• Natural Product Sciences
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• v.18 no.1
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• pp.60-66
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• 2012

Human skin is the first line of defense for the protection of the internal organs of the body from different stimuli. Ultraviolet B (UVB) irradiation induces skin damage and inflammation through the secretion of various cytokines, which are immune regulators produced by cells. To prevent the initiation of skin inflammation, keratinocytes that have been irreversibly damaged by radiation must be removed through the apoptotic mechanism. Ixeris dentata (family: Asteraceae) is a perennial medicinal herb indigenous to Korea. It has been used in Korea, China, and Japan to treat in digestion, pneumonia, diabetes, hepatitis, and tumors. To gain insight into the anti-inflammatory effects of I. dentata, we examined its influence on UVB-induced pro-inflammatory cytokine production in human keratinocytes (HaCaT cells), by observing cells that were stimulated with UVB in the presence or absence of I. dentata. In the present study, pro-inflammatory cytokine production was determined by performing enzyme-linked immunosorbent assay, reverse transcription polymerase chain reaction, and western blot analysis to measure the activation of mitogen-activated protein kinase (MAPKs). I. dentata inhibited UVBinduced production of the pro-inflammatory cytokine interleukin (IL)-6 in a dose-dependent manner. Further, I. dentata inhibited the UVB-induced expression of cyclooxygenase (COX)-2. Furthermore, I. dentata inhibited the phosphorylation of c-Jun NH2-terminal kinase and p38 MAPKs, suggesting that it inhibits the secretion of the pro-inflammatory cytokines IL-6 and IL-8, and COX-2 expression, by blocking MAPK phosphorylation. These results suggest that I. dentate can potentially protect against UVB-induced skin inflammation.

• KOREAN JOURNAL OF PACKAGING SCIENCE & TECHNOLOGY
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• v.13 no.2
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• pp.51-58
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• 2007

This research investigated the effect of different onggi containers (Korean earthenware) on the ripening of kochujang (Korean hot pepper paste). The physical characteristics of 'onggi', were evaluated as function of manufacturing variables such as raw material soils (onggi-specific soil, red brown soil, and fine powdered soil) and galzing treatments. The physical properties were then related to the compositional quality changes of the kochujang fermented at $30^{\circ}C$ for 4 months. The porosity of the onggi containers seems to be increased by the content of finer raw soil rather than the chemical component of soil (amount of CaO, MgO, $K_2O$ and $Na_2O$, acting as melting aid in the firing). Natural glaze was measured to contain higher contents of CaO, MgO, $K_2O$ and $Na_2O$ than the other soils, which is desirable property for the fired onggi. The glazed surface showed higher far-infrared radiation emissivity than the non-glazed part. The kochujang fermented in P0-BG (the glazed onggi from 100 % onggi soil) attained higher concentration of reducing sugar, amino nitrogen and nucleotides compared to those in the other onggis. All of these changes of kochujang in P0-BG resulted in significantly better sensory quality than the other treatments.

• The Korean Journal of Nuclear Medicine
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• v.31 no.4
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• pp.433-439
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• 1997

$^{166}Ho$-chitosan complex, or $^{166}Ho$-CHICO, is a candidate pharmaceutical for intracavitary radiation therapy of cystic brain tumors because of the desirable nuclear characteristics of $^{166}Ho$ for therapeutic use and the suitable biological and chemical characteristics of chitosan, not to mention its ready producibility The amount of $^{166}Ho$-CHICO to be administered to obtain the goal therapeutic effect can be suggested by predicting the dose to the cyst wall for a varying pharmaceutical dose. When $^{166}Ho$-CHICO is infused into the cyst, the major part of the energy delivery by beta particles emitted from $^{166}Ho$ occurs in the cyst wall within 4mm in depth from the cyst wall surface. Also, realizing the attachment of $^{166}Ho$-CHICO to the cyst wall surface would change the predictions of dose to the cyst wall.

