• 한국발생생물학회지:발생과생식
• /
• 제20권3호
• /
• pp.247-254
• /
• 2016

Cytological changes of the epithelial cells according to the developmenatal phases of the seminal vesicle related to the spermatogenic stages in the testicular lobules during spermagenesis in male Neptunea (Barbitonia) cumingii (Gastropoda: Buccinidae) were investigated monthly by electron microscopical and histological observations. N. (B) cumingii is dioecious, and an internal fertilization species. The male genital organ is located near the tentacles. The spermatozoon is approximatley $50{\mu}m$ in length. The axoneme of the tail flagellum consists of nine pairs of microtubles at the periphery and one pair at the center. The process of germ cell development during spermatogenesis can be divided into five succesive stages: (1) spermatogonia, (2) primary spermatocytes, (3) secondary spermatocytes, (4) spermatids, and (5) spermatozoa. A considerable amount of spermatozoa make their appearance in the testicular lobules (or acini) and some of them are tranported from the testis towards the seminal vesicles until late July. In this study, the developmental phases of the epithelial cells of the seminal vesicles of N. (B.) cumingii could be classified into four phases: (1) S-I phase (resting), (2) S-IIphase (early accumulating), (3) S-III phase (accumulating), and (4) S-IV phase (spent). However, in case of N. (B.) arthritica cumingii, the developmental phases of the seminal vesicle were devided into three phases: (1) resting, (2) accumulating and (3) spent. Granular bodies in the inner layer of the seminal vesicles are involved in resorption of digestion of residual spermatozoa.

• 한국주조공학회지
• /
• 제37권6호
• /
• pp.199-206
• /
• 2017

In this study, the variations of microstructures and tensile properties of Ti-(44-54)at.%Al binary alloys were investigated. The heat-treated microstructure depended greatly on their solidification structure and annealing temperature. We measured the variations of volume fractions of primary and secondary lamellar structure as a function of the heat treatment temperature in a Ti-47at.%Al alloy. The variation of ductility as a function of Al content was in good agreement with the change of fracture mode in the tensile fracture surface. It can be inferred that the variations of yield stress and hardness of ${\gamma}$ phase in a single ${\gamma}$-phase field region are enhanced by anti-site defects created by deviations from the stoichiometric composition. In a Ti-47at.%Al alloy within the (${\alpha}_2+{\gamma}$) two-phase field, the yield stress tended to be the maximum at a near equal volume fraction of lamellar and ${\gamma}$ grains. The ductility depended sensitively on the overall grain size and Al content. The calculation of fracture strain using Chan's model indicated that the change of ductility as a function of annealing temperature was primarily determined by the variations in the overall grain size and lamellar volume fraction.

• 한국조명전기설비학회:학술대회논문집
• /
• 한국조명전기설비학회 2007년도 추계학술대회 논문집
• /
• pp.337-340
• /
• 2007

In the dissertation, a power conversion system for fuel cell is composed of a PWM inverter with LC filter in order to convert fuel cell voltage to a single phase 220[V], In addition, new insulated DC-DC converters are proposed in order that fuel cell voltage is boosted to 380[V]. In this paper, it requires smaller components than existing converters, which makes easy control. The proposed DC-DC converter controls output power by the adjustment of phase-shift width using switch S5 and S6 in the secondary switch, which provides 93-97[%] efficiency in the wide range of output voltage. Fuel cell simulator is implemented to show similar output characteristics to actual fuel cell. Appropriate dead time td enables soft switching to the range where the peak value of excitation current in a high frequency transformer is in accordance with current in the primary circuit. Moreover, appropriate setting to serial inductance La reduces communication loss arisen at light-load generator and serge voltage arisen at a secondary switch and serial diode. Finally, TMS320C31 board and EPLD using PWM switching technique to act a single phase full-bridge inverter which is planed to make alternating current suitable for household.

• 전력전자학회논문지
• /
• 제10권5호
• /
• pp.457-467
• /
• 2005

본 논문은 해남에서 제주로 연결되어 운전중인 HVDC 시스템의 새로운 주파수 제어기에 대하여 연구하였다. 연구의 첫 번째 목적은 현재의 동기조상기를 제거하기 위하여 새로운 주파수 제어기를 개발하고, 평가를 수행하는 것이다. 모의실험 케이스를 만들기 위하여 PSCAD/EMTDC와 PSS/E를 혼합하여 사용하였고 주 시스템 연구는 과도상태 분석을 위하여 PSCAD/EMTDC을 사용하였다. 연구 케이스는 3상과 1상 지락 그리고 부하탈락에 대한 사고를 모의하였고 연구결과를 나타내었다. 결론적으로 AC 네트워크로부터 검출되는 새로운 주파수 측정 방법은 유효한 주파수 제어와 동적 성능을 나타냄을 알 수 있었다.

• Journal of Power Electronics
• /
• 제15권6호
• /
• pp.1508-1516
• /
• 2015

A single phase H-bridge inverter is employed in conventional Inductive Power Transfer (IPT) systems as the primary side power supply. These systems may not be suitable for some high power applications, due to the constraints of the power electronic devices and the cost. A high-frequency cascaded multi-level inverter employed in IPT systems, which is suitable for high power applications, is presented in this paper. The Phase Shift Pulse Width Modulation (PS-PWM) method is proposed to realize power regulation and selective harmonic elimination. Explicit solutions against phase shift angle and pulse width are given according to the constraints of the selective harmonic elimination equation and the required voltage to avoid solving non-linear transcendental equations. The validity of the proposed control approach is verified by the experimental results obtained with a 2kW prototype system. This approach is expected to be useful for high power IPT applications, and the output power of each H-bridge unit is identical by the proposed approach.

