• 제목/요약/키워드: present-age

검색결과 4,489건 처리시간 0.032초

Changes in Expression of Connexin Isoforms in the Caudal Epididymis of Adult Sprague-Dawley Rats exposed to Estradiol Benzoate or Flutamide at the Neonatal Age

  • Lee, Ki-Ho
    • 한국발생생물학회지:발생과생식
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    • 제20권3호
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    • pp.237-245
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    • 2016
  • Direct communication between neighboring cells via gap junction in tissue is important for maintenance and regulation of its physiological functions. Each epididymal region has different composition of cell types. It is well recognized that the epididymis is a steroid hormone-responsive tissue. The present study was designed to determine the effect of estradiol benzoate (EB) or flutamide exposured at the early postnatal age on the expression of connexin (Cx) isoforms in the caudal epididymis. The EB or flutamide was subcutaneously administrated to male Spragure Dawley rat at 7 days of age, and expressional changes of Cx isoforms in the adult corpus epididymis were determined by quantitative real-time PCR. The treatment of low-dose EB resulted in decreases of Cx30.3, Cx31.1, Cx37, and Cx45 expression but caused an increase of Cx32 expression. Exposure to high-dose EB led into expressional increases of Cx31, Cx31.1, Cx32, Cx40, and Cx43, even though a decrease of Cx37 expression was found with a high-dose EB treatment. A low-dose flutamide induced increases of Cx31, Cx31.1, Cx32, and Cx43 expression but a decrease of Cx37 expression. Expression of most Cx genes were significantly increased by a high-dose flutamide, while no expressional change of Cx26 and Cx40 was detected by a high-dose flutamide. These results indicate that expression of Cx isoforms in the caudal epididymis is altered by exposure to steroidal compounds at the prepubertal age. It is suggested that a contact with environmental exogenous materials during the early postnatal period would lead to alteration of epididymal functions at the adult.

계절별 경관의 시각적 선호도 (Viewers' Visual Preferences of Seasonal Landscape)

  • 정윤희;신지훈;임승빈
    • 한국조경학회지
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    • 제30권4호
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    • pp.19-27
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    • 2002
  • When we research a landscape or make a Landscape Impact Assessment, we use the image of a specific season like summer or fall. Since there are four distinct seasons, each with a different landscape, researchers need to understand viewers′visual preferences for individual seasonal landscapes. The purpose of this study is to investigate viewers′visual preferences according to seasonal change and the respondent′s age, gender and profession. In this research, the independent variable is season: suing, summer, fall, winter and snowy winter. Three landscape types used in the experiment: forest, street and agriculture. Each landscape type has two sites for reliability. The assessment media for this research are pictures featuring landscapes taken in each of the four seasons. The study used the "paired comparison" method for taking the score of visual preference. The results of this study are as follows: 1. The summer landscape has the highest visual preference score. However, spring and fall landscapes should also be considered for visual landscape evaluation. 2. The visual preference of winter landscape covered with snow is very high, but since snow is temporal and irregular, it is difficult to consider this factor for visual landscape evaluation. 3. The visual preference score of winter is the lowest of four seasons. The attractive factors of spring are flowers, summer is greenery and fall is autumnal tints. But these are not present in winter. 4. The result of visual preferences according to age groups, gender and profession have no serious differences. 5. Visual preference to scenery of 4 seasons by age group was not different from general preference and thus was concluded to have no connection with age. 6. As a result from the research of visual preference to scenery of 4 seasons by sex, women were shown to like snow-scene more than men. This study presents an indication of general preferences of seasonal landscapes. It is expected that more advanced study will proceed after this one.

유흥업소 종업원에 대한 사회의학적 조사 (Socio-medical Survey on the Entertainment Workers in Jeonju Area)

  • 유영준
    • Journal of Preventive Medicine and Public Health
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    • 제7권1호
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    • pp.147-152
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    • 1974
  • The author has conducted survey on the socio-medical status of the 157 entertainers (male:25, female:132) in Jeonju area, during 1 to 15 July 1974. As results of this survey, following conclusions were obtained. 1. The age distribution was revealed the peak in the age group of 20 to 24 years with 44.5 per cent. Average age of male entertainers was 28.0 years and female entertainer with 23.9 years. 2. By the educational background of the entertainers, the greatest proportion or 45.9 per cent was middle school, 28.7 per cent in primary school. 3. Most of the entertainers had no their parents, father or mother while the ones who had parents were 21.0 per cent. 4. The average age of menerache of the female entertainers was $14.2{\pm}0.87$ years. 5. Regarding the marital status of the entertainers, the unmarried were 81.5 per cent and present status of marriage, 79.3 per cent were seperated. 6. The average of the first marriage was 24.4 years in male, and 22.6 years in female. 7. Regarding the working duration of the entertainers, 79.1 per cent worked less than 1 year. 8. Regarding the sex experiences before marriage, 76.0 per cent of the male and 91.7 per cent of the female reported had such experiences. 9. Induced abortions were found to have been experienced 88.6 per cent of the female entertainers. 10. Point prevalence rate for gonorrhea including non-specific urethritis of the entertainers were found 16.0 per cent of the male and 17.4 per cent of the female.

