• Title/Summary/Keyword: psychiatric disorder

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Altered Complexin Expression in Psychiatric and Neurological Disorders: Cause or Consequence?

  • Brose, Nils
    • Molecules and Cells
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    • v.25 no.1
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    • pp.7-19
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    • 2008
  • Complexins play a critical role in the control of fast synchronous neurotransmitter release. They operate by binding to trimeric SNARE complexes consisting of the vesicle protein Synaptobrevin and the plasma membrane proteins Syntaxin and SNAP-25, which are key executors of membrane fusion reactions. SNARE complex binding by Complexins is thought to stabilize and clamp the SNARE complex in a highly fusogenic state, thereby providing a pool of readily releasable synaptic vesicles that can be released quickly and synchronously in response to an action potential and the concomitant increase in intra-synaptic $Ca^{2+}$ levels. Genetic elimination of Complexins from mammalian neurons causes a strong reduction in evoked neurotransmitter release, and altered Complexin expression levels with consequent deficits in synaptic transmission were suggested to contribute to the etiology or pathogenesis of schizophrenia, Huntington's disease, depression, bipolar disorder, Parkinson's disease, Alzheimer's disease, traumatic brain injury, Wernicke's encephalopathy, and fetal alcohol syndrome. In the present review I provide a summary of available data on the role of altered Complexin expression in brain diseases. On aggregate, the available information indicates that altered Complexin expression levels are unlikely to have a causal role in the etiology of the disorders that they have been implicated in, but that they may contribute to the corresponding symptoms.

Polymorphisms of the Dopamine Receptor Genes in Alcoholism (알코올 중독에서의 도파민 수용체 유전자 다형성)

  • Ryu, Seung Ho
    • Korean Journal of Biological Psychiatry
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    • v.9 no.1
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    • pp.15-24
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    • 2002
  • Even though alcoholism is a multi-factorial psychiatric disorder, it is reasonable to suppose that genetic factors play a substantial role in the manifestation of this disorder. Because alcohol is the reinforcing substance which manifests its effects through activation of the mesolimbic dopaminergic reward pathway of the brain, the gene encoding dopamine receptor subtypes can be a major natural candidate gene. Since 1990, many association studies have identified strong evidence implicating the dopamine D2 receptor(DRD2) gene in alcoholism, specifically TaqI A minor(A1) allele. Association studies have also been conducted on other dopamine receptor(DRD3 & DRD4) polymorphisms but the results have yet to be confirmed. Through a number of other approaches, each dopamine receptor gene has been investigated in association with different phenotypes in alcoholism, but further researches will be needed. In conclusion, studies in the past decade have shown that the TaqI A1 allele of the DRD2 gene is associated with alcoholism in various subject groups. Other dopamine receptor genes have since been added to the list but yet to be identified. Thus, the knowledge of these genes and their functional significance will enhance the understanding of the underlying biological mechanisms of alcoholism. Furthermore, it could lead to more helpful prevention and treatment approaches to alcoholism.

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Interaction between Personality and Depression Outcome (인격과 우울증 치료결과의 상호작용)

  • Park, Yong Chon;Kim, Seok Hyeon
    • Korean Journal of Biological Psychiatry
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    • v.8 no.1
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    • pp.47-52
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    • 2001
  • It is known that the personality is the crucial factor in the treatment outcome of depression. The authors tried to identify the results of such studies and various components which determine the treatment outcome of depression. Nearly 60 papers published between the year 1990 and 2000 about the treatment of depression and personality were reviewed. Among them about 30 papers were selected to compare the research methods, results and discussions. The arguments and critics of the papers were discussed. In the many debates, the authors admitted the fact that premorbid personality trait influences the treatment outcome of depression negatively regardless of treatment method. Subtyping of depression is feasible along the presence of good or bad predictors of treatment outcome for depression. Differentiation of depression and personality seems to have no problem, however test of personality state before the development of psychiatric disorder such as depression is not amenable. For example, cluster A personality trait is often misunderstood as depression in clinical setting. In some cases cognitive behavioral therapy is effective in the treatment of depression accompanying personality disorder. The authors insist that the analysis of personality in the dimensional aspect rather than in the categorical aspect gives more information in the research of personality influencing the treatment outcome of depression. In addition, the reason why we understand the relationship between depression and personality were discussed.

