• 한국산업보건학회지
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• 제24권2호
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• pp.219-228
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• 2014

Objectives: The major objective of this study was to develop a tier 2 exposure model combining tier 1 exposure model estimates and worker monitoring data and suggesting narrower exposure ranges than tier 1 results. Methods: Bayesian statistics were used to develop a tier 2 exposure model as was done for the European Union (EU) tier 2 exposure models, for example Advanced REACH Tools (ART) and Stoffenmanager. Bayesian statistics required a prior and data to calculate the posterior results. In this model, tier 1 estimated serving as a prior and worker exposure monitoring data at the worksite of interest were entered as data. The calculation of Bayesian statistics requires integration over a range, which were performed using a Riemann sum algorithm. From the calculated exposure estimates, 95% range was extracted. These algorithm have been realized on Excel spreadsheet for convenience and easy access. Some fail-proof features such as locking the spreadsheet were added in order to prevent errors or miscalculations derived from careless usage of the file. Results: The tier 2 exposure model was successfully built on a separate Excel spreadsheet in the same file containing tier 1 exposure model. To utilize the model, exposure range needs to be estimated from tier 1 model and worker monitoring data, at least one input are required. Conclusions: The developed tier 2 exposure model can help industrial hygienists obtain a narrow range of worker exposure level to a chemical by reflecting a certain set of job characteristics.

• 한국측량학회지
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• 제23권1호
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• pp.19-30
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• 2005

우리나라는 지적도면 전산화 사업의 일환으로 전국적인 지적도 데이터베이스를 구축 완료하였고, NGIS (National Geographic Information Systems) 사업으로 다량의 공간 데이터들을 구축하고 있다. 이러한 전반적인 사회적 여건을 고려할 경우, 현재 사회적으로 문제가 되고 있는 지적불부합지를 가장 효율적으로 해결하기 위해서는 현지 측량 방식에 기반하여 지적불부합지를 조사하기보다는 기 구축되어 있는 각종 전산화 데이터를 최대한 활용하여 광역적으로 지적불부합지를 조사할 수 있는 새로운 방법론이 필요하다. 이 연구에서는 지적도 전산화 데이터와 기 구축되어 있는 GIS 데이터를 이용하여 광역적으로 지적불부합지를 조사할 수 있는 자동화 방법론을 정립하고 이를 기반으로 한 프로토타입 시스템을 구현하였다. 그리고 이를 실제 실험지역에 적용하여 본 결과 지역별 불부합 정도의 측정과 함께 도곽별로 불부합 정도의 측정이 가능한 것으로 분석되었다. 이러한 자동화된 방법에 의한 지적불부합지 조사는 향후의 지적재조사 사업의 기획과 우선순위 등 여러 측면에서 많은 도움이 될 것으로 기대된다.

• Smart Structures and Systems
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• 제26권1호
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• pp.89-102
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• 2020

Shape memory alloy (SMA)-based Superelasticity-assisted Slider (SSS) is proposed as an engineering solution to practically exploit the well-accepted advantages of both sliding isolation and SMA-based recentering. Self-centering capability in SSS is provided by austenitic SMA cables (or wire ropes), recently attracting a lot of interest and attention in earthquake engineering and seismic isolation. The cables are arranged in various novel and conventional configurations to make SSS versatile for aseismic design and retrofit of structures. All the configurations are detailed with thorough technical drawings. It is shown that SSS is applicable without the need for Isolation Units (IUs). IUs, at the same time, are devised for industrialized applications. The proof-of-concept study is carried out through the examination of mechanical behavior in all the alternative configurations. Force-displacement relations are determined. Isolation capabilities are predicted based on the decreases in seismic demands, estimated by the increases in effective periods and equivalent damping ratios. Restoring forces normalized relative to resisting forces are assessed as the criteria for self-centering capabilities. Lengths of SMA cables required in each configuration are calculated to assess the cost and practicality. Practical implementation is realized by setting up a small-scale IU. The effectiveness of SSS under seismic actions is evaluated using an innovative computer model and compared to those of well-known Isolation Systems (ISs) protecting a reference building. Comparisons show that SSS seems to be an effective IS and suitable for earthquake protection of both structural and non-structural elements. Further research aimed at additional validation of the system are outlined.

