• The Journal of the Korean Society for Microbiology
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• v.22 no.3
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• pp.301-307
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• 1987

A total of 42 strains of Candida albicans were examined for susceptibility to three antifungal agents, amphotericin B(AMB), 5-fluorocytosine(5-FC), and ketoconazole(KTZ), using defined medium, synthetic amino acid medium-fungal(SAAM-F), supplemented yeast nitrogen base(SYNB) and undefined medium Sabouraud's dextrose broth(SDB) and Kimmig broth media. A tube dilution method was used with minimum inhibitory concentrations(MICs) determined after incubation for 24 hour and 48 hours. All testes were performed in duplicate. In general, MICs were more reproducible after 48 hour of incubation. Forthermore, MICs determined after incubation for 48 hours were significantly higher than those determined after 24 hours. The actural MICs obtained with the different antifungal agents were clearly influenced by the test medium used. The rank order of AMB MICs according to the test medium was as follows: SAAM-F>SYNB>SDB>Kimmig broth. With 5-FC, the following pattern was observed: SYNB>SAAM-F>SDB>Kimmig borth. For ketoconazole, the MICs according to the test medium was SAAM-F>SDB>SYNB> Kimmig broth. In amphotericin B, the MICs mean value with the test medium was as follows: SDB, 0.24 mcg/ml; Kimmig broth, 0.29 mcg/ml; SYNB, 0.21 mcg/ml and SAAM-F, 0.15mcg/ml. The actural value of 5-FC was; SDB, 37.20 mcg/ml; Kimmig broth, 67.41mcg/ml; SYNB, 21.29 mcg/ml and SAAM-F, 24.61 mcg/ml and in ketoconazole, the MICs value was; SDB, 1.83 mcg/ml; Kimmig broth, 4.08 mcg/ml; SYNB, 1.95 mcg/ml and SAAM-F, 1.41 mcg/ml. The results of this investigation suggested that broth dilution susceptibility testing of yeast and yeast-like fungi are best performed with an incubation period of 48 hours. Furthermore, medium composition can significantly influence the results of such testing.

• Journal of Gifted/Talented Education
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• v.20 no.3
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• pp.789-807
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• 2010

This study was carried out in order to explore possibility of artistic activity for strengthening creativity of the gifted children at home by analyzing influence of the gifted children's musical experience and interest level upon creativity. As a result of research, the gifted children's musical experience and interest level were distributed in the mid-lower rank as a whole. The mean in score of creativity was high. Among sub-spheres, originality, abstractness of titles, and resistance to premature closure were surveyed to be especially excellent. And the result of this study was indicated to be high in influence of musical experience and interest level upon creativity. Some conclusions and implications that were obtained through this study are as follows. First, to explore influence of musical experience as artistic activity upon creativity, first of all, the qualitative inspection needs to be given priority to musical activity itself, which is being experienced by the gifted children as the research subjects. Second, there is necessity of paying attention to the musical experience and interest level of the low gifted children. Third, for the gifted children prior to activation of art education, a clear reason why the art education is needed and the usefulness need to be presented.

• Journal of Korean Medical Science
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• v.33 no.50
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• pp.299.1-299.13
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• 2018

Background: Sarcopenia is associated with a poor prognosis in patients with liver cirrhosis. However, it is not known whether the rate of skeletal muscle depletion is also associated with a poor prognosis. We investigated the prognostic impact of the rate of skeletal muscle depletion in patients with liver cirrhosis. Methods: We included retrospectively all patients with liver cirrhosis who underwent both multiple computed tomography scans and hepatic venous pressure gradient (HVPG) measurements. Results: A total of 131 patients with liver cirrhosis were enrolled. The mean age of the patients was 53.7 years and alcoholic liver disease was the most common cause (61.8%). Sixty-four patients (48.9%) were diagnosed with sarcopenia. The median changes in skeletal muscle area per year (${\Delta}SMA/y$) were -0.89%. During a median follow-up period of 46.2 months (range, 3.4-87.6), 45 patients (34.4%) died. In multivariate analyses, age, Child-Pugh score, HVPG, presence of sarcopenia and ${\Delta}SMA/y$ were independently associated with mortality. Cumulative mortality was significantly higher in patients with ${\Delta}SMA/y$ < -2.4% than those with ${\Delta}SMA/y{\geq}-2.4%$ (log-rank test, P < 0.001). Conclusion: Both the presence and rate of change of sarcopenia are independently associated with long-term mortality in patients with liver cirrhosis.

