Journal of Korean Medicine Rehabilitation (한방재활의학과학회지)

The society of Korean Medicine Rehabilitation (한방재활의학과학회)
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Evaluation of the Effectiveness and Safety of Zanthoxylum piperitum Leaf Extract against Mild Degenerative Osteoarthritis of Knee: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

경증의 퇴행성 슬관절염에 대한 초피나무잎 추출물의 유효성 및 안전성 평가: 무작위 배정, 이중맹검, 위약대조 임상연구

  • Jeong, Ji-Hong (Department of Korean Medicine Rehabilitation, College of Korean Medicine, Semyung University) ;
  • Lee, Soo-Hwan (Department of Korean Medicine Rehabilitation, College of Korean Medicine, Semyung University) ;
  • Yoon, Hong-Ryoul (Department of Korean Medicine Rehabilitation, College of Korean Medicine, Semyung University) ;
  • Kim, Soon-Joong (Department of Korean Medicine Rehabilitation, College of Korean Medicine, Semyung University)
  • 정지홍 (세명대학교 한의과대학 한방재활의학교실) ;
  • 이수환 (세명대학교 한의과대학 한방재활의학교실) ;
  • 윤홍렬 (세명대학교 한의과대학 한방재활의학교실) ;
  • 김순중 (세명대학교 한의과대학 한방재활의학교실)
  • Received : 2021.09.16
  • Accepted : 2021.10.07
  • Published : 2021.10.31
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Abstract

Objectives Degenerative osteoarthritis of knee is a disease with an increasing number of patients worldwide and its general treatments have some side effects. Methods 102 subjects were classified into test group 1, test group 2, and control group, and clinical trial products were taken for 12 weeks. The effectiveness was evaluated with changes in visual analogue scale, Korean-Western Ontario and McMaster Universities Osteoarthritis Index, inducible nitric oxide synthase, and cyclooxygenase-2. Results Both test group 1 and test group 2 were effective in reducing the pain of degenerative osteoarthritis of knee, and only test group 2 was effective in improving the ability to perform daily activities. No clinically significant changes were observed for any safety parameter. Conclusions In conclusion, the data of this study indicate that Zanthoxylum piperitum leaf extract has effectiveness and safety against mild degenerative osteoarthritis of knee.

