• 제목/요약/키워드: quantification method type I

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Validation of an HPLC/UV-based method for Salicornia herbacea-derived isorhamnetin-3-O-glucoside and quercetin-3-O-glucoside quantification

  • Park, Jun Yeon;Paje, Leo Adrianne;Kang, Ki Sung;Lee, Sanghyun
    • Journal of Applied Biological Chemistry
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    • 제64권3호
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    • pp.285-290
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    • 2021
  • Salicornia herbacea is a type of salt marsh plant that has been used in traditional medicine to treat several diseases. Isorhamnetin-3-O-glucoside (I3G) and quercetin-3-O-glucoside (Q3G) are major flavonoids in S. herbacea that are known to exert various pharmacological activities. Therefore, our study sought to validate and optimize an HPLC/UV-based analytical method for I3G and Q3G yield quantification, as well as to determine its limit of detection, limit of quantification, linearity, precision, and accuracy. Upon testing a concentration range of 31.5-1.9 ㎍/mL the results exhibited good linearity (r2 ≥0.9996 and r2 ≥0.9999 for I3G and Q3G, respectively), and the procedure was deemed precise (relative standard deviation of ≤3.19 and ≤3.85%, respectively), and accurate (102.6-105.0 and 92.9-95.2%, respectively). The results showed that our proposed method could be used for rapid I3G and Q3G evaluation in S. herbacea.

수량화방법 I을 이용한 퇴적암 터널의 지질 인자별 변위 영향도 분석 (A Study on Geological Factors Affecting Behavior of Sedimentary Rock Tunnel Using Quantification Method Type I)

  • 임성빈;서용석;김창용;김광염
    • 지질공학
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    • 제17권2호
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    • pp.263-270
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    • 2007
  • 터널 시공 중 일상적으로 수행되는 계측에 의해 정량화되는 터널의 거동은 안정성 평가를 위한 주요한 항목이며, 이는 지역적인 지질학적 특성에 크게 의존한다. 본 연구에서는 지질학적 특성 차에 의한 RMR 항목별 터널 거동에 미치는 영향도를 분석하기 위하여, 터널의 face mapping 자료와 계측자료를 각각 설명변수와 종속변수로 한 수량화 분석을 실시하였다. 분석 결과, RMR 인자가 터널의 변위에 미치는 중요도의 평균은 R1, R2, R3, R4, R5 각각 17.0%, 20.4%, 20.4, 11.6%, 30.6%로서, 이는 분석지역의 지하수특성이 변위에 크게 영향을 미친 것으로 판단된다.

Exploring the Attractive Factors of App Icons

  • Ho, Chun-Heng;Hou, Kai-Chun
    • KSII Transactions on Internet and Information Systems (TIIS)
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    • 제9권6호
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    • pp.2251-2270
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    • 2015
  • More than 1 billion mobile apps (smartphone applications) have been released worldwide. Competition among developers of apps that are available in app stores has intensified because of increasing demand. App icons with an appealing design can instantly increase attention. Miryoku Engineering methods were used and combined with the Kansei interface model to examine the relationship between attractive icons and users. The evaluation grid method (EGM) is a qualitative method that was used to evaluate the icons, and Quantification Theory Type I is a quantitative method that was used to analyze the influence of design elements in icons. Eight attractive factors of app icons were determined using EGM, and six specific factors were identified using questionnaires. The quantitative results indicated that user cognition and emotion were influenced by the various design elements. The impact on the attractive factors of a single design element differed among users with diverse backgrounds. App icons were assessed on the basis of aesthetics to identify attractive factors and thereby assist designers in understanding and implementing design elements and improving the overall visual appeal of their apps. The result of this investigation is crucial to the presentation of app icons in online app stores.

The effects of uncertainties in structural analysis

  • Pellissetti, M.F.;SchueIler, G.I.
    • Structural Engineering and Mechanics
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    • 제25권3호
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    • pp.311-330
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    • 2007
  • Model-based predictions of structural behavior are negatively affected by uncertainties of various type and in various stages of the structural analysis. The present paper focusses on dynamic analysis and addresses the effects of uncertainties concerning material and geometric parameters, mainly in the context of modal analysis of large-scale structures. Given the large number of uncertain parameters arising in this case, highly scalable simulation-based methods are adopted, which can deal with possibly thousands of uncertain parameters. In order to solve the reliability problem, i.e., the estimation of very small exceedance probabilities, an advanced simulation method called Line Sampling is used. In combination with an efficient algorithm for the estimation of the most important uncertain parameters, the method provides good estimates of the failure probability and enables one to quantify the error in the estimate. Another aspect here considered is the uncertainty quantification for closely-spaced eigenfrequencies. The solution here adopted represents each eigenfrequency as a weighted superposition of the full set of eigenfrequencies. In a case study performed with the FE model of a satellite it is shown that the effects of uncertain parameters can be very different in magnitude, depending on the considered response quantity. In particular, the uncertainty in the quantities of interest (eigenfrequencies) turns out to be mainly caused by very few of the uncertain parameters, which results in sharp estimates of the failure probabilities at low computational cost.

