• Journal of Korean Biological Nursing Science
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• 제19권2호
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• pp.76-85
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• 2017

Purpose: The purpose of this study was to compare the effects of $21^{\circ}C\;CO_2$ and $37^{\circ}C\;CO_2$ pneumoperitoneum on body temperature, blood pressure, heart rate, and acid-base balance. Methods: Data were collected at a 1300-bed university hospital in Incheon, from February through September 2012. A total of 74 patients who underwent laparoscopic colectomy under general anesthesia with desflurane were randomly allocated to either a control group or an experimental group. The control group received $21^{\circ}C\;CO_2$ pneumoperitoneum; the experimental group received $37^{\circ}C\;CO_2$ pneumoperitoneum. The pneumoperitoneum of the two groups was under abdominal pressure 15 mmHg. Body temperature, systolic blood pressure, heart rate and acid-base balance were assessed at 30 minutes and 90 minutes after pneumoperitoneum, and again at 30 minutes after arriving at the Post Anesthesia Care Unit. Results: Body temperature in the $37^{\circ}C\;CO_2$ pneumoperitoneum group was significantly higher (F= 9.43, p< .001) compared to the $21^{\circ}C\;CO_2$ group. However, there were no statistically significant differences in systolic blood pressure (p= .895), heart rate (p= .340), pH (p= .231), PaCO2 (p= .490) and HCO3- (p= .768) between the two groups. Conclusion: Pneumoperitoneum of $37^{\circ}C\;CO_2$ is effective for the increase of body temperature compared to pneumoperitonium of $21^{\circ}C\;CO_2$, and it does not result in a decrease of blood pressure, heart rate or acid-base imbalance.

• 한방안이비인후피부과학회지
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• 제20권1호통권32호
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• pp.239-249
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• 2007

Background : Allergic rhinitis is the most frequently occuring immunological disorder. It affects men, women and children and represents significant cost in terms of suffering and loss of productivity. Objective & Methods : We referred to the information through Entrex Pubmed from 2004 to 2007 January about alternative medicine for allergic rhinitis, 9 treatises. Results : About 9 treatises, 2 treatises were for the acupuncture treatment, I treatise was for the acupuncture and chinese herbal medicine, 2 treatises were for the single substance(butterbur, soy sauce ingredients), 1 treatise was for the homeopathic preparation, 1 treatise was for the ayur-veda herbal treatment, 1 treatise was for the ultraviolet light phototherapy, 1 treatise was for the systematic review of alternative medicine. Except 2 treatises for the acupuncture treatment, 6 treatises used the double-blind, randomized, placebo-controlled methods. As a result, we found 5 treatises that treat group had more improvement than control group, 3 treatises that treat group had no difference control group on effect significantly. 1 review article exhibited the most of alternative medical literatures were inadequate methodologically and therapeutic efficacy alternative treatment for allergic rhinitis was not supported by currently available evidence. Conclusion : We found that treatises about the alternative medicine for allergic rhinitis were more and more published. We were supposed that many internal treatises were published adequately by methodology to prove Korean medical treatment effects for allergic rhinitis.

• Journal of Dental Anesthesia and Pain Medicine
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• 제18권3호
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• pp.151-159
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• 2018

Background: The pain involved in orthodontic treatments may involve inflammatory processes. This study evaluated the effect of using a naproxen patch for pain reduction in the separating stage of fixed orthodontic treatment. Methods: In this double-blind, randomized, controlled clinical trial of 35 orthodontic patients (age: 14-19 years) who had pain during separator placement, each patient randomly placed naproxen and placebo patches in the first permanent molar region, in opposite quadrants of the same jaw. Patches were replaced every 8 hours until 3 days after separator placement. Patients recorded their pain perception at 2, 6, and 24 hours, and on days 2 (6 PM), 3 (10 AM and 6 PM), and 7 (10 AM and 6 PM), using a visual analog scale. Mean pain scores were compared for the two patches, and effects of sex and age thereon determined. Results: Data from 29 patients (21 girls, eight boys) were analyzed. Mean pain values decreased over time for both patches (P < 0.001). Recorded pain did not differ significantly between the sexes (P = 0.059) or between those aged <16 and those ${\geq}16years$ (P = 0.106). Mean pain recorded with naproxen patches was statistically significantly less than that with placebo patches at all time points (P = 0.004). Conclusion: The naproxen patch was more efficient than the placebo patch for reducing pain at all time points. The highest pain score was recorded at 6 hours, and the least pain was recorded at the $7^{th}$ day after separator placement.

