• Title/Summary/Keyword: preventive repair

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Effects of Flavonol Derivatives on the Micronudei Formation by N-methyl-N'-nitro-N-nitrosoguanidine and the Enhancement of Bleomycin-induced Chromosome Aberration by N-methyl-N'-nitro-N-nitrosoguanidine

  • Heo, Moon-Young;Kwon, Chang-Ho;Sohn, Dong-Hun;Lee, Su-Jun;Kim, Sung-Wan;Kim, Jung-Han;William W. Au
    • Archives of Pharmacal Research
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    • v.16 no.3
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    • pp.196-204
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    • 1993
  • Flavonol derivatives were tested for their anticlastogenic effect against induction of micronuclei by n-methyl-n'-nitor-n-nitorsoguanidine(MNNG), and against induction of chromosome aberration by bleomycin or MNNG.belomycin. For micronudeus assay, each flavonol derivative (0, 0.001, 0.01, 0.1, 1, 10 and 100 mg/kg) was administered orally twice with 24 h interval, together with intraperitioneally administered MNNG(150 mg/kg). The result showed that msot flavonol derivatives tested were effective in suppresing the frequencies of micronude induced by MNNG. For chromosome aberration assy, each flavonol derivative (0, 0.1, 1, 10m and 100 mg/kg)was administered to mice orally in vivo, and then mice were sacrificed and spleen lymphocyte cultures were made. Bleomycin $(3\;\mu$g/ml) was treated to the mouse spleen hymphocyte cultures at 24 h after con A initiation. There wre nomarked decrease tendencies in chromosome aberration unless all doses of galangin and some doses of several flavonol derivatives tested. In the another experiment, we have evaluated the effect of flavonol derivatives on the enhancement of bleomycin-induced chromsome aberration by MNNG. Most of flavonol derivtives reduced the incidence of chromosome aberration induced by in vitro treatment of bleomycin followed by in vivo treatment of MNNG. Galangin particulary showed a dose-dependent decrease tendency. Other flavonol derivative showed slightly suggest that most of flavonol derivatives may be capable of protecting the inhibition of suggest that most of flavonol derivatives may be capable of protecting the inhibition of DNA-repair by MNNG. Our data indicate clearly that flavonol derivatives can suppress MNNG-induced genotoxicity such as an induction of MNPCEs. Therfore, our results could suggest that flavonol derivtives may be useful as a chemopreventive agent of MNNG.

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A SURVEY OF THE TREATMENT IN FREE MOBILE DENTAL CLINIC AT THE DISABLED RESIDENTIAL FACILITES (SURVEY OF FREE MOBILE DENTAL CLINIC: AT DISABLED RESIDENTIAL FACILITES) (장애인 거주시설을 방문하여 시행한 무료 이동식 치과 진료에 대한 2014년 통계 (시설거주장애인을 대상으로 한 이동치과진료에 대한 통계))

  • Lim, Hyun soo;Lee, Hyo-Seol;Choi, Sung Chul;Lee, Eun young;Kim, Kwang Chul
    • The Journal of Korea Assosiation for Disability and Oral Health
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    • v.11 no.2
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    • pp.58-61
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    • 2015
  • The people with disabilities living in residential facilities have more difficulty in caring oral hygiene than those living at home. The purpose of this study is to evaluate the recent 2014 dental treatment records of free mobile dental clinic service for disabled people in Korea. 203 disabled living in residential facilities participated in mobile dental clinic. Patients classified according to types of disability. Mental retardation were 75.3%, mental disorder were 6.0%, crippled disorder were 7.4%, brain disorder were 6.5%, visual disorder were1.4%, auditory and speech disorder were 2.3% and autism disorder were 0.9%. Performed treatments were 99 scaling and curettage, 88 fluoride varnish and TBI, 4 extraction, 1 endodontic treatment, 16 caries control (resin filling, GI filling), 1 denture repair and 8 refuse the treatment. Free mobile dental clinic can not provide complex dental treatment. So, the organization should systemize advanced dental treatment and regular preventive programs. Furthermore, we need to have a more concerns about the people with disabilities living in residential facilities and constantly participate on a dental voluntary work.

