• Journal of the Korean Arthroscopy Society
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• v.13 no.1
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• pp.82-85
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• 2009

Purpose: In anterior cruciate ligament (ACL) reconstruction, preservation of the remnant original tissue might promote graft healing and be helpful in proprioception. But this procedure is difficult and causes the notch impingement. So we introduce a surgical technique that makes a transtibial femoral tunnel at 10 or 2 o'clock position with preservation of remnant tissue. Surgical approach: We tried to preserve the remnant tissue and synovium as much as possible, especially those of tibial attachment and extending to the posterior cruciate ligament (PCL), so as to have some tension and to prevent notch impingement. We set the tibial drill guide at 40~45 degrees and the intra-articular guide tip was 1 mm anterior and medial to the conventional site. The starting point of tibial guide pin was proximal to the pes anserinus and anterior to the medial collateral ligament. When the reamer approached the cortical bone of the tibial articular surface, the reamer must be advanced very carefully to minimize injury to the remnant tissue. The tibial and femoral tunnel at 10 or 2 o'clock position were made with the reamer, the diameter of which was same with that of the graft. Conclusion: We report a remnant preserving technique in ACL reconstruction that makes a transtibial femoral tunnel at 10 or 2 o'clock position

• Journal of Acupuncture Research
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• v.19 no.2
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• pp.211-220
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• 2002

Objective : This study was undertaken to determine whether Scutellaria baicalensis Georgi extract (SbG) exerts the protective effect against oxidant-induced alterations in organic cation transport in the renal proximal tubule. Methods : Organic cation transport was estimated by examining alterations in tetraethylammonium (TEA) uptake in rabbit renal cortical slices. The slices were treated with 0.2 mM tBHP for 60 min at $37^{\circ}C$. tBl-IP caused an inhibition in TEA uptake by renal cortical slices. Such an effect was accompanied by depressed Na+-K+-ATPase activity and ATP depletion. Result : SbG prevented tBHP-induced inhibition of TEA uptake in a dose-dependent manner at the concentration ranges of 0.05-0.1%. SbG also prevented H2O2-induced reduction in TEA uptake. tBHP-induced inhibition of Na+-K+-ATPase activity and ATP depletion were significantly prevented by 0.05% SbG. Oxidants increased LDH release, which was blocked by SbG. Oxidants caused a significant increase in lipid peroxidation and its effect was prevented by SbG. Conclusion : These results suggest that SbG prevents oxidant-induced alterations in organic cation transport in rabbit renal cortical slices. Such protective effects of SbG may be attributed to inhibition of peroxidation of membrane lipid.

• The korean journal of orthodontics
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• v.12 no.2
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• pp.145-154
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• 1982

Plaster models were constructed and orthopantomographs were taken for 86 male and 70 female primary school pupils, whose upper and lower permanent 4 incisors and 1st molars were completely erupted without crowding; whose deciduous canines and molars were found almost uniformly even without any visible tooth fractures, dental caries or restorations on proximal surfaces of the teeth. Certain reference points on the orthophantomograph were set up and measured and the values were compared with actual or predicted values from the models. The following results were obtained: 1. In regards to available space, the values from the orthopantomograph were greater than the values from the models by a mean of 3.24% on the upper and 10.06% on the lower for males; 3.05% on the upper and 10.01% on the lower for females. 2. In regards to total mesiodistal widths of permanent canine, 1st and 2nd premolars, the values from the orthopantomograph were greater than the presumed values based on the size of lower permanent 4 incisors from the models by a mean of 18.50% on the upper and 24.09% on the lower for males; 14.54 on the upper and 20.51% on the lower for females. 3. Comparing the magnified values of total mesiodistal widths of permanent canine, 1st and 2nd premolars with those of available space, the regression constants of regression equation (Y = a + bX) between them were a=3.2336, b=0.6533 on the upper and a=5.0138, b=0.3290 on the lower for males; a=2.5994, b=0.6521 on the upper and a=3.0113, b=0.6586 on the lower for females. 4. The correlation coefficients between the magnified values of available space and permanent canine, 1st and 2nd premolars were moderately positive as 0.6474 in the upper and 0.505 on the lower for males; 0.6493 on the upper and 0.6183 on the lower for females. 5. In regards to magnified values of the available space from the orthopantomographs there were no significant difference between sexes, (P>0.05) but of the total mesiodistal widths of permanent canine, 1st and 2nd premolars, a significant difference between sexes was found.(p<0.01).

• The korean journal of orthodontics
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• v.34 no.6 s.107
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• pp.481-487
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• 2004

The purpose of this study was to clarify morphologic characteristics between mandibular clinical arch forms in Koreans with normal occlusions. The study included data from 102 Koreans. The most facial portion of 13 proximal contact areas was digitized from photocopied images of the mandibular dental arches. Clinical bracket points were calculated for each tooth based on mandibular tooth thickness data. Four linear and two proportional measurements were taken. The dental arches were classified into ovoid, square and tapered forms. The frequency distributions of the three mandibular arch form classifications were determined and compared between male and female subjects. No significant differences in arch form size were found between the sexes. However, there were a few differences in molar width. It was useful to classify mandibular clinical arch forms present in normal occlusion samples into ovoid, square and tapered categories. The frequency of the ovoid form was the highest, and that of the square form was the second highest. The tapered arch form was found in less than 10 percent of subjects. No significant differences in their frequency distributions and dimensions were shown between males and females.

