• Journal of KIISE:Computing Practices and Letters
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• v.10 no.4
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• pp.299-308
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• 2004

In this paper, we propose a probabilistic framework to predict the interaction probability of proteins. The notion of domain combination and domain combination pair is newly introduced and the prediction model in the framework takes domain combination pair as a basic unit of protein interactions to overcome the limitations of the conventional domain pair based prediction systems. The framework largely consists of prediction preparation and service stages. In the prediction preparation stage, two appearance probability matrices, which hold information on appearance frequencies of domain combination pairs in the interacting and non-interacting sets of protein pairs, are constructed. Based on the appearance probability matrix, a probability equation is devised. The equation maps a protein pair to a real number in the range of 0 to 1. Two distributions of interacting and non-interacting set of protein pairs are obtained using the equation. In the prediction service stage, the interaction probability of a Protein pair is predicted using the distributions and the equation. The validity of the prediction model is evaluated for the interacting set of protein pairs in Yeast organism and artificially generated non-interacting set of protein pairs. When 80% of the set of interacting protein pairs in DIP database are used as teaming set of interacting protein pairs, very high sensitivity(86%) and specificity(56%) are achieved within our framework.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.37 no.8
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• pp.975-981
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• 2013

A robust optimization is only one of the ways to minimize the effects of variances in design variables on the objective functions at the preliminary design stage. To predict the variances and to formulate the probabilistic constraints are the most important procedures for the robust optimization formulation. Though several methods such as the process capability index and the six sigma technique were proposed for the prediction and formulation of the variances and probabilistic constraints, respectively, there are few attempts using a percent defective which has been widely applied in the quality control of the manufacturing process for probabilistic constraints. In this study, the robust optimization for a lower control arm of automobile vehicle was carried out, in which the design space showing the mean and variance sensitivity of weight and stress was explored before robust optimization for a lower control arm. The 2nd order Taylor expansion for calculating the standard deviation was used to improve the numerical accuracy for predicting the variances. Simplex algorithm which does not use the gradient information in optimization was used to convert constrained optimization into unconstrained one in robust optimization.

• Journal of the Korean earth science society
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• v.37 no.3
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• pp.162-172
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• 2016

Since the Northridge earthquake in 1994 and the Kobe earthquake in 1995 occurred, the concept of performance based design has been introduced for designing various kinds of important structures and buildings. Uniform hazard spectra (UHS), with annual exceedance probabilities, corresponding to the performance level of each structure, are required for performance-based design. The probabilistic seismic hazard analysis was performed using spectral ground motion prediction equations, which were developed from both Korean Peninsula and Central and Eastern US region, and several seismotectonic models suggested by 10 expert panel members in seismology and tectonics. The uniform hazard spectra for 5 highly populated cities in Korea, with recurrence period of 500, 1,000, and 2,500 years using the seismic hazard at the frequencies of 0.5, 1.0, 2.0, 5.0, 10.0 Hz and Peak ground acceleration (PGA) were analyzed using the probabilistic seismic hazard analysis. The sensitivity analysis suggests that spectral ground motion prediction equations impact much more on seismic hazard than what seismotectonic models do. The uniform hazard spectra commonly showed a maximum hazard at the frequency of 10 Hz and also showed the similar shape characteristics to the previous study and related technical guides to nuclear facilities.

• Journal of the Korean Institute of Gas
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• v.22 no.2
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• pp.21-28
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• 2018

In recent years, payability of shale gas production has worsened due to oil and gas price declines resulting from sharply increasing shale gas production. Reliable economic evaluation in shale gas development has become important. In this study, Monte Carlo simulation of probabilistic analysis technique was applied to analyze the economic feasibility considering the uncertainty involved in shale gas development. For this, the range of major variables is set and a random number is generated to derive the probability distribution of Net Present Value(NPV) and Internal Rate of Return(IRR). Consequently, we estimated the probability that the feasibility of the project is evaluated to be positive when developing shale gas in the study area. In addition, sensitivity analysis of major parameters affecting economic efficiency in shale gas development was carried out, and the effect of major variables in economic evaluation for commercial production was identified. In the future, this study could be used to make decision for shale gas production by presenting the range of variation of economic index and probability value.

• Journal of the Korean Geotechnical Society
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• v.20 no.4
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• pp.89-102
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• 2004

The generated blasting pressure wave initiated under decoupled-charge condition is a function of peak blasting pressure, rise time, and wave-shape function. The peak blasting pressure and the rise time are also the function of explosive and rock properties. The probabilistic distributions of explosive and rock properties are derived from the results of their property tests. Since the probabilistic distributions of explosive and rock properties displayed a normal distribution, the peak blasting pressure and the rise time can also be regarded as a normal distribution. Parameter analysis and uncertainty analysis were performed to identify the most influential parameter that affects the peak blasting pressure and the rise time. Even though the explosive properties were found to be the most influential parameters on the peak blasting pressure and the rise time from the parameter analyses, the result of uncertainty analysis showed that rock properties constituted major uncertainties in estimating the peak blasting pressure and the rise time rather than explosive properties. Damage and overbreak of the remaining rock around the excavation line induced by blasting were evaluated by dynamic numerical analysis. A user-subroutine to estimate the rock damage was coded based on the continuum damage mechanics. This subroutine was linked to a commercial program called 'ABAQUS/Explicit'. The results of dynamic numerical analysis showed that the rock damages generated by the initiation of stopping hole were larger than those from the initiation of contour hole. Several methods to minimize those damages were proposed such as relocation of stopping hole, detailed subdivision of rock classification, and so on. It was found that fracture probability criteria and fractured zones could be distinctively identified by applying fuzzy-random probability.

• Journal of Environmental Impact Assessment
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• v.31 no.5
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• pp.321-333
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• 2022

In this study, the concentration and distribution characteristics of BTEX (benzene toluene, ethylbenzene, and xylene) emitted from Daesan Petrochemical Industrial Complex were examined to determine their potential hazards to local residents. Residents living nearby the complex areas may be exposed to the chemicals through various media (air, water, and soil), especially by air. This study evaluated human health risks by inhalation using both deterministic and probabilistic risk assessment approaches. As a result of the deterministic risk assessment, the non-cancer risk was much lower than the regulation limit of hazard index (HI 1.0) for all the points. However, in case of cancer risk evaluation, it was found that the risk of excess cancer for benzene at point A located in the industrial complex was 2.28×10^-6, which slightly exceeded the standard regulatory limit of 1.0×10^-6. In addition, the probabilistic risk assessment revealed that the percentile exceeding the standard of 1.0×10^-6was found to be 45.3%. The sensitivity analysis showed that exposure time (ET) had the greatest impact on the results. Based on the risk assessment study, it implied that ethylbenzene, toluene, and xylene had little adverse effects on potential human exposure, but benzene often exceeded the cancer risk standard (1.0×10^-6). Further studies on extensive VOCs monitoring are needed to evaluate the potential risks of industrial complex areas.

• The Journal of the Korea Contents Association
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• v.12 no.3
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• pp.34-43
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• 2012

Determining the similarity between two strings can be applied various area such as information retrieval, spell checker and spam filtering. Similarity calculation between Korean strings based on dynamic programming methods firstly requires a definition of the similarity between phonemes. However, existing methods have a limitation that they use manually set similarity scores. In this paper, we propose a method to automatically calculate inter-phoneme similarity from a given set of variant words using a PAM-like probabilistic model. Our proposed method first finds the pairs of similar words from a given word set, and derives derivation rules from text alignment results among the similar word pairs. Then, similarity scores are calculated from the frequencies of variations between different phonemes. As an experimental result, we show an improvement of 10.1%~14.1% and 8.1%~11.8% in terms of sensitivity compared with the simple match-mismatch scoring scheme and the manually set inter-phoneme similarity scheme, respectively, with a specificity of 77.2%~80.4%.

