• Title/Summary/Keyword: quantification method type I

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Validation of an HPLC/UV-based method for Salicornia herbacea-derived isorhamnetin-3-O-glucoside and quercetin-3-O-glucoside quantification

  • Park, Jun Yeon;Paje, Leo Adrianne;Kang, Ki Sung;Lee, Sanghyun
    • Journal of Applied Biological Chemistry
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    • v.64 no.3
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    • pp.285-290
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    • 2021
  • Salicornia herbacea is a type of salt marsh plant that has been used in traditional medicine to treat several diseases. Isorhamnetin-3-O-glucoside (I3G) and quercetin-3-O-glucoside (Q3G) are major flavonoids in S. herbacea that are known to exert various pharmacological activities. Therefore, our study sought to validate and optimize an HPLC/UV-based analytical method for I3G and Q3G yield quantification, as well as to determine its limit of detection, limit of quantification, linearity, precision, and accuracy. Upon testing a concentration range of 31.5-1.9 ㎍/mL the results exhibited good linearity (r2 ≥0.9996 and r2 ≥0.9999 for I3G and Q3G, respectively), and the procedure was deemed precise (relative standard deviation of ≤3.19 and ≤3.85%, respectively), and accurate (102.6-105.0 and 92.9-95.2%, respectively). The results showed that our proposed method could be used for rapid I3G and Q3G evaluation in S. herbacea.

A Study on Geological Factors Affecting Behavior of Sedimentary Rock Tunnel Using Quantification Method Type I (수량화방법 I을 이용한 퇴적암 터널의 지질 인자별 변위 영향도 분석)

  • Yim, Sung-Bin;Seo, Yong-Seok;Kim, Chang-Yong;Kim, Kwang-Yoem
    • The Journal of Engineering Geology
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    • v.17 no.2 s.52
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    • pp.263-270
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    • 2007
  • Tunnel behavior measured by monitoring during construction is a main item for safety evaluation and it depends widely upon local geological characteristics. To assess in this study how much the geological factors influence on tunnel behavior for each RMR factor, a quantification analysis was carried out using tunnel face maps and measurements as explanatory variables and dependent variables, respectively. The results showed that average significance of the influence of RMR factors - R1, R2, R3, R4 and R5, on tunnel displacements are 17.0%, 20.4%, 20.4%, 11.6% and 30.6%, respectively, and this probably indicates that the groundwater condition played a significant role for the tunnel displacement.

Exploring the Attractive Factors of App Icons

  • Ho, Chun-Heng;Hou, Kai-Chun
    • KSII Transactions on Internet and Information Systems (TIIS)
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    • v.9 no.6
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    • pp.2251-2270
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    • 2015
  • More than 1 billion mobile apps (smartphone applications) have been released worldwide. Competition among developers of apps that are available in app stores has intensified because of increasing demand. App icons with an appealing design can instantly increase attention. Miryoku Engineering methods were used and combined with the Kansei interface model to examine the relationship between attractive icons and users. The evaluation grid method (EGM) is a qualitative method that was used to evaluate the icons, and Quantification Theory Type I is a quantitative method that was used to analyze the influence of design elements in icons. Eight attractive factors of app icons were determined using EGM, and six specific factors were identified using questionnaires. The quantitative results indicated that user cognition and emotion were influenced by the various design elements. The impact on the attractive factors of a single design element differed among users with diverse backgrounds. App icons were assessed on the basis of aesthetics to identify attractive factors and thereby assist designers in understanding and implementing design elements and improving the overall visual appeal of their apps. The result of this investigation is crucial to the presentation of app icons in online app stores.

The effects of uncertainties in structural analysis

  • Pellissetti, M.F.;SchueIler, G.I.
    • Structural Engineering and Mechanics
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    • v.25 no.3
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    • pp.311-330
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    • 2007
  • Model-based predictions of structural behavior are negatively affected by uncertainties of various type and in various stages of the structural analysis. The present paper focusses on dynamic analysis and addresses the effects of uncertainties concerning material and geometric parameters, mainly in the context of modal analysis of large-scale structures. Given the large number of uncertain parameters arising in this case, highly scalable simulation-based methods are adopted, which can deal with possibly thousands of uncertain parameters. In order to solve the reliability problem, i.e., the estimation of very small exceedance probabilities, an advanced simulation method called Line Sampling is used. In combination with an efficient algorithm for the estimation of the most important uncertain parameters, the method provides good estimates of the failure probability and enables one to quantify the error in the estimate. Another aspect here considered is the uncertainty quantification for closely-spaced eigenfrequencies. The solution here adopted represents each eigenfrequency as a weighted superposition of the full set of eigenfrequencies. In a case study performed with the FE model of a satellite it is shown that the effects of uncertain parameters can be very different in magnitude, depending on the considered response quantity. In particular, the uncertainty in the quantities of interest (eigenfrequencies) turns out to be mainly caused by very few of the uncertain parameters, which results in sharp estimates of the failure probabilities at low computational cost.

