• 생약학회지
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• 제27권4호
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• pp.323-327
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• 1996

The ether soluble fraction of the roots of Angelicae gigantis Radix caused a significant prolongation of hexobarbital(HB) induced sleeping time in mice. Through systematic fractionation of the ether fraction monitored by bioassays, two pyranocoumarins, decursinol angelate and decursin were isolated as active principles. Decursin, as a main component, exhibited significant prolongation of HB-induced hypnosis as well as significant inhibition of hepatic microsomal drug metabolizing enzyme(DME) activities at relatively high dose which indicated that it is a weak DME inhibitor.

• The Korean Journal of Pain
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• 제31권1호
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• pp.3-9
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• 2018

Long QT syndrome is a cardiac repolarization disorder and is associated with an increased risk of torsades de pointes. The acquired form is most often attributable to administration of specific medications and/or electrolyte imbalance. This review provides insights into the risk for QT prolongation associated with drugs frequently used in the treatment of chronic pain. In the field of pain medicine all the major drug classes (i.e. NSAIDs, opioids, anticonvulsive and antidepressant drugs, cannabinoids, muscle relaxants) contain agents that increase the risk of QT prolongation. Other substances, not used in the treatment of pain, such as proton pump inhibitors, antiemetics, and diuretics are also associated with long QT syndrome. When the possible benefits of therapy outweigh the associated risks, slow dose titration and electrocardiography monitoring are recommended.

• Archives of Pharmacal Research
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• 제12권3호
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• pp.196-200
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• 1989

The methanolic extract of the Rhizome of Curcuma zedoaria exhibited a significant prolongation of hexobarbital (HB)-induced hypnosis. Through liquid chromatography of an ether soluble fraction. monitoring by bioassay, three sequiterpenes, germacrone (A), curzerenone (B) and germacrone epoxide (C) were isolated as active consituents. A single treatment (100-200 mg/kg, i.p.) of each compound showed not only a significant prolongation of HB-induced sleeping time but also a significant inhibition of aminopyrine N-demethylase activity in mice, and further exhibited a typical type I binding spectra with oxidized rat hepatic cytochrome P-450 induced by phenobarbital. All of the compounds provoked a sleep episode at a subhypnotic dose of HB, implying that they possess CNS depressant properties.

• 한국식품영양학회지
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• 제4권1호
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• pp.9-20
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• 1991

The purpose of this study Is to prove the propriety of prolongation in educational term of department of food and nutrition at junior college in Korea in order to Improve the quality of dietitian by giving substantial education. The prolongation of educational term from two to three years is necessary to cultivate a more excellent dietitian because of the following three reasons. First, the freshmen in junior colleges are poor in basic scholastic ability which is needed for the study of nutrition science. Second, many new subjects which will support the new rollers of dietitian, in accordance with social changes, should be supplemented In curriculum. Third, the subject of spot-practice for dietitian should be established as a regular course in curriculum.

• Journal of Dairy Science and Biotechnology
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• 제26권2호
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• pp.31-37
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• 2008

One hundred one years have passed since Metchnikoff made his first scientific contribution to probiotics study. Intestinal lactic acid bacteria (LAB) for humans are closely associated with the host's health because LAB is an important biodefense factor in preventing colonization and subsequent proliferation of pathogenic bacteria in the intestine. A probiotic is recently defined as "live microorganisms that when administered in adequate amount confer a health benefit on the host". Some species of LAB have been claimed as probiotics, such as Lactobacillus acidophilus, L. casei, L. fermentum, L. plantarum, L. reuteri, and Lactococcus lactis. For understanding the general mechanism of probiotics, this paper would explore the early studies relating to probiotics and intestinal microbiota, and briefly introduce the Prolongation of Life written by Elie Metctmikoff.