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A Case Report of ADHD Child treated with Neurofeedback (뉴로피드백을 이용한 주의력결핍 과잉행동장애 치료 1례(例))

  • Kang, Jun-Won;Park, Jeong-Gyung;Cheon, Yong-Woo;Han, Gook;Park, Hyun-Cheol;Yoo, Gyung;Jeong, Eun-Hee;Kim, Lak-Hyung
    • Journal of Oriental Neuropsychiatry
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    • v.16 no.2
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    • pp.243-249
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    • 2005
  • Attention Deficit Hyperactivity Disorder(ADHD) is a psychiatric disorder, characterized by the primary symptoms of inattention and/or impulsivity and hyperactivity. This study is a clinical report of 1 ADHD child treated with Neurofeedback therapy from Feb. to May 2005. Conners’ parent rating scale, Korean Personality Inventory for children(KPI-C), Basic Academic Skills Assessment(BASA : Reading) was compared between before and after Neurofeedback therapy, and the EEG data of each cession was analysed. The results show the Neurofeedback therapy is efficient in the treatment of ADHD.

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A Case Report of Various Oriental Medical Therapy in Combination with Learning Therapy on School Underachievement Child caused by ADHD (ADHD로 인한 학습부진아동 치험 1례)

  • Wy, Young-Man;Kang, Hyung-Won
    • Journal of Oriental Neuropsychiatry
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    • v.20 no.4
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    • pp.197-209
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    • 2009
  • Objectives : Attention Deficit Hyperactivity Disorder(ADHD) is a psychiatric disorder, characterized by the primary symptoms of inattention and/or impulsivity and hyperactivity. the aim of this study is to investigate the clinical efficiency of Various Oriental Medical Therapy combinated with Learning therapy in the treatment of ADHD. Methods : This study is a clinical report of 1 ADHD child treated with Various Oriental Medical Therapy(Herb-med, acupunture, etc.) in Combination with Learning therapy. CAR(Conner's abbreviated Rating Scale), K-CBCL, ADS(ADHD Diagnostic System) were compared between before and after treatment. Results : The results show the Various Oriental Medical Therapy in Combination with Learning therapy is efficient in the treatment of ADHD. Conclusions : Various Oriental Medical therapy including herb-med, pharmacopuncture, electroacupuncture is efficient in improvement of ADHD child. also In case of combination with Learning therapy, it is more effective in child's school life and school work. therefore, it is practical useful in the treatment of ADHD.

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3 Case Reports of Patients with ADHD Treated with the Oriental Medical Therapy and Art Therapy (ADHD 환자에게 미술치료와 한방치료를 병행하여 치료한 치험 3예)

  • Sung, Won-Young;Yoo, Jong-Ho;Hwang, Min-Young;Kim, Nam-Yeol
    • Journal of Oriental Neuropsychiatry
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    • v.25 no.3
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    • pp.253-262
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    • 2014
  • Objectives: Attention Deficit Hyperactivity Disorder (ADHD) is a psychiatric disorder, characterized by the primary symptoms of inattention and/or hyperactivity and impulsivity. The aim of this study is to investigate the clinical efficiency of the oriental medical therapy combined with art therapy in the treatment of ADHD. Methods: This study is clinical reports of 3 patients with ADHD who are being treated with the oriental medical therapy (Herb-med, acupuncture) and art therapy. K-ARS (Korean ADHD Rating Scale) was compared before and after 1 month of treatment. Results: The Oriental medical therapy including herb-med and acupuncture is effective in improving ADHD patients. Also, art therapy is effective in decreasing patients' anxiety and tension and helpful for patients themselves to make an objective observation. Therefore, it is practically useful in the treatment of ADHD. Conclusions: The results show the oriental medical therapy in combination with art therapy is effective in the treatment of ADHD.

Considerations about Evolutionary Ecological Study of Psychiatry (정신의학의 진화생태학적 연구 시 고려사항)

  • Park, Hanson
    • Korean Journal of Cognitive Science
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    • v.30 no.4
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    • pp.199-217
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    • 2019
  • Evolutionary research on mental disorders is relatively difficult compared to other medical studies. It is because the cause of mental disorder is unclear relative to other medical diseases, various proximate causations are involved. And it is difficult to distinguish cause and effect and to carry out experimental research. Despite these methodological difficulties, it is possible to establish an evolutionary hypothesis on mental disorders based on constructive reductionism, and to demonstrate actual data on the model based on this hypothesis. In this paper, I will discuss some conceptual definitions needed for applying ecological approaches to evolutionary psychiatric research. We will first discuss the appropriate level of explanations and the scope of the study subjects, then discuss the conceptual definition of behaviour and function, dysfunction and the appropriate level of selection.

