• 한국정보통신학회:학술대회논문집
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• 한국해양정보통신학회 2011년도 추계학술대회
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• pp.249-252
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• 2011

국가정보통신서비스는 행정안전부 주관으로 'A'그룹(회선서비스망), 'B'그룹(IP서비스망), 'C'그룹 (인터넷전화서비스, IP응용서비스)으로 인프라를 구성하여 제공하고 있다. 국가정보통신서비스 'C'그룹 사업자는 인터넷전화 서비스를 제공하고 있다. 본 논문에서는 국가정보통신서비스 'C'그룹 사업자의 국내통화, 국제통화, 이동통화 등의 기본 통화 서비스와 문자메시지, 영상통화, IP-Centrex 서비스 등 7개의 부가서비스를 연구한다. 또한 국가정보통신서비스 사업자의 사업 현황을 분석을 토대로 국가정보통신 인터넷전화망의 인터넷전화 이용 유형을 분석한다. 본 연구는 국가정보통신서비스 산업발전을 위한 기초 자료로 활용될 것이다.

• Fisheries and Aquatic Sciences
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• 제25권5호
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• pp.264-275
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• 2022

A non-destructive environmental DNA protocol for the genetic analysis of sea cucumber (Apostichopus japonicus) resources DNA was established. Among the several commercial DNA extraction kits, the DNeasy^® Plant Mini Kit was selected as the best choice to obtain the high-quality genomic DNAs from the mucous sea cucumber. As the temperature and incubation time increased, the amount of extracted environmental DNA was also large, but it was judged that the increased amount did not affect as much as 2-3 times. Therefore, these conditions were not considered to be the main factors to consider in actual environmental DNA extraction. However, the amount of seawater relative to the size of the sample was judged as a major consideration, and a sufficient amount of environmental DNA for analysis was secured when stored within 1 min while stirring the volume of seawater corresponding to the total sea cucumber weight (g). In securing the environmental DNA of sea cucumbers, the mortality rate of sea cucumbers in all experiments was 0, and it was judged that the effects of sea cucumbers were not significant through this treatment. Through the results of this study, sea cucumber DNA research, which has been conducted in a destructive method, can be conducted non-destructively through environmental DNA analysis. Through this study, we have secured a standard protocol that can successfully extract the sea cucumber DNA through environmental DNA. It is not only excellent in terms of time and cost of traditional DNA analysis method currently used, but it is completely non-destructive in the ecosystem of the survey area. It is believed that the system can be transformed in a way that does not affect it. However, it is thought that various standard protocols should be established considering the characteristics of each type.

• 인터넷정보학회논문지
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• 제23권5호
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• pp.135-143
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• 2022

지난 2020년부터 세계는 COVID-19 확산으로 인해 사회적 거리두기와 재택근무를 시행함에 따라 인터넷을 활용한 비디오 및 음성 관련 콘텐츠 서비스와 클라우드 컴퓨팅 활성화로 인터넷에 대한 의존도가 늘어나면서 라우팅 프로토콜 기반 실시간 스트리밍 세션이 증가하고 있다. BGP는 가장 많이 사용되는 라우팅 프로토콜로써 보안성을 향상시키기 위해 많은 연구들이 지속되고 있으나 분석의 실시간성과 알고리즘의 오탐을 판단하기 위한 시각적 분석이 부족하다. 본 논문은 정상 및 이상으로 분류된 BGP 데이터를 수집 및 전처리 후 통계적 기법과 Rule-based 기법을 융합한 이상징후 감지 알고리즘을 활용하여 실 데이터 기반으로 분석한다. 더불어 지도 및 Sankey Chart 기반 시각화 기법으로 알고리즘의 분석 결과와 직관적인 시각화 방안으로 인터랙티브한 시공간 분석 방안을 제시한다.

