• 한방재활의학과학회지
• /
• 제20권3호
• /
• pp.37-60
• /
• 2010

Objectives : The purpose of this study was to investigate the relationship between masseter and cervical muscle activity and temporomandibular disorder in female office workers. Methods : Experimental group of 24 healthy subjects complained of temporomandibular joint related to computer use which lasted more than 3 months in the past year and was present in the past 7 days as well as on the day of test. Control group of 20 healthy subjects had no complaints of minimal discomfort on the day of test, and had no discomfort in the past 7 days. If they had reported discomfort in the past 12 months, it was of a short duration(<3 months) and resolved at least 3 months prior to participation. Outcomes were assessed by meridian-electromyography(MEMG), whole spin x-ray, mandibular function impairment questionnaire(MFIQ), neck disability index(NDI), visual analog scale(VAS), Beck depression inventory(BDI), stress reaction inventory(SRI) and Holmes & Rahe social readjustment rating scale(SRRS). Results : The contraction power of masseter muscle, upper trapezius, sternocleido-mastoid muscle and erector spinae by MEMG was significantly higher in the experimental group. The muscle fatigue of masseter muscle and sternodeido-mastoid muscle by MEMG was significantly higher in the experimental group. SRI was significantly higher in experimental group. There was no significant difference between two groups in the Jackson's angle, Cobb's method and cranio-cervical posture. Conclusions : The results suggest that temporomandibular disorder related mental stress but physical stress does not change cervical structure significantly.

• 한국안전학회지
• /
• 제24권3호
• /
• pp.19-24
• /
• 2009

Currently the technique of composite material field is developed day by day. The many kinds industrial facility and life articles are coming to make with the composite material. But still the engineering works field the building and the bridge uses the material which is old era and is making. To here there is a various problem but the biggest problem the theory of the composite material is complicated too and means that the application is been delayed about constructive structure. When the composite material is used widely from constructive field, too with difficult theory in technical expert and easily with the research for the experiment data accumulation is necessary. The tensile and fatigue test of the carbon/epoxy which is a high-class composite material led from the present paper consequently and the change of the intensity coefficient which follows in repeated load researched.

• 대한한방내과학회지
• /
• 제32권2호
• /
• pp.278-287
• /
• 2011

Objectives : The object of this study was to observe the nephroprotective effects of Sojongchobisunki-tang (SCST), which has traditionally been used as Korean medicine for treating various renal diseases, on cisplatin-induced rat acute renal failure. Methods : Three different dosages of SCST were orally administered once a day for 23 days before cisplatin treatment (5 mg/kg, single intraperitoneally administered) and 5 days after cisplatin treatment (once a day for 28 days). 6 groups, of 8 rats per group were used in the present study after 7 days of acclimatization. Changes of the body weight, kidney weight, serum BUN and creatinine levels were observed, as well as changes of the kidney MDA and GSH contents. The results were compared with captopril 100 mg/kg of which the effects on cisplatin-induced acute renal failures are already confirmed. Results : Acute renal failure induced by cisplatin were induced by oxidative stress and related lipid peroxidation in the present study. However, these acute renal failures and inhibition of antioxidant effects induced by cisplatin were dose-dependently reduced by treatment at all three different dosages of SCST extracts. Conclusions : This study suggests that SCST extracts showed favorable effects on the cisplatin-induced rat ARF.

• The Korean Journal of Physiology and Pharmacology
• /
• 제14권5호
• /
• pp.345-352
• /
• 2010

The present study was undertaken to explore the potential of erythropoietin in memory deficits of mice. Memory impairment was produced by scopolamine (0.5 mg/kg, $i.p.$) and intracerebroventricular streptozotocin (i.c.v STZ, 3 mg/kg, $10{\mu}l$, $1^{st}$ and $3^{rd}$ day) in separate groups of animals. Morris water-maze test was employed to assess learning and memory. The levels of brain thio-barbituric acid reactive species (TBARS) and reduced glutathione (GSH) were estimated to assess degree of oxidative stress. Brain acetylcholinesterase enzyme (AChE) activity was also measured. Scopolamine/streptozotocin administration induced significant impairment of learning and memory in mice as indicated by marked decrease in Morris water-maze performance. Scopolamine/streptozotocin administration also produced a significant enhancement of brain AChE activity and brain oxidative stress (an increase in TBARS and a decrease in GSH) levels. Treatment of erythropoietin (500 and 1,000 IU/Kg i.p.) significantly reversed scopolamine- as well as streptozotocin-induced learning and memory deficits along with attenuation of those-induced rise in brain AChE activity and brain oxidative stress levels. It may be concluded that erythropoietin exerts a beneficial effect in memory deficits of mice possibly through its multiple actions including potential anti-oxidative effect.