Standardization of maintenance and failure of Transfer Crane (Transfer Crane의 고장 및 정비 작업 표준화)

  • Yun Won-Young;Lee You-Hyoun;Ha Young-Ju;Kim Gui-Rae;Son Beom-Sin
    • Proceedings of the Korean Institute of Navigation and Port Research Conference
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    • 2006.06b
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    • pp.363-366
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    • 2006
  • In the port, Yard Crane is very important. If container crane or transfer crane broke down, it costs much money for delaying of work during the period of repair or reorder. But, we can not have enough spare parts for its high cost. It is necessary for having the reliability of crane through the effective preventive maintenance and failure analysis. In this paper, we analysed the system's function and failure mechanism of transfer crane which is main equipment in the yard. Also, we standardized the failure and maintenance work using the historical data of failure and maintenance. This study which is the basic work for IT of equipment operation and maintenance is going to be new attempt for optimal design of next generation equipment and operation policy of equipment.

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Survey of Farmers' Perception and Behavior for Agricultural Water Saving - Applying to Irrigation Facility Monitors in Pohang and Yeongdeok Areas - (농업용수 물절약에 대한 농업인 의식 및 행동 조사 - 포항·영덕지역 수리시설감시원을 대상으로 -)

  • Lee, Seul-Gi;Choi, Kyung-Sook
    • Journal of Korean Society of Rural Planning
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    • v.26 no.3
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    • pp.39-47
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    • 2020
  • While agricultural water has been declared free in Korea to ensure access to these limited resource since the year 2000, farmers have however developed lackadaisical behavior towards water saving leading to its scarcity. To overcome this problem, a variety of experience-oriented education model was developed for farmers to promote the adoption of water conservation, and preventive measure against the drought impacts. In this study, farmers' awareness and their attitudinal behavior of agricultural water savings were investigated. The monitoring of water supply structure and the repair facilities in Pohang and Yeongdeok areas were conducted. The field visits and behavioral surveys showed a high degree of over-use and illegal water withdrawals by the farmers due to poor water-saving and management practices. We found that most of the KRC employees strongly admitted the necessity of water-saving education. On the other hand, the farmers showed good interest in the implementation of water-saving awareness through education. Besides this, most farmers agreed to adopt water-saving practices in the fields. Farmers also acknowledged the recklessness of water use was due to the aging of waterways, poor water management, and illegal water consumption. The majority of the farmers responded against imposing the water-use tariffs. However, there was a low response to paying the water-use charge. Aging agricultural facilities and the lack of institutional penalties or incentives were the major obstacles in achieving efficient water-saving. Considering the current drought frequency, urgent water-saving education of farmers was deemed necessary to prepare the farming community against the water shortages. Based on the results of this study, we have to identify the irrigation practices of farmers and provide water-saving education to enforce more efficient use and management of agricultural water.

A Study on Corrosion Resistance of CA2-Mixed Paste (CA2 혼입 페이스트의 부식저항성에 관한 연구)

  • Kim, Jae-Don;Jang, Il-Young
    • Journal of the Korean Society of Industry Convergence
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    • v.25 no.2_2
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    • pp.289-297
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    • 2022
  • Deterioration in durability of structures due to the steel corrosion is difficult to determine whether or not corrosion is initiated and how much propagated, and moreover, repair and maintenance are not easy to deal with. Therefore, preventive treatments can be the best option to avoid the deterioration. Various methods for preventing corrosion of steel, such as electrochemical treatments, anti-corrosion agents and steel surface coatings, are being developed, but economic and environmental aspects make it difficult to apply them to in-situ field. Thus, the purpose of this study was to improve corrosion resistance by using CA-based clinker that are relatively simple and expected to be economically profitable Existing CA-based clinkers had problems such as flash setting and low strength development during the initial hydration process, but in order to solve this problem, CA clinker with low initial reactivity were used as binder in this study. The cement paste used in the experiments was replaced with CA2 clinker for 0%, 10%, 20%, and 30% in OPC. And the mixture used in the chloride binding test for the extraction of water-soluble chloride was intermixed with Cl- 0.5%, 1%, 2%, and 3% by weight of binder content. To evaluate characteristic of hydration heat evolution, calorimetry analysis was performed and simultaneously chloride binding capacity and acid neutralization capacity were carried out. The identification of hydration products with curing ages was verified by X-ray diffraction analysis. The free chloride extraction test showed that the chlorine ion holding ability improved in order OC 10 > OC 30 > OC 20 > OC 0 and the pH drop resistance test showed that the resistance capability in pH 12 was OC 0 > OA 10 > OA 20 > OA 30. The XRD analyses showed that AFm phase, which can affect the ability to hold chlorine ions, tended to increase when CA2 was mixed, and that in pH12 the content of calcium hydroxide (Ca(OH)2), which indicates pH-low resistance, decreased as CA2 was mixed