• Journal of the Korea Society of Computer and Information
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• v.26 no.11
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• pp.149-156
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• 2021

Among various implementation techniques of recommender systems, collaborative filtering selects nearest neighbors with high similarity based on past rating history, recommends products preferred by them, and has been successfully utilized by many commercial sites. Accurate estimation of similarity is an important factor that determines performance of the system. Various similarity measures have been developed, which are mostly based on integrating traditional similarity measures and several indices already developed. This study suggests a similarity measure of a novel approach. It separates the common rating area between two users by the magnitude of ratings, estimates similarity for each subarea, and integrates them with weights. This enables identifying similar subareas and reflecting it onto a final similarity value. Performance evaluation using two open datasets is conducted, resulting in that the proposed outperforms the previous one in terms of prediction accuracy, rank accuracy, and mean average precision especially with the dense dataset. The proposed similarity measure is expected to be utilized in various commercial systems for recommending products more suited to user preference.

• KIPS Transactions on Software and Data Engineering
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• v.8 no.1
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• pp.27-36
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• 2019

In this paper, we propose a method to find the most similar answer to the user's response from the question-answer database in order to avoid generating a redundant question in retrieval-based automatic question generation system. As a question of the most similar answer to user's response may already be known to the user, the question should be removed from a set of question candidates. A similarity detector calculates a similarity between two answers by utilizing the same words, paraphrases, and sentential meanings. Paraphrases can be acquired by building a phrase table used in a statistical machine translation. A sentential meaning's similarity of two answers is calculated by an attention-based convolutional neural network. We evaluate the accuracy of the similarity detector on an evaluation set with 100 answers, and can get the 71% Mean Reciprocal Rank (MRR) score.

• Particle and aerosol research
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• v.15 no.2
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• pp.45-56
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• 2019

The public's concern on ambient $PM_{2.5}$ has been increasing in Korea. We have estimated (1) the annual and monthly mean $PM_{2.5}$ concentrations, (2) the frequency by the $PM_{2.5}$ concentration interval, and (3) the high concentration occurrence duration time between 2015 and 2018 at 16 administration regions. We found that there have been differences in all three above parameters' trends among the studied 16 regions in Korea. Still, Jeonbuk showed the highest rank in all three parameters' trends. In Jeonbuk, the average $PM_{2.5}$ concentration and the sum of the frequency fraction when the $PM_{2.5}$ concentration being over $75{\mu}g/m^3$ between 2016 and 2018 was $28.4{\mu}g/m^3$ and 9.0%, respectively. And the days when the $PM_{2.5}$ concentration is over $50{\mu}g/m^3$ between 2015 and 2018 were 149. Chungbuk was the only region with the increasing trend of $PM_{2.5}$ concentration between 2016 and 2018. And in Seoul and Gyeonggi, the average $PM_{2.5}$ concentrations decreased whereas the high concentration frequency fraction increased between 2016 and 2018. Also, it is found that there have been differences in the trends of the frequency by the $PM_{2.5}$ concentration interval and the high concentration occurrence duration time between $PM_{10}$ and $PM_{2.5}$.

• Journal of Korea Trade
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• v.25 no.5
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• pp.110-128
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• 2021

Purpose - The essential purpose of this study is to analyze the possibility of substitution of an individual job resulting from technological development represented by the 4th Industrial Resolution, considering the different effects of digital transformation on the labor market. Design/methodology - In order to estimate the substitution probability, this study used two data sets which the job characteristics data for individual occupations provided by KEIS and the information on occupational status of substitution provided by Frey and Osborne(2013). In total, 665 occupations were considered in this study. Of these, 80 occupations had data with labels of substitution status. The primary goal of estimation was to predict the degree of substitution for 607 of 665 occupations (excluding 58 with markers). It utilized three methods a principal component analysis, an unsupervised learning methodology of machine learning, and Ridge and Lasso from supervised learning methodology. After extracting significant variables based on the three methods, this study carried out logistics regression to estimate the probability of substitution for each occupation. Findings - The probability of substitution for other occupational groups did not significantly vary across individual models, and the rank order of the probabilities across occupational groups were similar across models. The mean of three methods of substitution probability was analyzed to be 45.3%. The highest value was obtained using the PCA method, and the lowest value was derived from the LASSO method. The average substitution probability of the trading industry was 45.1%, very similar to the overall average. Originality/value - This study has a significance in that it estimates the job substitution probability using various machine learning methods. The results of substitution probability estimation were compared by industry sector. In addition, This study attempts to compare between trade business and industry sector.

