• 제목/요약/키워드: radioactive medicine

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몬테카를로 방법을 이용한 임신한 여성 핵의학 종사자의 모체 장기 및 태아선량 평가 (Assessment of Maternal Organs and Fetal Doses in Pregnant Female Nuclear Medicine Practitioners Using the Monte Carlo Method)

  • 조용인
    • 대한방사선기술학회지:방사선기술과학
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    • 제45권4호
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    • pp.331-339
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    • 2022
  • The purpose of this study was to evaluate maternal organ and fetal doses by week of pregnancy for pregnant women nuclear medicine practitioners in the nuclear medicine field. In addition, we intend to present basic data for the management of exposure doses of female nuclear medicine practitioners. In this study, phantoms of childbearing women, 3, 6, 9 months pregnant women were simulated using MCNPX(Monte Carlo N-Particle Extended) among the Monte Carlo methods. First, volume source was constructed based on 10 cm of the anterior part of the lower abdomen of the phantom, and the organ and fetal doses were evaluated for each week of the pregnant woman according to the type of radioactive isotope. Second, the organ and fetal dose of pregnant women were evaluated by increasing the distance between the source and the abdominal surface by 50 and 100 cm. As a result, 18F sources showed high organ and fetal doses in pregnant women 0 to 3 months, and the dose distribution gradually decreased in 6 to 9 months pregnant women. The distribution of organ and fetal doses for 99mTc and 123I sources showed the same tendency as that of 18F, and the overall absorbed dose distribution was relatively lower than that of 18F. Through this study, it is considered that workers in the early stages of pregnancy within 3 months will need appropriate management to minimize occupational exposure dose.

방사성요오드 치료를 받는 갑상선암 환자의 삶의 질 변화와 영향요인 (Changes in Quality of Life and Related Factors in Thyroid Cancer Patients with Radioactive Iodine Remnant Ablation)

  • 유선희;최스미
    • 대한간호학회지
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    • 제43권6호
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    • pp.801-811
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    • 2013
  • Purpose: To investigate changes in Quality of life (QOL) and related factors in patients with thyroid cancer undergoing Radioactive Iodine remnant ablation (RAI). Methods: Data were collected longitudinally 3 times for 6 months (2 weeks post-surgery, post RAI, 3 months post RAI) in a hospital located in Seoul. Questionnaires were used to measure levels of physical symptoms, anxiety, depression, and QOL. Ninety-eight patients with thyroid cancer who had RAI were included in the analysis. Data were analyzed using SPSS (18.0). Results: Findings for the three data collection times respectfully were: mean scores for physical symptoms, 0.53, 1.21 and 0.62, patients with depression, 47%, 36.7% and 37.7%, patients with anxiety, 18.4 %, 19.4% and 20.4%, mean scores for QOL, 7.06, 7.01 and 7.28. QOL score was highest 3 months post RAI (p=.031). In the stepwise multiple regression analysis, depression and fatigue were predicting factors for low QOL at all data collection times. Dysponia was a predicting factor for low QOL post RAI and 3 months post RAI. Conclusion: To increase QOL, it is necessary to provide information in advance regarding physical & psychological symptoms and to develop nursing intervention programs to decrease depression and fatigue.

Identification of Toxicant-Specific Patterns of Gene Expressi on and Evaluation of Molecular Mechanisms in Cellular Responses to Environmental Toxicants Using by Radioactive cDNA Microarray - As an example of gene expression profiling in workers exposed to polycyclic aromatic hydrocarbons or 2,3,7,8-tetrachlorodedibenzo-p-dioxins using by micro array -

  • Kim, Meyoung Kon
    • 한국유전체학회:학술대회논문집
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    • 한국유전체학회 2005년도 The 14th Korea Genome Conference
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    • pp.65-65
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    • 2005
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Initial Management of Radiation Injuries

  • Linnemann Roger E.
    • Journal of Radiation Protection and Research
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    • 제5권1호
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    • pp.11-25
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    • 1980
  • The increasing utilization of radioactive isotopes in industry, medicine and research has raised the question, 'How should hospitals deal with radiation injuries when they occur?' A system for initial management of radiation injuries has been developed by Radiation Management Corporation. Radiation injuries are classified and a treatment plan outlined for each at the emergency and short term medical care phase. This system includes clinical prognosis as well as a detailed plan for quick set up or a Radiation Emergency Area in any hospital. Procedures for patient admission, preparation of the facility, general decontamination, sample taking, and wound decontamination are included.

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Re-evaluation of [18F]fluorobenzaldehyde as a prosthetic group

  • Choe, Yearn Seong
    • 대한방사성의약품학회지
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    • 제1권2호
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    • pp.75-79
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    • 2015
  • [$^{18}F$]Fluorobenzaldehyde, which is a versatile radioactive prosthetic group, can undergo reduction, reductive amination, or oxidation to be used for synthesis of diverse radiotracers. This review covers synthesis of [$^{18}F$]fluorobenzaldehyde and its conversion to secondary prosthetic groups, and also highlights its application to the development of radiotracers.

방사성 의약품 합성에 관한 연구(VI)-Auflatoxine-$B_1$의 방사성 요오드 표지와 그 생리작용 (Labelling Auflatoxine-$B_1$ by Radioactive Iodine)

  • 김유선;박경배;성호경;유용운
    • 대한핵의학회지
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    • 제12권1호
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    • pp.37-40
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    • 1978
  • Carcinogen으로 알려져 있는 auflatoxine계통 화합물의 방사성 표지 반응을 연구하였다. Auflatoxine계통 약품중에서 그 함유량이 가장 큰 auflatoxin-$B_1$을 초산(醋酸) 촉매하에 chloroamine-T를 사용하여 $^{125}I$로 표지한 결과 표지화합물을 방사화학적 수율 63.6%로 얻을 수 있었다. 생성물의 화학구조를 I.R. 및 N.M.R.로 검사한 결과 auflatoxine의 benzene고리에 표지되었음을 확인하였다. 쥐를 시험동물로 삼아 경구 투여후의 대사과정을 부검(剖檢)으로 조사한 결과 간 및 혈액에 방사능이 축적되고 요오드이온은 분리되지 않았음을 확인하였다.

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