• 대한약학회:학술대회논문집
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• 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2-2
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• pp.77.1-77.1
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• 2003

Prolongation of the QT interval may result in a potentially dangerous arrhythmia. The most commonly proposed mechanism for QT interval prolongation(LQT) by pharmaceuticals is inhibition of the rapid delayed rectifier potassium channel (I$\sub$Kr). The LQT potency of pharmaceuticals can be effectively evaluated by examining the effect on human ether-a go-go-related gene (hERG) channels expressed in CHO cells, known to be equal to I$\sub$kr/. We have transfected JERG into CHO cell lines transiently to express high levels of functional hERG channels. (omitted)

• 국제학술발표논문집
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• The 2th International Conference on Construction Engineering and Project Management
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• pp.150-159
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• 2007

More often than not, cost claims which are legitimately due and entitled to the contractor for works done, or for loss and expense incurred arising from disruption, prolongation and delay, are surprising not successfully recovered, whether in whole or in part, or none at all. One of the main reasons attributing to such scenario, is due to either the contractor, employer or the consultants and their poor understanding of and adherence to established and proper contractual rubric that is embodied in the building construction contract for the works. This paper explores some such pitfalls that could very well spell the ultimate financial disaster for many contractors, and highlights salient and essential intimations that contractors and consultants should watch out for.

• 대한수학회지
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• 제21권2호
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• pp.183-206
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• 1984

• 대한약리학회지
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• 제12권2호
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• pp.13-19
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• 1976

A fluid extract of Zizyphi Semen was employed in this experiment. The cardiac effects of Zizyphi Semen were examined on isolated rabbits atria and heart in situ of anesthetized cats and rabbits. The adrenergic blocking activity and refractory period of cardiac muscle were measured after administration of this drug. In rabbits and cats the antiarrhythmic action of Zizyphi Semen on atrial and ventricular arrhythmias produced by epinephrine or ouabain was examined. The results were following: 1. Zizyphi Semen produced a decrease in rate and contractile amplitude of the isolated rabbit atria and had a week blocking effect on epinephrine acceleration of atrial movement. 2. Zizyphi Semen effectively abolished the spontaneous arrhythmia occurring in the isolated rabbit atria ana the atrial arrhythmia induced by ouabain. 3. Zizyphi Semen produced a marked prolongation of the refractory period in isolated atrial muscle of rabbit. 4. Zizyphi Semen prevented the induction of ventricular arrhythmia arising from excessive dose of epinephrine in anesthetized rabbits and cats. 5. With regard to the ventricular arrhythmia induced by a continuous infusion of ouabain, Zizyphi Semen exerted suppressive effect and produced a marked prolongation of cardiac arrest time in anesthetized rabbits and cats. From the above results, it may be concluded that Zizyphi Semen is effective against atrial and ventricular arrhythmias. The antiarrhythmic effect of this drug may be the result of direct myocardial depressive and partially adrenergic beta receptor blocking activities including prolongation of the refractory period of cardiac muscle.

• 한국수산과학회지
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• 제41권2호
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• pp.125-133
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• 2008

To investigate the effect of repeated food deprivation and refeeding on the hyperphagia, compensatory growth, feed efficiency, body composition, hepatosomatic index (HSI), and survival rate of the juvenile olive flounder Paralichthys olivaceus, an experiment was conducted for 90 days. Feeding treatments consisted of the following five regimes for 90 days from August to October, 2005: C: daily satiation feeding (control), S1: 1-day satiation feeding after 1-day food deprivation, S2: 1-day satiation feeding after 2-day food deprivation, S3: 1-day satiation feeding after 3-day food deprivation and S4: 1-day satiation feeding after 4-day food deprivation, respectively. Although the monthly feed intake (MFI) of the control was significantly higher than that of all of the starved groups, the daily feed intake (DFI) was more higher in S1, S2, and S3 than that in the control as a result of hyperphagia after starvation. While the feed efficiency in the summer (to day 30) decreased in all of the starved groups with prolongation of the starvation period, the feed efficiency in the autumn (to day 90) was increased with prolongation of the starvation period. The whole body proximate composition and HSI were also affected by starvation. The crude protein, lipid, and HSI decreased with prolongation of the starvation period, whereas the crude ash and moisture increased. The growth rate and condition factor also decreased in proportion to the starvation period. The survival rate was highest in the control and was the lowest in S4. In this study, although hyperphagia occurred in the deprived groups, we knew that the compensatory growth did not always occur.