• 대한방사선기술학회지:방사선기술과학
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• 제46권5호
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• pp.401-408
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• 2023

Thyroid uptake measurements can be subject to measurement errors due to the scoping and positioning of the thyroid gland. To compensate for these limitations, the clinical utility of the thyroid simultaneous counting method as an alternative to thyroid uptake measurement was analyzed and evaluated experimentally through quantitative analysis of images acquired after thyroid scanning. Experimental data were obtained using a Gamma camera (GE infinia), a thyroid uptake system (KOROID 1), and a thyroid neck phantom. Based on the thyroid uptake rate of 1-5% according to the protocol of thyroid scan test (^99mTcO₄ - , 370 MBq) in normal results, ^99mTcO₄ - was set in the range of 3.7-18.5 MBq (Matrix: 256×256, Scan time: 1 min, collimator: pin hole, phantom-collimator distances: 7 cm). The acquired images were corrected for the attenuation of isotopes due to the set-up time and half-life by applying the Auto Region of interest (ROI) drawing system, and the significance of the experimental results was evaluated by Multiple linear regression analysis (SPSS, ver. 22, IBM). The thyroid uptake rate showed a significant correlation between the dose and the measured counts when using the thyroid uptake system equipment. Meanwhile, the quantitative analysis counts of phantom images using Gamma camera also showed a significant correlation. Thus confirmed that the correlation between these two experiments was statistically significant (P<0.05). The simultaneous counting protocol, which indirectly measures thyroid uptake from thyroid scans, is likely to be clinically relevant if complemented by additional studies with different variables in patients with thyroid disease.

• Clinical and Experimental Pediatrics
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• 제54권11호
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• pp.463-469
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• 2011

Purpose: To validate the Dinamap ProCare 200 blood pressure (BP) monitor against a mercury sphygmomanometer in children 7 to 18 years old in accordance with the 2010 International Protocol of European Society of Hypertension (ESH-IP2) and the British Hypertension Society (BHS) protocol. Methods: Forty-five children were recruited for the study. A validation procedure was performed following the protocol based on the ESH-IP2 and BHS protocols for children and adolescents. Each subject underwent 7 sequential BP measurements alternatively with a mercury sphygmomanometer and the test device by trained nurses. The results were analyzed according to the validation criteria of ESH-IP2. Results: The mean (${\pm}SD$) difference in the absolute BP values between test device and mercury sphygmomanometer readings was $1.85{\pm}1.65$ mmHg for systolic BP (SBP) and $4.41{\pm}3.53$ mmHg for diastolic BP (DBP). These results fulfilled the Association for the Advancement of Medical Instrumentation criterion of a mean${\pm}$SD below $5{\pm}8$ mmHg for both SBP and DBP. The percentages of test device-observer mercury sphygmomanometer BP differences within 5, 10, and 15 mmHg were 96%, 100%, and 100% for SBP, and 69%, 92%, and 100% for DBP, respectively, in the part 1 analysis; both SBP and DBP passed the part 1 criteria. In the part 2 analysis, SBP passed the criteria but DBP failed. Conclusion: Although the Dinamap ProCare 200 BP monitor failed an adapted ESH-IP2, SBP passed. When comparing BP readings measured by oscillometers and mercury sphygmomanometers, one has to consider the differences between them, particularly in DBP, because DBP can be underestimated.

• 한국과학교육학회지
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• 제37권6호
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• pp.961-970
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• 2017

본 연구에서는 KTOP (Korean Teaching Observation Protocol)을 과학과 교육실습에 적용하여 예비교사들의 수업 개선을 위한 과정을 돕고자 하였다. 4명의 예비교사와 지도교사가 KTOP을 이용하여 수업을 관찰, 분석하고, 협의 과정을 통해 다음 수업을 개선하는 과정으로 교육실습을 실시하였다. 그 결과, 예비교사들은 KTOP에 의한 수업분석 결과에 기초하여 협의 활동을 하여 KTOP이 예비교사들의 수업 개선에 실제적인 안내역할을 한다는 것을 알 수 있었다. 또 KTOP을 이용한 협의 활동이 다음 수업의 개선에도 도움을 주는 것을 볼 수 있었다. 그러나 보다 더 효과적인 수업 개선을 위해서는 더 많은 반복적인 적용이 필요하다는 것도 추론할 수 있었다. 교육실습과정에 대한 관찰과 면담, 설문을 통해 KTOP이 보다 더 효율적으로 활용되기 위해, 교사는 KTOP 활용에 대한 확신을 갖고 학생 중심의 수업이 되기 위해 노력하는 것이 필요하고, KTOP의 항목수를 줄이고, KTOP의 양식을 좀 더 편리하게 수정할 필요가 있음을 알 수 있었다. 그리고 학생들에게 학습이란 자기 주도적으로 수행되어야 한다는 인식을 갖도록 노력할 필요가 있다는 것도 추론할 수 있었다.

