• Archives of Pharmacal Research
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• v.29 no.8
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• pp.699-706
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• 2006

The present study evaluated antioxidant and neuroprotective activities of hesperidin, a flavanone mainly isolated from citrus fruits, and its aglycone hesperetin using cell-free bioassay system and primary cultured rat cortical cells. Both hesperidin and hesperetin exhibited similar patterns of 1,1-diphenyl-2-picrylhydrazyl radical scavenging activities. While hesperidin was inactive, hesperetin was found to be a potent antioxidant, inhibiting lipid peroxidation initiated in rat brain homogenates by $Fe^{2+}$ and L-ascorbic acid. In consistence with these findings, hesperetin protected primary cultured cortical cells against the oxidative neuronal damage induced by $H_2O_2$ or xanthine and xanthine oxidase. In addition, it was shown to attenuate the excitotoxic neuronal damage induced by excess glutamate in the cortical cultures. When the excitotoxicity was induced by the glutamate receptor subtype-selective ligands, only the N-methyl-D-aspartic acid-induced toxicity was selectively and markedly inhibited by hesperetin. Furthermore, hesperetin protected cultured cells against the $A_{{\beta}(25-35)}-induced$ neuronal damage. Hesperidin, however, exerted minimal or no protective effects on the neuronal damage tested in this study. Taken together, these results demonstrate potent antioxidant and neuroprotective effects of hesperetin, implying its potential role in protecting neurons against various types of insults associated with many neurodegenerative diseases.

• Steel and Composite Structures
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• v.47 no.1
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• pp.121-134
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• 2023

This paper tested 11 concrete-encased concrete-filled steel tube (CFST) composite columns and one reinforced concrete column under combined axial compression and lateral loads. The primary parameters, including the loading system, axial compression ratio, volume stirrup ratio, diameter-to-thickness ratio of the steel tube, and stirrup form, were varied. The influence of the parameters on the failure mode, strength, ductility, energy dissipation, strength degradation, and damage evolution of the composite columns were revealed. Moreover, a two-parameter nonlinear seismic damage model for composite columns was established, which can reflect the degree and development process of the seismic damage. In addition, the relationships among the inter-story drift ratio, damage index and seismic performance level of composite columns were established to provide a theoretical basis for seismic performance design and damage assessments.

• Nuclear Engineering and Technology
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• v.56 no.4
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• pp.1250-1253
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• 2024

Activity measurement of the primary circuit water of fission reactors is one method that can provide early detection of a damaged fuel assembly in the reactor core. This is an important aspect in the safe operation of the reactor and for radiation protection of staff. Radionuclides in the primary circuit water are produced by the activation of stable nuclides and the fission of fissile nuclides, mainly the isotope ²³⁵U. In the LVR-15 research reactor, measurement of the activity of the primary circuit water has been regularly undertaken since 1996. A water sample is taken from the primary circuit every week and the activities are measured four days later using gamma spectrometry. The results of these long-term measurements from 1996 to 2022 are presented. The activity time dependences of the individual radionuclides are discussed in relation to fuel assembly damage and for events connected to contamination of the water by objects inserted into the primary circuit during experiments carried out near the reactor core.

• Journal of the Earthquake Engineering Society of Korea
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• v.27 no.2
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• pp.119-127
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• 2023

In this paper, seismic performance evaluation was carried out for eight circular reinforced concrete columns designed seismically by KRTA[1]and KCI[8]. Primary design parameters for such columns included many longitudinal reinforcements, yield strength of reinforcements, the vertical spacing of spirals, aspect ratio, and axial force ratio. The test results showed that all the columns exhibited stable hysteretic and inelastic responses. Based on the test results, drift ratios corresponding to each damage state, such as initial yielding, initial cover spalling, initial core concrete crushing, buckling, and fracture of longitudinal reinforcement and final spalled region, were evaluated. Then, those ratios were compared with widely accepted damage limit states. The comparison revealed that the existing damage states were considerably conservative. This implies that additional research is required for the damage limit states of such columns designed seismically by current Korean design codes.

