• 동의생리병리학회지
• /
• 제27권5호
• /
• pp.530-539
• /
• 2013

This study reviews the latest articles about oriental and traditional medicine treatment of male sexual dysfunction. We searched the article from 2000 to 2012 using 5 data bases. There were no restrictions on the type of publication, but articles not available in full text were excluded. The methological quality of RCT study was assessed according to Jadad scores and Cochrane's assessment of risk of bias. 18 articles were included in this study. 5 articles published in Korea, the rest were foreign articles. 9 articles were randomized controlled trial(RCT), Case-control studies were 3, case reports were 3, One group pre-post test were 3. In RCT studies, Jadad scores were generally low, and risk of selection bias and performance bias were generally high, risk of detection bias was unclear. Oriental and traditional medicine treatment is as effective as western medicine treatment for male sexual dysfunction, more rigorous oriental medicine treatment studies should be warranted.

• 정보관리학회지
• /
• 제32권4호
• /
• pp.205-221
• /
• 2015

학술지의 인용빈도를 특정하여 산출된 지수로 단일 논문의 영향력을 평가하는 것에 대한 비판으로 인해 단일 논문의 인용 영향력을 측정하는 인용지수에 대한 연구가 다양하게 시도되었다. 이 연구에서는 8개의 단일 논문 인용영향력 평가 지수를 살펴보고 KCI 논문 데이터베이스를 대상으로 각 인용지수의 분야별 편향성을 조사하여 보았다. 대상 지수는 단순 인용빈도, 페이지랭크, f-값, CCI, c-지수, 단일문헌 h-지수, 단일문헌 hs-지수, cl-지수였다. 분석결과 페이지랭크가 학문 분야별 균등성, 학문 분야 내에서 학술지별 균등성 영역에서 가장 편향성이 없는 것으로 나타났다. 반면에 단순 인용빈도는 특정 학문분야나 특정 학술지에 편향된 결과를 산출할 가능성이 높은 것으로 나타났다. KCI 데이터베이스에서는 논문의 단순 인용빈도만 제공하고 있는데, 분야별 균등성을 가장 잘 유지하는 지수인 논문 페이지랭크를 함께 제공할 필요가 있다. 아울러 인용한 문헌의 인용빈도만으로 산출이 가능해서 이용자의 검색 결과로부터 바로 산출할 수 있는 지역 네크워크 지수 중에서는 cl-지수가 가장 균등성을 잘 유지하므로 계산 과정과 서비스가 손쉬운 지수로 함께 제공하는 것도 검토해야 한다.

• 디지털융복합연구
• /
• 제16권11호
• /
• pp.419-432
• /
• 2018

본 연구의 목적은 호스피스 간호중재 연구방향과 호스피스 간호중재 프로그램 활용의 기초자료를 제공하기 위한 메타분석연구이다. 연구주제어는 '호스피스', '중재'로 2002년부터 2017년부터 학술연구정보서비스 외 기타 호스피스 관련 학술지에 발표된 논문을 검색하여 최종 15편의 논문을 선정하였다. 선정된 논문 15편은 메타분석 소프트웨어인 CMA2를 이용하여 출판편향, 효과 크기산출, 비중복 백분위(U 3), 신뢰구간, 동질성 검증을 하였다. 연구결과 출판 편향성은 안정적이었으며 호스피스 간호중재 프로그램 효과 크기는. 99로 유의하였으며 조절 효과는 출판연도 2003~2007년(ES=1.24), 출판형식은 학술지(ES=1.33), 연구자의 주전공은 간호학(ES=1.02), 대상자의 나이 29~30세(ES=1.09), 추후 회기(ES=1.06), 아로마(ES=1.12)로 유의하였다. 본 연구는 국내 호스피스 간호중재 프로그램의 융, 복합적 변인에 관한 메타분석을 처음 시도한 것에 의의를 두며, 호스피스 중재연구 방향과 프로그램 활용에 구체적 방향을 제시하여 호스피스프로그램 운영에 도움이 될 것이다.

• 대한간호학회지
• /
• 제43권5호
• /
• pp.658-668
• /
• 2013

Purpose: The purpose of this study was to investigate the effects of psychosocial interventions on pain in cancer patients. Methods: Eight studies published between 1980 and 2012 in Korean and ten studies published between 2002 and 2012 in English met the inclusion criteria with a total of 1539 participants. Methodological quality assessed by Cochrane's Risk of Bias for randomized studies and Risk of Bias Assessment tool for non randomized studies. The data were analyzed by the RevMan 5.2 program of Cochrane library. Results: Overall, study quality was moderate to high. Effect sizes were heterogeneous and subgroup analysis was done. Cognitive behavioral therapy (CBT) were effective for pain (ES= -0.35; 95% CI= -0.56, -0.13). Pain education studies measured with NRS and VAS were effective for pain (ES= -0.77; 95% CI= -1.01, -0.52). Publication bias was not detected. Conclusion: This study support the use of psychosocial interventions administered to cancer patients for their pain management. However, more well-designed studies are needed.