• Proceedings of the KSME Conference
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• 2008.11a
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• pp.1314-1319
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• 2008

Fatigue reliability problems are nowadays actively considered in the design of mechanical components. Recently, Dimension Reduction Method using Kriging approximation (KDRM) was proposed by the authors to efficiently calculate statistical moments of the response function. This method, which is more tractable for its sensitivity-free nature and providing the response PDF in a few number of analyses, is adopted in this study for the reliability analysis. Before applying this method to the practical fatigue problems, accuracies are studied in terms of parameters of the KDRM through a number of numerical examples, from which best set of parameters are suggested. In the fatigue reliability problems, good number of experimental data are necessary to get the statistical distribution of the S-N parameters. The information, however, are not always available due to the limited expense and time. In this case, a family of curves with prediction interval, called P-S-N curve, is constructed from regression analysis. Using the KDRM, once a set of responses are available at the sample points at the mean, all the reliability analyses for each P-S-N curve can be efficiently studied without additional response evaluations. The method is applied to a spring design problem as an illustration of practical applications, in which reliability-based design optimization (RBDO) is conducted by employing stochastic response surface method which includes probabilistic constraints in itself. Resulting information is of great practical value and will be very helpful for making trade-off decision during the fatigue design.

• Journal of Preventive Medicine and Public Health
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• v.46 no.4
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• pp.201-209
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• 2013

Objectives: The goal of this study was to perform an economic analysis of a primary stenting with drug-eluting stents (DES) compared with bare-metal stents (BMS) in patients with acute myocardial infarction (AMI) admitted through an emergency room (ER) visit in Korea using population-based data. Methods: We employed a cost-minimization method using a decision analytic model with a two-year time period. Model probabilities and costs were obtained from a published systematic review and population-based data from which a retrospective database analysis of the national reimbursement database of Health Insurance Review and Assessment covering 2006 through 2010 was performed. Uncertainty was evaluated using one-way sensitivity analyses and probabilistic sensitivity analyses. Results: Among 513 979 cases with AMI during 2007 and 2008, 24 742 cases underwent stenting procedures and 20 320 patients admitted through an ER visit with primary stenting were identified in the base model. The transition probabilities of DES-to-DES, DES-to-BMS, DES-to-coronary artery bypass graft, and DES-to-balloon were 59.7%, 0.6%, 4.3%, and 35.3%, respectively, among these patients. The average two-year costs of DES and BMS in 2011 Korean won were 11 065 528 won/person and 9 647 647 won/person, respectively. DES resulted in higher costs than BMS by 1 417 882 won/person. The model was highly sensitive to the probability and costs of having no revascularization. Conclusions: Primary stenting with BMS for AMI with an ER visit was shown to be a cost-saving procedure compared with DES in Korea. Caution is needed when applying this finding to patients with a higher level of severity in health status.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.28 no.6C
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• pp.349-358
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• 2008

In performing the reliability analysis for predicting the settlement with time of alluvial clay layer at Kobe airport, the uncertainties of geotechnical properties were examined based on the stochastic and probabilistic theory. By using Terzaghi's consolidation theory as the objective function, the failure probability was normalized based on AFOSM method. As the result of reliability analysis, the occurrence probabilities for the cases of the target settlement of ${\pm}10%,\;{\pm}25%$ of the total settlement from the deterministic analysis were 30~50%, 60%~90%, respectively. Considering that the variation coefficients of input variable are almost similar as those of past researches, the acceptable error range of the total settlement would be expected in the range of 10% of the predicted total settlement. As the result of sensitivity analysis, the factors which affect significantly on the settlement analysis were the uncertainties of the compression coefficient Cc, the pre-consolidation stress Pc, and the prediction model employed. Accordingly, it is very important for the reliable prediction with high reliability to obtain reliable soil properties such as Cc and Pc by performing laboratory tests in which the in-situ stress and strain conditions are properly simulated.