• Asian Pacific Journal of Cancer Prevention
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• v.16 no.17
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• pp.7441-7447
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• 2015

Objective: This study evaluated the safety and objective response of combining $^{131}I$-labeled-metuximab (Licartin) with transarterial chemoembolization (TACE) in the treatment of unresectable hepatocellular carcinoma (HCC). Materials and Methods: In a multicenter open-label clinical trial, 341 enrolled patients with stage III/IV HCC according to TNM criteria were nonrandomly assigned to a trial group (n=167) and a control group (n=174), undergoing TACE following hepatic intra-arterial injection of licartin or TACE alone from July 2007 to July 2009. Radiopharmaceutical distribution was evaluated. The primary endpoint was overall survival; secondary endpoints included time-to-progression (TTP), toxicity and adverse events (AEs). Results: The radiobiological distribution demonstrated better localization of licartin in liver tumors than other tissues (P<0.01). The organ absorbed doses to liver and red marrow were $3.19{\pm}1.01Gy$ and $0.55{\pm}0.22Gy$, respectively. The 1-year survival rate was significantly higher [79.47% vs. 65.59%, hazard ratio (HR), 0.598, P=0.041] and TTP significantly improved ($6.82{\pm}1.28$ vs. $4.7{\pm}1.14months$, P=0.037) compared with the control group. Patients at stage III achieved more benefit of one year survival than stage IV in the trial group (86.9% vs. 53.8%, P<0.001). There were significant different toxicities in leukocytopenia, thrombocytopenia and increased total bilirubin level [P<0.001, P=0.013, P<0.01, relative risk (RR) 1.63, 1.33, 1.43], but no differences in severe AEs of upper GI hemorrhage and severe liver dysfunction between the groups (5.39% vs. 2.3%, P=0.136). Conclusions: Owing to excellent tumor-targeting, promised efficacy and favourable toxicity profile, the novel combination therapy of licartin and TACE could be applied in patients with unresectable HCC.

• Korean Journal of Agricultural Science
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• v.44 no.2
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• pp.254-260
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• 2017

The primary goals of this research were to evaluate the impact of diet supplemented with 25-hydroxyvitamin $D_3$ ($Hy{\cdot}D(R)$) on sow's body condition and reproduction performance. A total of sixteen multiparous sows [(Landrace ${\times}$ Yorkshire), average parity = $3.79{\pm}0.32$] and their litters were randomly allotted to 2 treatments to give 8 replicates per treatment. Diet treatments were randomized to receive a non-active (ND) or active 25-hydroxyvitamin $D_3$ (AD) diet (0.36 mg cholecalciferol/g) during pregnancy. The results of this experiment were observed at the gestation of d 58 - 75, d 76 - 95, d 96 - 110, and d 111 - 115. A corn-soybean meal-based diet was formulated to meet or exceed the nutrient requirements recommended by NRC (2012). Results indicated that the sows' farrowing duration was shortened (4.71, 5.38 h), and the average number of mummified fetuses decreased significantly (p < 0.05) in AD treatment compared with ND treatment (0.1, 0.5) while birth weight was significantly (p < 0.05) improved (1.44, 1.18 kg). There were no significant effects on body weight, backfat thickness, and fecal score during the gestation of sows in different phases (p > 0.05). And the total birth, stillbirth, live birth, and survival rates of the litter did not change (p > 0.05). The results of this study suggest that the farrowing duration of sow pigs will be shortened and the number of mummies will be decreased while their litters' body weight may be improved, if fed active 25-hydroxyvitamin $D_3$ (0.36 mg/g) during pregnancy phase.

• YAKHAK HOEJI
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• v.48 no.2
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• pp.159-164
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• 2004

Primary pro-inflammatory cytokines are a trio: tumor necrosis- $\alpha$ (TNF-$\alpha$), interleukine-$\beta$ (IL-$\beta$), and interleukine-6 (IL-6). These cytokines initiate and regulate the acute-phase inflammatory response during infection, trauma, or stress and appear to play an important role in the immune process. Nitric oxide (NO) is a multi-functional mediator, which plays an important role in regulating various biological functions in vivo. NO production by inducible nitric oxide synthase (iNOS) in macrophages is essential for the defense mechanisms against microorganisms and tumor cells. However, over-expression of iNOS by various stimuli, resulting in over-production of NO, contributes to the pathogenesis of septic shock and some inflammatory and auto-immune disease. Solvent fractions of sage ( Salvia officinalis L.), which is cultivated in Jeju-Do, was assayed for their effects on TNF-$\alpha$ and IL-6 production in LPS-stimulated RAW 264.7 macrophages. Hexane and ethylacetate (EtOAc) fraction of sage inhibited the protein and mRNA expression of TNF-$\alpha$ and IL-6 in LPS stimulated RAW 264.7 cells at the concentration of 100 $\mu\textrm{g}$/$m\ell$. Also, incubation of RAW 264.7 cells with the fraction of hexane or EtOAc (50 $\mu\textrm{g}$/$m\ell$) inhibited the LPS induced nitrite accumulation and the LPS/IFN-${\gamma}$ induced iNOS protein. And this inhibition of iNOS protein is concordant with the inhibition of iNOS mRNA expression. Above results suggest that extract of sage may have anti-inflammatory activity through the inhibition of pro-inflammatory cytokines (TNF-$\alpha$, IL-1$\beta$, IL-6), iNOS and NO.

