• Aerospace Engineering and Technology
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• v.6 no.1
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• pp.190-200
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• 2007

A pyrogen type igniter was designed to satisfy the requirements of KSLV-I Kick Motor system. To insure the reliability of the igniter before the production of the flight model, we have been performed the structure, environmental, combustion tests. The hydraulic test was carried out to confirm the strength of the components of the igniter. The shock and vibration tests were considered to check whether the igniter operates normally under the severe environmental condition. The combustion tests were also performed to understand the ignition characteristics with the variation of initial condition. Finally, we confirmed that the igniter could provide the acceptable energy to ignite the propellant of kick motor at the ground test.

• Journal of Power System Engineering
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• v.17 no.6
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• pp.79-87
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• 2013

The improvement of cooling efficiency for the cabinet of automatic controller is the most efficient method of it's application. Therefore, this study has been analyzed and investigated the improvement of cooling efficiency and reduction of energy for the cabinet of automatic controller, respectively. So this study was conducted to enhancement of cooling efficiency for the cabinet of automatic controller by making a structure which produces difference of air pressures in the entrance tube of external air. And the structure has capacity of the pyrogen source (PTC elements) to make temperature range from $145^{\circ}C$ to $155^{\circ}C$. Consequently, temperatures of the upper, the lower in the interior of the cabinet of automatic controller and the exhaust part were revealed $28.57^{\circ}C$, $23.38^{\circ}C$and $36.14^{\circ}C$(average temperature of the exhaust part in case of existing method : $45^{\circ}C$) in target test of this study, respectively. It was found that the cabinet of the automatic controller has better cooling ability than the cabinet of automatic controller by using an existing method.

• Archives of Pharmacal Research
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• v.25 no.3
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• pp.343-348
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• 2002

Carbon monoxide (CO) are produced by heme oxygenase (HO), and HO was detected in hypothalamus. However, the roles of CO produced in hypothalamus was not fully elucidated. So, we tested the effects of CO on body temperature because preoptic-anterior hypothalamus was known as the presumptive primary fever-producing site. CO-saturated aCSF ($4{\;}{\mu}l$, i.c.v.) and hemin ($10{\;}{\mu}g$, i.c.v.) elicited marked febrile response. Pretreatment with indomethacin completely inhibited CO- and hemin-induced fever. Zinc protoporphyrin-IX ($10{\;}{\mu}g$, i.c.v.) or ODQ ($50{\;}{\mu}g$, i.c.v.) partially reduced hemin-induced febrile response. Dibutyryl-cGMP ($100{\;}{\mu}g$, i.c.v.) produced profound febrile response and this febrile response was attenuated by indomethacin. These results indicate that endogenous CO may have a role as a pyrogenic mediator in CNS and CO-mediated pyresis is dependent on prostaglandin production and partially on activation of soluble guanylate cyclase.

• Journal of Acupuncture Research
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• v.20 no.3
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• pp.154-165
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• 2003

Objective : to research the trend of the study related to Bee venom and o establish the hereafter direction for the study on Bee Venom therapy. Methods : We reviewed the domestic papers published last ten years(1992-2001). Results: 1.We have searched 53 papers in 7 journals and the pattern of study was as follow: the experimental studies were 33, the clinical studies were 10 and the reviewed studies were 10. 2. The experimental studies were 2 papers of analysis of Bee Venom, 3 papers of safety assessment, 1 paper on production of antibody against Bee Venom and 26 paper of safety assessment. 3. Bee Venom used in studies was made in Korea, China and U.S.A.. There were differences of component and effect according to the place of production. 4. There were the experimental studies of LD50 in mouse, acute toxicity, local irritation test, antigenicity and pyrogen test of Bee Venom. Conclusions : We need more studies of unification of term about Bee Venom, difference according to the place of production, clinical safety and effects.

• The Korean Journal of Nuclear Medicine
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• v.21 no.1
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• pp.61-68
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• 1987

Investigation with $^{57}Co-Bleomycin$ in patients with the various cancers and in tumor bearing animals are descirbed. In the patients, $^{57}Co-Bleomycin$ appears to be one of the useful tumor-seeking radiopharmaceuticals, and worth applicable to clinical uses. Labelled yield of $^{57}Co-Bleo$ was about 97 % by thin layer chromatography. The pyrogen free tests were performed to meet U.S.P. critical ranges. In clinical studies with $^{57}Co-Bleo$, 4 cases out of 5 patients with lung cancer., 2 cases among 3 thyroid cancer patients, and all 3 hepatoma patients showed positive tumor scans. The patients with stomach cancer, and the esophageal cancer showed false negative scintigraphy. A case with pulmonary tuberculosis showed a positive scan while liver abscess showed a negative picture. The merits of $^{57}Co-Bleomycin$ scintigraphy seems to be its relatively high affinity to tumors and low radiation hazard in spite of long physical half life.

• The Korean Journal of Nuclear Medicine
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• v.28 no.3
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• pp.326-330
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• 1994

A $^{82}Sr/^{82}Rb$ generator was prepared by loading $^{82}Sr$ to preconditioned tin dioxide column. The generator was eluted by normal saline with flow rate up to 8m1/min, and the eluted radioactivity was monitored by dose calibrator. Radioactivity began to come out at 5ml and reached to peak around 9ml. The total eluted radioactivity increased linearly with flow rate, and the maximum obtained radioactivity was 35mCi at 8m1/min. The $^{82}Rb$ preparation was proven to be free from both strontium radioactivity and pyrogen. The $^{82}Rb$ was injected to normal female volunteer and positron emission tomographic Image of heart was obtained successfully.