• 한국게임학회 논문지
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• 제9권5호
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• pp.25-41
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• 2009

본 연구는 MMO(Massive1y Multi-player Online) 게임플레이 경험에 관한 게이머의 행동을 체계적으로 코드화 할 수 있는 분석적 틀을 개발하고 문제해결과정으로서의 게임플레이를 실증적으로 규명하는데 목적이 있다. MMO 게임플레이 경험에 관한 분석틀은 모델휴먼프로세서, 내용기반연구, 절차기반연구를 고찰하여 전체적인 틀을 구축하였다. 게임플레이에 관한 구체적인 행동과 내용은 MMO 게임에 관한 실증적 실험 진행과 동시조서 분석을 통하여 도출되었다. 그 결과를 통해서 MMO 게임플레이 행동은 운동, 지각 기능 표상 시뮬레이션, 법칙 행동(휴리스틱스, 법칙적용, 법칙초월)들로 분류되어 MMO 게임에 적합한 새로운 분석틀이 개발되었다. 본 실험결과 시행착오를 통해 게임의 법칙을 발견하는 '휴리스틱행동' 해당 법칙을 따르는 '법칙적용행동', 해당법칙을 초월하는 '법칙초월행동'이 발견되었다. 특히 문제공간에서 '법칙적용행동'과 '법칙초월행동'이 시행되는 두 가지 법칙공간이 발견되었다. 새로 발견된 법칙공간과 게임플레이 패턴은 MMO 게임의 레벨디자인 요소에 해당하는 지역특성, 몬스터의 속성, 아이템, 스킬 등을 결정하는데 중요한 기초를 마련한다. 그래서 본 연구결과는 MMO 게임의 품질을 향상하기 위한 게임디자인 방법론에 중요한 시사점을 제공할 것이다.

• Asian Pacific Journal of Cancer Prevention
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• 제17권7호
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• pp.3515-3519
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• 2016

Background: In Thailand, a national treatment protocol for childhood leukemia and lymphoma (LL) was implemented in 2006. Access to treatment has also improved with the National Health Security system. Since these innovations, survival of childhood LL has not been fully described. Materials and Methods: Trends and survival of children under 15 with childhood cancers diagnosed between 1993 and 2012 were investigated using the hospital-based data from the Khon Kaen Cancer Registry, Srinagarind Hospital, Faculty of Medicine, Khon Kaen University, Thailand. Childhood cancers were classified into 12 diagnostic groups, according to the ICCC based on the histology of the cancer. Survival rates were described by period, depending on the treatment protocol. For leukemias and lymphomas, survival was assessed for 3 periods (1993-99, 2000-5, 2006-12) while for solid tumors it was for 2 periods (before and after 2000). The impacts of sex, age, use of the national protocol, and catchment area on leukemia and lymphoma were evaluated. Overall survival was calculated using the Kaplan-Meier method while the Cox proportional hazard model was used for multivariate analysis. Trends were calculated using the R program. Results: A total of 2,343 childhood cancer cases were included. Survival for acute lymphoblastic leukemia (ALL) from 1993-9, 2000-5, and 2006-12 improved significantly (43.7%, 64.6%, and 69.9%). This was to a lesser extent true for acute non-lymphoblastic leukemia (ANLL) (28.1%, 42.0%, and 42.2%). Survival of non-Hodgkin lymphoma (NHL) also improved significantly (44%, 65.5%, and 86.8%) but not for Hodgkin disease (HD) (30.1%, 66.1%, and 70.6%). According to multivariate analysis, significant risk factors associated with poor survival in the ALL group were age under 1 and over 10 years, while not using the national protocol had hazard ratios (HR) of 1.6, 1.3, and 2.3 respectively. In NHL, only non-use of national protocols was a risk factor (HR 3.9). In ANLL and HD, none of the factors influenced survival. Survival of solid tumors (liver tumors, retinoblastomas) were significantly increased compared to after and before 2000 while survival for CNS tumors, neuroblastoma and bone tumors was not changed. Conclusions: The survival of childhood cancer in Thailand has markedly improved. Since implementation of national protocols, this is particularly the case for ALL and NHL. These results may be generalizable for the whole country.