• 유체기계공업학회:학술대회논문집
• /
• 유체기계공업학회 1998년도 강연회 및 연구개발 발표회 논문집
• /
• pp.11-28
• /
• 1998

Crack initiation and propagation of blades is a serious matter in turbomachinery. Outages are common due to these problems that occur during the service of the machine resulting in a huge loss of revenue. Once in a while, the problems become serious and cause major shutdowns which can in some cases result in the loss of the whole machine in a catastrophic manner. In this presentation, we will discuss the crack initiation studies of a hydraulic machine runner blade by local stress strain approach and crack propagation at the root of a low pressure stage steam turbine blade by means of stress intensity factor approach. In both the cases, we will show how the present day technologies can predict actual field observations.

• 대한한의진단학회지
• /
• 제16권3호
• /
• pp.49-58
• /
• 2012

Objectives: This research was designed to study the characteristics of heart rate variability in acute dyspepsia patients compared with normal group. Methods: The testing of HRV was carried out at Oriental Medical Center of ${\bigcirc}{\bigcirc}$University with the participation of 94 acute dyspepsia patients and 85 control group people. We checked HRV of the 2 groups that were checked on the first visit day and compared HRV index between groups. Results: In the frequency domain analysis, HF, LF, VLF, LF/HF ratio, TP were significantly lower than control group on acute dyspepsia patient group. HF, LF, VLF, LF/HF ratio, TP were not significantly associated with age. Conclusions: According to this study, autonomic nerve system was more decreased on the acute dyspepsia patient group compared with the control group. Though further studies will be needed, the present finding provide us the possibility that stress is a major cause of the acute dyspepsia along with food factor.

• 한국임상수의학회지
• /
• 제27권1호
• /
• pp.35-41
• /
• 2010

Among the dogs boarding at an animal hospital, 10 dogs each were selected as a free boarding group and a kennel boarding group. Each group was further divided into 5 puppies and 5 mature dogs to examine the changes in their serum cortisol concentrations during boarding (5 days). We collected blood at day 8 and then analyzed the blood corpuscles, ran a biochemical serum test, and an additional urine test before boarding to check their health status. After collecting the dog's blood at 9:00 am, 3:00 pm, and 9:00 pm, we analyzed the cortisol concentration by the radioimmunoassay (RIA) method. The daily serum cortisol concentration at 9:00 am, 3:00 pm, and 9:00 pm, had a circadian rhythm during both the free and kennel boarding periods in both puppies and adults. Furthermore, the average daily serum cortisol concentration was significantly increased during the 1st, 2nd, and 3rd day after free boarding in the puppy group (P < 0.01). In adults from the free boarding group, the serum cortisol concentration dramatically increased on the 1st day (P < 0.01), as well as on the 2nd and 3rd day (P < 0.05). Interestingly, the average daily serum cortisol concentration was significantly increased on the 1st day after kennel boarding as well as during the entire period of kennel boarding in the puppy group (P < 0.05). In the adult kennel boarding group, serum cortisol concentration was significantly increased during the whole kennel boarding period (P < 0.01). An interesting result was that circadian rhythmicity in the sum of the daily serum cortisol concentrations was present in the free boarding group, but not in the kennel boarding group in both puppies and adults. In summary, cortisol was released depending on the degree of stress in free and kennel boarded dogs. Taken together, these results suggest that cortisol, a stress hormone, should be maintained at physiological concentrations in a circadian rhythm when the animals are hospitalized.

• 한국작물학회:학술대회논문집
• /
• 한국작물학회 2017년도 9th Asian Crop Science Association conference
• /
• pp.236-236
• /
• 2017

Low soil pH causes from $H^+$ rhizotoxicity results in nutrients unavailability in the growing media, inhibits plant growth, development and reduces crop yields. The present study was carried out to reveal morpholophysiological and biochemical responses of wheat (Triticum aestivum L.) to acidity stress. Four wheat varieties viz. BARI Wheat-21, BARI Wheat-25, BARI Wheat-26 and BARI Wheat-30 were used in the study. Eight-day-old seedlings were exposed to different pH levels (3.5, 4.5, 5.5 and 6.5) of growing media. Acidity stress at any level reduced biomass, water, and chlorophyll contents in all the varieties; whereas BARI Wheat-26 showed the least damage. $H^+$ rhizotoxicity also caused oxidative stress through excess production of reactive oxygen species and methylglyoxal which increase lipid peroxidation in all the varieties but the lowest oxidative damage was observed in BARI Wheat-26 due to better performance of the antioxidant defense and glyoxalase systems. Considering the growth, physiological and biochemical attributes BARI Wheat-26 may be considered as acidity stress tolerant, among the variety examined.