• Journal of Oral Medicine and Pain
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• v.35 no.2
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• pp.155-163
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• 2010

Dermatomyositis (DM) is an idiopathic inflammatory connective tissue disorder and a systemic autonomic immune disease which shows a progressive muscle weakness and characteristic rash. It is identified by a characteristic rash accompanying, or more often preceding muscle weakness. Pathognomonic skin lesions are a blue-purple discoloration on the upper eyelids with edema (heliotropic rash), a flat red rash on the face and upper trunk, and erythema of the knuckles with a raised violaceous scaly eruption (Gottron's papule). The myopathy represents inflammatory and degenerative changes primarily affecting proximal muscles. DM often involves GI tract and respiratory system with as risk of 15-25% internal malignancy. It's managed with sun protection since muscle weakness as well as a rash could be aggravated by sun exposure. Systemic corticosteroid is an initial therapy and other immunosuppressive agent has been used as alternatives. Facial muscles are unaffected and masticatory muscles are rarely affected in DM. We present trismus close to muscle contracture in a patient with DM. Therefore, it needs continuous mouth-opening exercise to prevent progressive muscle contracture and to ensure normal mouth opening.

• The Journal of Korean Academy of Prosthodontics
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• v.33 no.4
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• pp.611-633
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• 1995

The pupose of this study was to compare the fracture strength of five kinds of all-ceramic crowns(Vintage, Dicor Empress-staining, Empress-layering, In-Ceram) luted with glass ionomer cerment and composite resin cement and to evaluate the effect of cements on the fracture stregth of all ceramic crowns. Five groups of twelve uniform sized all-ceramic crown specimens were fabricated. Six specimens of each group were cemented with glass ionomer cement(Fuji G.I. Cement) and the remaining six specimens of each group were etched, silane-treated, and cemented with composite resin cement(Bistite resin cement). The crowns were stored in water$(37^{\circ}C)$ for 1 day prior to loading in an Instron, using a steel ball(diameter 4mm) at a crosshead speed of 0.5mm/min. The crowns were angled $30^{\circ}$, so the steel ball contacted with the crowns 2mm lingual from the mid-incisal edge. The results obtained were summarized as follows ; 1. With G.I. cement, mean fracture load(Kg) Were : Intage : $18.33{\pm}1.47$ ; Empress-staining : $23.92{\pm}6.67$ ; Dicor : $24.0{\pm}5.81$ ; Empress-layering : $26.92{\pm}2.80$ ; In-Ceram : $51.58{\pm}6.87$ ; ANOVA revealed a significant difference existed(p<0.05) between the group A(Vintage, Dicor, Empress-staining, Empress-layering) and group B(In-Ceram). 2. With Resin cement, mean fracture load(Kg) were : Intage : $22.75{\pm}4.97$ ; Dicor : $42.75{\pm}7.07$ ; Empress-staining : $44.08{\pm}7.99$ ; Empresslayering : $50.42{\pm}5.43$ ; In-Ceram : $52.58{\pm}6.51$ ; ANOVA revealed a significatnt difference existed(p<0.05) between the group A(Vintage) and B(Dicor, Empress-staining Empress-alyering, In-Ceram). 3. Resin cement significantly increased the fracture strength of the all-ceramic crowns for Dicor(156%), Empress-staining(185%), Empress-alyering(187%)(p<0.05); but did not increase the fracture strength of Vintage(128%) and In-Ceram(101%)(p>0.05). 4. Majority of the all-ceramic crowns show a wedge fracture extending through proximal surfaces to an apex, usually apical third(with G.I. cement) or middle third(with Resin cement) of the facial surface.

• BMB Reports
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• v.39 no.6
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• pp.696-702
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• 2006

Recently three proteins, playing central roles in the bidirectional transport of urate in renal proximal tubules, were identified: two members of the organic anion transporter (OAT) family, OAT1 and OAT3, and a protein that designated renal urate-anion exchanger (URAT1). Antibodies against these transporters are very important for investigating their expressions and functions. With the cytokine gene as a molecular adjuvant, genetic immunization-based antibody production offers several advantages including high specificity and high recognition to the native protein compared with current methods. We fused high antigenicity fragments of the three transporters to the plasmids pBQAP-TT containing T-cell epitopes and flanking regions from tetanus toxin, respectively. Gene gun immunization with these recombinant plasmids and two other adjuvant plasmids, which express granulocyte/macrophage colony-stimulating factor and FMS-like tyrosine kinase 3 ligand, induced high level immunoglobulin G antibodies, respectively. The native corresponding proteins of URAT1, OAT1 and OAT3, in human kidney can be recognized by their specific antibodies, respectively, with Western blot analysis and immunohistochemistry. Besides, URAT1 expression in Xenopus oocytes can also be recognized by its corresponding antibody with immuno-fluorescence. The successful production of the antibodies has provided an important tool for the study of UA transporters.