• Proceedings of the KSR Conference
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• 2009.05a
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• pp.1489-1497
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• 2009

The rectifier for Electric railway is one of the most important facilities in DC urban railway which converts power from KEPCO(AC 22.9kV) to the electric mil car(DC 1.5kV), therefore it should be managed as the best condition for the drive. There are several things to cause performance degradation and deterioration of parts such as pollutants occurred by it established under the ground such as dust or foreign substances, rapid changes of driving current, and pyrogen which put the rectifier for Electric railway in malfunction. On the flow of time, the rectifier for Electric railway is causing a malfunction or failure which drive electric rail car in operations as well as loss of life. In this research we try to find the way of removing the various components of mal-functions in the performance of the rectifier for Electric railway by Over-Haul and reform itself, which gives us to get the chance investment of the reduction, the reliability of power supply to the electric rail car.

• Journal of East-West Nursing Research
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• v.1 no.1
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• pp.40-49
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• 1997

This study was done for understanding the desirable direction of eastern and western nursing by comparing the nursing practice for the Pyrexia patient occuring most commonly. Body temperature usually maintains around $37^{\circ}C$ owing to the thermoregulatory center but pyrexia is caused by exogenous pyrogen like infection, cancer or disturbances in body's homeostatic heat balance. Pyrexia is defined that body temperature rise above $37.2^{\circ}C$. It has chill phase, course of the fever, termination accompanied various symptoms. Oriental medicine explains that pyrexia comes from Yang's(陽) abundance and Yin's(陰) lack. Pyrexia mainly happens when body constitution is in bad condition by Six Dirty's(六陰) affection to Wi Area (偉分). It also occurs because of unbalance between Qi (氣) and Yin(陰) caused by the lack in Seven Emotions, labor, food. The Sanghanron(傷寒論), explains that pyrexia is categorized exogenous fever like Poong Han(風寒), Poong Yul(風熱), Sup Yul(濕熱) and endogenous fever due to the Qi and blood deficiency. Explained above, even though pyrexia has different meaning in oriental medicine and western medicine, but this study have compared the oriental and western medicine assuming that pyrexia is rise of body temperature. From this point of view, oriental and western nursing shows the similarity in the field of 1) use of antipyretic to control the body temperature 2) rest and comfort 3) watering 4) nutrition and case study was executed in nursing practice. From the above study, western nursing has superiority in decreasing the patient's risen body temperature using antipyretic and ice bag. But in case of empty heat, oriental nursing which recommends the patient's body keep warm and prevent the use of ice bag as the first step and helps patient's sweating by drinking of hot water was comparatively effective. In conclusion, it is desirable that oriental nursing emphasizing the supportive nursing and western nursing should be harmonized according to the status of pyrexia patient and it is needed to study the nursing method appropriate in our culture.

• Journal of Microbiology and Biotechnology
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• v.16 no.1
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• pp.136-140
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• 2006

In this study, we investigated the synergistic effects of Staphylococcus aureus extracts (membranes and walls) and lipopolysaccharide (LPS) derived from Escherichia coli on tumor necrosis factor (TNF) production in the pathogenesis of silica-induced inflammation. The synergistic induction of TNF by silica particles $(<20\;{\mu}m)$ in combination with either S. aureus extracts or LPS was examined in J774A.1 cell cultures. Media from the treated and untreated cell cultures were assayed for TNF, using the mouse WEHI 164 cell cytotoxicity assay and enzyme immunoassay. Cells exposed simultaneously to silica and $0.5\;{\mu}g/ml$ S. aureus extracts (or 0.5 ng/ml of LPS) produced a significantly higher level of TNF than those produced by the inducer alone. Our results indicate that device-associated infections (or pyrogen contamination) could enhance inflammatory responses, because of particles produced by the wear of medical implants or particulate biomaterials used for clinical purposes.

• Korean Journal of Veterinary Service
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• v.34 no.2
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• pp.159-166
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• 2011

This study was carried out to develope enzyme-linked immunosorbent assay (ELISA) for detection of canine brucellosis in dogs experimentally inoculated with Brucella abortus 1119-3 and B. canis RM666. Groups A, B and C of dogs (each group consisting of three dogs) were orally inoculated with approximately $5{\times}10^9$ colony-forming units of B. abortus and B. canis, and with sterile pyrogen-free PBS, respectively. The animals were monitored at regular intervals upto the 12th week post inoculation (PI) by standard tube agglutination test (STAT), plate agglutination test (PAT), Rose Bengal test (RBT), 2-mercaptoethanol rapid slide agglutination test (2ME-RSAT) and ELISA. The induced antibody titers in group A dogs were detected from the first week PI to the eighth week PI in STAT, PAT and RBT using the inactivated whole cells of B. abortus 1119-3 as antigens, while no sera in groups B and C dogs reacted with the antigens. In 2ME-RSAT using whole cells of B. canis M-strain as antigens, the induced antibody titers in group B dogs were observed at the second week PI and persisted for the 12th week PI, while sera of groups A and C dogs did not react with the whole cells. In ELISA using cytoplasmic fractions antigen of B. abortus 1119-3, the mean optical density of antibodies in groups A and B was detected from the first and second weeks PI, respectively, and persisted for 12th week PI, while sera of group C did not cross-react with the fractions antigen. However, in ELISA using the hot saline extracts of B. canis M- as an antigen, the induced antibody titers in only group B dogs were detected from second week PI and persisted for until the end of this study. These results indicate that the ELISA using B. abortus 1119-3 cytoplasmic fractions as antigens can be a good candidate for detection of brucellosis by B. abortus as well as B. canis in dogs.