• Asian Pacific Journal of Cancer Prevention
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• 제13권5호
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• pp.2015-2020
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• 2012

Oleanolic acid (OA) is a naturally occurring triterpenoid in food materials and is a component of the leaves and roots of Olea europaea, Viscum album L., Aralia chinensis L. and more than 120 other plant species. There are several reports validating its antitumor activity against different cancer cells apart from its hepatoprotective activity. However, antitumor activity against skin cancer has not beed studied well thus far. Hence the present study of effects of OA against HaCaT (immortalized keratinocyte) cells - a cell-based epithelial model system for toxicity/ethnopharmacology-based studies - was conducted. Radical scavenging activity ($DPPH{\cdot}$) and FRAP were determined spectrophotometrically. Proliferation was assessed by XTT assay at 24, 48 and 72 hrs with exposure to various concentrations (12.5-200 ${\mu}M$) of OA. Apoptotic induction potential of OA was demonstrated using a cellular DNA fragmentation ELISA method. Morphological studies were also carried out to elucidate its antitumor potential. The results revealed that OA induces apoptosis by altering cellular morphology as well as DNA integrity in HaCaT cells in a dose-dependent manner, with comparatively low cytotoxicity. The moderate toxicity observed in HaCaT cells, with induction of apoptosis, possibly suggests greater involvement of programmed-cell death-mediated mechanisms. We conclude that OA has relatively low toxicity and has the potential to induce apoptosis in HaCaT cells and hence provides a substantial and sound scientific basis for further validation studies.

• 대한영양사협회학술지
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• 제12권2호
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• pp.200-215
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• 2006

This study carried out to assess the quality of the information presented on the internet about nutrition specifically in the field of health functional food by monitoring with 10 panels from May, 2004 to October. Four hundred seven relevant websites were initially selected from a process using 5 search engines and the keywords ‘food’ and ‘nutrition’, and 404 sites actually met all inclusion criteria. Most of the sites evaluated 219 (54.20%) were commercial sites and then distributed noncommercial organization site 93 (23.0%), individual site 92(22.8%). Assessment quality indicator was carried out using the 17 necessary requisites, which has been developed to enable users and information providers to judge the quality of food and nutrition information. The mean score for quality grade was 11.07, five site out of a maximum score of 17 and two sites with the lowest total scores for the quality of food and nutrition information. Noncommercial organization site assessed achieved the highest score in accurate and useful informations to the public. Low ranked sites had the most inaccurate or misleading information, emphasizing only the positive aspects of the information, with little or no evidence. Many commercial sites used personal testimony as the most popular ‘proof’ for the effectiveness of product. This was anecdotal rather than scientific evidence based on which the objective validation was difficult to be made. Therefore, it can be challenging for both public and health professionals, to sort out useful information from a plethora of advertisements and promotions on the web sites. Our results suggest that nutrition professionals should talk about useful information of health, food and nutrition with public and help them find the best available information when using the internet.

• 한국동물위생학회지
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• 제44권4호
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• pp.283-290
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• 2021

This is a study on the improvement of the chemical treatment method of the livestock carcass treatment newly introduced in the livestock infectious disease prevention method in order to improve the problems of the existing burial-centered carcass treatment method when a livestock infectious disease occurs. It was conducted to establish detailed treatment standards for the chemical treatment method of pig carcasses based on the results of proof of the absence of infectious diseases in pigs. After inoculating pig carcasses with 10 pathogens (6 viruses [FMDV, ASFV, CSFV, PCV2, PRRSV, PEDV] and 4 bacteria [Lawsonia intracellularis, Clostridium perfringens type C, E. coli, Salmonella Typhimurium]) It was treated at 90℃ for 5 hours in a potassium hydroxide (KOH) liquid solution corresponding to 15% of the body weight. This method liquefies all cadaveric components and inactivates all inoculated pathogens. Based on these results, it was possible to prove that chemical treatment of pig carcasses is effective in killing pathogens and is a safe method without the risk of disease transmission. Although there are problems to be solved in the processing and operation of the chemical treatment products of livestock carcasses, the chemical treatment method of livestock carcasses can be suggested as an alternative to the current domestic burial-centered livestock carcass treatment method, preventing environmental pollution, and contributing to public health.

• 국제학술발표논문집
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• The 9th International Conference on Construction Engineering and Project Management
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• pp.1256-1263
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• 2022

With the advent of the Fourth Industrial Revolution, the amount of energy used in buildings has been increasing due to changes in the energy use structure caused by the massive spread of information-oriented equipment, climate change and greenhouse gas emissions. For the efficient use of energy, it is necessary to have a plan that can predict and reduce the amount of energy use according to the type of energy source and the use of buildings. To address such issues, this study presents a model embedded in a digital twin that predicts energy use in buildings. The digital twin is a system that can support a solution of urban problems through the process of simulations and analyses based on the data collected via sensors in real-time. To develop the energy use prediction model, energy-related data such as actual room use, power use and gas use were collected. Factors that significantly affect energy use were identified through a correlation analysis and multiple regression analysis based on the collected data. The proof-of-concept prototype was developed with an exhibition facility for performance evaluation and validation. The test results confirm that the error rate of the energy consumption prediction model decreases, and the prediction performance improves as the data is accumulated by comparing the error rates of the model. The energy use prediction model thus predicts future energy use and supports formulating a systematic energy management plan in consideration of characteristics of building spaces such as the purpose and the occupancy time of each room. It is suggested to collect and analyze data from other facilities in the future to develop a general-purpose energy use prediction model.

