• The Korean Journal of Physiology and Pharmacology
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• v.19 no.4
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• pp.357-363
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• 2015

The purpose of this study was to compare the inhibitory effect of bevacizumab on human Tenon's fibroblasts (HTFs) cultured from primary and recurrent pterygium. Cultured HTFs were exposed to 2.0, 5.0, 7.5, and 15.0 mg/mL concentration of bevacizumab for 24 hours. The 3-[4,5-dimethylthiazol- 2-yl]-2,5-diphenyl tetrazolium bromide and lactate dehydrogenase leakage assays were then performed to assess fibroblast metabolism and viability. The matrix metalloproteinase (MMP), procollagen type I C terminal propeptide (PIP), and laminin immunoassays were performed to examine extracellular matrix production. Changes in cellular morphology were examined by phase-contrast and transmission electron microscopy. Both metabolic activity and viability of primary and recurrent pterygium HTFs were inhibited by bevacizumab in a dose-dependent manner, especially at concentrations greater than 7.5 mg/mL. Both types of HTFs had significant decreases in MMP-1, PIP, and laminin levels. Distinctly, the inhibitory effect of bevacizumab on MMP-1 level related with collagenase in primary pterygium HTFs was significantly higher than that of recurrent pterygium. Significant changes in cellular density and morphology both occurred at bevacizumab concentrations greater than 7.5 mg/mL. Only primary pterygium HTFs had a reduction in cellular density at a bevacizumab concentration of 5.0 mg/mL. Bevacizumab inhibits primary and recurrent pterygium HTFs in a dose-dependent manner, especially at concentrations greater than 7.5 mg/mL. As the primary HTFs produces larger amounts of MMP-1 compared to recurrent HTFs, significant reduction in MMP-1 level in primary pterygium HTFs after exposure to bevacizumab is likely to be related to the faster cellular density changes in primary pterygium HTFs.

• Biomolecules & Therapeutics
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• v.23 no.4
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• pp.327-332
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• 2015

Primary cilia have critical roles in coordinating multiple cellular signaling pathways. Dysregulation of primary cilia is implicated in various ciliopathies. To identify specific regulators of autophagy, we screened chemical libraries and identified mefloquine, an anti-malaria medicine, as a potent regulator of primary cilia in human retinal pigmented epithelial (RPE) cells. Not only ciliated cells but also primary cilium length was increased in mefloquine-treated RPE cells. Treatment with mefloquine strongly induced the elongation of primary cilia by blocking disassembly of primary cilium. In addition, we found that autophagy was increased in mefloquine-treated cells by enhancing autophagic flux. Both chemical and genetic inhibition of autophagy suppressed ciliogenesis in mefloquine-treated RPE cells. Taken together, these results suggest that autophagy induced by mefloquine positively regulates the elongation of primary cilia in RPE cells.

• Journal of Korean Neurosurgical Society
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• v.60 no.1
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• pp.40-46
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• 2017

Objective: To assess role of some inflammatory mediators in patients with primary and recurrent lumbar disc herniation. Expression of IL-6, transforming growth factor (TGF)-1, insulin-like growth factor (IGF)-1, and Bcl-2-associated X protein (BAX) have been shown to be more intense in the primary group than the recurrent goup, but this mediators may be important aspects prognostic. Methods: 19 patients underwent primary and revision operations between June 1, 2009 and June 1, 2014, and they were included in this study. The 19 patients' intervertebral disc specimens obtained from the primary procedures and reoperations were evaluated. Expression of IL-6, TGF-1, IGF-1, and BAX were examined immunohistochemically in the 38 biopsy tissues obtained from the primary and recurrent herniated intervertebral discs during the operation. Results: For IL-6 expression in the intervertebral disc specimens, there was no difference between the groups. The immunohistochemical study showed that the intervertebral disc specimens in the primary group were stained intensely by TGF-1 compared with the recurrent group. Expression of IGF-1 in the primary group was found moderate. In contrast, in the recurrent group of patients was mild expression of IGF-1. The primary group intervertebral disc specimens were stained moderately by BAX compared with the recurrent group. Conclusion: The results of our prognostic evaluation of patients in the recurrent group who were operated due to disc herniation suggest that mediators may be important parameters.

