• 제목/요약/키워드: radiation response

검색결과 1,304건 처리시간 0.026초

A Case of Locally Advanced Well-Differentiated Fetal Adenocarcinoma of the Lung Treated with Concurrent Chemoradiation Therapy

  • Kyung, Chanhee;Kim, Sang Young;Lim, Beom Jin;Cha, Jung-Joon;Kim, Hyung Jung;Ahn, Chul Min;Park, Heejin;Cho, Eun Na;Chang, Yoon Soo
    • Tuberculosis and Respiratory Diseases
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    • 제74권5호
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    • pp.226-230
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    • 2013
  • Fetal adenocarcinoma is a rare adenocarcinoma subtype of pulmonary blastoma. A 48-year-old male patient is being referred to our hospital due to progressive dyspnea. A chest X-ray showed a lung mass of unknown origin that was obstructing the right main bronchus. After relieving the airway obstruction with stent insertion via bronchoscopy, a diagnosis of fetal adenocarcinoma is being confirmed through thoracoscopic biopsy. Due to the locally advanced state of the lung cancer, it seemed to be inoperable, and concurrent chemo-radiation therapy was being administered with docetaxel. The stent was removed after improvements in the airway obstruction followed by a lung mass shrinkage. Comparing to other contexts which describe fetal adenocarcinoma as lower grade malignancy with low-associated mortality, herein, we describe a case of locally-advanced fetal adenocarcinoma (T4N3M0). This is the first documented case being treated with concurrent chemoradiation therapy. The followed-up image studies represent a partial response and the patient is currently under further observations.

방사선과 자외선에 대한 고추 식물체 및 배양세포의 생장반응과 Capsidiol 생합성 유전자의 발현 차이 (Differential Growth Response and Gene Expression in Relation to Capsidiol Biosynthesis of Red Pepper Plant and Cultured Cells by γ-Ray and UV Stress)

  • 안정희;김재성;정정학;오세명;권순태
    • Journal of Plant Biotechnology
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    • 제30권2호
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    • pp.201-206
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    • 2003
  • Differential responses of red pepper plant and cultured cells to enhanced ${\gamma}$-ray($^{60}$ Co) and ultraviolet(UV) stress were investigated. In seed treatment, 1 Gy of ${\gamma}$-ray increased seedling dry weight up to 19.1%, but 50 Gy treatment markedly ingibited seed germination and subsequent growth of seedling. UV treatment to seed did not change the germination ability of seeds and the growth of seedlings regardless of duration of UV treatment until 24 hrs. In case of UV treatment to seedlings, plant injury was seriously progressed even after the seedlings were returned to no UV condition, and eventually all the leaves showed chlorosis by the stress. However, progress of plant injury by ${\gamma}$-ray stress slower than that caused by UV stress, and even at the high dose of ${\gamma}$-ray 50 Gy, did not caused the cholrosis of stressed plant leaf. Amount of electrolytes leakage from plant leaf by UV treatment for 24hrs was increased up to 28.8 folds in comparison with untreated control, whereas that of 50 Gy of ${\gamma}$-ray was increased only 1.2 folds. UV stress induced the production of capsidiol, antimicrobial phytoalexin, by activation of gene expression involved in capsidiol biosynthesis, such as sesquiterpene cyclase and cyclase and cytochrome P450 hydroxylase in the leaf and cultured cell, but ${\gamma}$-ray stress induced neither the production of capsidiol nor expression of the genes.

다차원 해석법을 이용한 자동차 공조시스템의 기여도분석 (Coherent Analysis of vehicle HVAC Using the MDSA Method)

