• Proceedings of the Korean Vacuum Society Conference
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• 2013.08a
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• pp.278.1-278.1
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• 2013

Among the prerequisites for stable neural interfacing are the long-term stability of electrical performance of and the excellent biocompatibility of conducting materials in implantable neural electrodes. Reduced graphene oxide offers a great potential for a variety of biomedical applications including biosensors and, particularly, neural interfaces due to its superb material properties such as high electrical conductivity, decent optical transparency, facile processibility, and etc. Nonetheless, there have been few systematic studies on the graphene-based neural interfaces in terms of biocompatibility of electrode materials and long term stability in electrical characteristics. In this research, we prepared the primary culture of rat hippocampal neurons directly on reduced graphene oxide films which is chosen as a model electrode material for the neural electrode. We observed that the viability of primary neuronal culture on the present structure is minimally affected by nanoscale graphene flakes below. These results implicate that the multilayer films of reduced graphene oxides can be utilized for the next-generation neural interfaces with decent biocompatibility and outstanding electrical performance.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• v.36 no.5
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• pp.417-422
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• 2010

Introduction: Bone density is one of the important factors for the long term success of endosseous implants. The bone density varies from site to site and from patient to patient. A preoperative evaluation of the bone density is quite useful to oral surgeons for planning dental implantation. More accurate information on the bone density will help surgeons identify suitable implant sites, thereby increase the success rate of dental implantation. This study examined the correlation between the bone density measured preoperatively by computed tomography (CT) and the implant primary stability measured by resonance frequency analysis. Furthermore, the effects of the implant sites, gender, age and generalized systemic disorder patients on the bone density and primary implant stability were examined. Materials and Methods: One hundred and fourteen patients were selected. None of the patients had undergone a tooth extraction or bone graft history in the previous year. Preoperatively, the patients underwent CT scanning to evaluate the Hounsfield unit (HU), and resonance frequency analysis (RFA) was used to evaluate the implant primary stability at the time of implant installation. All implants were 4.0 mm diameter and 11.5 mm length US II. All patients were recorded and the HU and implant stability quotient (ISQ) value were evaluated according to the sites, gender and age. Results: The highest HU values were found in the mandibular anterior site ($827.6{\pm}151.4$), followed by the mandibular molar site ($797{\pm}135.1$), mandibular premolar site ($753.8{\pm}171.2$), maxillary anterior site ($726.3{\pm}154.4$), maxillary premolar site ($656.7{\pm}173.8$) and maxillary molar site ($621.5{\pm}164.9$). The ISQ value was the highest in the mandibular premolar site ($81.5{\pm}2.4$) followed by the mandibular molar site ($80.0{\pm}5.7$), maxillary anterior site ($77.4{\pm}4.1$), mandibular anterior site ($76.4{\pm}11.9$), maxillary premolar site ($74.2{\pm}14.3$) and maxillary molar site ($73.7{\pm}7.4$). The mean HU and ISQ value were similar in females and males. (HU: P=0.331, ISQ: P=0.595) No significant difference was also found in the age group respectively. However, the correlation coefficients between the variables showed a closed correlation between the HU and ISQ value. Conclusion: These results showed close correlation between the bone density (HU) and primary stability value (ISQ) at the time of implant installation (Correlation coefficients=0.497, P<0.01). These results strengthen the hypothesis that it might be possible to predict and quantify the initial implant stability and bone density from a presurgical CT diagnosis.

• Journal of Communications and Networks
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• v.14 no.2
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• pp.162-168
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• 2012

This paper considers the scenario in which a set of nodes share a common channel. Some nodes have a rechargeable battery and the others are plugged to a reliable power supply and, thus, have no energy limitations. We consider two source-destination pairs and apply the concept of cognitive radio communication in sharing the common channel. Specifically, we give high-priority to the energy-constrained source-destination pair, i.e., primary pair, and low-priority to the pair which is free from such constraint, i.e., secondary pair. In contrast to the traditional notion of cognitive radio, in which the secondary transmitter is required to relinquish the channel as soon as the primary is detected, the secondary transmitter not only utilizes the idle slots of primary pair but also transmits along with the primary transmitter with probability p. This is possible because we consider the general multi-packet reception model. Given the requirement on the primary pair's throughput, the probability p is chosen to maximize the secondary pair's throughput. To this end, we obtain two-dimensional maximum stable throughput region which describes the theoretical limit on rates that we can push into the network while maintaining the queues in the network to be stable. The result is obtained for both cases in which the capacity of the battery at the primary node is infinite and also finite.

• Journal of Korean Society for Atmospheric Environment
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• v.34 no.2
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• pp.331-341
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• 2018

Hazardous air pollutants(HAPs) in the atmosphere are regulated as major air pollutants in Korea by the Air Pollution Control Act. In order to manage and control HAPs, accurate standards, which are traceable to the International System of Units(SI), are required. In this study, primary standard gas mixtures(PSMs) of volatile organic compounds(VOCs) which are specified as HAPs were developed at $1{\mu}mol/mol$ levels. The selected fourteen VOCs include Benzene, Toluene, Ethylbenzene, m-Xylene, Styrene, o-Xylene, Chloroform, 1,1,2-Trichloroethane, Trichloroethylene, Tetrachloroethylene, 1,1-Dichloroethane, Carbon tetrachloride, 1,3-Butadiene, and Dichloromethane. The HAPs PSMs were gravimetrically prepared in aluminum cylinders and their consistency was verified within the relative expanded uncertainty of 0.71% (k=2). Potential adsorption loss onto the internal surface of cylinders was estimated by cylinder-to-cylinder division method. No adsorption loss was observed within the uncerainty of 0.53%. The long-term stability of the HAPs PSMs was evaluated comparing with freshly prepared HAPs PSMs. The HAPs PSMs were stable for one year within the uncertainty of 0.38%. The final uncertainty of the PSMs was determined by combining the preparation uncertainty, verification uncertainty, and stability uncertainty. Finally, traceable and stable HAPs PSMs at $1{\mu}mol/mol$ levels were developed with the uncertainty of less than 0.76% in high-pressure aluminum cylinders.

• Journal of Periodontal and Implant Science
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• v.47 no.2
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• pp.106-115
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• 2017

Purpose: The possibility of immediate or early loading has become popular in implant dentistry. A prerequisite for the immediate or early loading of an implant prosthesis is the achievement of initial stability in the implant. Moreover, in response to clinicians' interest in verifying clinical stability to determine the optimal time point for functional loading, a non-invasive method to assess implant stability has been developed on the basis of resonance frequency analysis (RFA). The primary objective of this study was to monitor the stability of sandblasted, large-grit, and acid-etched (SLA) implants with different diameters during the early phases of healing by RFA. The secondary objective was to evaluate how the initial stability of implants varied depending on different surface modifications and other contributing factors. Methods: Thirty-five implants (25 SLA implants and 10 resorbable blasting media [RBM] implants) placed in 20 subjects were included. To measure implant stability, RFA was performed at baseline and at 1, 2, 3, 4, 6, and 10 weeks after surgery. Results: The longitudinal changes in the implant stability quotient (ISQ) values were similar for the SLA implants with different diameters and for the RBM implants. During the initial healing period, the ISQ decreased after installation and reached its lowest values at 1 week and 2 weeks, respectively. The mean ISQ values in the SLA implants were significantly higher in ${\varnothing}5.0mm$ implants than in ${\varnothing}4.0mm$ implants. Men showed a higher ISQ than women. Mandibular sites showed a higher ISQ than maxillary sites. Conclusions: All implants used in this study are suitable for immediate or early loading under appropriate indications. A wider diameter and SLA surface treatment of implants could improve the stability, if the implant is fixed with at least 30 Ncm of insertion torque.

• Journal of Korean Society for Atmospheric Environment
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• v.21 no.2
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• pp.243-257
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• 2005

The effects of Traffic Control Program (TCP) on the ambient urban air quality of SO$_{2}$, NO$_{2}$, O$_{3}$, and PM$_{10}$ were evaluated in Seoul metropolitan area by using the lower atmospheric vertical stability index and daily mean wind speeds. The vertical stability index; temperature lapse rate between 1000 hPa and 850 hPa geopotential height fields, were used to identify daily vertical stability index during the 2002 World Cup period where traffic amount was reportedly reduced to half the number of vehicles. The indicated air quality levels of TCP days were then compared with those of the cases observed with analogous vertical stability during the recent 3 years from 2000 to 2002. The result indicates that the effect of TCP on the primary air pollutants are found to be approximately 39$\%$, 23$\%$ and 20$\%$ lower for SO$_{2}$, NO$_{2}$ and PM$_{10}$, respectively. The secondary air pollutant; ozone, showed relatively smaller decreasing rate (13$\%$) of daily mean concentrations (even increased during the night time). The comparison of daily maximum or peak concentrations reveals that the pronounced decreasing effects of TCP on the ambient air quality for both primary and secondary air pollutants, suggesting that TCP is one of the effective strategies to control peak or higher concentrations for most urban scale air pollutants in and around the Seoul metropolitan area.

• Journal of Periodontal and Implant Science
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• v.45 no.1
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• pp.30-35
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• 2015

Purpose: Implant beds with an insufficient amount of cortical bone or a loss of cortical bone can result in the initial instability of a dental implant. Thus, the objective of this study was to evaluate the effect of bone cement grafting on implant initial stability in areas with insufficient cortical bone. Methods: Two different circumferential defect depths (2.5 mm and 5 mm) and a control (no defect) were prepared in six bovine rib bones. Fourteen implants of the same type and size ($4mm{\pm}10mm$) were placed in each group. The thickness of the cortical bone was measured for each defect. After the implant stability quotient (ISQ) values were measured three times in four different directions, bone cement was grafted to increase the primary stability of the otherwise unstable implant. After grafting, the ISQ values were measured again. Results: As defect depth increased, the ISQ value decreased. In the controls, the ISQ value was $85.45{\pm}3.36$ ($mean{\pm}standard$ deviation). In circumferential 2.5-mm and 5-mm defect groups, the ISQ values were $69.42{\pm}7.06$ and $57.43{\pm}6.87$, respectively, before grafting. These three values were significantly different (P<0.001). After grafting the bone cement, the ISQ values significantly increased to $73.72{\pm}8.00$ and $67.88{\pm}10.09$ in the 2.5-mm and 5.0-mm defect groups, respectively (P<0.05 and P<0.001). The ISQ value increased to more than double that before grafting in the circumferential 5-mm defect group. The ISQ values did not significantly differ when measured in any of the four directions. Conclusions: The use of bone cement remarkably increased the stability of the implant that otherwise had an insufficient level of stability at placement, which was caused by insufficient cortical bone volume.

• Molecules and Cells
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• v.43 no.4
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• pp.373-383
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• 2020

Our previous study revealed a novel role of Fas-associated death domain-containing protein (FADD) in islet development and insulin secretion. Insulin-degrading enzyme (IDE) is a zinc metalloprotease that selectively degrades biologically important substrates associated with type 2 diabetes (T2DM). The current study was designed to investigate the effect of FADD phosphorylation on IDE. We found that the mRNA and protein levels of IDE were significantly downregulated in FADD-D mouse livers compared with control mice. Quantitative real-time polymerase chain reaction analysis showed that FADD regulates the expression of IDE at the transcriptional level without affecting the stability of the mRNA in HepG2 cells. Following treatment with cycloheximide, the IDE protein degradation rate was found to be increased in both FADD-D primary hepatocytes and FADD-knockdown HepG2 cells. Additionally, IDE expression levels were reduced in insulin-stimulated primary hepatocytes from FADD-D mice compared to those from control mice. Moreover, FADD phosphorylation promotes nuclear translocation of FoxO1, thus inhibiting the transcriptional activity of the IDE promoter. Together, these findings imply a novel role of FADD in the reduction of protein stability and expression levels of IDE.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• v.49 no.1
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• pp.13-20
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• 2023

Objectives: Ultra-wide implants may be used as a replacement if existing implants fail. This study was conducted to evaluate the factors influencing the prognosis and failure of ultra-wide implants. Patients and Methods: This study evaluated whether sex, age, site, diameter, length, additional surgery, implant stability (primary and secondary), and reason for ultra-wide implant placement affect the 5-year survival and success rates and marginal bone loss (MBL) of ultra-wide implants. Seventy-eight ultra-wide implants that were placed in 71 patients (39 males and 32 females) from 2008 to 2010 were studied. One-way ANOVA analysis was conducted to evaluate the statistical significance of MBL according to the patient's sex, implant site, and diameter. Independent sample t-tests were used to determine the statistical significance of MBL analysis which was used to determine the significance of the 5-year success and survival rates related to the variables. One-way ANOVA was conducted to evaluate the statistical significance of sex, implantation site, diameter, and MBL. Independent sample t-tests were used to evaluate the correlation between implantability and MBL for implantation reasons, while additional surgery, length, and Kaplan-Meier analysis were used to evaluate 5-year survival and success rates. Results: The mean age of patients was 54.2 years with a survival rate of 92.3% and a success rate of 83.3% over a mean 97.8-month period of observation. MBL averaged 0.2 mm after one year of prosthetic function loading and 0.54 mm at the time of final observation. Success rates correlated with primary stability (P=0.045), survival rates correlated with secondary stability (P=0.036), and MBL did not correlate with any variables. Conclusion: Ultra-wide implants can be used to achieve secure initial fixation in the maxillary and mandibular molar regions with poor bone quality or for alternative purposes in cases of previous implant failure.

• Journal of Korean Tunnelling and Underground Space Association
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• v.12 no.4
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• pp.285-294
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• 2010

As there are increasing number of tunneling works these days, shotcrete is used as primary supports in order to secure the stability of tunnels. The quality of shotcrete has a direct influence on tunnels, because it is a primary support which secures the stability of completed tunnels as well as the stability of tunnels under excavation. Especially in case that ordinary shotcrete is used under weak rock conditions or at water gushing sections, more shotcrete is needed and rebound ratio increases. As a result, it is hard to keep economic feasibility. In addition to it, in subway construction, there are cases of separated excavation and it may have a bad influence on construction period or quality. Therefore, in this study, we are going to evaluate the early strength of powder type accelerator.