• Title/Summary/Keyword: radioactivity

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Metabolism of $\textrm{N}_{G}$-Monomethyl-L-arginine Formation of N-Monomethylurea in rat ($\textrm{N}_{G}$-Monomethyl-L-arginine의 대사 : 흰쥐에서 N-monomethylurea의 생성)

  • 조영봉
    • Environmental Analysis Health and Toxicology
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    • v.1 no.1
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    • pp.81-86
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    • 1986
  • After oral administration of $^{14}$ C-labelled $N^{G}$-mono[$^{14}$ C-methyl]-L-arginine into rats, 66.3% of the administered radioactivity has been recovered in the urine, and 86.2% of the total of the recovered radioactivity is recovered in the first 24-hr urine. Distributions of the radioactivity of the acidic, basic, and neutral portions and unmetabolized $N^{G}$-monomethyl-L-arginine are 33.3%, 40.2%, 12.5% , and 0.3%, respectively. The radioactivity corresponding N-monomethylurea is about 50% of the neutral portion and 6% of the administered radioactivity.ity.

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Multi-Radioactivity Measurement System Design for Indoor Environmental Monitoring (실내 환경 모니터링을 위한 다중 방사능계측 시스템 설계)

  • Sagong, Byung-Il;Kim, Nam-Ho
    • Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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    • 2022.05a
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    • pp.459-461
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    • 2022
  • In this paper, we propose a measurement system for measuring radioactivity detected in an indoor environment. This is to measure and prevent radiation generated in various spaces such as general house, workplace, and research institutes. Multi-radioactivity sensors are used to measure multiple spaces simultaneously. The measured radioactivity data is transmitted to the PC in real time through ZigBee and monitored. Even with a small amount of radioactivity, it is considered that it must be installed in a place where radiation exposure is expected, such as a laboratory or workplace, for prevention from chronic radiation syndrome.

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Development of a real-time mobile gamma-ray measurement system for shipboard use

  • Chang-Jong Kim;Mee Jang;Hyuncheol Kim;Jong-Myoung Lim;Wanno Lee;Gyu-Seong Cho
    • Nuclear Engineering and Technology
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    • v.55 no.11
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    • pp.4077-4082
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    • 2023
  • Large areas must be rapidly screened to monitor radiation in marine environments. For this purpose, this study developed a mobile real-time gamma-ray measurement system for shipboard use and evaluated its performance. The system was developed to measure engine or generator cooling water by installing a canister inside the ship. The minimum detectable activity of the system is about 0.8 Bq/L for a 60 s measurement period, and real-time data transmission and remote control are possible. The system was tested in the field and is currently being installed and operated on ships in service. Such a ship-based real-time gamma-radiation measurement system is suitable for a wide range of marine radiation surveillance applications and is expected to be rapidly deployed.

제 3세대 백금착체 항암제 신약개발 3. General pharmacology and pharmacokinetic study of SKI 2053R

  • 정명희;김명석;김용식;고광호;이신웅;신상구;방영주;조용백;류근호
    • Proceedings of the Korean Society of Applied Pharmacology
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    • 1993.04a
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    • pp.75-75
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    • 1993
  • The general pharmacological profiles of SKI 2053R were investigeted on the central nervous system, autonomic nervous system, respiratory-cardiovascular system, digestive system and other systems. SKI 2053R had no significant pharmacological effects. Pharmacokinetic studies on time-course of blood levels, tissue distribution and excretion of SKI 20S3R were performed in rats and beagle dogs after intravenous administration of $^{14}$ C-labeled SKI 2053R. The blood level of radioactivity decreased in bi-or tri-exponential manners: rapidly decreased at $\alpha$-phase but slowly decreased at $\beta$-or ${\gamma}$-phase. $^{14}$ C SKI 2053R was well distributed to all tissues except central nervous system. Tissue concentration profiles of radioactivity were almost consistent wi th those of blood, but higher than those of plasma from 1 to 168 hrs after administration. Also, these results were consistent wi th those of whole body ARG study. The urinary and fecal excretions of radioactivity within 168 hr after administration were 84-87 and 9-11 % of total radioactivity of $^{14}$ C-SKI 2053R administered. In lactating rats, the levels of radioactivity in the milk were significantly lower than that in the blood, but slightly higher than that in the plasma. The disapperance of the radioactivity from the milk was similar as that in the plasma.

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A study on the consumption of fishery products in relation with radioactivity-related safety information (방사능 관련 안전정보의 수산물 소비 영향에 관한 연구)

  • Kang, Jong-Ho
    • The Journal of Fisheries Business Administration
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    • v.46 no.1
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    • pp.145-155
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    • 2015
  • This study aims to look at the change in consumer awareness and behavior after Japan's 2013 nuclear power plant's radioactive water leakage and draw implications about them. Findings show that 81% of respondents decreased their consumption of fishery products after the nuclear incident, and kept on showing avoidance of imported fishery products including those from Japan. Also it showed that consumers more importantly considered safety when buying imported fishery products after the nuclear incident. The most common channel of receiving radioactivity safety information on fishery products were TV and online. However, the main reason for decreasing the consumption of fishery products was founded to be based on the inaccuracy of the information provided. However, many people said that they will increase their consumption of all fishery products if provided with accurate radioactivity information. Therefore, if accurate radioactivity information were to be spread effectively to the public, positive consumption rates of fishery products can be shown in the future. The inaccuracy of radioactivity safety information caused the rapid decrease of fishery products consumption in 2013 to be amplified. Therefore, this study showed the importance of the delivery of rapid, accurate and consistent information to consumers.