• YAKHAK HOEJI
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• v.49 no.1
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• pp.30-37
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• 2005

Xuesaitong Ruanjiaonang (XR), a soft capsule containing Panax notoginseng saponins as main ingredients, is believed to remove extravasated blood and increase cerebral blood flow by improving blood circulation, and therefore, has been used in China to treat ischemic stroke or hemiplegia caused by cerebral thrombosis. To characterize pharmacological actions of XR, the present study evaluated its effects on neuronal cell damage induced by various oxidative insults or excitotoxic amino acids in primary cultured rat cortical cells. The neuronal cell viability was not affected by XR with the exposure for 2 h at the concentrations tested in this study ($10{\sim}1000\;{\mu}g/ml$). However, significant reduction of the cell viability was observed when the cultured cells were exposed to XR at $1000\;{\mu}g/ml$ for 24 h. XR was found to concentration-dependently inhibit the oxidative neuronal damage induced by $H_{2}O_2$, xanthine/xanthine oxidase or $Fe^{2+}$/ascorbic acid. In addition, it dramatically inhibited the excitotoxic damage induced by glutamate or N-methyl-D-aspartate (NMDA). We found that the NMDA-induced neurotoxicity was inhibited more effectively and potently than the glutamate-induced toxicity. Moreover, XR was found to exert mild inhibition of lipid peroxidation induced by $Fe^{2+}$/ascorbic acid in rat brain homogenates and some 1,1-diphenyl-2-picrylhydrazyl radical scavenging activity. Taken together, these results demonstrate neuroprotective and antioxidant effects of XR, showing inhibition of oxidative and excitotoxic damage in the cultured cortical neurons, as well as inhibition of lipid peroxidation and its radical scavenging activity. Considering that excitotoxicity and oxidative stress pl ay crucial roles in neuronal cell damage during ischemia and reperfusion, these results may provide pharmacological basis for its clinical usage to treat ischemic stroke.

• Korean Journal of Construction Engineering and Management
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• v.20 no.2
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• pp.44-52
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• 2019

The frequency and severity of damage caused by extreme climate events are increasing due to climate change. If the infrastructure is not prepared for the risks of climate change, property loss may occur in the facility itself and its surrounding areas. Therefore, climate change adaptation technology should be introduced to reduce future losses. Policy makers need to understand the economic impacts of each technology in order to select an appropriate option. Both the primary damage, which is the direct damage to the facility, and the secondary damage, which is the damage to the surrounding area due to climate change, should all be identified for understanding the economic impact from adaptation. This paper presents a procedure for deriving primary and secondary damage reductions from introducing adaptation technologies and suggests a methodology for evaluating adaptation technology specific to each infrastructure.

• The Korean Journal of Physiology and Pharmacology
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• v.15 no.6
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• pp.353-361
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• 2011

In this study, cyanidin-3-glucoside (C3G) fraction extracted from the mulberry fruit (Morus alba L.) was investigated for its neuroprotective effects against oxygen-glucose deprivation (OGD) and glutamate-induced cell death in rat primary cortical neurons. Cell membrane damage and mitochondrial function were assessed by LDH release and MTT reduction assays, respectively. A time-course study of OGD-induced cell death of primary cortical neurons at 7 days in vitro (DIV) indicated that neuronal death was OGD duration-dependent. It was also demonstrated that OGD for 3.5 h resulted in approximately 50% cell death, as determined by the LDH release assay. Treatments with mulberry C3G fraction prevented membrane damage and preserved the mitochondrial function of the primary cortical neurons exposed to OGD for 3.5 h in a concentration-dependent manner. Glutamate-induced cell death was more pronounced in DIV-9 and DIV-11 cells than that in DIV-7 neurons, and an application of $50{\mu}M$ glutamate was shown to induce approximately 40% cell death in DIV-9 neurons. Interestingly, treatment with mulberry C3G fraction did not provide a protective effect against glutamate-induced cell death in primary cortical neurons. On the other hand, treatment with mulberry C3G fraction maintained the mitochondrial membrane potential (MMP) in primary cortical neurons exposed to OGD as assessed by the intensity of rhodamine-123 fluorescence. These results therefore suggest that the neuroprotective effects of mulberry C3G fraction are mediated by the maintenance of the MMP and mitochondrial function but not by attenuating glutamate-induced excitotoxicity in rat primary cortical neurons.

