• Archives of Pharmacal Research
• /
• 제17권2호
• /
• pp.104-108
• /
• 1994

trans-Ethyl 1, 2, 3, 4a, 5, 6, 8a-cotahydro-2-benzyl-4-hydroxy-6-methyl-5-isoquinoline-carboxylate was prepared by intramolecular Diels-Alder reaction as a precusor of newly designed aza-analogue of mevinolin.

• 대한화학회지
• /
• 제46권4호
• /
• pp.402-404
• /
• 2002

• Bulletin of the Korean Chemical Society
• /
• 제13권5호
• /
• pp.571-573
• /
• 1992

• Bulletin of the Korean Chemical Society
• /
• 제31권2호
• /
• pp.447-452
• /
• 2010

A series of 5-alkoxy-tetrazolo[1,5-a]quinolines were synthesized to evaluate their anticonvulsant and antidepressant effects. Anticonvulsant effects and neurotoxicity of the compounds when injected intraperitoneally to mice were determined by a maximal electroshock (MES) test and a rotarod test, respectively. Only three of the synthesized compounds (4a, 4b, 4c) displayed anticonvulsant activity at a dose of 300 mg/kg. Most of the compounds significantly reduced immobility times during the forced swimming test (FST) at a dose of 100 mg/kg, indicative of antidepressant activity. Among the compounds, 5-(2-fluorobenzyloxy)tetrazolo[1,5-a]quinoline (4k) reduced immobility time by 66.85% at 30 mg/kg compared with the same dose of Fluoxetine, which reduced immobility time by 52.30%. According to the results of the 5-Hydroxytryptophan induced head-twitch test and yohimbine toxicity potentiation test, the noradrenergic system seems not to be involved in the antidepressant-like effect of compound 4k while the serotonergic system seems a little to be involved.

• Carbon letters
• /
• 제26권
• /
• pp.43-50
• /
• 2018

In this research, a novel and efficient quinoline thioacetamide functionalized magnetic graphene oxide composite ($GO@Fe_3O_4@QTA$) was synthesized and utilized for dispersive magnetic solid phase preconcentration of Cd(II) and Ni(II) ions in urine and various food samples. A number of diverse methods were employed for characterization of the new nanosorbent. The design of experiments approach and response surface methodology were applied to monitor and find the parameters that affect the extraction performance. After sorption and elution steps, the concentrations of target analytes were measured by employing FAAS. The highest extraction performance was achieved under the following experimental conditions: pH, 5.8; sorption time, 6.0 min; $GO@Fe_3O_4@QTA$ amount, 17 mg; 2.4 mL $1.1mol\;L^{-l}$ $HNO_3$ solution as the eluent and elution time, 13.0 min. The detection limit is 0.02 and $0.2ng\;mL^{-1}$ for Cd(II), and Ni(II) ions, respectively. The accuracy of the new method was investigated by analyzing two certified reference materials (sea food mix, Seronorm LOT NO 2525 urine powder). The interfering study revealed that there are no interferences from commonly occurring ions on the extractability of target ions. Finally, the new method was satisfactorily employed for rapid extraction and determination of target ions in urine and various food samples.

• Journal of Korean Vacuum Science & Technology
• /
• 제4권1호
• /
• pp.1-5
• /
• 2000

The C 1s photoelectron energy loss spectra of tris (8-hydroxy-quinoline) aluminum (Alq$_3$) and N,N'-diphenyl-N,N'-bis (3-methyl phenyl)-1,1'-bi-phenyl-4,4'-diamine (TPD) thin films have been investigated. Two major loss structures, namely the plasmon dominated loss lines and shake-up satellites, have been observed. The shake-up spectrum of the C 1s photoelectron line is directly related to the $\pi$-$\pi$$\^$*/ energy gap of the molecule which plays an important role in organic electroluminescent materials. The molecular orbitals of Alq$_3$ and TPD and their major components, quinolime and benzene, have been calculated with the AMI semi-empirical method. The amount of the plasma-dominated loss of Alq$_3$ and TPD, which has to do with the delocalization of electrons through the molecule, was about 24 eV, alike in both cases. The main peak of the C 1s shake-up spectrum of Alq$_3$ and TPD, however, was 5.2 eV and 6.8 eV respectively. It was found that the main shake-up peak reflects more the local $\pi$\longrightarrow$\pi$$\^$*/ transition of quinoline and benzene component rather than the excitation of the whole molecule of Alq$_3$ and TPD. The C 1s shake-up spectra, however, revealed some correlation with the optical energy gap of the organic eletroluminescent materials.