Derivation of Suitable-Site Environmental Factors in Robinia pseudoacacia Stands Using Type I Quantification Theory (수량화이론 I방법에 의한 아까시나무 임분의 적지 환경인자 도출)

  • Kim, Sora;Song, Jungeun;Park, Chunhee;Min, Suhui;Hong, Sunghee;Lim, Jongsoo;Son, Yeongmo
    • Journal of Korean Society of Forest Science
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    • v.111 no.3
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    • pp.428-434
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    • 2022
  • This study was conducted to derive the site index of forest productivity of Robinia pseudoacacia (honey plant) to characterize suitable planting sites and to investigate the effect of the site environmental factors on the site index using the quantification theory I method. The data used in the analysis were growth factors (stand age, dominant height, etc.) of the 6th national forest resources survey and various site environmental factors of a forest soil map (1:5,000). The average site index value of the R. pseudoacacia stand in Korea was 14 (range, 8 to 18). The environmental factors affecting the site index were parent rock, climatic zone, soil texture, local topography, and altitude. The accuracy of the estimation model using quantification theory I was only 33%. However, the correlation between the site index and the site environmental factors was statistically significant at the 1% level. Results of quantification analysis between site index and site environmental factors revealed that metamorphic and igneous rocks received high grades as parent rocks, climate zones received higher grades than central temperate zone, clay loam and silt loam received high grades in soil texture, and hillside received a high grade in local topography. Analysis of the partial correlation between site topographical factors and forest productivity (site index) found that soil class and altitude were partially correlated to x by 0.4129 and 0.4023, respectively, indicating that these factors are the most influential variables.

A Usability Assessment Metric for Ubiquitous Services: Quantification of the Interactivity Attribute in Inter-personal Services

  • Lee, Joo-Hwan;Song, Joo-Bong;Yun, Myung-Hwan
    • Journal of the Ergonomics Society of Korea
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    • v.31 no.1
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    • pp.63-76
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    • 2012
  • Objective: The main objective of this study is to propose a user-centered assessment metric for ubiquitous services. Background: As the ubiquitous era took off, the interactions between ubiquitous services and users have come to take an important position. It is essential to conceptualize a new assessment model that considers human-system interaction capability with a user-centered design perspective. Method: The evaluation model for the interactivity of ubiquitous service was approached from the concept of usability and inter-personality of services. As a validation study, suggested assessment metric was utilized to evaluate the u-Home service. Priority weighting of each assessment metric was derived using the quantification type-I analysis. Results: To evaluate interactivity, this study suggested a quantitative metric for user testing performed after classifying the interactivity characteristics to contextualization; ubiquity; user experience; and service capability. Conclusion: This study suggest the metric for the ubiquitous service that are experienced in real life, and introduced the concept of ubiquitous service interactivity. Application: The suggested evaluation metric can be used to evaluate interactivity level of ubiquitous service and identify the potential problem and usability requirements at the early stage of service development.

Development of a model to forecast the external migration rate in development projects reflecting city characteristics

  • Kim, Ki-Bum;Park, Joon;Seo, Jee-Won;Yu, Young-Jun;Hyun, In-Hwan;Koo, Ja-Yong
    • Environmental Engineering Research
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    • v.23 no.4
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    • pp.406-419
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    • 2018
  • In planning public service systems such as waterworks, the design population is very important factor. Owing to the limitations of the indirect method, two new models, which take into consideration urban characteristics, were developed to accurately predict external migration rate (EMR), which is an essential component in estimating reliably the design population. The root mean square error (RMSE) between the model values and observed values were 10.12 and 15.58 for the metropolitan cities and counties respectively and were lower compared to RMSE values of 27.31 and 28.79 obtained by the indirect method. Thus, the developed models provide a more accurate estimate of EMR than the indirect method. In addition, the major influencing factors for external migration in counties were development type, ageing index, number of businesses. On the other hand, the major influencing migration factors for cities were project scale, distance to city center, manufacturing size, population growth rate and residential environment. Future medium and long-term studies would be done to identify emerging trends to appropriately inform policy making.

