Different Effect of Blood Lead on Zinc Protoporphyrin by Gender in Korean Lead Workers

연 폭로시 성별에 따른 혈중 Zinc Protoporphyrin의 양-반응 관계

  • Kim, Yong-Bae (Department of Preventive Medicine and Institute of Industrial Medicine, School of Medicine, Soonchunhyang University) ;
  • Lee, Gap-Soo (Department of Preventive Medicine and Institute of Industrial Medicine, School of Medicine, Soonchunhyang University) ;
  • Hwang, Kyu-Yoon (Department of Preventive Medicine and Institute of Industrial Medicine, School of Medicine, Soonchunhyang University) ;
  • Lee, Sung-Soo (Department of Preventive Medicine and Institute of Industrial Medicine, School of Medicine, Soonchunhyang University) ;
  • Ahn, Kyu-Dong (Department of Preventive Medicine and Institute of Industrial Medicine, School of Medicine, Soonchunhyang University) ;
  • Lee, Byung-Kook (Department of Preventive Medicine and Institute of Industrial Medicine, School of Medicine, Soonchunhyang University) ;
  • Ahn, Hyun-Cheol (Department of Preventive Medicine and Institute of Industrial Medicine, School of Medicine, Soonchunhyang University)
  • 김용배 (순천향대학교 의과대학 예방의학교실 및 산업의학연구소) ;
  • 리갑수 (순천향대학교 의과대학 예방의학교실 및 산업의학연구소) ;
  • 황규윤 (순천향대학교 의과대학 예방의학교실 및 산업의학연구소) ;
  • 이성수 (순천향대학교 의과대학 예방의학교실 및 산업의학연구소) ;
  • 안규동 (순천향대학교 의과대학 예방의학교실 및 산업의학연구소) ;
  • 이병국 (순천향대학교 의과대학 예방의학교실 및 산업의학연구소) ;
  • 안현철 (순천향대학교 의과대학 예방의학교실 및 산업의학연구소)
  • Published : 1999.12.01

Abstract

Objectives : To evaluate whether a relation between blood lead and zinc proto porphyrin(ZPP) was modified by gender in Korean lead workers. Methods : A cross-sectional study was conducted with 1,304 male and 101 female subjects in 1997. The relation between blood lead and ZPP were evaluated with linear, exponential, and quadratic models. Then, the different effect of gender on the relation was examined by adding the interaction terms in the each model. Results : $Mean{\pm}SD$ of blood lead and ZPP level was different between male$(27.7{\pm}10{\mu}g/dl\;and\;51.3{\pm}23.4{\mu}g/dl)$ and female subjects$(22.5{\pm}9.2{\mu}g/dl\;and\;78.7{\pm}38.6{\mu}g/dl)$. After adjusting for possible confounders, the effect modification by gender was significant in linear$(\beta=1.119,\;p<0.001)$, exponential$(\beta=Exp(0.008),\;p<0.05)$, and quadratic model$(\beta=1.388,\;p<0.001)$. In separate analysis, a quadratic relation between blood lead and ZPP was shown in male lead workers$(\beta=0.036,\;p<0.001)$, but an exponential relation in female lead workers$(\beta=Exp(0.029), p<0.001)$. Conclusion : Our data showed that the increasing rate of ZPP in female were always higher than in male lead workers, suggesting that females were more susceptible to occupational lead exposure than males.

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