• The Korean Journal of Pain
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• 제33권1호
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• pp.81-89
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• 2020

Background: For children with cleft palates, surgeries at a young age are necessary to reduce feeding or phonation difficulties and reduce complications, especially respiratory tract infections and frequent sinusitis. We hypothesized that dexmedetomidine might prolong the postoperative analgesic duration when added to bupivacaine during nerve blocks. Methods: Eighty patients of 1-5 years old were arbitrarily assigned to two equal groups (forty patients each) to receive bilateral suprazygomatic maxillary nerve blocks. Group A received bilateral 0.2 mL/kg bupivacaine (0.125%; maximum volume 4 mL/side). Group B received bilateral 0.2 mL/kg bupivacaine (0.125%) + 0.5 ㎍/kg dexmedetomidine (maximum volume 4 mL/side). Results: The modified children's hospital of Eastern Ontario pain scale score was significantly lower in group B children after 8 hours of follow-up postoperatively (P < 0.001). Mean values of heart rate and blood pressure were significantly different between the groups, with lower mean values in group B (P < 0.001). Median time to the first analgesic demand in group A children was 10 hours (range 8-12 hr), and no patients needed analgesia in group B. The sedation score assessment was higher in children given dexmedetomidine (P = 0.03) during the first postoperative 30 minutes. Better parent satisfaction scores (5-point Likert scale) were recorded in group B and without serious adverse effects. Conclusions: Addition of dexmedetomidine 0.5 ㎍/kg to bupivacaine 0.125% has accentuated the analgesic efficacy of bilateral suprazygomatic maxillary nerve block in children undergoing primary cleft palate repair with less postoperative supplemental analgesia or untoward effects.

• 대한한방부인과학회지
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• 제30권4호
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• pp.45-58
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• 2017

Objectives: The aim of this trial is to investigate the effect of Ginseng and Wild Cultivated Ginseng to Heat pattern subject. Methods: Eighty-nine Subjects were diagnosed as heat pattern by Cold-Heat Patternization and divided into Ginseng group (n=30), Wild Cultivated Ginseng group (n=31) and Placebo group (n=28) in their 1 st visit. In each visit, The researchers measured the subject's facial temperature using the infrared thermometer (Testo 835-T1). After that, The subjects were asked to mark the current score of flushing on the Visual Analogue Scale (VAS) and to complete the Chalder-Fatigue Scale (CFS) in each visit. The subjects took the test drug for one week and returned the remaining drug on the 2nd visit. The trial result was analyzed with one-way ANOVA using SPSS for Windows version 18. Results: 1. Systolic blood pressure was significantly lower in the Ginseng group and Wild Cultivated Ginseng group than in the control group (p=0.021). 2. There was no significant difference in facial temperature between each groups. 3. The current score of flushing showed the greatest decrease in the Ginseng group compared to the other groups but there was no significant difference (p=0.205). 4. The score of Chalder-Fatigue Scale was decreased in all groups but not statistically significant (p=0.180). Conclusions: This study showed that taking Ginseng extract and Wild Cultivated Ginseng extract do not affect to heat-rising reaction to the subjects diagnosed as heat pattern.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제22권6호
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• pp.545-553
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• 2019

Purpose: Feeding tolerance is extremely important in preterm infants. This study aimed to evaluate whether preterm infants receiving Lactobacillus reuteri DSM 17938 would develop fewer symptoms of feeding intolerance. Secondary outcomes were duration of parenteral nutrition, time to reach full feeding, length of hospital stay, sepsis, necrotizing enterocolitis (NEC), diarrhea, and mortality. Methods: This double-blind randomized controlled trial of L. reuteri DSM 17938 versus placebo included 94 neonates with a gestational age of 28-34 weeks and birth weight of 1,000-1,800 g. Results: Feeding intolerance (vomiting and/or distension) was less common in the probiotic group than in the placebo group (8.5% vs. 25.5%; relative risk, 0.33; 95% confidence interval, 0.12-0.96; p=0.03). No significant intergroup differences were found in proven sepsis, time to reach full feeding, length of hospital stay, or diarrhea. The prevalence of NEC (stages 2 and 3) was 6.4% in the placebo group vs. 0% in the probiotic group (relative risk, 1.07; 95% confidence interval, 0.99-1.15; p=0.24). Mortality rates were 2.1% in the probiotic group and 8.5% in the placebo group, p=0.36). Conclusion: The administration of L. reuteri DSM 17938 to preterm infants was safe and significantly reduced feeding intolerance. No significant differences were found in any other secondary outcomes.

• 한방재활의학과학회지
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• 제31권4호
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• pp.167-191
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• 2021

Objectives Degenerative osteoarthritis of knee is a disease with an increasing number of patients worldwide and its general treatments have some side effects. Methods 102 subjects were classified into test group 1, test group 2, and control group, and clinical trial products were taken for 12 weeks. The effectiveness was evaluated with changes in visual analogue scale, Korean-Western Ontario and McMaster Universities Osteoarthritis Index, inducible nitric oxide synthase, and cyclooxygenase-2. Results Both test group 1 and test group 2 were effective in reducing the pain of degenerative osteoarthritis of knee, and only test group 2 was effective in improving the ability to perform daily activities. No clinically significant changes were observed for any safety parameter. Conclusions In conclusion, the data of this study indicate that Zanthoxylum piperitum leaf extract has effectiveness and safety against mild degenerative osteoarthritis of knee.