• 재활치료과학
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• 제8권4호
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• pp.77-92
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• 2019

목적 : 본 연구의 목적은 낙상 위험 주거환경 평가인 HOME FAST의 국내사용을 위해 체계적인 절차를 통해 한국어로 번안하여 내용이해도 및 신뢰도를 검증하고자 하였다. 연구 방법 : 한글로 번역된 HOME FAST의 내용이해도를 알아보기 위해 작업치료사 총 21명에게 한글번역본의 이해도 평가하게 하였다. 이후 한글번역본을 역번역 하여 원문과 비교하고 문장구조 및 의미 유사성을 평가하였다. 아울러 신뢰도 검증을 위해 지역사회에 거주하고 있는 낙상 고위험군 노인 75명을 대상으로 평가를 진행하고 내적 일치도를 검증하였다. 그중 9명의 대상자의 경우 2명의 작업치료사가 방문하여 각각 평가한 뒤 검사자 간 신뢰도를 검증하였다. 결과 : 작업치료사를 대상으로 한 내용이해도 검증 결과에서 11개 문장이 이해도가 떨어지는 것으로 나타났다. 이해도 검증 결과의 의견을 바탕으로 검증위원회를 통해 구문을 수정하고 한글번역본을 완성하였다. 한글판을 역번역하여 유사성 검증을 한 결과 문장구조에서는 3문항이 유사하지 않음으로 평가되었고, 의미적 측면에서는 총 6문항이 유사하지 않음으로 평가되었다. 최종적으로 반복적 역번역 과정을 통해 한글판 HOME FAST의 내용 타당도를 확보하였다. 한글번역본의 내적일치도는 .62(p<.01)로 나타났고, 검사자 간의 신뢰도는 .97 (p<.01)로 매우 높은 것으로 나타났다. 결론 : 본 연구는 체계적 번역-역번역 과정을 통해 HOME FAST를 한국어로 번역하였다. 아울러 한글판의 내용이해도를 검증하였고, 내적일치도 및 검사자간 신뢰도 검증을 통해 신뢰도를 입증하였다.

• 분석과학
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• 제34권6호
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• pp.259-266
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• 2021

대마는 전 세계적으로 가장 많이 남용되고 있는 물질 중의 하나이며, 우리나라에서는 메트암페타민 다음으로 많이 남용되고 있으며, 1976년부터 국내에서 마약류관리법에 의해 규제되고 있다. 소변 중 대마성분의 검출을 위하여는 대마의 유효 성분인 Δ⁹-tetrahydrocannabinol (THC)의 생체내 주된 대사체인 11-nor-Δ⁹-carboxy-tetrahydrocannabinol (THCCOOH)을 확인하는 것이 일반적이며, 이는 과학수사 및 사법처리와 관련된 법과학 분야에서 중요한 증거로 받아들여지고 있다. 본 연구에서는 소변 중 대마 대사체의 분석을 위하여 분석법이 간단하고 단시간이 소요되는 분석방법으로 THCCOOH 및 THCCOOH-glucuronide를 액상 추출하고 액체크로마토그라피/질량분석법(LC-MS/MS)을 사용하여 동시 분석하는 방법을 확립하였다. 내부표준물질로는 THCCOOH-D₃ 및 THCCOOH-glucuronide-D₃를 사용하였다. 시험방법의 유효화를 위하여 매질 효과, 회수율, 직선성, 정밀도, 정확도, 시험과정의 효율성 및 안정성 등을 시험하였고, 모든 결과가 적합함을 알 수 있었다. 실험 과정에서의 carryover는 나타나지 않았으며, 선택성 및 간섭성도 우수하였다. THCCOOH 및 THCCOOH-glucuronide의 검출 한계는 각각 0.3 및 0.2 ng/mL 이었다. 확립된 분석방법을 면역시험법과 가스크로마토그라피/질량분석법(GC/MS)법에서 대마 양성으로 최종 판정된 28개의 실제 소변에 적용하여 분석법의 적합성을 검토하였다. 28개 소변 중 THCCOOH 및 THCCOOH-glucuronide의 농도는 각각 정량 한계 미만~226.90 ng/mL 및 6.43~2133.03 ng/mL이었고, 모든 시료에서 THCCOOH-glucuronide가 THCCOOH 보다 많이 검출되었다. 본 분석법을 소변 중 대마의 흡연여부를 판정하는 감정시험에 적용함으로써 단시간에 효율적인 분석을 실시할 수 있게 되어 과학수사 발전에 기여할 수 있을 것으로 사료된다.