CARE OF POSTTRAUMATIC PAIN SYNDROME IN THE PSYCHIATRIC DISORDER PATIENT : REPORT OF CASES (정신 장애 환자에서 외상후 통증증후군의 관리 : 증례보고)

  • Oh, Ji-Hyeon;Yoo, Jae-Ha;Kim, Jong-Bae
    • The Journal of Korea Assosiation for Disability and Oral Health
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    • v.11 no.1
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    • pp.9-16
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    • 2015
  • Pain and sensory disorder resulting from injury to peripheral nerves of the face and jaws are a major source of patient dissatisfaction and suffering. The majority of patient who sustain injuries to the peripheral sensory nerves of the face and jaws experience a slow but orderly return of sensation that is functional and tolerable in quality, if not "normal". For many patients, however, the long-term effects are a source of aggravation, and for a few, a significant cause of suffering. Common complaints relate to reduced sensory information causing embarrassing food accumulations or drooling, biting a burning the lip or tongue, and difficulty in performing routine activities such as shaving and apply makeup. For some patients posttraumatic symptoms become pathological and frankly painful. The predominent pain components are (1) numbing anesthesia dolorosa pain, (2) triggered neuralgiaform pain, (3) burning, aching causalgiaform pain, and (4) phantom pain. This is a report of cases about posttraumatic pain syndrome associated with dental treatment in a psychologically disabled patient.

The Case Study of a Patient with Simbiyangheo type Ul-zeong who has treared by Bibliotherapy and Neurofeedback (독서요법과 뉴로피드백을 시행한 심비양허형(心脾兩虛型) 울증(鬱證)환자 치험(治驗) 1례(例))

  • Lim, Jung-Hwa;Choi, Kang-Wook;Jung, In-Chul;Lee, Sang-Ryong
    • Journal of Oriental Neuropsychiatry
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    • v.17 no.2
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    • pp.187-198
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    • 2006
  • Bibliotherapy is the field of clinical counceling to treat the emotional, psychiatric and social maladjustment. Neurofeedback is a means by which participants can team voluntary control of the EEG and has been applied to a range of clinical conditions such as epilepsy, attention deficit hyperactivity disorder, depressive disorder. 'Ul-zeong' comes from obstruction of qi by stress. The mind affect the body. The patient has depressed mood, irritable sign, chest discomfort, flank pain, angry state and some strange feeling on the throat. In this case, a female patient, 30 years old, who complained of amnesia, deficiency of the power of the attention and concentration depersonalization, depressed mood, insomnia ect. We treated the patient with bibliotherapy, neurofeedback and oriental medical treatment such as heral medicine, acupuncture treatment and aroma therapy. In result, the symptoms which she complained were improved.

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Familial, Cognitive, and Behavioral Characteristics of Adolescents with Depression

  • Lee, Yeeun;Kim, Bung-Nyun;Park, Min-Hyeon;Park, Subin
    • Journal of the Korean Academy of Child and Adolescent Psychiatry
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    • v.28 no.3
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    • pp.168-173
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    • 2017
  • Objectives: Adolescent depression is a complex disorder influenced by a variety of personal and familial factors. In this study, we compared the familial, cognitive, and behavioral characteristics of adolescents with and without diagnosed depression. Methods: Forty adolescents with depressive disorder were recruited from two psychiatric clinics, along with 46 healthy adolescents from a middle school and a high school. We then compared the participants' cognitive and behavioral characteristics and the child-rearing attitudes of their parents. Results: Compared to the healthy adolescents, the adolescents with depression exhibited lower self-esteem, higher emotional reappraisal, greater disruptive behavior, and lower attention. Furthermore, compared to the mothers of the healthy adolescents, the mothers of those with depression reported less affective, less autonomic, and more rejecting parenting attitudes towards their children. Conclusion: We found that attentional problems, negative parenting attitudes, negative self-cognition, and expressive suppression are all associated with adolescent depression. Parenting education and interventions appear to be needed to correct the negative cognitions of adolescents with depression.