• Journal of Dental Anesthesia and Pain Medicine
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• 제22권1호
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• pp.19-27
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• 2022

Background: Myofascial pain dysfunction syndrome (MPDS) is the most common type of temporomandibular disorder. This study compared the efficacies of low-level diode laser therapy (LLLT) and laser acupuncture therapy (LAT) in the treatment of MPDS. Methods: This double-blind randomized controlled clinical trial included 24 patients with MPDS who were randomly divided into two equally sized groups. Patients in the LLLT group received 12 sessions of low-level diode laser irradiation applied to the trigger points of the masticatory muscles during 1 month. The same protocol was also used in the LAT group according to the specific trigger points. We measured pain intensity and maximum mouth opening in both groups at baseline, during treatment, and 2 months after treatment completion. Results: The pain intensities decreased from 6.58±1.31 to 0.33±0.65 and from 7.08 ± 1.37 to 0 in the LLLT and LAT groups, respectively. The maximum mouth openings increased from 32.25 ± 8.78 mm to 42.58 ± 4.75 mm and from 33 ± 6.57 mm to 45.67 ± 3.86 mm in the LLLT and LAT groups, respectively. Pain intensity (P = 0.839) and level of maximum mouth opening (P = 0.790) did not differ significantly between the groups. Conclusion: Our results showed similar efficacy between LLLT and LAT in the treatment of MPDS signs and symptoms.

• 한국치위생학회지
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• 제23권1호
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• pp.33-42
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• 2023

연구목적: 본 연구는 스마트 폰을 활용한 증강현실의 기반의 칫솔질 가이드 프로그램을 이용하여 어린이의 치면세균막 제거 효율이 어떻게 변화하는지 알아보고자 하였다. 연구방법: 이중맹검 교차임상시험을 통하여, 5-12세 어린이 20명을 대상으로 일반 칫솔질 후 치면세균막 제거효율을 측정하고 워시아웃기간 이후, 증강현실 기반 칫솔질 수행 후 치면세균막 제거효율을 평가하여 비교하였다. 연구결과: 전반적으로 증강현실 기반 양치질이 일반 양치질보다 플라그 제거 효율이 우수하였다(p<0.05). 세부적으로 분류하면 전치부에서는 두 가지 칫솔질 방법 간 플라그 제거율에서 유의한 차이가 없었으나(p=0.056), 구치부에서는 플라그 제거율에서 유의한 차이가 있음을 확인하였다(p<0.05). 결론: 증강현실 기반을 기반으로 스마트폰을 이용한 양치질에 대한 치태 제거 효능을 확인하였으며, 향후 ICT 기술을 접목한 구강보건교육에 활용할 수 있을 것으로 판단된다.

• 한국식품위생안전성학회:학술대회논문집
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• 한국식품위생안전성학회 2004년도 추계심포지움 및 학술발표회 : 건강기능식품의 안전성 평가와 개발
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• pp.50-58
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• 2004

성인을 대상으로 펩타이드의 강압효과를 검토하기 위해, 경증고혈압증군(輕症高血壓症群) (평균연령 50.2${\pm}$5.6세, 남9명, 여1명) 및 정상고혈압군 (평균연령 47.7${\pm}$2.8세, 남9명) 에 있어서, 플라시보를 이용한 2중맹검법(2重盲檢法)에 따른 비교대조시험을 실시했다. 경증고혈압증군에서는 Valy-Tyrosine(VY) 환산으로 125${\mu}$g/day의 '펩타이드 음료'에 의해 혈압 저하의 경향이 확인되었고 VY 환산250${\mu}$g/day의 펩타이드 음용량으로 플라시보군에 비해서 유의한 강압이 확인되었다. (음용개시 4주후에서 수축기혈압 17.8${\pm}$2.5mmHg: p <0.01, 확장기혈압 11.0${\pm}$2.0mmHg: p (0.05). 정상고치혈압군(正常高値血壓群)에서는 유의한 혈압강하를 확인하지 못했다. 양 군(群)에서 공히 심박수의 변화는 없었다. 경증고혈압군 (평균연령 50.6${\pm}$4.6세, 남10명) 에 있어서 VY 125${\mu}$g/day의 음용량에서는 전후기 각 4주간의 비교대조교차실험을 했다. 펩타이드 전기 음용군(0-4주)에서는, 음용개시 1주후에 수축기 · 확장기 혈압 모두 유의한 혈압저하작용이 확인되었다. (수축기혈압의 변화율-6.9%, 확장기혈압의 변화율-5.8%, p <0.05) 펩타이드 후기 음용군(10-14주)에서는, 수축기혈압이 음용개시 3주후(변화율-6.7%, p <0.05)에, 확장기혈압이 음용개시 2주후(변화율 6.0%, p <0.05)에 각각 유의한 강압이 확인되었다. 양 군 모두 음용 중지 후에 혈압의 완만한 복귀가 관찰되었다. 전 대상자에 있어서 자각증상, 타각소견(他覺所見)과 함께 이상(異常)은 확인되지 않았으며 부작용도 없었다. 이상의 결과로부터, ‘펩타이드 음료’는 경증고혈압 혹은 경계역고혈압자(境界域高血壓者)의 혈압을, 자각증상 및 혈액${\cdot}$뇨검사에도 전혀 영향을 미치지 않고 저하시킨다고 결론지었다.