• 대한화학회지
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• 제55권5호
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• pp.805-807
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• 2011

The synthesis of different derivatives of isoxazolo[5,4-b]quinoline by the cyclization reaction of various substituted oximes of quinoline using mild base at ambient temperature. The formation of isoxazolo[5,4-b]quinoline, as a consequence of cheaper and more readily available $K_2CO_3$ and DMF participating in the reaction, is documented.

• Journal of Microbiology and Biotechnology
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• 제15권3호
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• pp.646-651
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• 2005

The growth responses of Ruta chalepensis leaf-derived materials toward human intestinal bacteria were examined. The biologically active constituent of the R. chalepensis extract was characterized as quinoline-4-carboxaldehyde($C_{10}H_{7}NO$). The growth responses varied depending on the bacterial strain, chemicals, and dose tested. At 0.25 and 0.1 mg/disk, quinoline-4-carboxaldehyde strongly inhibited the growth of Clostridium perfringens and weakly inhibited the growth of Escherichia coli without any adverse effects on the growth of three lactic acid bacteria. Furthermore, at 0.05 and 0.025 mg/disk, this isolate showed moderate activity against C. perfringens. In comparison, chloramphenicol at as low as 0.01 mg/disk significantly inhibited the growth of all bacteria tested, and cinnamaldehyde at 0.25 mg/disk did not inhibit Bifidobacterium bifidum, B. longum, E. coli, and Lactobacillus acidophilus, with the exception of C. perfringens. The structure-activity relationship revealed that quinoline-3-carboxaldehyde had strong growth inhibition against C. perfringens, but quinoline, quinoline-3-carboxylic acid, and quinoline-4-carboxylic acid did not inhibit the growth of B. bifidum, B. longum, C. perfringens, E. coli, and L. acidophilus. These results indicate that the carboxyl aldehyde functional group of quinolines seems to be required for growth-inhibiting activity against C. perfringens, thus indicating at least one of the pharmacological actions of R. chalepensis leaf.

• 약학회지
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• 제35권2호
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• pp.73-84
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• 1991

Quinoline, pyrazolo-[5, 4-b]-pyridine, isoxazolo-[5, 4-b]-pyridine, pyrazolo-[4, 3-c]-quinoline, isoxazolo-[5, 4-e]-thiazine, and isothiazolo-[5, 4-e]-thiazine derivatives were prepared as possible antiinflammatory agents. Some of the synthesized compounds showed antiinflammatory activities comparable to Aspirin and Naproxen.

• 대한화학회지
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• 제51권2호
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• pp.154-159
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• 2007

유리 및 고정화된 Bacillus brevis에 의한 큐놀린의 분해를 조사하였다. 코코넛 껍질 탄소에 고정화된 Bacillus brevis에 의한 큐놀린 분해 속도는 폼조각에 고정화되었거나 유리된 미생물에 의한 속도보다 빠르다. 시료에 존재하는 큐놀린 100 ppm을 완전히 제거하기 위해서는 코코넛 껍질 탄소에 고정화된 Bacillus brevis로 만든 생촉매를 물속에서 20시간 유지시키면 되었다. 이 생촉매는 꽤 긴 보존기간과 적절한 재생력을 가지고 있었다.

• 한국산업융합학회 논문집
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• 제14권3호
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• pp.101-104
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• 2011

In this study, the experiments for surface enhancement of silver surfaces were done, where we checked the characteristics of silver surfaces made by Tollen's method. The surface enhancement of Quinoline was analyzed by three kind of silver mirror substrates. The assignments of the vibrational bands shown in SERS spectra are given based on both literature and the semi-empirical calculations at the PM3 methods. Finally, we deduced that the adsorption orientation of quinoline was little tilted flat to the silver mirror surfaces by using of the surface selection rules.

• Bulletin of the Korean Chemical Society
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• 제23권7호
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• pp.964-970
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• 2002

We synthesized three kinds of chromophores incorporating aromatic quinoline unit as a $\pi-conjugated$ bridge in order to prepare more thermally stable nonlinear optical (NLO) chromophores than general stilbene unit. The NLO poly(methylmethacrylate) copolymer, polyimides, and polyester were successfully synthesized by these corresponding quinoline-based monomers. Their physical and optical properties were investigated by thermogravimetry, gel permeation chromatography, ultraviolet-visible spectroscopy, second harmonic generation (SHG) and electro-optic (EO) measurement. All the polymers exhibited better thermal stability,however their NLO activity was a little lower than that of general stilbene-based NLO polymers. Among three kinds of polymers, the PMMA copolymer with quinoline chromophores had the largest SHG coefficient d33 value of 27 pm/V (at 1.064 $\mu\textrm{m})$ and EO coefficient r33 value of 6.8 pm/V (at 1.3 $\mu\textrm{m}$).