Study on the characteristics of airborne gross alpha and gross beta activities in the vicinity of nuclear facilities

  • Da-Young Gam;Chae-yeon Lee;Ji-Young Park;Hyuncheol Kim;Jong-Myoung Lim
    • Nuclear Engineering and Technology
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    • v.55 no.12
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    • pp.4554-4560
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    • 2023
  • Continuous monitoring of radioactive substances over a prolonged duration can yield crucial insights into the levels of radiation exposure through inhalation, both in the vicinity of nuclear facilities and/or general environments. In this study, we evaluated long-term measurements (2012-2022) of gross alpha-beta activities in the air in the vicinity of nuclear facilities and reference site, distribution characteristics of temporal trends and spatial fluctuations, and factors affecting radioactivity levels. The average airborne gross-α (in mBq m-3) for onsite and off-site were 0.124 and 0.117, respectively, and the average airborne gross-β (in mBq m-3) measurements were 1.10 and 1.04, respectively. The activity ratio (AR) of gross-α and gross-β were calculated as a ratio of 0.12. The distribution characteristics of gross-α and gross-β activities in this study area are likely influenced by the meteorological factors and variations in airborne PM concentrations rather than the operation of the nuclear facility.

Experiment to Calculate the Dosage of Radiopharmaceutical Products during the Bone Scan Tests (Bone Scan 검사 시 실제 환자에게 투여되는 용량 계산을 위한 실험)

  • Lee, Wang-Hui;Ahn, Sung-Min
    • The Journal of the Korea Contents Association
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    • v.15 no.4
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    • pp.357-362
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    • 2015
  • In this experiment, we are to know the administered radioactivity in the actual patients by measuring the remained radioactivity when administering the isotope with noted MDP, the radiopharmaceutical product, to 50 visited patients for the bone scan, confirmed the radioactivity administered to actual patients. We confirmed the actual administered amount of remained radioactivity in the syringe and 3-way by using a gauger after administering the isotope with MDP noted via 3-way with 50 patients maintaining 3-way after CT or MRI among the visited patients for the bone scan in the department of nuclear medicine. As a result of radioactivity in the 3-way and syringe pre and post injection of radiopharmaceutical products in 50 patients, average radioactivity of pre-injection is 31.75 mCi, average remained radioactivity in the syringes after injection is 1.22 mCi, and the average remained radioactivity in 3-way after injection is 0.95 mCi. The average of actual administered radioactivity is 29.57, so it is obvious that average 2.18 mCi was administered for less than the dosage that we initially intended to inject. When determining the dosage in view of the radioactivity that remains in the 3-way with the syringe, it would be possible to accurately dose the desired dosage to be administered to actual patients.

The Preoperative Diagnosis of Thyroid Cancer in $^{18}F$-FDG PET/CT Dual Time Imaging of SUV and Evaluation of Radioactivity Measurement (갑상선암 수술 전 진단목적의 $^{18}F$-FDG PET/CT Dual Time Point영상에서 SUV값과 방사능 농도 측정법의 유용성 평가)

  • Lee, Hyun-Kuk;Khang, Hyun Soo;Yang, Seoung-Oh;Han, Man-Seok
    • The Korean Journal of Nuclear Medicine Technology
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    • v.16 no.2
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    • pp.99-105
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    • 2012
  • Purpose : This study is designed to compare two parameters reflecting $^{18}F$-FDG uptake, SUV and radioactivity, for diagnosis of thyroid cancer in dual time $^{18}F$-FDG PET/CT imaging and to find which parameter is more useful to decide whether the tumor is malignant or not. Materials and Methods : We performed retrospective study for 40 patients. All patients are diagnosed as primary thyroid cancer and examined $^{18}F$-FDG PET/CT. First, we got the dispersion of scattering beam of neck and lung apex to set a background and compared each dispersion, mean value, standard deviation of maxSUV and radioactivity. Also, mean maxSUV, ${\Delta}maxSUV$, ${\Delta}maxBq$/ml(%) and radioactivity between groups according to lesion's size based on biopsy are compared with independent-sample t-test. Results : the values that were from maxSUV and radioactivity measurement technique were compensated and calculated to practical values for mean comparison and patients were divided to two groups based on tumor size, Group1 ($size{\leq}1$ cm, n=21), Group2 (size>1 cm, n=19) for accurate comparison. In Group1, maxSUV (semi-quantitative analysis) was increased from $5.64{\pm}5.85$ (1.89~17.84) at first image to $5.90{\pm}5.01$ (1.95~18.22) at second image and radioactivity (Bq/ml) (quantitative analysis) showed similar increase from $5.93{\pm}6.38$ (2.50~16.75) at first image to $6.01{\pm}5.25$ (2.66~16.58) at second image. In Group2, TFmaxSUV was $10.54{\pm}14.36$ (2.54~33.89) in true first image, TSmaxSUV was $9.85{\pm}12.88$ (2.62~26.20) in true second image separately. The maxSUV showed a significant difference in the mean comparison between the two groups (p=0.035) But, mean radioactivity (Bq/ml) was $5.93{\pm}6.38$ (4.81~40.99) in true first image, $6.01{\pm}5.25$ (4.51~36.93) in true second image and didn't show a significant difference statistically (p=0.126) Conclusion : In diagnosis of thyroid tumor, SUV and radioactivity depending on $^{18}F$-FDG uptake showed high similarity with coefficient of determination (R2=0.939) and malignant evaluation results using dual time also showed similar aspect. Radioactivity for evaluation of malignant tumor didn't show better specificity or sensitivity than maxSUV.