  • 오재응;황동건;아미누딘;이정윤;김성수
    • 한국정밀공학회지
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    • 제22권8호
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    • pp.143-150
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    • 2005
  • To verify applicability of multi-dimensional spectral analysis (MDSA) fur noise source identification two different approaches which are frequency response and coherent function have been investigated. The coherence function approach appears able to separate the correlated system when the noise sources were coherent. In this study, we identify contribution of structure-borne-noise of vehicle HVAC system using MDSA method. Firstly, to identify the applicability of MDSA method, 4-inputs of vehicle HVAC system were the signals measured by accelerometers attached on the selected noise sources which were composed of blower, evaporator, heater and duct. While 1-output which was driver's position sound was the SPL signals measured by a remote microphone, when the blower motor was operating. We identify efficiency of systems modeled with four Inputs/single output through ordinary coherence function (OCF) and partial coherence function (PCF). As a result of experiment, the blower accounted for $62-88\%$ of the overall level of sound energy density. Also, according to the analysis of acoustic signal and vibration signals measurement, an investigation of the noise source identification in the vehicle HVAC is presented. With the sound intensity method, the major sources of the vehicle HVAC radiation are verified. Also the method of improving the noise reduction is proposed by attaching damping patch access to blower motor and noise reduction is verified.

5-Aza-2'-deoxycytidine Induces Hepatoma Cell Apoptosis via Enhancing Methionine Adenosyltransferase 1A Expression and Inducing S-Adenosylmethionine Production

  • Liu, Wei-Jun;Ren, Jian-Guo;Li, Ting;Yu, Guo-Zheng;Zhang, Jin;Li, Chang-Sheng;Liu, Zhi-Su;Liu, Quan-Yan
    • Asian Pacific Journal of Cancer Prevention
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    • 제14권11호
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    • pp.6433-6438
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    • 2013
  • In hepatocellular cancer (HCC), lack of response to chemotherapy and radiation treatment can be caused by a loss of epigenetic modifications of cancer cells. Methionine adenosyltransferase 1A is inactivated in HCC and may be stimulated by an epigenetic change involving promoter hypermethylation. Therefore, drugs releasing epigenetic repression have been proposed to reverse this process. We studied the effect of the demethylating reagent 5-aza-2'-deoxycitidine (5-Aza-CdR) on MAT1A gene expression, DNA methylation and S-adenosylmethionine (SAMe) production in the HCC cell line Huh7. We found that MAT1A mRNA and protein expression were activated in Huh7 cells with the treatment of 5-Aza-CdR; the status of promoter hypermethylation was reversed. At the same time, MAT2A mRNA and protein expression was significantly reduced in Huh7 cells treated with 5-Aza-CdR, while SAMe production was significantly induced. However, 5-Aza-CdR showed no effects on MAT2A methylation. Furthermore, 5-Aza-CdR inhibited the growth of Huh7 cells and induced apoptosis and through down-regulation of Bcl-2, up-regulation of Bax and caspase-3. Our observations suggest that 5-Aza-CdR exerts its anti-tumor effects in Huh7 cells through an epigenetic change involving increased expression of the methionine adenosyltransferase 1A gene and induction of S-adenosylmethionine production.

Clinical Observation and Prognostic Analysis of Pemetrexed plus Platinum as First-line Treatment in Patients with Advanced Non-small Cell Lung Cancer

  • Wang, Ji-Ying;Cai, Yong
    • Asian Pacific Journal of Cancer Prevention
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    • 제14권11호
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    • pp.6267-6271
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    • 2013
  • Objective: To determine clinical efficacy, safety and prognostic factors of pemetrexed plus platinum as first-line treatment in patients with advanced non-small cell lung cancer (NSCLC). Materials and Methods: Clinical characteristics, short-term efficacy, survival and adverse reactions of 47 advanced non-squamous NSCLC patients who had received pemetrexed plus platinum as first-line treatment in Shanghai Pulmonary Hospital from January 2009 to June 2011 were retrospectively analyzed. The Chi-squared test was applied to statistically analyze the overall response rate (ORR), disease control rate (DCR) and toxicity reactions in both groups, while survival data wereanalyzed by Kaplan-Meier and logrank methods, and the COX proportional hazards model was adopted for a series of multi-factor analyses. Results: Only two patients were lost to follow-up. The ORR, DCR, medium progression-free survival time (PFS) and medium overall survival (OS) were 31.9%, 74.5%, 5 months and 15.2 months, while 1- and 2-year survival rates were 63.8% (30/47) and 19.2% (9/47), respectively. Single-factor analysis showed that tumor pathological patterns and efficacy were in association with medium PFS (P<0.05), whereas tumor pathological patterns, smoking history and efficacy were closely connected with medium OS (P<0.05). Multi-factor analyses demonstrated that pathological patterns and efficacy were independent factors influencing OS (P<0.05). The rate of toxicity reactions in degree III/IV was low, including hematologic toxicity marked by decline in white blood cell count and decrease in the platelet count (PLT), and non-hematologic toxicity manifested by gastrointestinal reactions, such as nausea and vomiting. Conclusions: Pemetrexed plus platinum as first-line treatment has excellent efficacy and slight adverse reactions with favorable drug-tolerance in patients with advanced non-squamous NSCLC.