• Bulletin of the Korean Chemical Society
• /
• 제35권11호
• /
• pp.3326-3330
• /
• 2014

A quinoline-thiooxorhodamine conjugate fluorescent sensor (1) has been synthesized. Sensor 1 exhibits high selectivity and sensitivity to $Hg^{2+}$ in $H_2O$/DMSO (95/5, v/v, HEPES 20 mM, pH = 7.4) solution with fluorescence detection. Other tested metal ions do not induce any significant fluorescence intensity changes. Sensor 1 interacts with $Hg^{2+}$ through a 1:1 binding stoichiometry with a good anti-inference ability. In addition, fluorescent imaging of $Hg^{2+}$ in Hela cells is also successfully demonstrated.

• Carbon letters
• /
• 제10권3호
• /
• pp.198-201
• /
• 2009

Among other filters such as light filter, wave filter, air filter, ultra filter and filter paper, a novel adsorption filter from thermostable polyester nonwoven fabrics immobilized with functional super activated carbon by means of quinoline soluble, activateable isotropic pitch binder were developed in this study. The activated carbon precursor is available in the market branded as coconut shell based activated carbon(CCS-AC) produced by Dongyang Carbon Co. Ltd. BET-surface area of this precursor was $1,355\;m^2/g$, after KOH-activation it increased over $2,970\;m^2/g$ and was named as super activated carbon. In the preliminary research, this precursor was impregnated with $PdCl_2$(0.188 wt%) $KMnO_4$(3 wt%) and redox-agent(CuCl2, 0.577 wt%) in order to promote TOF up to 100/h and Selectivity up 99% and patented as a functional AC for the ethylene adsorption. The enhancement of the isotropic pitch binder to the AC-immobilized adsorption filter was BET-surface area upgraded by $266\;m^2/g$ and promoted the Iodine- and MB-adsorption by 1.4 times, respectively and also micro pore wide ranges < $5{\AA}{\sim}30\;{\AA}$ >.

• 공업화학
• /
• 제25권3호
• /
• pp.330-336
• /
• 2014

추출-증류-결정의 조합에 의해 모델 콜타르 흡수유 중에 함유된 인돌의 정제를 검토했다. 흡수유는 4종류의 질소고리 화합물(9.2% 퀴놀린, 2.4% 이소퀴놀린, 4.7% 인돌, 2.4% 퀴날딘), 3종류의 2환 방향족 화합물(14.2% 1-메틸나프탈렌, 31.8% 2-메틸나프탈렌, 23.5% 디메틸나프탈렌), 5.5% 비페닐과 3.3% 페닐에테르의 9종류의 화합물로 구성되어 있다. 포름아미드 추출-증류-노말헥산을 사용한 용액 결정화의 조합의 채택에 의해 99.5% 인돌을 회수할 수 있었다. 본 연구를 통해 얻어진 실험적 결과를 이용하여 콜타르 흡수유 중에 함유된 인돌의 회수공정을 검토했다.

• 농약과학회지
• /
• 제7권4호
• /
• pp.302-309
• /
• 2003

신규 화합물 triazolyl quinoline 유도체 230여개의 벼 도열병, 벼 잎집무늬마름병, 토마토 잿빛곰팡이병, 토마토 역병, 밀 붉은녹병과 보리 흰가루병에 대하여 방제효과를 조사하고, 녹병과 흰가루병에 대하여 예방효과가 우수한 KSI-4315와 KSI-4317을 선발하여 밀 붉은녹병과 보리 흰가루병에 대한 작용 특성을 실험하였다. Triazolyl quinoline 유도체인 KSI-4315와 KSI-4317 두 화합물은 구조에서 탄소 4번 위치에 각각 MeS moiety와 MsO moiety를 가진 화합물이다. 두 화합물은 밀 붉은녹병과 보리 흰가루병에 대하여 우수한 예방효과와 치료효과를 나타냈다. KSI-4317은 보리 흰가루병에 대하여, KSI-4315 는 밀 붉은녹병에 대하여 더 높은 예방효과와 치료효과를 보였다. 또한 두 화합물은 지속성도 우수하였다. 밀 붉은녹병에 대하여는 두 약제가 유사하였으나, KSI-4317은 보리 흰가루병에 대하여 특히 약효 지속성이 뛰어나 약제처리 7일 후 에 접종하여도 90% 이상의 방제가를 보였다. 약제의 침투이행성을 엽육이행, 엽간이행과 뿌리로부터 지상 부로의 침투이행에 대하여 실험한 결과, 밀에서 KSI-4315와 KSI-4317은 거의 침투 이행하지 않았으나, 보리에서는 KSI-4315 보다 KSI-4317이 높은 침투이행성을 보였다. 이상의 결과로부터 KSI-4317은 포장에서 밀 붉은녹병과 보리 흰가루병을 효과적으로 방제하리라 생각된다.