• 통합자연과학논문집
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• 제9권1호
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• pp.1-9
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• 2016

Leucine rich repeat kinase 2 (LRRK2) is a highly promising target for Parkinson's disease (PD) that affects millions of people worldwide. A three-dimensional quantitative structure-activity relationship (3D-QSAR) analysis was performed on a series of pyrrolopyrimidine-based selective LRRK2 kinase inhibitors. This study was performed to rationalize the structural requirements responsible for the inhibitory activity of these compounds. A reliable 3D-QSAR model was developed using comparative molecular field analysis (CoMFA) technique. The model produced statistically acceptable results with a cross-validated correlation coefficient ($q^2$) of 0.539 and a non-cross-validated correlation coefficient ($r^2$) of 0.871. Robustness of the model was further evaluated by bootstrapping and progressive scrambling analysis. This work could assist in designing more potent LRRK2 inhibitors.

• Journal of the Korean Physical Society
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• 제73권12호
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• pp.1849-1854
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• 2018

The present study aims to investigate the feasibility of using a simple nonlinear acoustic method for the assessment of bone status and osteoporosis in trabecular bone. Correlations of linear and nonlinear ultrasound parameters with the apparent bone density were obtained in 32 bovine femoral trabecular bone samples. Highly significant positive correlations were observed between the apparent bone density and the two linear ultrasound parameters, the speed of sound (SOS) and the normalized broadband ultrasound attenuation (nBUA), with Spearman's correlation coefficients of r = 0.85 and 0.77. In contrast, the apparent bone density was found to be negatively correlated with the nonlinear ultrasound parameter introduced in the present study, the logarithmic difference between the power spectrum levels of the fundamental frequency and the second harmonic (PSL1-PSL2), with the highest correlation coefficient of r = -0.92. These results suggest that the PSL1-PSL2, in addition to the SOS and the nBUA, may be useful for the assessment of bone status and osteoporosis.

• 한방재활의학과학회지
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• 제24권1호
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• pp.101-109
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• 2014

Objectives The relationship between metabolic syndrome causes and bone mineral density (BMD) was explored by taking 60 female chronic low back pain patients with age 61 years old or elder having metabolic syndrome and osteoporosis as study subjects. Methods Fasting blood glucose, serum total-cholesterol, triglyceride and HDL were measured by biochemical tests. Anthropometric elements and blood pressure were measured. Results Average BMD and T-score of part number 1 to 3 of lumbar vertebra were estimated by Quantitative Computed Tomography (QCT). In order to find the relationship between clinical factors and osteoporosis, correlation analysis was done on T-score. Age (r=0.679, p<0.01) had significant negative correlation and weight (r=0.342, p<0.01) and height (r=0.475, p<0.01) had significant positive correlation. Blood glucose, blood pressure, total cholesterol, triglyceride, HDL and body mass index did not have significant correlation. BMD had negative correlation with age (r=0.317, p<0.05). Regression analysis was done by taking T-score as independent variables and taking other factors as dependent variables. It was possible to know that age ($\beta$=-0.471, t=-7.050) with p<0.001, height ($\beta$=0.277, t=4.120) and weight ($\beta$=2.856, t=2.780) with p<0.05 have significant impact on osteoporosis. Conclusions Therefore, it was possible to know that T-score and BMD decrease as one gets older and T-score and BMD increase as one is taller and heavier.

• 한국환경과학회지
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• 제29권10호
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• pp.1003-1010
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• 2020

In this study, the necessity for a village unit Automatic Weather System (AWS) was suggested to obtain correct agricultural weather information by comparing the data of AWS of the weather station with the data of AWS installed in agricultural villages 7 km away. The comparison sites are Hyogyo-ri and Hongseong weather station. The seasonal and monthly averaged and cumulative values of data were calculated and compared. The annual time series and correlation was analyzed to determine the tendency of variation in AWS data. The average values of temperature, relative humidity and wind speed were not much different in comparison with each season. The difference in precipitation was ranged from 13.2 to 91.1 mm. The difference in monthly precipitation ranged from 1.2 to 75.4 mm. The correlation coefficient between temperature, humidity and wind speed was ranged from 0.81 to 0.99 and it of temperature was the highest. The correlation coefficient of precipitation was 0.63 and the lowest among the observed elements. Through this study, precipitation at the weather station and village unit area showed the low correlation and the difference for a quantitative comparison, while the elements excluding precipitation showed the high correlation and the similar annual variation pattern.

• 한국수자원학회:학술대회논문집
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• 한국수자원학회 2008년도 학술발표회 논문집
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• pp.805-809
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• 2008

Measurement of leaf area index (LAI) is useful for understanding rice growth, water use, and canopy light interception. The top nitrogen content(TNC) per unit area is an important quantitative index of the condition of nitrogen nutrition in rice production. The rapid and simple method of estimation of TNC, with the use of the existing nondestructive analyzing instruments chlorophyll meter SPAD-502 and plant canopy analyzer (PCA) LAI-2000, was scrutinized. Destructive measurement is time consuming and labor intensive. Our objective was to evaluate sampling procedures using the Li-Cor LI-1800, LAI 2000 plant canopy analyzer (PCA) for nondestructive estimation of rice LAI, and SPAD-502 on the Northern Plains of Cheongju. The LAI estimated by PCA tended to underestimate the LAI determined by actual measurement by about 20%. The estimation of LAI by PCA was judged to have a sufficient accuracy as a practical technique. A high positive correlation was obtained between the values of the SPAD reading and LAI. NDVI and LAI also showed a very high correlation. The values of the SPAD reading and LAI, and NDVI gave a high positive correlation. These results indicated that the method described in this study was effective as a simple and rapid method for the estimation of rice growth.