• Journal of Family Relations
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• v.21 no.3
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• pp.3-23
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• 2016

Objectives: The purpose of this study is to examine the effects of symptoms of dementia elderly on the primary caregiver's depression. In addition, moderating effect of family support was examined. Based on the results, the necessity for intervention in the level of social welfare as a way to mitigate primary caregiver's depression was suggested. Method: In order to accomplish these purposes, a total of 197 who are spouse and adult-children of dementia elderly using day care facilities or services in Seoul, Gyeonggi, Busan province, South Korea were utilized. Data were analyzed by frequency analysis and descriptive statistics, regression model analysis with SPSS 18.0. Results: In case of analysis results, the mean value was reported 0.9 out of four point about primary caregiver's depression and the mean value of family support was reported 3.34 out of five point. And besides, the analysis result of dementia elderly's symptoms showed that prevalence of depression/dysphoria were 62.2%, prevalence of aberrant motor were 61.3%, prevalence of apathy/indifference were 56.6%. Crucial findings are as follows: the symptoms of dementia elderly was significantly associated with the primary caregiver's depression. At the same time, family support significantly influenced lower level of the primary caregiver's depression. While, in the relationship between the symptoms of dementia elderly and the primary caregiver's depression, family support has a moderation effect by important protection factor. Conclusions: From these findings, the necessities to provide the care service for dementia elderly to help improve symptoms of dementia as well as the policy and service to manage the mental health of the family as primary caregiver were suggested. Also, the necessities to provide the family therapy program to improve the relationship with family members were suggested.

• The Journal of Korean Obstetrics and Gynecology
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• v.35 no.3
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• pp.122-136
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• 2022

Objectives: The aim of this study is to investigate Heart Rate Variability (HRV) characteristics of patients with primary dysmenorrhea at the menstrual phase. Methods: 7 databases (Pubmed, Cochrane library, CNKI, RISS, KISS, OASIS, ScienceON) were searched for eligible studies published before 2021 December. The studies comparing HRV between patients with primary dysmenorrhea and controls were included. A random-effects model was used to evaluate differences of HRV parameters between patients with primary dysmenorrhea and controls. Results: 4 articles were included in this review based on inclusion and exclusion criteria. SDNN (Standard deviation of NN intervals), RMSSD (Square root of the mean squared difference of successive NN intervals), mean PR (Mean of pulse rate), LF (Low frequency), HF (High frequency), was the most frequently used as HRV parameters. RMSSD was significantly lower in patients with primary dysmenorrhea than controls. There was no statistically significant difference of other HRV parameters between patients with primary dysmenorrhea and controls. Conclusions: This study suggests that parasympathetic activity and overall functions of autonomic nervous system might be decreased in patients with primary dysmenorrhea at the menstrual phase. In the future, well-designed clinical studies using HRV and additional meta-analysis should be conducted to obtain a wealth of information about HRV characteristics of patients with primary dysmenorrhea.

• Journal of the korean academy of Pediatric Dentistry
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• v.51 no.1
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• pp.11-21
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• 2024

This study aimed to analyze the prevalence and severity of infraoccluded primary molars (IPM) and their correlation with the agenesis of permanent successors (APS). A total of 4,011 panoramic radiographs from children aged 4 to 11 years who had all 8 primary molars were examined. The prevalence of APS was analyzed based on the severity and tooth type of IPM. The prevalence of IPM was 13.0%, and there was no difference between genders. The majority of the children had two IPMs each. In all tooth types, mild infraocclusion was the most prevalent, whereas severe infraocclusion was the least frequent. Among the types of primary molars, the lower primary first molar (62.3%) was the most affected, followed by the lower primary second molar (27.7%), the upper primary second molar (5.8%), and the upper primary first molar (4.2%). Infraocclusion was 11.2 times more prevalent in the mandible than in the maxilla, with no significant difference between the left and right sides. The correlation between IPM and APS was also investigated. Among the subjects, 177 had one or more agenesis of premolars, of whom 54 (30.5%) had IPM. Additionally, among the 521 individuals with IPM, 54 individuals exhibited APS (10.4%). This study identified a noteworthy prevalence of infraocclusion, with notable variations among molar types. The LPFM was particularly affected. The majority of cases were classified as mild in severity. Furthermore, a compelling association between IPM and APS was established. Understanding this connection may enhance treatment strategies for infraoccluded teeth and tooth agenesis.