A Cohort Study of Incidence Rate and Causes of School Accidents in a Boys' Middle School in Taegu (남자중학교 학생의 학교사고 발생률과 사고원인에 관한 코호트 연구)

  • Park, Jung-Han;Park, Mi-Wha
    • Journal of Preventive Medicine and Public Health
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    • v.20 no.2 s.22
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    • pp.331-340
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    • 1987
  • To determine the incidence rate of school accidents and its associated factors, a cohort observation was carried out in a boys' high school of a total of 2,324 students for an academic year from March 1986 to February 1987. Data for accidents were collected by the author (school nurse) as students came to the school health station for treatment of accidental injury. Data for school activities were obtained from the diary of academic affairs. A total of 603 students made 1,126 visits to the station for accidental injury during the study period that gave an average 1.9 accidents per student. The average number of visits for accidental injury per day was 5.1 and the incidence rate of accidental injury was 2.2 per 1,000 student days. Each class had about 30 accidents on the average in a year. However there were two classes that had exceptionally high incidence rate of accidents; 54 accidents in one class where 10 athletes were assigned and 58 accidents in the other class where the teacher in charge was On vacation for two months. The highest incidence rate of accident was observed in June (3.4 per 1,000 student days) and the lowest rates were in December and February (1.5 and 0.7 per 1,000 student days, respectively) and there were no appreciable difference by day of week. Accidents were caused by mischief or carelessness of students in 62.2% and by the inappropriate tools and facilities of school in 18.6% . The accidents caused by tools and facilities were mainly due to the antiquated chairs and tables. Referral rate to hospital for severe injury was three times higher in cloudy days and five times higher in rainy days than in clear days. There was almost no accident during the examination period but increased after the examination. Based on these findings, following measures are recommended to prevent school accident: disperse the athletes throughout the classes: should the teacher in charge leave the class for a long period, replace with another teacher who is familiar with the class to keep order; replace or repair the inappropriate tools and facilities; and warn the students for the risk of accident or broadcast music or let the students have light physical exercise to relieve the tension in cloudy or rainy day and after examination.

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Development of Portable X-ray CT System II - CT Image Reconstruction of Wood using Density Distribution - (현장 적용이 가능한 X선 CT 시스템 개발 II- 밀도분포를 이용한 목재의 CT영상 구성 -)

  • Kim, Kwang-Mo;Lee, Sang-Joon;Lee, Jun-Jae
    • Journal of the Korean Wood Science and Technology
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    • v.34 no.1
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    • pp.23-31
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    • 2006
  • X-ray transit materials with straight path and the its intensity is proportional to the density of materials. Therefore, X-ray has been extensively used as a nondestructive evaluation (NDE) method in various fields. This study was carried out for development of a portable X-ray CT (computed-tomography) system to detect deteriorations of wood members in buildings. Based on the results of our previous study, a procedure of CT image reconstruction was established In order to verify the applicability of developed system, CT images of three wood disks were reconstructed by newly developed procedure and compared with the prototypes. From the results of this study, it was shown that the newly developed system could be used not only to determine the shape, size, and position of defects, but also to find the density distribution in cross section of wood structure members. The density distribution may be utilized to clarify the reason of wood deterioration and to provide the preventive method on how to treat or repair wood buildings. Because it was initial stage of system development, there were some limitations concerned with measuring equipment and image reconstruction algorithm. Especially, measuring time including equipment setup time was longer and measuring accuracy was lower than we expected. Therefore, we planned some additional studies on improvement of equipment and algorithm to enhance the capability of X-ray CT system.