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서울대학교 중상류층 성인의 식습관 변화 (Changes in Dietary Habits of Adults with Middle and Upper Income Levels in Seoul)

  • 장남수
    • Journal of Nutrition and Health
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    • 제29권5호
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    • pp.547-558
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    • 1996
  • A rapid increase in urbanization and industrialization brings about a change in economic status which results in considerable changes in lifestyle including food habits and disease and mortality patterns. The purpose of the present study was to investigate recent food habit changes if any, reasons for food habit change, current food consumption patterns, and breakfast practices among urban adults with middle and upper income levels. Three hundred men and women, aged 20-60 years, were randomly selected and interviewed individually by trained interviewers. Among the twenty food groups studied, subjects reported that, compared to two years ago, they are now eating more fast foods, meats, fish, vegetables and fruits, and less rice, noodles, pastries, and salt. The changes in fast foods, fruits, and rice consumption patterns varied significantly between age, sex, income level, and BMI groups. The two most primary reasons for food habit changes were 'for my own health' and 'for my family's health', which shows that health seems to be the major concern in changing food habits. Among meals, the breakfast meal was rated as the most important one, and was not affected by the sociodemographic variables. However, the average rate of skipping breakfast was found to be as high as 33% with a greater rate in younger age groups. The rats of breakfast skipping was found to vary between different income, education, and BMI groups. Among the subjects who eat breakfast meals daily, a traditional Korean breakfast of rice and soup was found to be still a predominant choice, although younger age groups, upper income groups, and people with more education choice, although younger age groups, upper income groups, and people with more education tended to eat a western-style breakfast more frequently. These findings are applicable at the planning and implementation stages of various nutritional improvement projects as a part of the National health Promotion Law.

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어린이용품 함유 유해인자의 위해성평가를 위한 노출계수 조사 (Survey of Exposure Factors for Risk Assessment of Hazardous Materials in Child-Specific Products)

  • 김정곤;서정관;김탁수;박건호
    • 한국환경보건학회지
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    • 제40권1호
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    • pp.17-26
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    • 2014
  • Background: Despite children's unique characteristics that distinguish them from adults, relatively few attempts have been made to measure exposure factors for characterization of children's exposure to hazardous chemicals in child-specific products (CSP). This study was conducted to establish the child-specific exposure factors for exposure and risk assessment of hazardous substances in CSP. Methods: We investigated the exposure factors (e.g., time use of child-products, time and frequency of object-to-body contact, time and frequency of object-to-mouth contact) influencing children's exposure to CSP (e.g., toys, playmats, oil pastels, etc.) in 650 children through a parent-completed questionnaire using a web-based survey. Participants were recruited in five age groups, <1, 1-2, 2-3, 3-6, and 6-12 years of age. Results: The child-specific exposure factors were presented as the mean, median, $95^{th}$ percentile, minimum, and maximum values. Time activity for play mats was the longest among CSP and infants spent more time on them than did elder age groups (189.3-224.7 min/day for <1-2 years vs. 91.2 min/day for 6-12 years). It is apparent that time and frequency of toy block- and plastic toy-to-mouth contact significantly decreased as a function of age. When the variation of CSP use patterns was compared by gender, the only variable that was statistically different between genders was time activity in child-products exposure space. Conclusion: We believe the five child-specific exposure factors suggested in the present study will be valuable for reducing uncertainty in the estimation of chemical exposure during risk assessment of CSP and furthermore, in the appropriate regulations to protect children's health.

Transcranial Doppler Ultrasonography를 이용한 편두통의 진단: 예비연구 (Application of Transcranial Doppler Ultrasonography(TCD) for the Diagnosis of Migraine : Preliminary Results)

  • 이용석;김병건
    • Annals of Clinical Neurophysiology
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    • 제1권1호
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    • pp.31-35
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    • 1999
  • Dignosis of migraine is only based on the medical history, and objective methods to aid the clinical diagnosisare absent. Although transcranial Doppler ultrasonography (TCD) abnormalities in headache-free migraineurs have been reported previously, diagnostic criteria for migraine is still lacking and this may limit the practical application of TCD for migraine. We prospectively studied several abnormal TCD indices in interictal migraineurs and their sensitivity and specificity to define the optimal diagnostic criteria. Young (20 yrs$age=29.0{\pm}6.1yrs$) were compared to 69 controls (M:F=25:44, Mean $age=31.2{\pm}5.5yrs$). Elevated MFV (> 2SD)was observed in 63% of migraineurs while n 12% of control (p<0.01). High AI (>25%) or high HI (>3.0) was present in 17% of migraineurs, while 3% and none in controls (p<0.01). Sensitivity of elevated MFV, high AI, and high HI was 63%, 17%, 17% and specificity was 88%, 97%, 100%, respectively. If all these indices were combined, sensitivity and specificity reached 69% and 86%. These preliminary results suggest pathophysiological implication of vasospasm in interictal migraineurs, and TCD may be practically applicable for migraine. Optimal diagnostic criteria and therapeutic options for patients with abnormal TCD findings remain to bo determined.

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TORCH (toxoplasmosis, rubella, cytomegalovirus, and herpes simplex virus) screening of small for gestational age and intrauterine growth restricted neonates: efficacy study in a single institute in Korea

  • Chung, Mi Hae;Shin, