• Journal of Korean Public Health Nursing
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• v.13 no.2
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• pp.183-201
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• 1999

This descriptive correlational study was conducted to identify the variables related to health promoting lifestyle of girls in High school students. 156 high school students and 88 vocational high school students who lives in Taegu city were selected by a convenience sampling method. The data were collected by self-reported questionnaires from August 24 to September 4. 1998. Pender and others' Health Promoting Lifestyle Profile. Shere et al's. Self-Efficacy scale. Wallston et al.' s Internal Health Locus of Control scale. Wares' Health self rating scale and Cohen & Hoberman's Social support scale were used. The data were analyzed by using descriptive statistics, Pearson correlation coefficient. t-test. MANOVA. ANOVA. Tukey verification and Stepwise multiple regression with SAS progrom. The results of this study were as follows : 1. The average score of health promoting lifestyle performance was 2.34(SD=.36)points by the 4 point scale. 2. The combination of self-efficacy. internal health locus of control. mather's educational level and type of school explained $41.31\%$ of the variance of health promoting lifestyle. 3. Health promoting lifestyle showed significant positive correlations with self efficacy(r=.5173. p=.001), perceived health status(r=.254, p=.001) and internal health locus of control(r=.321. p=.001). On the basis of the above findings, self-efficacy in cognitive factors. and social support in modifying factors were identified as the variables which explained the most part of the Pender's health-promotion model. Nursing strategies enhancing self-efficacy which has the most significant effect on health promoting lifestyle should be developed. Further research is required to find out the factors influencing health pormoting lifestyle of high school students.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.36 no.8
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• pp.797-806
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• 2008

In a double-passage cascade apparatus, only two blades are installed in order to increase the accuracy of experimental result by applying bigger blade than the size of multi-blades on the same apparatus. However, this causes difficulties to make correct periodic condition. In this study, sidewalls are designed to meet periodic condition without removing the operating fluid or adjusting tail boards. Surface Mach number on the blade surface is applied to a responsible variable, and 12 design variables which are related with sidewall profile control are selected. A gradient-based optimization is adopted for wall design and CFX-11 is used for the internal flow computation. The computed result shows that it could obtain the same flow structure by modifying only the sidewalls of the double-passage cascade apparatus.

• Journal of the Korean Wood Science and Technology
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• v.39 no.2
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• pp.148-155
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• 2011

Thermal treatment techniques are used for modifying wood and wood-based materials to improve dimensional stability and hygroscopicity. This study investigated the effects of press pressure and temperature on density, vertical density profile, thickness swelling and surface hardness of eucalyptus wood boards. The experimental wood boards were prepared from Turkish River Gum ($Eucalyptus$ $camaldulensis$ Dehn.). The surface hardness value increased with increasing press pressure in the treated groups. The application of a higher pressure at the same temperature level increased the amount of swelling of wood. It means that it is not needed for application of higher pressure to enhance the dimensional stability of wood. It is expected that it is possible to produce increased hardness, dimensional stability and durability by application of hot pressing treatment. This research showed that different press pressure and temperature values should be used to improve the performance properties of eucalyptus wood so that the end-use of the wood materials could be expanded.

• Journal of Nutrition and Health
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• v.26 no.7
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• pp.829-838
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• 1993

This study was designed to compare the effect of different dietary fats on the incidence of colorectal tumor, the level of plasma thromboxane B2(TXB2) and fatty acid profiles of platelet and colonic mucosal lipids in N - methyl - N - nitro - N - nitrosoguanidine(MNNG) - treated rats. Male Sprague Dawley rats, at 8 weeks old, were divided into 2 groups and infused intrarectally with saline(control group) or with 2mg MNNG(carcinogen-treated group) twice a week for 3 weeks. Each group was again divided into 4 groups and fed one of four diets(BT, CO, PO, FO) containing dietary fat at 9%(w/w) level for 37 weeks, Dietary fats were beef tallow(7.2%)+corn oil(1.8%) for BT, corn oil(9.0%) for CO, perilla oil(9.0%) for PO, fish oil (6.5%)+corn oil (2.5%) for FO diets. MNNG-treated rats had colonic tumor, while no tumors(adenocarcinoma and adenoma) than others. Tumor sizes in BT-MNNG rats ranged from 2mm papillary form to 15mm of polypoid. However, the size of tumors in PO-MNNG or FO-MNNG rats could not be measured by gross examination. BT-MNNG and CO-MNNG groups were higher in the level of plasma TXB2 and the ratio of c20 : 4/c20 :5 platelet. PO-MNNG groups were lower in the ratio of c20 : 4/c20 : 5(p<0.05) in fatty acid of colonic mucosal lipids suggesting that perilla oil and fish oil could reduce the level of PGE2 and TXB2 by modifying its precursor content and restrain tumor promotion in colon. Effect of perilla oil rich in $\alpha$-linolenic acid on colon carcinogenesis was similar to that of fish oil and thus perilla oil could have a protective effect against colon cancer possibly by inhibiting the production of arachidonic acid metabolite.