• Asian Pacific Journal of Cancer Prevention
• /
• 제16권18호
• /
• pp.8313-8319
• /
• 2016

We have recently shown that thymoquinone (TQ) has a potent cytotoxic effect and induces apoptosis via caspase-3 activation with down-regulation of XIAP in mouse neuroblastoma (Neuro-2a) cells. Interestingly, our results showed that TQ was significantly more cytotoxic towards Neuro-2a cells when compared with primary normal neuronal cells. In this study, the effects of TQ on cell-cycle regulation and the mechanisms that contribute to this effect were investigated using Neuro-2a cells. Cell-cycle analysis performed by flow cytometry revealed cell-cycle arrest at G2/M phase and a significant increase in the accumulation of TQ-treated cells at sub-G1 phase, indicating induction of apoptosis by the compound. Moreover, TQ increased the expression of p53, p21 mRNA and protein levels, whereas it decreased the protein expression of PCNA, cyclin B1 and Cdc2 in a dose-dependent manner. Our finding suggests that TQ could suppress cell growth and cell survival via arresting the cell-cycle in the G2/M phase and inducing apoptosis of neuroblastoma cells.

• Bulletin of the Korean Chemical Society
• /
• 제34권3호
• /
• pp.907-911
• /
• 2013

Numbers of matrix- and analyte-derived ions and their sum in matrix-assisted laser desorption ionization (MALDI) of a peptide were measured using 2,5-dihydroxybenzoic acid (DHB) as matrix. As for MALDI with ${\alpha}$-cyano-4-hydroxy cinnamic acid as matrix, the sum was independent of the peptide concentration in the solid sample, or was the same as that of pure DHB. This suggested that the matrix ion was the primary ion and that the peptide ion was generated by matrix-to-peptide proton transfer. Experimental ionization efficiencies of $10^{-5}-10^{-4}$ for peptides and $10^{-8}-10^{-7}$ for matrices are far smaller than $10^{-3}-10^{-1}$ for peptides and $10^{-5}-10^{-3}$ for matrices speculated by Hillenkamp and Karas. Number of gas-phase ions generated by MALDI was unaffected by laser wavelength or pulse energy. This suggests that the main role of photo-absorption in MALDI is not in generating ions via a multi-photon process but in ablating materials in a solid sample to the gas phase.

• 대한기계학회논문집
• /
• 제8권5호
• /
• pp.416-424
• /
• 1984

본 연구에서는 다회로의 단상(single-phase) 자연순환계에 관한 실험 및 수치 해석적 연구로서, RWR에서의 자연순환 현상을 모사할 수 있는 fast-running code를 개 발하고 이를 실험을 통하여 입증하며, 또한 자연순환계에서 일어나는 여러 현상을 정 성적으로 관찰하는 것을 목적으로 삼았다. 이론부분은 저자의 다른 논문에 발표되었 으므로 여기에서는 요약하여 소개하며, 실험은 2-회로 PWR(고리 1호기) 1차계통을 약 1/15로 축소시킨 실험장치에서 행하였다.

• Asian Pacific Journal of Cancer Prevention
• /
• 제14권8호
• /
• pp.4641-4646
• /
• 2013

Objective: To explore clinical experience and propose new ideas for treating children diagnosed with orbital rhabdomyosarcoma (RMS). Methods: We retrospectively analyzed the clinical data for30 patients (16 males and 14 females, with a median age of 6.2 years) with primary orbital RMS who were enrolled in the Department of Eye Oncology and Pediatrics of our hospital from November 2004 to December 2012. International Rhabdomyosarcoma Organization Staging Standards indicated that among the 30 patients, 4 cases were in phase II, 20 were in phase III, and 6 were in phase IV. All patients underwent a multidisciplinary collaborative model of comprehensive treatment (surgery, chemotherapy, external radiotherapy, $^{125}I$ radioactive particle implantation, and autologous peripheral blood stem-cell transplantation). Results: Follow-up was conducted until March 2013, with a median follow-up time of 47.2 months (5 to 95 months), and 7 deaths occurred. The 2-year estimated survival rate reached 86.1%, the ${\geq}3$-year estimated survival rate was 77%, and the 5-year estimated survival rate was 70.6%. Conclusions: The multidisciplinary collaborative model can be a safe and effective approach to the comprehensive treatment of children with orbital RMS. It has clinical significance in improving the tumor remission rate.

• International Journal of Aeronautical and Space Sciences
• /
• 제16권3호
• /
• pp.370-379
• /
• 2015

Handling constantly evolving configurations of aircraft can be inefficient and frustrating to design engineers, especially true in the early design phase when many design parameters are changeable throughout trade-off studies. In this paper, a physics-based design framework using parametric modeling is introduced, which is designated as DIAMOND/AIRCRAFT and developed for structural design of transport aircraft in the conceptual and preliminary design phase. DIAMOND/AIRCRAFT can relieve the burden of labor-intensive and time-consuming configuration changes with powerful parametric modeling techniques that can manipulate ever-changing geometric parameters for external layout of design alternatives. Furthermore, the design framework is capable of generating FE model in an automated fashion based on the internal structural layout, basically a set of design parameters describing the structural members in terms of their physical properties such as location, spacing and quantities. The design framework performs structural sizing using the FE model including both primary and secondary structural levels. This physics-based approach improves the accuracy of weight estimation significantly as compared with empirical methods. In this study, combining a physics-based model with parameter modeling techniques delivers a high-fidelity design framework, remarkably expediting otherwise slow and tedious design process of the early design phase.