• Tribology and Lubricants
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• v.27 no.5
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• pp.240-248
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• 2011

Mechanical face seal installed in primary heat transport pump used for heavy water reactor prevents leakage of working fluid using thin working fluid film between primary seal ring and mating ring. If the leakage of working fluid exceeds the allowable volume, serious accident can be happened by the trouble of primary heat transport pump. The thinner fluid film exists between primary seal ring and mating ring, the less working fluid leaks out. On the other hand, if the thickness of fluid film is not enough, the life of mechanical face seal will be reduced by friction and wear. Therefore appropriate design is necessary to maximize the performance and life of mechanical face seal. In this study, numerical analysis using finite volume method was conducted to investigate the performance of mechanical face seals which have same deep straight groove and 11 different net coning values. As results, equilibrium clearance between primary seal ring and mating ring, leakage volume of working fluid, friction torque on sealing surface and stiffness of working fluid film were obtained. With increasing net coning value, equilibrium clearance and leakage volume increase, and friction torque and stiffness of fluid film decrease.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.7 no.11
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• pp.2561-2576
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• 2013

The ship ad-hoc network (SANET) extends the coverage of the high data-rate terrestrial communications to the ships with the reduced cost in maritime communications. Cognitive radio (CR) has the ability of sensing the radio environment and dynamically reconfiguring the operating parameters, which can make SANET utilize the spectrum efficiently. However, due to the dynamic topology nature and no central entity for data fusion in SANET, the interference brought into the primary network caused by the hidden primary user requires to be carefully managed by a sort of decentralized cooperative spectrum sensing schemes. In this paper, we propose a self-weighted decentralized cooperative spectrum sensing (SWDCSS) scheme to solve such a problem. The analytical and simulation results show that the proposed SWDCSS scheme is reliable to detect the primary user in SANET. As a result, secondary network can efficiently utilize the spectrum band of primary network with little interference to primary network. Referring the complementary receiver operating characteristic (ROC) curves, we observe that with a given false alarm probability, our proposed algorithm reduces the missing probability by 27% than the traditional embedded spectrally agile radio protocol for evacuation (ESCAPE) algorithm in the best condition.

• Research in Mathematical Education
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• v.9 no.4 s.24
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• pp.317-328
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• 2005

The aim of this study is to investigate future teachers' skills that can make problem solving methods concrete for 7-11 year old students. For the students in the concrete operations level, solutions of word problems should also be taught by concreting. But most of teacher candidates can not solve the problems without algebra because they got used to solve the word problems with algebra during their high school and university education. In this study, whether the teacher candidates have the skills of solving the primary school level problems without using algebra or not are being observed. At the end of this observation it is determinated that primary level teacher candidates generally prefer using algebra operations because of their former habits. The results show that in the education of the primary level teacher candidates, there is the need of developing the solving skills using figures and diagrams without algebra rather than algebraic solutions in word problems.

• Journal of the Korean Society of School Health
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• v.32 no.3
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• pp.152-164
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• 2019

Purpose: This study was a descriptive methodological study to develop protocols for school health practice to manage health problems of primary school students effectively. Methods: The protocols were verified by 12 experts and 10 health teachers, respectively, to secure a two-step content validity. Results: The main 8 health problems of primary school students were headache, abdominal pain, musculo-skeletal, respiratory, circulatory, ophthalmic, and oral-dental problems, and fever. The developed protocols consist of 8 algorithms, which are to help decision making in the course of assessing health problems and to identify and link related factors and associated symptoms, 8 school nursing records based on the Omaha classification system, and the list of 441 links between nursing assessment and nursing intervention. Conclusion: The use of the protocols is expected to make it easier for health teachers to apply the nursing process in solving the health problems of primary school students and supporting the rational decision making process, eventually improving the quality of primary school health. Repeated studies for protocol standardization as well as studies dealing with various health problems not included in the protocols should be performed for the development of school health practice protocols.