Estimation of Growing Stock and Carbon Stock based on Components of Forest Type Map: The case of Kangwon Province (임상도 특성에 따른 임목축적 및 탄소저장량 추정: 강원도를 중심으로)

  • Kim, So Won;Son, Yeong Mo;Kim, Eun Sook;Park, Hyun
    • Journal of Korean Society of Forest Science
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    • v.103 no.3
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    • pp.446-452
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    • 2014
  • This research aimed to provide a method to estimate growing stock and carbon stock using the characteristics of forest type map such as the age-class, DBH class and crown density class. We transformed the growing stock data of national forest inventory (mainly Kangwon-do province) onto those of time when the forest type map was established. We developed a simulation model for the growing stock using the transformed data and the characteristics of forest type map by the quantification method I. By comparing partial correlation coefficient, we found that quantification of growing stock was largely affected by age-class followed by crown density class, forest type and DBH class. The growing stock, was estimated as minimum in the broadleaved forest with age-class II, DBH class 'Small', and crown density class 'Low' as $20.0m^3/ha$, whereas showed maximum value in the coniferous forest with age-class VI, DBH class 'Large', and crown density class 'High' as $305.0m^3/ha$. The growing stock for coniferous, broadleaved, and mixed forest were estimated as $30.5{\sim}305.0m^3/ha$, $20.0{\sim}200.4m^3/ha$, and $23.8{\sim}238.1m^3/ha$, respectively. When we compared the carbon stock by forest type, the carbon stock by age class based on growing stock was maximum when DBH class was 'Large' and crown density class was 'High' regardless of forest type. This estimation of growing stock by using characteristic of forest type can be used to estimate the changes in growing stock and carbon stock resulting from deforestation or natural disaster. In addition, we hope it provide a useful advice when forest officials and policy makers have to make decisions in regard to forest management.

Extracting Method of Kansei Design Rules Based on Rough Set Analysis

  • Nishino, Tatsuo;Nagamachi, Mitsuo
    • Proceedings of the Korean Society for Emotion and Sensibility Conference
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    • 2002.05a
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    • pp.201-204
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    • 2002
  • Kansei design knowledge acquisition stage is a crucial stage in kansei designing process and kansei engineering (KE) methodology. In kansei engineering methodology, it is essential to extract design knowledge or rules on relationships between customer's kansei and product design element. We attempt to construct a more powerful melted for extracting the design rules from kansei expremental data. We constucted a kansei experiment concerning color kansei evaluation, and analyzed the sane data by both conventional quantification theory type I and rough set theory. Finally, we compared the effectiveness of both methods for extracting rules and examined the extensions of rough set theory in kansei engineering.

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Screening of Nitrosamine Impurities in Sartan Pharmaceuticals by GC-MS/MS

  • Chang, Shu-Han;Ho, Hui-Yu;Zang, Chi-Zong;Hsu, Ya-Hui;Lin, Mei-Chih;Tseng, Su-Hsiang;Wang, Der-Yuan
    • Mass Spectrometry Letters
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    • v.12 no.2
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    • pp.31-40
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    • 2021
  • Probable human carcinogenic compounds nitrosamines, have been detected as by-product impurities in sartan pharmaceuticals in recent years which has drawn worries for medication safety. To provide a sensitive and effective method for the quality control of sartan pharmaceuticals, this study established a feasible gas chromatography-tandem mass spectrometry (GC-MS/MS) method for simultaneous determination of 13 nitrosamines. The target analytes were separated on a DB-WAX Ultra Inert column (30 m × 0.25 mm; i.d., 0.25 ㎛) and were then subjected to electron impact ionization in multiple reaction monitoring mode. The established method was validated and further employed to analyze authentic samples. Limits of detection (LODs) and limits of quantification (LOQs) of the 13 nitrosamines were 15-250 ng/g and 50-250 ng/g, respectively, which also exhibited intra-day and inter-day accuracies of 91.4-104.8%, thereby satisfying validation criteria. Five nitrosamines, viz., N-nitrosodiethylamine, N-nitrosodimethylamine, N-nitrosodiphenylamine, N-nitrosomorpholine, and N-nitrosopiperidine were detected at concentrations above their LODs in 68 positive samples out of 594 authentic samples from seven sartans.