• Journal of the Korean Society for Nondestructive Testing
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• v.28 no.2
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• pp.131-136
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• 2008

Using ultrasonic standing waves, micro particles submerged or flowing in fluid can be manipulated. Due to acoustic radiation force of ultrasound, particles are forced to move to pressure nodal or antinodal lines. In this work, we propose a method to control the position of micro particle in a flow by adjusting the frequency of the standing wave. To this end, standing wave field generation system including a few millimeter thick micro channel was established using an immersible ultrasonic transducer. The present generation system works valid in a frequency range between 2.0 MHz and 2.5 MHz. We observed the SiC particles in water moved to pressure nodal lines by the standing wave. The effect of the channel thickness and operating frequency was also investigated. Interestingly, it was shown that the operating frequency have a close relation with the location of the pressure nodal line. Consequently, it fan be said that the position of particle movement rail be controlled by adjusting the ultrasound frequency. The maximum range of the controllable position was about 261 micrometers under the given condition. The resulted observations reveal the possibility of various applications of the ultrasonic standing wave to the manipulation of particles submerged in a fluid.

• Journal of Yeungnam Medical Science
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• v.10 no.2
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• pp.380-387
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• 1993

Local excision and axillary dissection followed by radiation therapy to the breast has been shown to achieve equivalent local control and survival as mastectomy in an prospective randomized trials. We analyzed 28 cases of early breast cancer in order to evaluate the therapeutic effects of conservative surgery and definitive radiotherapy in the management of early breast cancer as possible alternative of simple mastectomy, retrospectively. Obtained results were as follows : 1. Treatment related acute side reactions are more prominant in the case of chemoradiotherapy group than radiotherapy alone group. 2. There were no cases of primary, regional or systemic failures on the last follow up examination. 3. Cosmetic results after treatment were satisfactory in 26 cases out of 28 cases on the last follow up examination. 4. There were no demonstrable differences of tumor control and cosmetic results between the treatment groups. Although, these results suggested that definitive radiotherapy after local excision would be a possible and desirable alternative instead of total mastectomy in the management of early breast cancers, analyzed cases were too small and follow up period was too short to evaluate the therapeutic effect of primary radiotherapy after local excision, exactly.

• Journal of Dairy Science and Biotechnology
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• v.23 no.2
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• pp.93-98
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• 2005

Effects of heat and gamma irradiation on chemical, microbiological, and immunological changes of raw milk were compared. Free fatty acid content of milk showed increasing tendency according to the increase of heating temperature and irradiation dose, and showed similarity in UHT (ultra high temperature) and 5 kGy irradiation. Total bacterial counts and coliforms were not detected after treatment of LTLT (low temperature long time), HTST (high temperature short time), UHT, and irradiation from 1 to 10 kGy in the milk with initial microbial load at $10^3$ CFU/mL initially, but after 7 day storage, were not detected in UHT milk and that irradiated at 3 kGy or above. Heat treatment decreased (p<0.05) arginine, asparate, iso-leucine, lysine, and methionine content compared to raw milk while irradiation decreased (p<0.05) asparate, histidine, iso-luecine, leucine, and lysine content, which means irradiation could change primary structure of milk proteins. It was concluded that f kGy gamma irradiation treatment of raw milk could give a similar effect to UHT treatment in chemical and microbiological viewpoint, and may reduce allergenicity of raw milk.

• Horticultural Science & Technology
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• v.32 no.4
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• pp.507-516
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• 2014

The present study was conducted to determine the effect of electron beam irradiation on control of Botrytis cinerea and postharvest quality of cut roses. Electron beam doses of 0.1, 0.2, 0.4, 0.6, 0.8, 1, 2, 10, and 20 kGy were applied with a 10-MeV linear electron beam accelerator (EB Tech, Korea). Electron beams inhibited spore germination and mycelial growth of B. cinerea with increasing irradiation doses. Conidia of B. cinerea were more tolerant to irradiation than were mycelia: the effective irradiation doses for 50% inhibition ($ED_{50}$) of spore germination and mycelial growth were 2.02 kGy and 0.89 kGy, respectively. In addition, electron beam irradiation was more effective in reducing mycelial growth of B. cinerea at $10^{\circ}C$ than at $20^{\circ}C$. Analysis of in vivo antifungal activity revealed that elevated irradiation doses exhibited increased control efficacy for tomato gray mold. Flower longevity and fresh weight of cut roses decreased when the irradiation dose was increased. In addition, flower bud opening tended to be inhibited in a dose-dependent manner. Although 'Decoration', 'Il se Bronze', 'Queen Bee', and 'Revue' roses tolerated and maintained overall postharvest quality up to 0.4 kGy, 'Vivian' did not, demonstrating that the irradiation sensitivity of cut roses varies according to cultivar.