• Journal of the Korean Society for Precision Engineering
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• v.28 no.3
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• pp.292-300
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• 2011

Control systems in machinery equipment provide correction signals to motion units in order to reduce or cancel out the mismatches between sensor feedback signals and command or desired values. In this paper, we introduce a simulator for control characteristics of machinery equipment. The purpose of the simulator development is to provide mechanical system designers with the ability to estimate how much dynamic performance can be achieved from their design parameters and selected devices at the designing phase. The simulator has a database for commercial parts, so that the designers can choose appropriate components for servo controllers, motors, motor drives, and guide ways, etc. and then tune governing parameters such as controller gains and friction coefficients. The simulator simulates the closed-loop control system which is built and parameter-tuned by the designer and shows dynamic responses of the control system. The simulator treats the moving table as a 6 degrees-of-freedom rigid body and considers the motion guide blocks stiffness, damping and their locations as well as sensor locations. The simulator has been under development for one and a half years and has a few years to go before the public release. The primary achievements and features will be presented in this paper.

• Journal of the korean society of oceanography
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• v.35 no.1
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• pp.16-33
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• 2000

In order to measure the vertical fluxes of particles and reactive radionuclides such as thorium and polonium isotopes, Dunbar-type sediment traps were freely deployed at the Ulleung Basin and in warm and cold water masses around the polar front of the East Sea. We estimated the ratios of the catched (F) to the predicted $^234$Th fluxes (P) using natural tracers pair $^234$Th-$^238$U. The F/P ratios are decreased with increasing water depth. Whereas the concentrations of suspended particles are homogeneous in water column, the mass fluxes are also decreased with increasing water depth like the F/P ratios. These facts indicate that organic matters of settling particles are destructed within the euphotic layer due to decomposition. Whereas regenerations of sinking particles are negligible in the cold water mass, about 80% of them are regenerated in the warm water mass during falling of large particles. These downward mass fluxes are closely correlated with their primary productions in euphotic zone. The activities of $^234$Th, $^228$Th and $^210$Po in the sinking material were increased with water depth. Because $^234$Th steadily produced in the water column are cumulatively adsorbed on the surface of sinking particles, vertical $^234$Th fluxes were observed to increase with water depth. Therefore, these sinking particles play important roles in transporting the particle reactive elements like thorium from surface to the deep sea. The scavenging processes including adsorption and settling reactions generate radio-disequilibrium between daughter and parent nuclides in water column. The activity ratios of $^234$Th/$^238$U and $^228$Th/$^228$Ra were observed to be < 1.0 in the surface water and approached to be equilibrium below the thermocline. The extent of the deficiency of daughter nuclides compared to the parents nuclide was highly correlated with the vertical particle flux. Because most of the $^210$Po in the surface water are scavenged on a labile phase and are recycled at sub-surface depths (< 200 m), the $^210$Po are always observed to be excess activities compared to $^226$Ra in surface water.

• Biomolecules & Therapeutics
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• v.22 no.5
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• pp.445-452
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• 2014

The purpose of this study was to investigate the therapeutic effects of DA-9801, an optimized extract of Dioscorea species, on diabetic peripheral neuropathy in a type 2 diabetic animal model. In this study, db/db mice were treated with DA-9801 (30 and 100 mg/kg, daily, p.o.) for 12 weeks. DA-9801 reduced the blood glucose levels and increased the withdrawal latencies in hot plate tests. Moreover, it prevented nerve damage based on increased nerve conduction velocity and ultrastructural changes. Decrease of nerve growth factor (NGF) may have a detrimental effect on diabetic neuropathy. We previously reported NGF regulatory properties of the Dioscorea genus. In this study, DA-9801 induced NGF production in rat primary astrocytes. In addition, it increased NGF levels in the sciatic nerve and the plasma of type 2 diabetic animals. DA-9801 also increased neurite outgrowth and mRNA expression of Tieg1/Klf10, an NGF target gene, in PC12 cells. These results demonstrated the attenuation of diabetic peripheral neuropathy by oral treatment with DA-9801 via NGF regulation. DA-9801 is currently being evaluated in a phase II clinical study.