• 한국자원식물학회지
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• 제7권2호
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• pp.109-114
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• 1994

Followings are resulted through the analysis of the maln characters and the leaf ingredients, which is on the purpose of getting the basic materials to improve jaso and increase its production.Of the introduced varieties, Jukyeubjaso-stem length is 180cm, ear length is 37cm, No. of branches ofstem is 27, leaf length Is 16cm, leaf width Is 15cm-has better character than any other. Gurye local-stem length is 179cm, ear length is 38cm-is taken to be the best in the Geo-ecotypic.In the yield of leaf and seed, JukyeubJaso Is 727kg/10a, the greatest of all. In the leaf softness, allthe Inirorluced varieties are about 3.5 degrees, the Geo-ecotypic, about 2. The qualify of the introducedvat'ieties is better· than that of the Geo-ecotypic. Estimating on the chemical analysis of leaf,Jukyeubjaso has Protein 21.84%, Total carbohydrate 7.91%, Fe 126ppm, and Gurye lacal has Protein21.7 a, Total carbohydrate 8.4%, Fe 148ppm, expressing the highest. In correlation coefficients of leafchemical components, between protein and Total carbohydrate, Protein and Mn, protein and Fe, Pro-tein and Cu all the sorts show the positive correlation. Among them the Geo-ccoyplcs show the hlghestsignificance.

• 한국지반공학회:학술대회논문집
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• 한국지반공학회 2005년도 춘계 학술발표회 논문집
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• pp.1175-1182
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• 2005

Using KUCCS, which enables real-time monitoring and controlling, the various boundary condition and in-situ field stress condition was simulated, to derive the correlation among ${{\sigma}_v}'-Dr-N$in domestic sandy soils. Soil specimens, having various relative density and confined stress, were formulated to evaluate N-value from the SPT. and Pile Driving Analyzer, PDA, was employed as a measuring device for the energy transfer efficiency in the rod. From the quantitative analysis of N-value, the correlating equation, $N_{60}/{D_r}^2=16.35+14.45{{\sigma}_v}'$ was obtained on the basis of Skempton's method(1986). More reliable soil parameters can be obtained from the N-value by using this study which considered regional characters and the correlation among ${{\sigma}_v}'-Dr-N$.

• 성인간호학회지
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• 제25권3호
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• pp.332-343
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• 2013

Purpose: The purpose of this study was to analyze the research trends of spiritual care in Korea and to make suggestions for future studies. Methods: 209 researches from 1981 to 2012 were analyzed. Results: Among the 209 studies reviewed. 74 were thesis studies and 135 for reported research in academic journal. There were 169 quantitative studies, 11 qualitative studies and 29 other types studies. The most frequently used study design was correlational. The majority of study participants were patients, followed by nursing students, nurses or non-medical participants. In the correlation studies, the variable of spiritual well-being had a positive correlation with hope, self-esteem and spiritual nursing care and a negative correlation with depression, anxiety and loneliness. In the experimental studies, the independent variables were spiritual nursing intervention, spiritual care education program and spiritual promoting intervention. The main theme of qualitative studies were the experience of spiritual care, spiritual experience and the most frequent designs were grounded theory, phenomenology and interpretative phenomenology. Conclusion: The domestic research about spiritual care needs to utilize a variety of approaches including concept or tool development study suitable for Korean peoples, multi-disciplinary research, qualitative study and program development study.

• Near Infrared Analysis
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• 제1권2호
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• pp.35-39
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• 2000

The purpose of this research was to find out suitable soil sample preparation and sample holding tools for NIR reflection radiation for estimating soil components. NIR reflectance was scanned at 2nm intervals from 1,100 to 2,500nm with an InfraAlyzer 500(Bran+Luebbe Co.). Coarse(2.0mm) and fine(0.5mm) soil sample and various sample holding tools were used to obtain mean diffuse reflection of the soil for the calibration and validation of the calibration set in estimating moisture, organic matter and total nitrogen of the soils. Multiple linear regression was used to obtain the best correlation of NIR spectroscopy method. Correlation of NIR spectroscopy method. Correlation of NIR spectra for finely and coarsely sized soil did not show much difference. The standard errors of prediction(SE) using different types of sample holding tools for organic matter, total nitrogen and soil moisture were better than 0.765, 0.041 and 0.63% respectively. From the results it can be concluded that NIR spectroscopy with flow type cell could be used as a fast routine testing method in quantitative determination of organic matter, total nitrogen and soil moisture.

• 대한물리의학회지
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• 제8권2호
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• pp.209-217
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• 2013

PURPOSE: The purpose of this study was to investigate the clinical availability of the pendulum test (through reliability and validity) using a NK table attached electrogoniometer for spasticity measurement in patients with brain lesions. METHODS: Thirty-one stroke and traumatic brain injury subjects participated in the study. Intraclass correlation coefficient (ICC) was used to verify the test-retest reliability of spasticity measures of the pendulum test. Pearson's product correlation coefficient was used to examine the validity of the pendulum test through the amplitude of the deep tendon reflex (DTR) test known for objective and quantitative measure of spasticity. RESULTS: In these results, the test-retest reliability was showed significantly high correlation between pendulum tests (ICCs=.95~.97, p<.01). There were significant negative correlations between the amplitude of the DTR test and all measures of spasticity of the pendulum test(r=-.77~-.85, p<.01). CONCLUSION: Thus, it is possible to use the pendulum test using a NK table as an objective measure of spasticity, rather than other expensive equipment, which is more complicated to use. Further studies are needed to explore the therapeutic effects of spasticity using a newly designed pendulum test equipment in this study.