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Evaluation of Residual Radiation and Radioactivity Level of TRIGA Mark-II, III Research Reactor Facilities for Safe Decommissioning (TRIGA Mark-II, III 연구로 시절의 폐로를 위한 시설의 잔류 방사선/능 평가)

  • Lee, B.J.;Chang, S.Y.;Park, S.K.;Jung, W.S.;Jung, K.J.
    • Journal of Radiation Protection and Research
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    • v.24 no.2
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    • pp.109-120
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    • 1999
  • Residual radiation and radioactivity level in TRIGA Mark-II, III research reactors and facilities at the KAERI Seoul site, which are to be decommissioned, have been measured, analyzed and evaluated to know the current status of radiation and radioactivity level and to establish and to provide the technical requirements for the safe decommissioning of the facilities which shall be applied in minimizing the radiation exposure for workers and in preventing the release of the radioactive materials to the environment. Radiation dose rate and surface radioactivity contamination level on the experimental equipments, floors, walls of the facilities, and the surface of the activated materials within the reactor pool structure were measured and evaluated. Radioactivity and radionuclides in the pool and cooling water were also analyzed. In case of the activated reactor pool structures which are very difficult to measure the radiation and radioactivity level, a computer code Fispin was additionally used for estimation of the residual radioactivity and radionuclides. The radiation and radioactivity data obtained in this study were effectively used as basic data for decontamination and dismantling plan for safe decommissioning of TRIGA Mark-II, III facilities.

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Analysis of Radioactivity Concentration in Naturally Occurring Radioactive Materials Used in Coal-Fired Plants in Korea (국내 석탄연소 발전소에서 취급하는 천연방사성물질의 방사능 농도 분석)

  • Kim, Yong Geon;Kim, Si Young;Ji, Seung Woo;Park, Il;Kim, Min Jun;Kim, Kwang Pyo
    • Journal of Radiation Industry
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    • v.10 no.4
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    • pp.173-179
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    • 2016
  • Coals and coal ashes, raw materials and by-products, in coal-fired power plants contain naturally occurring radioactive materials (NORM). They may give rise to internal exposure to workers due to inhalation of airborne particulates containing radioactive materials. It is necessary to characterize radioactivity concentrations of the materials for assessment of radiation dose to the workers. The objective of the present study was to analyze radioactivity concentrations of coals and by-products at four coal-fired plants in Korea. High purity germanium detector was employed for analysis of uranium series, thorium series, and potassium 40 in the materials. Radioactivity concentrations of $^{226}Ra$, $^{228}Ra$, and $^{40}K$ were $2{\sim}53Bq\;kg^{-1}$, $3{\sim}64Bq\;kg^{-1}$, and $14{\sim}431Bq\;kg^{-1}$ respectively in coal samples. For coal ashes, the radioactivity concentrations were $77{\sim}133Bq\;kg^{-1}$, $77{\sim}105Bq\;kg^{-1}$, and $252{\sim}372Bq\;kg^{-1}$ in fly ash samples and $54{\sim}91Bq\;kg^{-1}$, $46{\sim}83Bq\;kg^{-1}$, and $205{\sim}462Bq\;kg^{-1}$ in bottom ash samples. For flue gas desulfurization (FGD) gypsum, the radioactivity concentrations were $3{\sim}5Bq\;kg^{-1}$, $2{\sim}3Bq\;kg^{-1}$, and $22{\sim}47Bq\;kg^{-1}$. Radioactivity was enhanced in coal ash compared with coal due to combustion of organic matters in the coal. Radioactivity enhancement factors for $^{226}Ra$, $^{228}Ra$, and $^{40}K$ were 2.1~11.3, 2.0~13.1, and 1.4~7.4 for fly ash and 2.0~9.2, 2.0~10.0, 1.9~7.7 for bottom ash. The database established in this study can be used as basic data for internal dose assessment of workers at coal-fired power plants. In addition, the findings can be used as a basic data for development of safety standard and guide of Natural Radiation Safety Management Act.