• Obstetrics & gynecology science
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• v.61 no.6
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• pp.655-661
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• 2018

Objective There is concern regarding the safety of delayed cord clamping (DCC) in babies born at less than 34 weeks' gestation. Therefore, the primary objective of this study was to compare the rates of hyperbilirubinemia and polycythemia during initial 7 days in infants born at less than 34 weeks' gestation and randomized to receive DCC by 120 seconds or early cord clamping (ECC) within less than 30 seconds. Methods One hundred pregnant women were randomly subjected to DCC or ECC at the time of birth in a tertiary referral hospital setting. Blood samples were obtained from each newborn at 48 hours and 7 days for hematocrit measurement. Serum bilirubin levels were estimated once the infant had clinically significant jaundice or at 72 hours. For the statistical analysis, the ${\chi}^2$ test, Student's t-test, or Wilcoxon rank sum test was used. Results The hematocrit was significantly higher in the DCC group than in the ECC group (P<0.001). None of the babies had polycythemia. Mean total serum bilirubin level was 6.6 mg/dL in the DCC group and 8.7 mg/dL in the ECC group (P<0.001). There was no increased risk of hyperbilirubinemia in the DCC group. Conclusion DCC benefits preterm neonates with no significant adverse effects.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• v.24 no.4
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• pp.384-391
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• 2021

Purpose: The Cow's Milk-related Symptom Score (CoMiSS^TM) was developed as an awareness tool for evaluating cow's milk-related symptoms in otherwise healthy children. Using a convenience sample of participants, this cross-sectional study aimed to determine CoMiSS^TM values of symptomatic infants based on retrospectively or prospectively obtained information. Methods: CoMiSS^TM values were determined in infants aged <12 months with symptoms suggestive of cow's milk protein allergy or functional gastrointestinal disorders. The exclusion criteria were previous diagnosis with acute or chronic disease, treatment with a therapeutic formula, and in case of breastfeeding, an elimination diet followed by the mother. Two CoMiSS^TM values were assessed. A retrospective collection was defined as the collection of data after initial contact with the medical center but before the first medical consultation. A prospective collection was defined as the collection of data within 24 hours from the time of medical consultation but before starting any therapeutic intervention. The CoMiSS^TM total and individual component scores obtained retrospectively or prospectively were compared between groups using the Wilcoxon signed-rank test. Results: This study was performed between August and November 2019. Data of 110 children (62 males and 48 females), with a mean±standard deviation age of 18.2±11.7 weeks, were obtained. The total CoMiSS^TM value (p<0.001) and some individual component scores (crying, regurgitation, and stool) were significantly lower when collected prospectively than when collected retrospectively. Conclusion: CoMiSS^TM values were retrospectively and prospectively determined. Lower CoMiSS^TM values were obtained during prospective evaluation. Possible differences should be considered when using CoMiSS^TM in clinical practice.

• Journal of Korean Medicine Rehabilitation
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• v.33 no.1
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• pp.77-85
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• 2023

Objectives This study is designed to evaluate the safety of palmul-tang soft extract in healthy male volunteers. Methods Twelve healthy male volunteers were recruited. And this study was conducted in a single center. As a result of the laboratory test, the safety was evaluated by collecting vital signs of volunteers. Twelve subjects were assigned by serial number according to the registration order. For safety evaluation, blood samples were collected and vital signs were checked four times throughout the test period, including screening, pre-administration, post-administration (after 48 hours) and post-administration (after 7 days). The difference in variables was summarized as the mean±standard deviation. The normality was performed using Kolmogorov-Smirnov and Shapiro-Wilk test. If normality is satisfied, a paired t-test is applied. Otherwise, the Wilcoxon sign rank test, which is a nonparametric method, is applied. The significance was p<0.05. The incidence of all side effects is expressed as a percentage. Results In the case of red blood cell, hemoglobin, and hematocrit values, the result of normality test of variables for the difference value before and after administration is significant level p<0.05. However, all laboratory test values before and after administration did not deviate from the normal range. Also the deviations in the normal range could not be seen as significance related to this clinical trial. And no side effects related to clinical trial drugs were observed. Conclusions The soft extract of palmul-tang was considered safe for healthy male volunteers.