• Journal of Cadastre & Land InformatiX
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• v.47 no.2
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• pp.121-133
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• 2017

Technical regulations in the spatial information domain have been developed by a variety of independent organizations and raised inconsistent and overlapping problems with spatial information standards. Many research projects have been done to solve these problems but due to the difficulty of changing or modifying existing administrative regulations, almost nothing has happened for the harmonization. As a response to the fundamental problem, KATS (Korean Agency for Technology and Standards) recently switched the existing system to "trans- governmental participatory standard operation system" and the administrative change created an independent and consistent standard system in the Ministry of Land, Infrastructure and Transport. The Ministry, as a part of the effort, established its own KSDI(Korean Spatial Data Infrastructure) Standard system. From this context this paper presents a redefinition of technical regulation for the harmonization with spatial information standards, an association model between the standards and regulations, and a maintenance methodology to solve the fore-mentioned problems.

• Molecules and Cells
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• v.41 no.6
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• pp.545-552
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• 2018

Spleen tyrosine kinase (SYK) is a cytosolic non-receptor protein tyrosine kinase. Because SYK mediates key receptor signaling pathways involving the B cell receptor and Fc receptors, SYK is an attractive target for autoimmune disease and cancer treatments. To date, representative oral SYK inhibitors, including fostamatinib (R406 or R788), entospletinib (GS-9973), cerdulatinib (PRT062070), and TAK-659, have been assessed in clinical trials. Here, we report the crystal structures of SYK in complex with two newly developed inhibitors possessing 4-aminopyrido[4,3-D]pyrimidine moieties (SKI-G-618 and SKI-O-85). One SYK inhibitor (SKI-G-618) exhibited moderate inhibitory activity against SYK, whereas the other inhibitor (SKI-O-85) exhibited a low inhibitory profile against SYK. Binding mode analysis indicates that a highly potent SYK inhibitor might be developed by modifying and optimizing the functional groups that interact with Leu377, Gly378, and Val385 in the G-loop and the nearby region in SYK. In agreement with our structural analysis, one of our SYK inhibitor (SKI-G-618) shows strong inhibitory activities on the ${\beta}$-hexosaminidase release and phosphorylation of SYK/Vav in RBL-2H3 cells. Taken together, our findings have important implications for the design of high affinity SYK inhibitors.

• Journal of the Korean Institute of Gas
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• v.12 no.2
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• pp.92-98
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• 2008

A combination of the instrumented indentation and 3D morphology measurement has been tried in order to perform a real-time property measurement of degraded materials in gas pipelines; three-dimensional indent morphologies were recorded using a reflective laser scanner after a series of insturmented indentations on three metallic specimens. Dimensions of the permanent deformation zone and contact boundary were analyzed from the cross-sectional profile over an remnant indent and used for estimating yield strength and hardness, respectively. Estimated yield strength was comparable with that from uniaxial tensile test and actual hardness implying material pile-up effects was lower than the calculated value from indentation curve by $20{\sim}30%$. It means that this 3D image analysis can explain the material pile-up effects on the contact properties. Additionally, a combined system of indentation and laser sensor was newly designed by modifying a shape of the indentation loading fixture.

• Progress in Medical Physics
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• v.23 no.4
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• pp.317-325
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• 2012

The Varian PORTALVISION (Varian Medical Systems, US) shows significant overresponses as the off-center distance increases compared to the predicted dose. In order to correct the dose discrepancy, the off-axis correction is applied to VARIAN iX linear accelerators. The portal dose for $38{\times}28cm^2$ open field is acquired for 6 MV, 15 MV photon beams and also are predicted by PDIP algorithm under the same condition of the portal dose acquisition. The off-axis correction is applied by modifying the $40{\times}40cm^2$ diagonal beam profile data which is used for the beam profile calibration. The ratios between predicted dose and measured dose is modeled as a function of off-axis distance with the $4^{th}$ polynomial and is applied to the $40{\times}40cm^2$ diagonal beam profile data as the weight to correct measured dose by EPID detector. The discrepancy between measured dose and predicted dose is reduced from $4.17{\pm}2.76$ CU to $0.18{\pm}0.8$ CU for 6 MV photon beam and from $3.23{\pm}2.59$ CU to $0.04{\pm}0.85$ CU for 15 MV photon beam. The passing rate of gamma analysis for the pyramid fluence patten with the 4%, 4 mm criteria is improved from 98.7% to 99.1% for 6 MV photon beam, from 99.8% to 99.9% for 15 MV photon beam. IMRT QA is also performed for randomly selected Head and Neck and Prostate IMRT plans after applying the off-axis correction. The gamma passing rare is improved by 3% on average, for Head and Neck cases: $94.7{\pm}3.2%$ to $98.2{\pm}1.4%$, for Prostate cases: $95.5{\pm}2.6%$, $98.4{\pm}1.8%$. The gamma analysis criteria is 3%, 3 mm with 10% threshold. It is considered that the off-axis correction might be an effective and easily adaptable means for correcting the discrepancy between measured dose and predicted dose for IMRT QA using EPID in clinic.