• Journal of Oral Medicine and Pain
• /
• 제33권3호
• /
• pp.247-256
• /
• 2008

일상생활에서 우리는 항상 스트레스에 노출되어 있으며, 스트레스에 대한 반응은 우리 삶의 질과 건강에 중요한 영향을 미친다. 특히 정서적으로 중요한 구강안면영역에도 다양한 스트레스성 질환이 존재한다. 그러나 스트레스와 질병에 관한 오랜 연구에도 불구하고 스트레스성 구강안면질환의 병인은 아직 명확하지 않다. 이에 저자는 최근 임상의학에서 관심이 집중되어지고 있는 스트레스와 질병에 대한 분자생물학적 접근의 일환으로 스트레스성 구강안면질환의 병인을 규명하고자 본 연구에 임하였다. 즉, 스트레스 단백질로 알려진 clusterin이 스트레스의 생리적 반응으로서 세포보호작용 결과 발현된다는 사실에 기초하여, 스트레스 부여 후 타액선 조직 내에서의 그 발현변화를 추적하였다. Sprague-Dawley계 웅성 백서(200-230g/bw)를 구속 스트레스 부여군(구속장치에 구속한 후 0, 3, 5일에 희생) 및 정상군으로 나누고, 각각 악하선을 적출하였으며, 면역조직화학법 및 Northern Blot을 이용하여 Clusterin의 변화를 관찰하였다. 그 결과는 다음과 같다. 1. 구속 스트레스 부여군의 clusterin 단백질은 실험 즉일군에서 증가되었고, 그 이후에는 감소되었다. 2. 구속 스트레스 부여 3일군과 5일군에서 핵붕괴 및 핵농축 등의 핵변화를 동반한 apoptosis가 유도되었다. 3. 구속 스트레스 부여 결과, 선포세포가 도관세포보다 일찍 세포사하였다. 4. 구속 스트레스 부여군의 clusterin mRNA는 실험 즉일군에서만 미약하게 관찰되었다. 즉, 타액선 조직은 스트레스 단백질인 clusterin을 생산하여 세포를 보호함으로써 스트레스 상황에 적응하지만, 생리적 적응한계를 넘는 스트레스에 노출될 때에는 조직이 apoptosis됨이 확인되었다. 따라서, 본 연구결과는 구강건조증등 스트레스성 타액선관련 증상 및 질환의 병리적 기전에 대한 규명에 도움이 되리라고 생각하며, 또한 clusterin은 향후 생체에 가해진 스트레스에 대한 표식자(marker)로 사용될 수 있을 것으로 사료된다.

• 한국환경보건학회지
• /
• 제46권6호
• /
• pp.667-675
• /
• 2020

Objectives: Exposure to fine dust (PM10) could contribute to the occurrence of cardiovascular disease or respiratory abnormalities. Since garlic is known to possess an anti-oxidative stress effect, the present study was performed to evaluate the effect of garlic intake on fine dust-mediated pulmonary toxicity. Methods: Rats were intratracheally instilled with fine dust at 15 mg/kg body weight (BW)/day for five days following five-day intragastric intubation of garlic at 0.7 or 1.4 g/kgBW/day, or 13.1 mg/kgBW/day S-allyl-cysteine (SAC) as a reference component in garlic. Blood and bronchoalveolar lavage fluid (BALF) were collected. Results: Deposit of fine dust was visually and histopathologically observed in the lungs. Body weight gain during the instillation period was significantly lowered in all the groups instilled with fine dust. Neutrophil numbers in blood were significantly elevated in the fine dust alone group, but this alteration was diminished in the groups administered with garlic. Levels of serum glutathione were lower in the rats instilled with fine dust alone, and this decrease in the glutathione level seems dose-dependently compensated among the groups administered with garlic. Similar findings were observed in the BALF with statistical significance. Typical pulmonary histopathological observation related with inflammation was demonstrated in the lungs of the rats exposed to fine dust alone, whereas such histopathologic findings were not improved in the groups administered with garlic. Conclusion: The present study suggests that garlic intake could alleviate fine dust-mediated pulmonary or systemic toxicities. Further investigation is necessary to delineate the mechanism of garlic-mediated effects on pulmonary function.