수량화이론 I방법에 의한 아까시나무 임분의 적지 환경인자 도출 (Derivation of Suitable-Site Environmental Factors in Robinia pseudoacacia Stands Using Type I Quantification Theory)

  • 김소라;송정은;박천희;민수희;홍성희;임종수;손영모
    • 한국산림과학회지
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    • 제111권3호
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    • pp.428-434
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    • 2022
  • 본 연구는 밀원식물인 아까시나무의 적지적수 조림을 위해 임지생산력을 나타내는 지위지수를 도출하고, 지위지수에 어떠한 입지환경인자가 영향을 미치는 지를 수량화이론 I방법으로 구명하고자 수행되었다. 분석에 사용된 자료는 6차 국가산림자원조사와 1/5,000 산림입지토양도 상의 임령, 우세목 수고 및 각종 입지환경인자였다. 6차 국가산림자원조사에 의한 우리나라 아까시나무 임분의 지위지수는 평균 14였으며, 범위는 8에서 18 사이에 있는 것으로 분석되었다. 그리고 지위지수에 영향하는 입지환경인자는 모암, 기후대, 토양성질, 국소지형과 해발고였으며, 수량화이론 I방법을 적용한 추정모델의 적합도는 33%였다. 이 추정모델의 적합도는 낮으나 1% 수준에서 유의성이 인정되어 지위지수와 입지환경인자 간의 상호 연관성을 설명할 수 있었다. 지위지수와 입지환경인자 간의 수량화 분석 결과, 모암은 변성암, 화성암이, 기후대는 온대중부지역 이상에서, 토성은 식양토, 미사질양토가, 국소지형은 산복 지역에서 높은 점수를 갖는 것으로 나타났다. 임지생산력(지위지수)에 영향하는 입지환경인자 각각의 편상관을 분석한 결과, 산림 내 토양의 성질과 해당 입지의 해발고에 대한 편상관계수가 0.4129, 0.4023으로 각각 나타나, 이들이 가장 영향력이 높은 인자임을 알 수 있었다.

A Usability Assessment Metric for Ubiquitous Services: Quantification of the Interactivity Attribute in Inter-personal Services

  • Lee, Joo-Hwan;Song, Joo-Bong;Yun, Myung-Hwan
    • 대한인간공학회지
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    • 제31권1호
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    • pp.63-76
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    • 2012
  • Objective: The main objective of this study is to propose a user-centered assessment metric for ubiquitous services. Background: As the ubiquitous era took off, the interactions between ubiquitous services and users have come to take an important position. It is essential to conceptualize a new assessment model that considers human-system interaction capability with a user-centered design perspective. Method: The evaluation model for the interactivity of ubiquitous service was approached from the concept of usability and inter-personality of services. As a validation study, suggested assessment metric was utilized to evaluate the u-Home service. Priority weighting of each assessment metric was derived using the quantification type-I analysis. Results: To evaluate interactivity, this study suggested a quantitative metric for user testing performed after classifying the interactivity characteristics to contextualization; ubiquity; user experience; and service capability. Conclusion: This study suggest the metric for the ubiquitous service that are experienced in real life, and introduced the concept of ubiquitous service interactivity. Application: The suggested evaluation metric can be used to evaluate interactivity level of ubiquitous service and identify the potential problem and usability requirements at the early stage of service development.

Development of a model to forecast the external migration rate in development projects reflecting city characteristics

  • Kim, Ki-Bum;Park, Joon;Seo, Jee-Won;Yu, Young-Jun;Hyun, In-Hwan;Koo, Ja-Yong
    • Environmental Engineering Research
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    • 제23권4호
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    • pp.406-419
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    • 2018
  • In planning public service systems such as waterworks, the design population is very important factor. Owing to the limitations of the indirect method, two new models, which take into consideration urban characteristics, were developed to accurately predict external migration rate (EMR), which is an essential component in estimating reliably the design population. The root mean square error (RMSE) between the model values and observed values were 10.12 and 15.58 for the metropolitan cities and counties respectively and were lower compared to RMSE values of 27.31 and 28.79 obtained by the indirect method. Thus, the developed models provide a more accurate estimate of EMR than the indirect method. In addition, the major influencing factors for external migration in counties were development type, ageing index, number of businesses. On the other hand, the major influencing migration factors for cities were project scale, distance to city center, manufacturing size, population growth rate and residential environment. Future medium and long-term studies would be done to identify emerging trends to appropriately inform policy making.