• 대한화학회지
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• 제6권1호
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• pp.69-72
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• 1962

Spectrophotometric studies have been made on the solutions of elementary iodine in pyridine and quinoline, in the absence of light. The results shown that triiodide ion is produced in both solutions with different rates, and that triiodide ion behaves differently in both solutions. Iodine reacts slowly with pyridine, giving rise to triiodide ion, which is relatively stable in this solvent, hereas, iodine reacts rapidly with quinoline, forming triiodide ion, which interacts further with the medium at slow rate. It has been thought that the difference of the behavior of triiodide ion in both solutions may be due to the stronger basicity of quinoline than pyridine.

• Bulletin of the Korean Chemical Society
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• 제24권1호
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• pp.27-31
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• 2003

A Polythiophene-quinoline/glassy carbon (PTQ/GC) modified electrode was developed for the determination of trace mercury in industrial waste water, natural water, soil, and other media. The electrode was prepared by the cyclic voltammetric polymerization of thiophene and quinoline on glassy carbon (GC) electrode by the potential application from -0.6 V to +2.0 V (50 mV/sec) in a solution of 0.1 M thiophene, quinoline and tetrabutyl ammonium perchlorate (TBAP) in acetonitrile. Optimum thickness of the polymer membrane on the GC electrode was obtained with 20 repeated potential cyclings. The redox behavior of Cu(Ⅱ) and Hg(Ⅱ) were almost identical on this electrode. The addition of 4-(2-pyridylazo)resorcinol (PAR) to the solution containing Cu(Ⅱ) and Hg(Ⅱ) allowed the separation of the components due to the formation of the Cu(Ⅱ)-PAR complex reduced at -0.8V, which was different from the Hg(Ⅱ) reduced at -0.5 V on a saturated calomel electrode (SCE). The calibration graph of Hg(Ⅱ) shows good linear relationship with the correlation factor of 0.9995 and the concentration gradient of 0.33 ㎂/㎠/ppb down to 0.4 ppb Hg. The method developed was successfully applied to the determination of mercury in samples such as river, waste water, and sea water.

• Bulletin of the Korean Chemical Society
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• 제18권9호
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• pp.939-945
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• 1997

Several types of 4-substituted-quinoline-2-carboxylic acid derivatives possessing different substituents at C4-position such as sulfonyl, phosphonyl, carbonyl groups, or a flexible alkyl chain have been synthesized and evaluated for their in vitro antagonistic activity at the glycine site on the N-methyl-D-aspartate (NMDA) receptor. Of them, 5,7-dichloro-4-(tolylsulfonylamino)-quinoline-2-carboxylic acid 9 was found to have the best in vitro binding affinity with IC50 of 0.57 μM. On the other hand, in compounds 21 and 22 the introduction of flexible alkyl chains on C4 of the quinoline mother nuclei caused a significant decrease of the in vitro binding affinity. In addition, replacement of polar carboxylic acid group on C2 by neutral bioisosteres in compounds 23a-d also seems to be disadvantageous to in vitro activity. In the structure-activity relationship (SAR) study of the 4-substituted quinoline-2-carboxylic acid acid derivatives, it was realized that the substitution pattern on C4 significantly influences on the binding affinity for the glycine site of NMDA receptor and the binding affinity might be increased by the introduction of a suitable electron rich substituent at C4 which has the ability of H-bonding donor.

• 대한화학회지
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• 제66권3호
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• pp.194-201
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• 2022

A simple, efficient, and cost-effective method has been employed for the synthesis of 2,4,5-trisubstituted imidazole derivatives (3a-j) containing quinoline substituent at 2^nd position. Title compounds were obtained by multicomponent reaction (MCR), involving aryl substituted 1,2-diketone, quinoline carbaldehyde and ammonium acetate in the presence of acetic acid solvent under mild reaction conditions. The newly synthesized quinoline containing imidazole derivatives were confirmed through FT-IR, ¹H-NMR, ¹³C-NMR and mass spectral analysis. In-vitro microplate alamar blue assay (MABA) to determine the MIC (minimum inhibitory concentration) values against Mycobacterium tuberculosis H37Rv was performed for the synthesized compounds. The synthesized compounds exhibited activity against Mycobacterium tuberculosis and among which compounds, 3d, 3f and 3i showed good activity. The highest activity was showed with compound 3i. The anti-mycobacterial activity results are well correlated with the computational molecular docking analysis, which was performed for the synthesized compounds prior to the evaluation of the activity.