• 대한예방의학회:학술대회논문집
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• 2001.10a
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• pp.343-344
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• 2001

• 대한예방의학회:학술대회논문집
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• 2002.10a
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• pp.396-397
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• 2002

• Journal of Society of Preventive Korean Medicine
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• v.3 no.2
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• pp.91-100
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• 1999

Today, toxicology is used for many purpose, in many fields. Classification of special toxic effect is related next 4 important principles. 1. The chemical substance must move to target organ or tissue that can induce Biological effect. For this movement, we have to understand the physical-chemical characteristic of substance, and the rout of absorption, metabolism, diffusion and excretion of toxic substance. 2. Every biological effect that induced by chemical substance is not harmful. For example, some specific chemical substance is not harmful in liver enzyme system. 3. The strength of biological effect induced by chemical substance is deep related with dose. Nearly all substance is not effective below the specific dose, and it may toxic to death over the specific dose. It is the 'Dose - response relationship' But carcinogen may toxic whether it is law dose or not. 4. The information that was obtained by experimental animal test, could have to adapt in human biology. Because biological effect of chemical substance could be different in every biological species. In past, drugs was obtained by animal or plants. But in the future, it could be obtained by biochemistry, and genome project. Therefore, in Oriental medicine, research and approach is needed at this time, and have to develop new method of experience in toxic method.

• Journal of Preventive Medicine and Public Health
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• v.32 no.4
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• pp.499-504
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• 1999

Objectives : To evaluate whether a relation between blood lead and zinc proto porphyrin(ZPP) was modified by gender in Korean lead workers. Methods : A cross-sectional study was conducted with 1,304 male and 101 female subjects in 1997. The relation between blood lead and ZPP were evaluated with linear, exponential, and quadratic models. Then, the different effect of gender on the relation was examined by adding the interaction terms in the each model. Results : $Mean{\pm}SD$ of blood lead and ZPP level was different between male$(27.7{\pm}10{\mu}g/dl\;and\;51.3{\pm}23.4{\mu}g/dl)$ and female subjects$(22.5{\pm}9.2{\mu}g/dl\;and\;78.7{\pm}38.6{\mu}g/dl)$. After adjusting for possible confounders, the effect modification by gender was significant in linear$(\beta=1.119,\;p<0.001)$, exponential$(\beta=Exp(0.008),\;p<0.05)$, and quadratic model$(\beta=1.388,\;p<0.001)$. In separate analysis, a quadratic relation between blood lead and ZPP was shown in male lead workers$(\beta=0.036,\;p<0.001)$, but an exponential relation in female lead workers$(\beta=Exp(0.029), p<0.001)$. Conclusion : Our data showed that the increasing rate of ZPP in female were always higher than in male lead workers, suggesting that females were more susceptible to occupational lead exposure than males.

• Journal of Preventive Medicine and Public Health
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• v.34 no.3
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• pp.262-268
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• 2001

Objectives : To integrate the results of studies which assess an association between blood lead and blood pressure. Methods : We surveyed the existing literature using a MEDLINE search with blood lead and blood pressure as key words, including reports published from January 1980 to December 2000. The criteria for quality evaluation were as follows: 1) the study subjects must have been workers exposed to lead, and 2) both blood pressure and blood lead must have been measured and presented with sufficient details so as to estimate or calculate the size of the association as a continuous variable. Among the 129 articles retrieved, 13 studies were selected for quantitative meta-analysis. Before the integration of each regression coefficient for the association between blood pressure and blood lead, a homogeneity test was conducted. Results : As the homogeneity of studies was rejected in a fixed effect model, we used the results in a random effect model. Our quantitative meta-analysis yielded weighted regression coefficients of blood lead associated with systolic blood pressure and diastolic blood pressure results of 0.0047 (95% confidence interval [CI]: -0.0061, 0.0155) and 0.0004 (95% CI: -0.0031, 0.0039), respectively. Conclusions : The published evidence suggested that there may be a weak positive association between blood lead and blood pressure, but the association is not significant.