임상도 특성에 따른 임목축적 및 탄소저장량 추정: 강원도를 중심으로 (Estimation of Growing Stock and Carbon Stock based on Components of Forest Type Map: The case of Kangwon Province)

  • 김소원;손영모;김은숙;박현
    • 한국산림과학회지
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    • 제103권3호
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    • pp.446-452
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    • 2014
  • 본 연구는 임상도 상의 특성인 영급, 경급 및 수관밀도를 이용하여 임목의 축적 및 탄소저장량을 추정하는 기법을 개발하고자 하였다. 먼저 국가산림조사(강원도 중심)를 바탕으로 한 임목축적 자료를 임상도 제작 당시의 축적으로 전환하였으며, 이 자료와 임상도 특성과의 관계를 수량화I방법을 통하여 임목축적 추정 모형을 개발하였다. 임상도 특성이 임목축적 추정에 기여하는 바를 알 수 있는 제곱 편상관계수의 크기를 비교해 본 결과, 영급이 가장 큰 기여를 하고 있었으며, 다음이 수관밀도, 임상, 경급의 순이었다. 임목축적 추정치 중 최소치는 활엽수림의 영급 II, 경급 '소', 수관밀도 '소'인 분류기준에서 ha당 $20.0m^3$이고, 최대치는 침엽수림의 영급 VI, 경급 '대', 수관밀도 '밀'인 분류기준에서 ha당 305.0이었다. 임상별로 침엽수림은 ha당 $30.5{\sim}305.0m^3$, 활엽수림은 ha당 $20.0{\sim}200.4m^3$, 혼효림은 ha당 $23.8{\sim}238.1m^3$로 추정되었다. 임상별 탄소저장량을 비교해 보면, 임상에 무관하게 경급 '대', 수관밀도 '밀'인 분류기준에서 임목축적에 따른 영급별 탄소저장량이 최대인 것으로 나타났다. 본 임상도 특성을 이용한 임목축적 추정은 산지 전용 또는 산지 재해에 의한 임목축적의 감소 및 탄소저장량 변화를 충분히 추정할 수 있을 것이며, 일선 산림관계자 또는 정책입안자의 산림경영 의사결정에도 유효한 도움을 줄 수 있을 것이라 판단된다.

Extracting Method of Kansei Design Rules Based on Rough Set Analysis

  • Nishino, Tatsuo;Nagamachi, Mitsuo
    • 한국감성과학회:학술대회논문집
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    • 한국감성과학회 2002년도 춘계학술대회 논문집
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    • pp.201-204
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    • 2002
  • Kansei design knowledge acquisition stage is a crucial stage in kansei designing process and kansei engineering (KE) methodology. In kansei engineering methodology, it is essential to extract design knowledge or rules on relationships between customer's kansei and product design element. We attempt to construct a more powerful melted for extracting the design rules from kansei expremental data. We constucted a kansei experiment concerning color kansei evaluation, and analyzed the sane data by both conventional quantification theory type I and rough set theory. Finally, we compared the effectiveness of both methods for extracting rules and examined the extensions of rough set theory in kansei engineering.

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Screening of Nitrosamine Impurities in Sartan Pharmaceuticals by GC-MS/MS

  • Chang, Shu-Han;Ho, Hui-Yu;Zang, Chi-Zong;Hsu, Ya-Hui;Lin, Mei-Chih;Tseng, Su-Hsiang;Wang, Der-Yuan
    • Mass Spectrometry Letters
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    • 제12권2호
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    • pp.31-40
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    • 2021
  • Probable human carcinogenic compounds nitrosamines, have been detected as by-product impurities in sartan pharmaceuticals in recent years which has drawn worries for medication safety. To provide a sensitive and effective method for the quality control of sartan pharmaceuticals, this study established a feasible gas chromatography-tandem mass spectrometry (GC-MS/MS) method for simultaneous determination of 13 nitrosamines. The target analytes were separated on a DB-WAX Ultra Inert column (30 m × 0.25 mm; i.d., 0.25 ㎛) and were then subjected to electron impact ionization in multiple reaction monitoring mode. The established method was validated and further employed to analyze authentic samples. Limits of detection (LODs) and limits of quantification (LOQs) of the 13 nitrosamines were 15-250 ng/g and 50-250 ng/g, respectively, which also exhibited intra-day and inter-day accuracies of 91.4-104.8%, thereby satisfying validation criteria. Five nitrosamines, viz., N-nitrosodiethylamine, N-nitrosodimethylamine, N-nitrosodiphenylamine, N-nitrosomorpholine, and N-nitrosopiperidine were detected at concentrations above their LODs in 68 positive samples out of 594 authentic samples from seven sartans.