• 한국콘텐츠학회논문지
• /
• 제14권3호
• /
• pp.203-214
• /
• 2014

본 연구는 메타분석을 통해 뇌손상 환자를 대상으로 한 최근 연구들의 지역사회재활의 효과를 ICF 요소별로 알아보고, 최근 지역사회재활 프로그램 적용방법 등을 알아봄으로써 지역사회재활 프로그램의 개발 및 활성화를 위한 기초자료를 제시하고자 하였다. 선정기준에 적합한 논문은 총 15건을 ICF 요소별로 나누어 효과크기 값을 구하였으며 대상 논문들의 동질성 검정과 출판편견 검정을 실시하였다. 그 결과 지역사회 재활 프로그램의 전체 효과크기는 0.22였고, ICF 요소별 효과크기는 신체기능과 구조 0.21, 활동과 참여 0.20으로 작은(small) 효과크기를 보였다. 또한 메타분석에 포함된 연구들은 통계적 이질성이나 출판편견이 없는 것으로 간주되어 본 연구 결과는 객관적이고 신뢰할 수 있었다. 이러한 결과는 뇌손상 환자의 지역사회재활 프로그램이 ICF 요소들인 신체기능과 구조, 활동과 참여 요소에 대한 변화 정도 즉 개입 효과를 잘 설명해 주고 있음을 알 수 있었다.

• Asian Pacific Journal of Cancer Prevention
• /
• 제16권6호
• /
• pp.2361-2368
• /
• 2015

Objective: To evaluate the diagnostic accuracy of contrast-enhanced ultrasonography (CEUS) in differentiating between benign and malignant enlarged lymph nodes using meta-analysis. Materials and Methods: Pubmed, Embase, SCI and Cochrane databases were searched for studies (up to September 1, 2014) reporting the diagnostic performance of CEUS in discriminating between benign and malignant lymph nodes. Inclusion criteria were: prospective study; histopathology as the reference standard; and sufficient data to construct $2{\times}2$ contingency tables. Methodological quality was assessed using Quality Assessment of Diagnostic Accuracy Studies-2 (QUADAS-2). Patient clinical characteristics, sensitivity and specificity were extracted. The summary receiver operating characteristic curve was used to examine the accuracy of CEUS. A meta-analysis was performed to evaluate the clinical utility in identification of benign and malignant lymph nodes. Sensitivity analysis was performed after omitting outliers identified in a bivariate boxplot and publication bias was assessed with Egger testing. Results: The pooled sensitivity, specificity and AUROC were 0.92 (95%CI, 0.85-0.96), 0.91 (95%CI, 0.82-0.95) and 0.97 (95%CI, 0.95-0.98), respectively. After omitting 3 outlier studies, heterogeneity decreased. Sensitivity analysis demonstrated no disproportionate influences of individual studies. Publication bias was not significant. Conclusions: CEUS is a promising diagnostic modality in differentiating between benign and malignant lymph nodes and can potentially reduce unnecessary fine-needle aspiration biopsies of benign nodes.

• Asian Pacific Journal of Cancer Prevention
• /
• 제13권6호
• /
• pp.2687-2693
• /
• 2012

Objective: Passive smoking has been considered as a risk factor of many cancers. To examine whether it might also pose a risk for cervical cancer, we performed a meta-analysis based on published case-control studies. Methods: We searched the PubMed database and references of included studies up to February 10th, 2012 for relevant studies. After two authors independently assessed the methodological quality and extracted data, a meta-analysis was conducted using CMA v2 software. Publication bias was evaluated by funnel plot, using Egger's and Begg's tests. Results: Finally 11 eligible studies yielded, involving 3,230 cases and 2,982 controls. The results showed that women who never smoke but exposed to smoking experience a 73% increase in risk of cervical cancer compared with non-exposed women (OR = 1.73, 95% CI = 1.35 - 2.21, p<0.001). Subgroup and sensitivity analyses indicated this result to be robust. Moderate publication bias was detected by visualing funnel plot, Egger's and Begg's tests. Conclusion: Based on currently available evidence, the findings of this meta-analysis suggests that passive smoking significantly and independently increases the risk of cervical cancer.