• The Journal of Korean Society for School & Community Health Education
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• v.11 no.1
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• pp.27-39
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• 2010

Objectives: This study was conducted to find out caries preventive effect on permanent teeth among children who brush teeth with fluoride-containing toothpaste by supervised weekly fluoride mouthrinsing program in elementary schools. Methods: The epidemiologic dental survey was performed on the elementary schoolchildren of supervised weekly fluoride mouthrinsing program (FMR) with 0.2 percent neutral sodium fluoride solution and control group in 2007. Caries preventive effect on permanent teeth by fluoride mouthrinsing program were calculated by DMFT index and DMFS index between FMR group and control group. Results: By DMFT index between FMR group and control group, caries rates on permanent teeth of the fourth-, fifth- and sixth-grade children participating in FMR program were 34.1%, 40.8% and 31.5%, respectively. By the DMFS index between FMR group and control group, caries preventive rates on permanent teeth of the fourth-, fifth- and sixth-grade children participating in FMR program were calculated 25.4%, 37.7% and 33.5%, respectively. Conclusions: We suggest that fluoride mouthrinsing program should be developed to all elementary schools to prevent dental caries.

• Journal of Preventive Medicine and Public Health
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• v.37 no.4
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• pp.321-328
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• 2004

Objectives : The purpose of this study was to investigate the effect of genetic polymorphism of cytochrome P450 2E1 (CYP2E1) and aldehyde dehydrogenase 2 (ALDH2) on the xylene metabolism. Methods : Among 247 workers, 116 were occupationally exposed to xylene and 131 were not. Workers exposed to xylene had different work such as spray, touch-up, mix & assist, and pre-treat. Questionnaire variables were age, sex, use of personal protective equipment, smoking, previous night's drinking and work duration. The urinary methylhippuric acid was measured in the urine collected in the afternoon and corrected by urinary creatinine concentration. The genotypes of CYP2E1 and ALDH2 were investigated by using PCR-RFLP (polymerase chain reaction-restriction fragment length polymorphism) methods with DNA extracted from venous blood. Results : 1. The urinary concentrations of o-, m-, and p-methylhippuric acid and total methylhippuric acid in the exposed group were significantly higher than those in the non-exposed group (p<0.001). 2. In multiple regression analysis, the urinary methylhippuric acid concentration was significantly influenced by exposure grade (Job-exposure matrixes), smoking, drug use and kind of protective equipment (p<0.1). 3. Genetic polymorphism of CYP2E1 and ALDH2 did not affect urinary methylhippuric acid level in the exposed group (p>0.05). Conclusions : Exposure grade, smoking, drug use and kind of protective equipment affected urinary methylhippuric acid level, whereas genetic polymorphism of CYP2E1 and ALDH2 did not. However, further investigation for the effect of genetic polymorphism on the metabolism of xylene with a larger sample size is needed.

• Journal of Society of Preventive Korean Medicine
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• v.5 no.1
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• pp.103-115
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• 2001

Background : Gamisamryungbaekchul-san(加味蔘?白朮散) is a herbal medicine which has been used for the traditional therapeutic agent of augmentation of the spleen and reinforcement of the Qi. Objective : This Study was performed to investigate the effect of Gamisamryungbaekchul-san on the tumor and immune response in the moose B16 melanoma tumor model. Materials and Methods : The tumor was induced by subcutaneous inoculation of B16BL6 melanoma cells in the shaved dorsal region of mice. Mice were orally administered with Gamisamryungbaekchul-san extract(26.3mg/mouse) for 14days after inoculation. For making examination of antitumor effect, the Increase of life span, Tumor growth inhibition rate, change of body weight were measured and evaluated. For the immune response increasing effect, the percentage of T lymphocyte and B Lymphocyte in the peripheral blood, the percentage of CD4+ T-cell, CD8+ T-cell and CD4+/CD8+ ratio in the peripheral blood and spleen, interleukin-2 productivity were measured and evaluated. Results : Gamisamryungbaekchul-san showed 16.59% increase of life span, 31.64% tumor growth inhibition rate and increase of body weight. Gamisamryungbaekchul-san increased the percentage of T lymphocyte in the peripheral blood, CD4+ T cell percentage of peripheral blood and spleen, and Interleukin-2 productivity as compared with the Control group. Whereas Gamisamryungbaekchul-san had no effect on the percentage of B lymphocyte in the peripheral blood, the percentage of CD8+ T cell, CD4+/CD8+ T-cell ratio in both of peripheral blood and spleen as compared with the Control group. Conclusion : This study shows that Gamisamryungbaekchul-san has anti-tumor effects and immunoregulatory effects on the B16 melanoma tumor model. It is suggested that Gamisarmyungbaekchul-san could be a useful immunomodulator and anti-tumor agent.

