• 제목/요약/키워드: radionuclides

검색결과 596건 처리시간 0.029초

Optimization of Artificial Neural Network Model in Scaling Factor Determination Method

  • Lee, Sang-Chul;Hwang, Ki-Ha;Kang, Sang-Hee;Lee, Kun-Jai
    • 한국방사성폐기물학회:학술대회논문집
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    • 한국방사성폐기물학회 2004년도 학술논문집
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    • pp.254-254
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    • 2004
  • Final disposal of radioactive waste generated from Nuclear Power Plant (NPP) requires the detailed information about the characteristics and the quantities of radionuclides in waste package. Most radionuclides are difficult to measure and expensive to assay. Thus it is suggested to the indirect method by which the concentration of the Difficult-to-Measure (DTM) nuclide is estimated using the correlations of concentration-it is called the scaling factor-between Easy-to-Measure (Key) nuclides and DTM nuclides with the measured concentration of the Key nuclide.(omitted)

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Targeted alpha therapy (TAT) for cancer using metallic radioisotopes

  • Kang, Chi Soo;Lee, Kyo Chul;Lee, Yong Jin
    • 대한방사성의약품학회지
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    • 제5권2호
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    • pp.135-144
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    • 2019
  • Targeted alpha therapy (TAT) based on metallic radionuclides has attracted a lot of attention lately due to its impressive therapeutic efficacy displayed in couple of clinical studies for cancer. Representative metallic radionuclides emitting alpha-particle include 225Ac, 213Bi, and 227Th, and there have been variety of TAT formulations based on different targeting moiety and chelating agents. In this review, we introduce strategies to label metallic radioisotopes with biomolecules and look at some of recent preclinical and clinical results of TAT for cancer.

방사면역치료를 위한 알파 방출 방사성 동위원소 생산 (Alpha-emitting Radioisotopes Production for Radioimmunotherapy)

  • 전권수
    • Nuclear Medicine and Molecular Imaging
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    • 제41권1호
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    • pp.1-8
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    • 2007
  • This review discusses the production of alpha-particle-emitting radionuclides in radioimmunotherapy. Radioimmunotherapy labeled with alpha-particle is expected to be very useful for the treatment of monocellular cancer (e.g. leukemia) and micrometastasis at an early stage, residual tumor remained in tissues after chemotherapy and tumor resection, due to the high linear energy transfer (LET) and the short path length in biological tissue of alpha particle. Despite of the expected effectiveness of alpha-particle in radioimmunotherapy, its clinical research has not been activated by the several reasons, shortage of a suitable a-particle development and a reliable radionuclide production and supply system, appropriate antibody and chelator development. Among them, the establishment of radionuclide development and supply system is a key factor to make an alpha-immunotherapy more popular in clinical trial. Alpha-emitter can be produced by several methods, natural radionuclides, reactor irradiation, cyclotron irradiation, generator system and elution. Due to the sharply increasing demand of $^{213}Bi$, which is a most promising radionuclide in radioimmunotherapy and now has been produced with reactor, the cyclotron production system should be developed urgently to meet the demand.

Dynamic Fixedbed Adsorption of Radionuclides from Aqueous Solutions by Inorganic Adsorbents

  • Lee, Hoo-Kun;Park, Geun-Il;Byeon, Kee-Hoh;Ro, Sung-Gy;Park, Hyun-Soo
    • 한국원자력학회:학술대회논문집
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    • 한국원자력학회 1996년도 춘계학술발표회논문집(3)
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    • pp.409-414
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    • 1996
  • Radionuclides such as Cs and Sr were removed from dilute aqueous solutions by means of inorganic adsorbents, 13X and chabazite. The physical adsorption obeyed the DA equation and non-equilibrium dynamic adsorption model, which describes surface diffusion mechanism with the DA equation, simulated the adsorption behavior of cesium and strontium on zeolite in fixed bed adsorbers. The dynamic model simulated the adsorption behavior of cesium and strontium.

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