• Journal of Welding and Joining
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• v.13 no.3
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• pp.106-115
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• 1995

To know the bonding phenomena of Ti/Cu brazed joint, a characteristic of microstructures in bonding interlayer of vacuum brazed pure Ti to Cu has been studied in the temperature range from 1088 to 1133K for various bonding times using Ag-28wt%Cu filler metal. Also intermediate phases formed in bonded interlayer and behavior of layer growth have been investigated. The obtained results in this study are as follows: 1) Liquid insert metal width at the each brazing temperature was proportional to the square root of brazing time, and it was considered that the liquid insert metal width was controlled by the diffusion rate process of primary .alpha.-Cu formed at the Ti side. 2) Intermediate phases formed near the Ti interface were .betha.-Ti and intermetallic compounds TiCu, Ti$_{2}$Cu, Ti$_{3}$Cu, and TiCu. 3) .betha.-Ti formed in Ti base metal durig brazing transformed to lamellar structure, .alpha.-Ti + Ti$_{2}$Cu. The structure came from the eutectoil decomposition reaction in cooling. And the width of .betha.-Ti layer was proportional to the square root of brazing time, and it was considered that the growth of .betha.-Ti layer was controlled by interdiffusion rate process in .betha.-Ti. 4) The layer growth of TiCu, Ti$_{3}$Cu$_{4}$ and TiCu, phases formed near the Ti interface was linerface was linearly proportional to the brazing time, and it was considered that the layer growth of these phases was controlled by the chemical reaction rate at the interface.

• Journal of Korean Society of Water and Wastewater
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• v.32 no.5
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• pp.445-451
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• 2018

Urban sanitary sewer systems can aid in preventing inundation, and can improve civil health by effectively disposing stormwater and wastewater. However, since sewage odor can cause adverse effects, numerous technical and administrative studies have been conducted for reducing such odor. European countries and the United States of America (USA) built modern sewer systems in the late 19th century, and have since been endeavoring to eliminate sewage odors. Several cities of the USA, such as Los Angeles (LA) that has a separate sewer system and San Francisco (SF) that has a combined sewer system, have produced and distributed odor control master plan manuals. Features common in the odor reduction plans of both these cities are that the odor reduction programs are operated in all the respective local regions and are supported by administrative systems. The primary aspectual difference between the two said programs is that the city of LA employs a sewage air purification system, whereas the city of SF controls the emission of major odor causing compounds. Compared to the existing sewer odor reduction systems of these two cities, South Korea is still in the initial phase of development. Through technical studies and policy implementations for sewer odor reduction, a foundation can be laid for improving the civil health quality.

• Journal of Korea Technical Association of The Pulp and Paper Industry
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• v.31 no.1
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• pp.72-79
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• 1999

The binder plays important roles in determining the quality of pigment coating. In addition to its primary role of binding the pigment to the base paper, the binder performs several other important functions. The binder, also referred to as the adhesive, is the dominant in the aqueous phase of the formulation. Thus it plays a major role in determining viscosity, rheology, water release, and setting time for the coating. Latices based on styrene-butadiene dominate the market for synthetic paper coating binders. Consumption is high and is expected to increase further due to the present tendeyncy toward high-solids coating. The purpose of this study is understanding the impact of various parameters of latex(i.e. Tg, Particle size) affecting prontabilities and optical properties of the coated papers, as well as providing basic information on the use of amphoteric latex for improving print qualities of coated papers. Recently, amphoteric latices, Which are cationic at low pH's but turn anionic at high pH's have attracted interests of paper scientists and engineers. Therefore we investigated the effect of the Tg(glass transition temperature) and particle size of amphoteric latex on the coating qualities. We also studied the effect of mixing ratios (Amphoteric / Anionic)of latex on the coating qualities. Our results showed that Tg and particle size of amphoteric latex have to be controlled for optimizing coated paper qualities. The formulation consisting of 10 parts of amphoteric latex and 5 parts of anionic latex gave best results in ink receptivity, smoothness, air permeability, opacity and sheet gloss. If the results hold for the industrial paper coatings, the amount of expensive amphoteric latex can be reduced while achieving best available printing quality.

• Journal of the Korean Ceramic Society
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• v.45 no.12
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• pp.827-831
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• 2008

Spark plasma sintering (SPS) of AlN ceramics were carried out with ${Y_2}{O_3}$ as sintering additive at a sintering temperature $1,550{\sim}1,700^{\circ}C$. The effect of ${Y_2}{O_3}$ addition on sintering behavior and thermal conductivity of AlN ceramics was studied. ${Y_2}{O_3}$ added AlN showed higher densification rate than pure AlN noticeably, but the formation of yttrium aluminates phases by the solid-state reaction of ${Y_2}{O_3}$ and ${Al_2}{O_3}$ existed on AlN surface could delay the densification during the sintering process. The thermal conductivity of AlN specimens was promoted by the addition of ${Y_2}{O_3}$ up to 3 wt% in spite of the formation of YAG secondary phase in AlN grain boundaries because ${Y_2}{O_3}$ addition could reduced the oxygen contents in AlN lattice which is primary factor of thermal conductivity. However, the thermal conductivity rather decreased over 3 wt% addition because an immoderate formation of YAG phases in grain boundary could decrease thermal conductivity by a phonon scattering surpassing the contribution of ${Y_2}{O_3}$ addition.