• Journal of Forest and Environmental Science
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• v.30 no.2
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• pp.243-252
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• 2014

Forest tree species usually takes for long periods to be harvested and cultivated but spearmints are a good model system for woody plant because of reducing and shortening cultivation time. Spearmints are good model plants (Mentha species) for research about terpenoids production and industrial essential oil manufacture. Isopentenyl pyrophosphate isomerase (Iso) and limonene synthase (Limo) are the key enzymes of terpenoid biosynthesis pathway. Transgenic and wild spearmints (Mentha spicata, MS) were cultured in vitro and assessed for the essential oil contents. The content of essential oil of transgenic spearmint also was enhanced slightly depending on the target terpenoid genes. In an attempt to increase productivity of terpenoids further, salt and fungal elicitation strategy was adopted on transgenic Mentha spicata. The salt (800 mM NaCl) as abiotic and two fungi (Botrytis cinerea and Glomerella cingulata) as biotic were used for elicitors. In the absence of salt stress four terpenoids were detected from the spearmint extracts, all of them being monoterpenes. On the other hand, the transgenic (MSIso) extracts contained eleven terpenoids (10 monoterpenes and 1 phenylpropene) while transgenic (MSLimo) extracts contained seven monoterpenes. After 3 days of fungal infection, the resistance indices further increased to 4.38, 3.89 and 2.04 for wild type, MSIso and MSLimo, respectively. The salt and fungal elicitators proved beneficial towards modifying both the terpenoids profile and improvement in the composition of essential oil. These results have important applications for the large-scale production of essential oils and forest biotechnology with respect to spearmint.

• Journal of Korean Academy of Nursing
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• v.27 no.3
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• pp.541-549
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• 1997

This study was done to describe health promoting lifestyle and determine affecting factors in elderly based on the Heath Promotion Model by Pender. Cognitive-perceptual factors that were included in this study were self-efficacy and hardiness. Modifying factors were demographic characteristics (sex, age, partner, previous illness, education level. income and religion). The specific purpose of this study was to examine the relationships of self-efficacy, hardiness and the demographic chasteristics to health promoting lifestyle and to determine causal factors affecting the elderly. The subjects were a volunteer sample of 98 elderly in one city in? The instruments for this study were Health Promoting Lifestyle Profile(47items, 4scale), Health Related Hardiness Scale(22i1ems, 6scale), general Self-Efficacy Scale(13i1ems, 5scale). Frequency, percentage, t-test, ANOVA, Pearson's correlation coefficient and Stepwise Multiple regression technique with SAS program were used to analyse the data. The Results of the study are as follows : 1) The average item score for the health promoting lifestyle was 2.63, the highest score on the subscales was interpersonal support (M=3.3), followed by self-actulization(M=2.9), nutrition(M=2.8), stress management(M=2.7), health responsibility(M=2.1) with the lowest bring exercise(M=2.0) 2) A significant difference between education level, income, religion and health promoting lifestyle were found. 3) All of the subscales on health promoting lifestyle were positively related to total hardiness (r=0.330, p<0.001). The hardiness subscale of control was positively related to self-actulization(r=0.276, p<0.01), and commitment was positively related to self-actualization(r=0.315, p<0.001), exercise /nutrition(r=0.245, p<0.01), interpersonal support(r=0.278, p<0.01), stress management(r=0.250, p<0.01). Challenge was positively related to self-actualization(r=0.315, p<0.001), exercise /nutrition(r=0.245, p<0.01). There was no significant correlation between self-efficacy and all of the subscales of health promoting lifestyle. Self-efficacy showed a significant correlation only with control(r=0.469, p<0.001), comittment(r=0.507, p<0.001), challenge (r=0.489, p< 0.001). 4) Comittment, self-efficacy and income explained 25.01% of the variance for the total health promoting lifestyle. The results of this study show that commitment, self efficacy and income predicted the health promoting lifestyle of the elderly. So health promoting programs that increase commitement and self-efficacy should be developed to promote a healthy lifestyle of the elderly, especially those who have low income.