• The Journal of the Convergence on Culture Technology
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• v.3 no.2
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• pp.37-42
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• 2017

An internet primary bank, which is formed by internet and banks combined, is called the essence of fin-tech, and is currently experiencing rapid growth. 'K-Bank' and 'Kakao Bank', the representative internet primary banks this year, received positive responses as the origin of financial revolution. internet primary banks provide convenient financial services, benefits in time and money for customers. Not long ago, however, undesirable fraud cases caused by a used commodity dealer have happened. The damage exceeds 20,000,000 won. It is because the newborn banks are unable to check the fraud history through the bank account. In this paper, We will analyze the trend in internet primary banks, offer damages and examples, in addition, prevention of damage, and strategies for development.

• Earthquakes and Structures
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• v.22 no.4
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• pp.387-399
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• 2022

To study the seismic damage of masonry structures and understand the characteristics of the multi-intensity region, according to the Dujiang weir urbanization of China Wenchuan earthquake, the deterioration of 3991 masonry structures was summarized and statistically analysed. First, the seismic damage of multistory masonry structures in this area was investigated. The primary seismic damage of components was as follows: Damage of walls, openings, joints of longitudinal and transverse walls, windows (lower) walls, and tie columns. Many masonry structures with seismic designs were basically intact. Second, according to the main factors of construction, seismic intensity code levels survey, and influence on the seismic capacity, a vulnerability matrix calculation model was proposed to establish a vulnerability prediction matrix, and a comparative analysis was made based on the empirical seismic damage investigation matrix. The vulnerability prediction matrix was established using the proposed vulnerability matrix calculation model. The fitting relationship between the vulnerability prediction matrix and the actual seismic damage investigation matrix was compared and analysed. The relationship curves of the mean damage index for macrointensity and ground motion parameters were drawn through calculation and analysis, respectively. The numerical analysis was performed based on actual ground motion observation records, and fitting models of PGA, PGV, and MSDI were proposed.

• Structural Engineering and Mechanics
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• v.72 no.3
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• pp.313-327
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• 2019

Damage evolution in the form of void nucleation, propagation and coalescence is the primary cause that is responsible for the ductile failure of microalloyed steels. The Gurson-Tvergaard-Needleman (GTN) damage model has proven to be extremely robust for characterizing the microscopic damage behavior of ductile metals. Nonetheless, successful applications of the model on a given metal type are limited by the correct identification of damage parameters as well as the validation of the calculated void growth rate. The purpose of this study is two-fold. First, we aim to identify the damage parameters of the GTN model for Q345 steel (Chinese code), due to its extensive application in mechanical and civil industries in China. The identification of damage parameters is facilitated by the well-suited response surface methodology, followed by a complete analysis of variance for evaluating the statistical significance of the identified model. Second, taking notched Q345 cylinders as an example, finite element simulations implemented with the identified GTN model are performed in order to analyze their microscopic damage behavior. In particular, the void growth rate predicted from the simulations is successfully correlated with experimentally measured acoustic emissions. The quantitative correlation suggests that during the yielding stage the void growth rate increases linearly with the acoustic emissions, while in the strain-hardening and softening period the dependence becomes an exponential function. The combined experimental and finite element approach provides a means for validating simulated void growth rate against experimental measurements of acoustic emissions in microalloyed steels.