Nonchange of Grounding Current due to Equipment Measuring Insulation Resistance (절연저항 측정 장치에 의한 지락사고 전류의 비변화)

  • Um, Kee-Hong;Lee, Kwan-Woo
    • The Journal of the Institute of Internet, Broadcasting and Communication
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    • v.15 no.3
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    • pp.175-180
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    • 2015
  • With progress in industrialization, facilities for generating, delivering, and receiving high levels of electric power are in great demand. The scale of electric power equipment is increasing in both size and complexity. This has contributed to the development of our modern, high-tech and information-based society. However, if the generation of electric power is suspended due to unexpected accidents at power facilities or power stations, a range of equipment the operations of which are dependent on electric power can be damaged, causing substantial socioeconomic losses in an industrial society. A great deal of time and money would be expended to repair damaged facilities at a power station, causing enormous economic loss.In order to detect the deterioration processes of power cables, and to prevent the destruction of power cables, the operation status of power cables should be monitored on a regular basis. We have installed equipment at Korea Western Power Co., Ltd., located in Taean, in order to predict and prevent the destruction of power cables. This is an entirely new installation: a set of equipment invented specifically to measure the insulation resistance of power cables. Installation of the equipment does not cause the flow of earth fault current. This ensures accurate measurement of insulation resistance values by the equipment. We have been studying this equipment in order to develop preventive technology that would show the deterioration processes of power cables.

A Study on the IT Outsourcing for Service Level Agreement in Public Agencies (공공기관에서의 서비스 수준 협약(SLA)에 따른 IT 아웃소싱에 관한 연구)

  • Lee, Sung Ho;Kim, Hee Wan;Kim, Dong Soo
    • Journal of Service Research and Studies
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    • v.2 no.1
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    • pp.47-59
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    • 2012
  • With the rapid development of the Internet, public agencies and private companies introduced 'IT outsourcing in order to maintain and repair the information systems. Also they have utilized the SLA in order to manage it. Although IT outsourcing as a way to promote effective SLA are being introduced, the introduction of service level agreements or those introduced universal effectiveness did not demonstrate in the public agencies. The importance of outsourcing in the information systems is growing, but the increase in size of the business information, IT technology diversification, expansion of information between systems interconnection, information system operating and maintenance costs with the increase of information systems to streamline operations, increase the need for versatility is growing gradually. In this paper we investigates IT outsourcing in public agencies as a way to promote effective service level agreement(SLA) with the introduction and consideration, and through the application of SLA mutual customers and IT service organizations make a clear point of management and IT service levels and IT services for improved mind and strengthen the effectiveness of preventive activities can be seen.

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Immunohistochemical Expression of O6-methylguanine-DNA Methyltransferase (MGMT) in Korean Patients with Non-Small Cell Lung Cancer. (한국인의 비소세포폐암종에서 O6-methylguanine-DNA methyltransferase (MGMT)의 발현도 분석)

  • Lee, Kyung-Eun;Hong, Young-Seoub;Choi, Phil-Jo;Roh, Mee-Sook
    • Journal of Life Science
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    • v.18 no.4
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    • pp.580-584
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    • 2008
  • $O^6-methylguanine-DNA$ methyltransferase (MGMT) is a DNA repair protein that protects cells against the carcinogenic effects of alkylating agents. The loss of MGMT expression was commonly known due to hypermethylation of CpG islands in its promoter region. We evaluated the expression of MGMT by immunohistochemistry in order to examine the relationship between loss of MGMT expression and clinicopathological characteristics in 74 Korean patients with non-small cell lung cancers. Loss of MGMT was detected in 25 (33.8%) of 74 cases. The loss of MGMT expression was frequently seen in the adenocarcinoma than in the squamous cell carcinoma (p=0.021). However, there was no significant differences between loss of MGMT expression and other clinicopathological characteristics, including age, gender, smoking status, tumor size, tumor T stage, and lymph node metastasis (p>0.05). In conclusion, loss of MGMT expression was related with the histologic type of lung cancer. Further methylation study of MGMT promoter is needed to evaluate the relationships with immunohistochemical expression of MGMT and to clarify the role of MGMT in lung cancer.