• The Journal of the Convergence on Culture Technology
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• v.6 no.2
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• pp.369-386
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• 2020

The purpose of this study is to examine causality closely about the mediating effect of management entity's self-checking between effects that not only mobilization for regular patrol of the relevant administrative agency, but also checking for Preventive Safety Guidance have on fire correspondence. The results of the analysis are as follows: First, not only mobilization for regular patrol of the relevant administrative agency, but also preventive safety guidance all together have been revealed to have an positive effect on management entity's self-checking. Results of these analysis have been revealed that the more not only the number of mobilization for regular patrol of the relevant administrative agency, but also the numbers of preventive safety guidance and fire fighting safety supervisor's self-checking are many, the more capability of not only management entity, but also fire fighting safety supervisor's self checking heighten. Second, not only mobilization for regular patrol of the relevant administrative agency, but also checking investigation for preventive safety guidance have been revealed to have an positive effect on fire correspondence. Results of these analysis have been revealed that the more not only the number for regular patrol of the relevant administrative agency, but also the number of fire fighting safety supervisor's checking times for preventive safety guidance are many, the more fire correspondence for the apartment house are being fulfilled much better. Finally, it has been found that both mobilization for regular patrol of the relevant administrative agency and management entity's self-checking have an effect on fire correspondence. Therefore, the effect that the relevant administrative agency's mobilization for regular patrols and preventive safety guidance, and management entity's self-checking have on fire correspondence was analyzed into what the relevant administrative agency's mobilization for regular patrols and preventive safety guidance is not only significant to do self-checking of management entity at the first stage, but also the relevant administrative agency's mobilization for regular patrols, and preventive safety guidance, and management entity's self-checking have an mediating effect in the relation between influences that have on fire correspondence.

• Korean Journal of Health Education and Promotion
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• v.24 no.1
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• pp.1-16
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• 2007

Objctives: This study purposed to examine the intention to participate in the preventive program of depression of Internet user and to offer the baseline data for development of mental health promotion program. Methods: The internet survey was performed using a self-reported questionnaire on intention to participate in the preventive program of depression, depressive symptom(with Zung's SDS) and so forth from 1,000 internet user (aged $13{\sim}49$ years) via two web sites at Feb($1st{\sim}10th$), 2006. We analyzed the intention to participate in preventive program of depression and the factors related with that intention by depressive level. Results: In the normal group, the intention to participate in a preventive program of depression was influenced significantly by counselling experience(s) on depression(p<.001), and perceived control(p<.001) over the barriers to participation in the preventive program of depression, and marginally by gender. In the depressive group, the smoking habit revealed marginal effect(p=.051) and perceived control over the barriers to participation in the preventive program of depression influenced on that intention significantly(p<.001). Conclusion: Among internet users, especially the solutions of barriers to participate in the preventive program of depression is more important at the intervention program for prevention of depression. In the normal group, we need to consider the use of messages tailored by counselling experience(s) on depression. Some intervention program dealing with two subjects, smoking cessation and prevention of depression concurrently, will be appropriate for the depressive group.