음선 역전파 기반의 선박 위치 추정 (Ray backpropagation-based ship localization)

  • 조성일;변기훈;변성훈;김재수
    • 한국음향학회지
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    • 제37권4호
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    • pp.196-205
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    • 2018
  • 본 논문은 선박소음 데이터에 음선 역전파 기법을 적용하여 수동 선박 위치 추정 알고리듬을 제시한다. 기존의 방법 [S. H. Abadi, D. Rouseff and D. R. Dowling, J. Acoust. Soc. Am. 131, 2599-2610 (2012)]은 음선 기반 블라인드 디컨벌루션 및 음선 역전파 기법을 활용하여 배열의 기울기가 없는 근거리 환경에서 음원의 위치를 추정하였다. 하지만 위 방법은 배열의 기울기에 따른 위치 추정 오차가 크게 발생한다는 단점이 존재한다. 이를 극복하기 위해 본 논문에서는 음선 기반 블라인드 디컨벌루션 및 음선 역전파 기법을 사용하되, 배열의 기울기를 보정하여 음원의 위치를 추정할 수 있는 알고리듬을 제안한다. 제안된 알고리듬의 성능은 SAVEX15(Shallow-water Acoustic Variability EXperiment in 2015)해상 실험의 선박소음 데이터를 이용하여 검증하였다.

두경부암 환자에 병발된 위암 2예 (Two Cases of Stomach Cancer in Patients with Head and Neck Cancer)

  • 강진형;문찬수;김훈교;이경식;김동집;윤세철;조승호;서병도
    • 대한두경부종양학회지
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    • 제8권1호
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    • pp.25-30
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    • 1992
  • The causes of treatment failure in head and neck cancer are locoregional recurrence, distant metastasis and second primary cancer. The favorite sites of second primary cancer are head and neck, lung and esophagus. But, the incidence of stomach cancer in Korea is the highest of all, high incidence of stomach cancer is expected in head and neck cancer patients. We experienced 2 cases of stomach cancer after successful treatment of primary head and neck cancer at Kang Nam St. Mary's hospital. The first case was a 60-year-old male with nasopharyngeal non-keratinizing carcinoma(stage III, T1N1M0). He received three cycles of induction chemotherapy including cisplatin and 5-fluorouracil followed by radiotherapy which resulted in complete response. Five months after completion of radiotherapy. stomach adenocarcinoma(stage IV, T4N2M1) was diagnosed. He received one cycle of FAM chemotherapy and died 4 months after diagnosis of stomach cancer. The second case was a 50-year-old male with pyriform sinus squamous cell carcinoma(stage II, T2N0M0). He received curative partial pharyngolaryngectomy followed by radiotherapy which result in free of disease. Four months after completion of radiotherapy. stomach adenocarcinoma(stage IV, T4N2M1) was diagnosed. Bypass gastrojejunostomy was performed. The screening test for stomach cancer including upper gastrointestinal X-xay series and/or endoscope of the stomach should be performed periodically for the patients with head and neck cancer in Korea.

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종격동내 혼합 생식 세포종과 폐전이를 동반한 혈관육종이 동시에 존재한 중복암 1예 (A Case of Combined Mixed Germ Cell Tumor and Angiosarcoma within the Mediastinum)

  • 류헌모;최희진;신경철;정진홍;이관호;이현우;이동혁;이정철;한승세;심영란;김동석
    • Tuberculosis and Respiratory Diseases
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    • 제41권4호
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    • pp.413-417
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    • 1994
  • 저자들은 최근 2개월간의 각혈, 기침, 체중 감소를 주소로 입원한 19세 남자에서 종격동내 혼합 생식 세포종과 폐전이를 동반한 혈관육종이 동시에 존재한 중복암 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다.

