• BMB Reports
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• v.52 no.1
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• pp.13-23
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• 2019

Aging is accompanied by a time-dependent progressive deterioration of multiple factors of the cellular system. The past several decades have witnessed major leaps in our understanding of the biological mechanisms of aging using dietary, genetic, pharmacological, and physical interventions. Metabolic processes, including nutrient sensing pathways and mitochondrial function, have emerged as prominent regulators of aging. Mitochondria have been considered to play a key role largely due to their production of reactive oxygen species (ROS), resulting in DNA damage that accumulates over time and ultimately causes cellular failure. This theory, known as the mitochondrial free radical theory of aging (MFRTA), was favored by the aging field, but increasing inconsistent evidence has led to criticism and rejection of this idea. However, MFRTA should not be hastily rejected in its entirety because we now understand that ROS is not simply an undesired toxic metabolic byproduct, but also an important signaling molecule that is vital to cellular fitness. Notably, mitochondrial function, a term traditionally referred to bioenergetics and apoptosis, has since expanded considerably. It encompasses numerous other key biological processes, including the following: (i) complex metabolic processes, (ii) intracellular and endocrine signaling/communication, and (iii) immunity/inflammation. Here, we will discuss shortcomings of previous concepts regarding mitochondria in aging and their emerging roles based on recent advances. We will also discuss how the mitochondrial genome integrates with major theories on the evolution of aging.

• Steel and Composite Structures
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• v.29 no.6
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• pp.785-802
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• 2018

In this paper, two different computational methods, called Rayleigh-Ritz and collocation are developed to estimate the ultimate strength of composite plates. Progressive damage behavior of moderately thick composite laminated plates is studied under in-plane compressive load and uniform lateral pressure. The formulations of both methods are based on the concept of the principle of minimum potential energy. First order shear deformation theory and the assumption of large deflections are used to develop the equilibrium equations of laminated plates. Therefore, Newton-Raphson technique will be used to solve the obtained system of nonlinear algebraic equations. In Rayleigh-Ritz method, two degradation models called complete and region degradation models are used to estimate the degradation zone around the failure location. In the second method, a new energy based collocation technique is introduced in which the domain of the plate is discretized into the Legendre-Gauss-Lobatto points. In this new method, in addition to the two previous models, the new model named node degradation model will also be used in which the material properties of the area just around the failed node are reduced. To predict the failure location, Hashin failure criteria have been used and the corresponding material properties of the failed zone are reduced instantaneously. Approximation of the displacement fields is performed by suitable harmonic functions in the Rayleigh-Ritz method and by Legendre basis functions (LBFs) in the second method. Finally, the results will be calculated and discussions will be conducted on the methods.

• Steel and Composite Structures
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• v.50 no.1
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• pp.107-122
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• 2024

Following an internal column failure, adjacent double-span beams above the failed column will play a critical role in the load transfer and internal force redistribution within the remaining structure, and the span-to-depth ratios of double-span beams significantly influence the structural resistance capacity against progressive collapse. Most existing studies have focused on the collapse-resistant performances of single-story symmetric structures, whereas limited published works are available on the collapse resistances of multi-story steel frames with unequal spans. To this end, in this study, numerical models based on shell elements were employed to investigate the structural behavior of multi-story steel frames with unequal spans. The simulation models were validated using the previous experimental results obtained for single- and two-story steel frames, and the load-displacement responses and internal force development of unequal-span three-story steel frames under three cases were comprehensively analyzed. In addition, the specific contributions of the different mechanism resistances of unequal-span, double-span beams of each story were separated quantitatively using the energy equilibrium theory, with an aim to gain a deeper level of understanding of the load-resistance mechanisms in the unequal-span steel frames. The results showed that the axial and flexural mechanism resistances were determined by the span ratio and linear stiffness ratio of double-span beams, respectively.