Keywords

References

  1. The Society of Korean Medicine Rehabilitation. Korean rehabilitation medicine. 5th ed. Paju:Globooks. 2020:116-7.
  2. Kim JH. Orthopedics for primary care physicians diagnosis and treatment. 2nd ed. Seoul:Daehan Medical Book Inc. 2016:226.
  3. Han TR, Bang MS, Jeong SG. Rehabilitation medicine. 5th ed. Seoul:Goonja Publisher Co. 2014:1161.
  4. Davis T, Loudermilk E, DePalma M, Hunter C, Lindley D, Patel N, Choi D, Soloman M, Gupta A, Desai M, Buvanendran A, Kapural L. Prospective, multicenter, randomized, crossover clinical trial comparing the safety and effectiveness of cooled radiofrequency ablation with corticosteroid injection in the management of knee pain from osteoarthritis. Reg Anesth Pain Med. 2018; 43(1):84-91. https://doi.org/10.1097/aap.0000000000000690
  5. Lee YJ, Jo HR, Kim SH, Sung WS, Kim EJ. Efficacy and safety of pharmacopuncture and bee venom acupuncture for knee osteoarthritis: a systematic review and meta-analysis. J Korean Med. 2020;41(1):55-83.
  6. Park YK. Inhibitory effects of Zanthoxylum piperitum on the LPS-induced production of nitric oxide and proinflammatory cytokines in RAW264.7 cells. Kor J Herbol. 2006;21(4):69-76.
  7. Jang MJ, Rhee SJ, Cho SH, Woo MH, Choi JW. A study on the antioxidative, anti - inflammatory and anti - thrombogenic effects of Zanthoxylumpiperitum DC. extract. Journal of the Korean Society of Food Science and Nutrition. 2006;35(1):21-7. https://doi.org/10.3746/JKFN.2006.35.1.021
  8. Metcalf MH, Larson RV. Painful disorders of the thigh and knee. In Bonica's management of pain. Philadelphia: Lippincott Williams & Wilkins. 2001:1593-613.
  9. KOSIS. Status of frequent sickness benefits by disease subclassification of the elderly aged 65 or older [Internet] 2015 [cited 2021 Sep 6]. Available from: URL: https://kosis.kr/statHtml/statHtml.do?orgId=350&tblId=DT_35001_A657111&conn_path=I2.
  10. KOSIS. Status of frequent sickness benefits by disease subclassification of the elderly aged 65 or older [Internet] 2021 [cited 2021 Sep 6]. Available from: URL: https://kosis.kr/statHtml/statHtml.do?orgId=350&tblId=DT_35001_A090111&conn_path=I2.
  11. Jung HC, Jeong SH. A clinical study of knee joint osteoarthritis patients on the effect of Korean traditional medicine treatment with acupuncture, cupping, physical therapy and Ganghwalijetong-yeum (Qianghuochutong-yin): case series. The Journal of the Society of Korean Medicine Diagnostics. 2015;19(2):125-32.
  12. Lee JA, Ha HK, Lee HY, Jung DY, Lee JK, Huang DS, Shin HK. Anti-inflammatory activities of herbal formulas for sasang constitutional medicine. J Sasang Constitut Med. 2010;22(4):56-64.
  13. Katz N. The impact of pain management on quality of life. J Pain Symptom Manage. 2002;24(1):S38-47. https://doi.org/10.1016/S0885-3924(02)00411-6
  14. The Korean Orthopaedic Association. Orthopaedics. Seoul:Choisin Euihaksa. 2003:1133-5.
  15. Cashman JN. The mechanisms of action of NSAIDs in analgesia. Drugs. 1996;52:801-20. https://doi.org/10.2165/00003495-199600525-00004
  16. Kim TY, Kim JH, Park JH, Lee JK, Han C, Kum CJ, Oh JW. The domestic trends of traditional Korean medicine treatments on degenerative knee arthritis. The Journal of Korea CHUNA Manual Medicine for Spine & Nerves. 2014;9(2):69-79.
  17. Kim JK, Ha JK, Li H, Jeong JM. Animal and clinical study of the efficacy of mulberry extract complex on degenerative arthritis. Kor J Herbol. 2015;30((3):25-34. https://doi.org/10.6116/KJH.2015.30.3.25.
  18. Park BJ. Herbal diet of obese with osteoarthristis. J Korean Med Obes Res. 2004;4(1):201-11.
  19. Korean Traditional Knowledge Portal. Zanthoxylum piperitum [Internet] 2007 [cited 2021 Sep 6]. Available from: URL: https://doi.org/10.20929/KTKP.MED.0000080222.
  20. Korean Traditional Knowledge Portal. Zanthoxylum bungeanum Maxim [Internet] 2007 [cited 2021 Sep 6]. Available from: URL: https://doi.org/10.20929/KTKP.MED.0000080339.
  21. Kim MH, Lee HS, Ha IJ, Yang WM. Zanthoxylum piperitum alleviates the bone loss in osteoporosis via inhibition of RANKL-induced c-fos/NFATc1/NF-κB pathway. Phytomedicine. 2021;80:153397. https://doi.org/10.1016/j.phymed.2020.153397
  22. Ha SY, Youn HN, Song CS, Kang SC, Bae JJ, Kim HT, Lee KM, Eom TH, Kim IS, Kwak JH. Antiviral effect of flavonol glycosides isolated from the leaf of Zanthoxylum piperitum on influenza virus. Journal of Microbiology. 2014;52(4):340-4. https://doi.org/10.1007/s12275-014-4073-5
  23. Ko TS, Kim SY, Lee JS. Reliability and validity of the Korean Western Ontario and McMaster Universities (WOMAC) osteoarthritis index in patients with osteoarthritis of the knee. J Korean Med Rehabil. 2009;19(2): 251-60.
  24. Hwang KA, Kwon JE, Noh YH, Park BK, Jeong YJ, Lee SM, Kim SY, Kim IH, Kang SC. Effects of Zanthoxylum piperitum ethanol extract on osteoarthritis inflammation and pain. Biomedicine & Pharmacotherapy. 2018;105:481-90. https://doi.org/10.1016/j.biopha.2018.05.109
  25. Chacon MR, Ceperuelo-Mallafre V, Maymo-Masip E, Mateo-Sanz JM, Arola L, Guitierrez C, Fernandez-Real JM, Ardevol A, Simon I, Vendrell J. Grape-seed procyanidins modulate inflammation on human differentiated adipocytes in vitro. Cytokine. 2009;47:137-42. https://doi.org/10.1016/j.cyto.2009.06.001