• Journal of the Mineralogical Society of Korea
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• v.31 no.2
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• pp.87-101
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• 2018

The Manjang deposit developed in the Hwajeonri formation of the Okcheon metamorphic belt consists of the Central and Main orebodies of Cu-bearing hydrothermal vein type and the Western orebody of Fe-skarn type. This study focuses on the Cu mineralization of the Central and Main orebodies to compare with the genetic environments of the Western orebody previously studied. The Central orebody produced pyrrhotite and chalcopyrite as major ore minerals with vein texture, while the Main orebody contains pyrite, arsenopyrite, and chalcopyrite as major ore minerals with vein, massive, and brecciated texture. Sphalerite, galena, magnetite, ilmenite, rutile, cassiterite, wolframite, and stannite are also accompanied. Local occurrence of skarn is dominated by grossular and hedenbergite, reflecting the reduced condition of the skarnization. Geothermometries of sphalerite-stannite in the Central orebody and arsenopyrite-pyrite in the Main orebody indicate the formation temperature of $204-263^{\circ}C$ and $383-415^{\circ}C$, respectively. Sulfur fugacity of $10^{-6}-10^{-7}atm$. in the Main orebody decreased toward the Central orebody. Sulfur isotope compositions of sulfide minerals from the Central and Main orebodies are 4.6-7.9‰ and 4.3-7.0‰, respectively, reflecting magmatic origin with slight influence by host rock. Considering ore mineralogy, texture as well as physicochemical conditions, the Main and Central orebodies of hydrothermal Cu mineralization reflect the characteristics of proximal and distal type ore mineralization, respectively, related to hidden igneous rocks, and they were generated under different hydrothermal systems from the Fe-skarn Western orebody.

• The KIPS Transactions:PartB
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• v.19B no.2
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• pp.99-106
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• 2012

The purpose of this study was to determine the evaluation parameters' osteoporosis predictability in accordance with measuring regions by analyzing the correlations between bone mineral density and trabecular patterns derived from different measuring regions. Experimental subjects were a total of 40 female patients after menopause aged over 40 years, and were classified into 20 control and 20 osteoporotic groups according to the T-score. Bone mineral density was measured on femoral neck, trochanter and ward's triangle by DEXA(Dual Energy X-ray Absorptiometry). We designated ROI(Region of Interest) with $50{\times}50$ pixel size on each measuring regions, and extracted trabecular patterns by using existing image processing method. We also selected a total of eight evaluation parameters that are categorized into structural(mean gray level, area, perimeter, thickness and terminal distance), skeletonized parameters(number, length) and fractal dimension. As a result, it was observed that area, perimeter, thickness, terminal distance, number, length and fractal dimension reflected the bone mineral density with high statistical validity(p<0.003). We also confirmed that the evaluation parameters could predict the osteoporosis more efficiently.

• The Korean Journal of Pain
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• v.22 no.1
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• pp.16-20
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• 2009

Background: Zaprinast is an inhibitor of phosphodiesterase 5, 6 and 9. Phosphodiesterase inhibitors could produce anti-nociceptive effects by promoting the accumulation of cGMP. We hypothesized that intrathecal zaprinast could attenuate the allodynia induced by chronic constriction injury of the sciatic nerve in rat. Methods: Sprague-Dawley rats were prepared with four loose ligations of the left sciatic nerve just proximal to the trifurcation into the sural, peroneal and tibial nerve branches. Tactile allodynia was measured by applying von Frey filaments to the lesioned hindpaw. The thresholds for the withdrawal responses were assessed. Zaprinast ($3-100{\mu}g$) was administered intrathecally by the direct lumbar puncture method to obtain the dose-response curve and the 50% effective dose ($ED_{50}$). Measurements were taken before and 15, 30, 45, 60, 90, 120, and 180 min after the intrathecal doses of zaprinast. The side effects were also observed. Results: Intrathecal zaprinast resulted in a dose-dependent antiallodynic effect. The maximal effects occurred within 15-30 min and then they gradually decreased down to the baseline level over time in all the groups. There was a dose dependent increase in the magnitude and duration of the effect. The $ED_{50}$ value was $17.4{\mu}g$ (95% confidence intervals; $14.7-20.5{\mu}g$). No severe motor weakness or sedation was observed in any of the rats. Conclusions: Intrathecally administered zaprinast produced a dose-dependent antiallodynic effect in the chronic constriction injury neuropathic pain model. These findings suggest that spinal phosphodiesterase 5, 6 and 9 may play an important role in the modulation of neuropathic pain.