• Asian Pacific Journal of Cancer Prevention
• /
• 제14권12호
• /
• pp.7203-7206
• /
• 2013

Recent studies suggested that the ovarian cancers with negative excision repair cross-complementation group 1 enzyme (ERCC1) expression have a better response to platinum-based chemotherapy than those with positive ERCC1 expression. The objective of this study was to evaluate whether ERCC1 expression is associated with response to platinum-based chemotherapy in ovarian cancers. MEDLINE, PubMed, Web of Science and CNKI databases were used for searching studies relating to ERCC1 protein expression and response to platinum-based chemotherapy in ovarian cancers. Statistical analysis was based on the method for a fixed effects meta-analysis. Pooled odds ratios (ORs) with 95% confidence intervals for ERCC1 protein expression and response to platinum-based chemotherapy were generated. Publication bias was investigated with Begg's test. Five studies involving 306 patients with ovarian cancer were included. Compared to patients with positive ERCC1 expression, those with negative ERCC1 expression had a better response to platinum-based chemotherapy. The pooled OR was 5.264 (95% CI: 2.928-9.464, P < 0.001) and publication bias was not found (P = 0.904). The result was similar in both in Asians and Caucasians (P < 0.001 and P = 0.028, respectively). ERCC1 protein expression status is significantly associated with response to platinum-based chemotherapy in ovarian cancers.

• Asian Pacific Journal of Cancer Prevention
• /
• 제16권14호
• /
• pp.5625-5633
• /
• 2015

Background: ${\beta}$-catenin plays a crucial role in the progression of breast cancer (BC) and a prognostic role of in BC patients has been widely reported. However, controversy still remains. Materials and Methods: Identical search strategies were used to search relevant literature in electronic databases updated to July 1, 2014. Individual hazard ratios (HRs) and 95% confidence intervals (CIs) were extracted and pooled HRs with 95%CIs were used to evaluate the strength of association between positive ${\beta}$-catenin expression in different subcellular locations and survival results of BC patients. Subgroup and meta-regression analyses were performed to explore heterogeneity. Funnel plots of Begg's and Egger's linear regression test were used to investigate publication bias. Heterogeneity and sensitivity were also assessed. All the work was completed using STATA. Results: A total of 2,204 patients from 12 evaluative studies were finally included. Pooled HRs and 95%CIs suggested that ${\beta}$-catenin expression in cytoplasm/nucleus had an unfavorable impact on both overall survival (OS) (HR: 1.93, 95%CI: 1.40-2.65) and disease free survival (DFS)/ recurrent free survival (RFS) (HR: 1.60, 95%CI: 1.20-2.13) in BC patients. However, here was no significant association between ${\beta}$-catenin expression in the membranes with OS (HR: 0.65, 95%CI: 0.42-1.02) or DFS/RFS (HR: 0.66, 95%CI: 0.38-1.13). Publication bias was absent in all of the four outcomes. Sensitivity analysis revealed that the results of this meta-analysis were robust. Conclusions: Positive ${\beta}$-catenin expression in cytoplasm/nucleus rather than in membrane is a significant prognostic factor in patients with BC who have been surgically treated.

• Asian Pacific Journal of Cancer Prevention
• /
• 제16권14호
• /
• pp.5939-5944
• /
• 2015

Background: There is still a great deal of controversy with regard to the prognostic role of chemotherapy-induced amenorrhea (CIA) in breast cancer patients. To confirm whether CIA can serve as a useful factor in predicting clinical effects of systemic adjuvant chemotherapy, we performed this meta-analysis. Materials and Methods: Relevant studies were identified using PubMed, and Embase databases. Eligible study results were pooled and summary hazard ratios (HRs) with corresponding confidence intervals (CIs) were calculated. Subgroup analyses and an assessment of publication bias were also conducted. Results: A total of 8,333 patients from 11 published studies were identified through searching the databases. The pooled HRs for disease-free survival (DFS) suggested that CIA was associated with a significant reduction in the risk of recurrence, especially in patients with hormone receptor-positive lesions (overall HR=0.65, 95%CI 0.53-0.80, $I^2=41.3%$). When the five studies reporting the HR for overall survival (OS) were pooled (n=4193), a favorable trend was found (HR=0.69, 95%CI 0.52-0.91, $I^2=51.6%$). No publication bias was observed in this study. Conclusions: This meta-analysis suggests that CIA predicts a better outcome in premenopausal hormone receptor-positive breast cancer patients.