• 한국정보처리학회논문지
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• 제5권12호
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• pp.3047-3062
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• 1998

본 논문은 ITU-T에서 제안한 영상회의 시스템에서 오디오/비디오 스트림 데이터를 회의 참여자에 송수신하거나 또는 수신된 멀티미디어 데이터들에 대한 QoS 정보를 송신측에 피드백 하기 위해 제공되는 RTP/RTCP 프로토콜(RFC1889,1890)에 관한 설계 및 구현에 관해 기술한다. RTP는 인코더로부터 전달된 오디오/비디오 데이터를 고정 포맷으로 패킷화하여 모든 회의 참여자에 멀티캐스팅하고, RTCP모듈은 RTP와 함께 연동되면서 수신 패킷을 모니터하여 지연, 지연변이 및 패킷 손실 등의 QoS 값들을 검출하고, 이를 비-정기적으로 송신측에 피드백하도록 구현하였다. 이들 프로토콜은 Windows NT에서 멀티쓰래드 방식으로 구현되었으며, 하위 프로토콜로 socket I/F를 통해서 U에/IP-Multicast를 이용하였다. 또한, 인터넷 환경에서 영상회의 시스템을 수행했을 때 나타나는 여러 QoS 값들을 검출하여 분석하였다. 시험은 오디오 데이터 전송을 이용하였으며 통신 부하가 심한 시간 구간에서 지연과 지연 변이는 음성 인식에 대체로 허용 범위에 충족되나 다량의 패킷 손실에 따른 품질 저하를 분석할 수 있었으며, 대부분의 손실된 패킷들은 비-연속적인 특성을 갖는 것으로 나타났다.

• Journal of Gastric Cancer
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• 제20권1호
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• pp.60-71
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• 2020

Purpose: The utility of 18-fluordesoxyglucose positron emission tomography ([¹⁸F]-FDG-PET) combined with computer tomography or magnetic resonance imaging (MRI) in gastric cancer remains controversial and a rationale for patient selection is desired. This study aims to establish a preclinical patient-derived xenograft (PDX) based [¹⁸F]-FDG-PET/MRI protocol for gastric cancer and compare different PDX models regarding tumor growth and FDG uptake. Materials and Methods: Female BALB/c nu/nu mice were implanted orthotopically and subcutaneously with gastric cancer PDX. [¹⁸F]-FDG-PET/MRI scanning protocol evaluation included different tumor sizes, FDG doses, scanning intervals, and organ-specific uptake. FDG avidity of similar PDX cases were compared between ortho- and heterotopic tumor implantation methods. Microscopic and immunohistochemical investigations were performed to confirm tumor growth and correlate the glycolysis markers glucose transporter 1 (GLUT1) and hexokinase 2 (HK2) with FDG uptake. Results: Organ-specific uptake analysis showed specific FDG avidity of the tumor tissue. Standard scanning protocol was determined to include 150 μCi FDG injection dose and scanning after one hour. Comparison of heterotopic and orthotopic implanted mice revealed a long growth interval for orthotopic models with a high uptake in similar PDX tissues. The H-score of GLUT1 and HK2 expression in tumor cells correlated with the measured maximal standardized uptake value values (GLUT1: Pearson r=0.743, P=0.009; HK2: Pearson r=0.605, P=0.049). Conclusions: This preclinical gastric cancer PDX based [¹⁸F]-FDG-PET/MRI protocol reveals tumor specific FDG uptake and shows correlation to glucose metabolic proteins. Our findings provide a PET/MRI PDX model that can be applicable for translational gastric cancer research.