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Follow-Up Consultations for Cervical Cancer Patients in a Mexican Cancer Center. Comparison with NCCN Guidelines

  • Serrano-Olvera, Alberto;Cetina, Lucely;Coronel, Jaime;Duenas-Gonzalez, Alfonso
    • Asian Pacific Journal of Cancer Prevention
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    • 제15권20호
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    • pp.8749-8752
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    • 2014
  • Purpose: This study aimed to determine the patterns of follow-up visits for cervix cancer in a national cancer center in Mexico. Materials and Methods: The National Cancer Institute of Mexico is cancer center with 119 beds that mostly cares for an underserved and socially disadvantaged population. The medical records of cases of cervical cancer that had at least one year of clinical follow-up after being in complete response at the end of primary treatment were analyzed. We recorded the numbers of total and yearly follow-up visits and these were compared with the number of follow-up visits recommended by the National Comprehensive Cancer Network 2013, version 2 for cervical cancer. Results: Between March and June 2007, the medical records of 96 consecutive patients were reviewed. Twenty (21%) of these met inclusion criteria and were selected. In the first year the median number of visits was 11 (4-20). In the ensuing years, $2^{nd}$, $3^{rd}$, $4^{th}$ and $5^{th}$, the number of analyzed patients remaining in follow-up decreased to 17, 14, 13 and 9 respectively. There were 462 follow-up visits to primary treating services (Gynecology Oncology, Radiation Oncology and Medical Oncology) as compared to 220 suggested by the NCCN guidelines ($X^2$ test p<0.0001). There were 150 additional visits to other services. Conclusions: Our results suggest that in our institution there is an overuse of oncological services by cervical cancer patients once treatment is completed.

고사리 (Pteridium aquilinum) Ethanol 추출액(抽出液)에 의한 혈압강하작용(血壓降下作用) (Effect of Ethanol Extracts of Raw and Boiled Bracken on Blood Pressure in Cats)

  • 고상돈;김기순
    • The Korean Journal of Physiology
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    • 제18권2호
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    • pp.171-180
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    • 1984
  • The death of cattle from acute bracken poisoning has been recognized for many years. Acute bracken poisoning is characterized by mucoidal nasal and anal hemorrhage, severe anorexia. pyrexia, gastric ulcer and myocardial damage. In 1958 Evans first suggested that clinical picture of bracken poisoning was very much similar to that of radiation injuries such as aplastic anemia, leucopenia, thrombocytopenia and increased capillary fragility. Bracken has been clearly demonstrated to contain a carcinogen as well as thiaminase. However, the nature of carcinogen in bracken has not definetely elucidated. Also it was warned by several workers that bracken could be a causative factor for stomach cancer in Korean and Japanese. It appears that little is known on the e(feet of bracken on the function of cardiovascular system. Therefore the present study was designed to explore effects of ethanol extract of raw and toiled bracken (RBEE:BBEE) on blood pressure in cats. Also studied was the mechanism underlying changed in blood pressure of cats by bracken. The result obtained were as follows; 1) Mean arterial blood pressure was invariably decreased following administration of either RBEE or BBEE. Tn general depressor responses to RBEE persisted longer than that to BBEE. Generally, depressor responses were proportional to debases of RBEE and BBEE administered. 2) After administration of 60 mg/kg RBEB and BBEE, blood Pressure decreased by $62.1{\pm}1.7mmHg$ and $68.0{\pm}3.0mmHg$, respectively. No change was observed between depressor responses to RBEE and that to BBEE. 3) Depressor responses to BBEE and RBEE were not affected by vagotomy, propranolol and regitine. 4) In atropinized animal depressor responses to BBEE and RBEE were reduced by 30-40% showing part of depressor response was resulted from cholinergic effect of bracken.

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