dry skull were taken from multi-detector spiral CT. Slice thickness were 1, 2, 3 and 4 mm respectively. Three-dimensional image model reconstruction using 3-D visualization medical software (V-works /sup TM/ 3.0) and RP model fabrications were followed. 2-RP models were 3D printing (Z402, Z Corp., Burlington, USA) and Stereolithographic Apparatus model. Linear measurements of anatomical landmarks on dry skull, 3-D image model, and 2-RP models were done and compared according to slice thickness and RP model type. Results: There were relative error percentage in absolute value of 0.97, 1.98,3.83 between linear measurements of dry skull and image models of 1, 2, 3 mm slice thickness respectively. There was relative error percentage in absolute value of 0.79 between linear measurements of dry skull and SLA model. There was relative error difference in absolute value of 2.52 between linear measurements of dry skull and 3D printing model. Conclusion: These results indicated that 3-dimensional image model of thin slice thickness and stereolithographic RP model showed relative high accuracy.