• Korean Journal of Soil Science and Fertilizer
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• v.30 no.2
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• pp.184-188
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• 1997

To investigate the absorption and transfer factor(TF) of Sr-85 by rice(Oryza sativa L.), experiments were carried out through pot cultivations on a sandy-loam soil treated 74 and 222Bq per gram of soil in a plastic film house. Sr-85 absorption rates of Ilpoombyeo, late maturing variety and Odaebyeo, early maturing variety, at harvesting stage, were 0.39-0.43% and 0.66-0.73%, respectively. Sr-85 absorption rates of Odaebyeo were about 1.5 times higher than those of Ilpoombyeo. Ratios of Sr-85 radiation and Sr-85 concentration in brown rice were much lower compared with those in straw and husk. Sr-85 concentrations in each part of Odaebyeo were remarkably higher than those of Ilpoombyeo. Transfer factor of Sr-85 from soil to plant ranged from 0.037 of brown rice to 4.13 of rice straw at harvesting stage. The order of the Sr-85 transfer factor in plant parts was straw>husk>brown rice. Sr-85 concentrations treated in soil had no effect on the growth and yield of rice.

• Journal of the Institute of Electronics Engineers of Korea SC
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• v.45 no.3
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• pp.59-67
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• 2008

Due to the fast increase in cellular phone users, public interest on health effect of electromagnetic fields(EMFs) by cellular phonos is gradually increasing. Some EHS(electromagnetic hypersensitivity) patients complain of psycho-neurophysiological symptoms such as headaches, insomnia, memory loss resulting from RF radiation by CDMA cellular phones. However, EHS is difficult to diagnose and depends on the individual's subjective judgement. And we don't know clearly if the cause of EHS is uneasiness or real exposure. There have been various EHS volunteer studies on heart rate, blood pressure and subjective symptoms using GSM phones. But there are few studies on experimental case-control study investigating physiological parameters, subjective symptoms, and perception of EMFs. In this study, two volunteer groups of 17 self-declared EHS and 19 controls were exposed to both sham and real RF exposure by CDMA cellular phones for half an hour each. We investigated not only the physiological parameters such as heart rates, respiration rates and HRVs(hear rate variability), but also the perception of EMFs and subjective symptoms. As the results, EMF exposure did not have any effects on the subjective symptoms or physiological parameters for both groups. For the EMF perception, there was no evidence that EHS group perceived the EMFs correctly than the control group.

• Fashion & Textile Research Journal
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• v.7 no.3
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• pp.315-320
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• 2005

With regard to the fact that temperature of human body remains almost constant at $37^{\circ}C$, changes by circadian variation, this study intended to investigate the effect of circadian rhythm on physiological responses of human body according to body fat rate. Fifteen healthy adult women were recruited for this study and were measured body fat as a method of bio impedance. We organized subjects into three groups ; low body fat group(group L-less than 20% of body fat), medium body fat group(group M-20%~30% of body fat) and high body fat group(group H-more than 30% of body fat). The experiment was carried out in a climate chamber of $32^{\circ}C$, 60% RH with the repeat of 'Exercise' and 'Rest' period. Subjects participated in two experiments, one is morning experiment(called 'AM'), the other is afternoon experiment (called 'PM'). The results of this study are as follows ; As to the variation of rectal temperature, group L and M had a significant difference in the time of the day between AM and PM, but group H had almost the same rectal temperature in the two kinds of experimental time. The reason why group H had a smaller difference in the circadian rhythm of rectal temperature in this study is estimated at the Budd et al.(1991)'s results that body fat had effects on reduction in thermogenesis, radiation, mean skin temperature, and increase in insulation of the tissues. Group M had the highest mean skin temperature in the 'PM'. All the 3 groups didn't have stable values in 'AM'. But it showed more stable in 'PM' than 'AM'. Sweat rate was the highest in group H in both 'AM' and 'PM'. Group M had larger sweat rate in 'PM' than 'AM'. but in group L and H, sweat rate was almost the same in two kinds of time of the day. This result suggests that who have more or less body fat have larger difference in sweat rate between morning and afternoon than who have normal body fat.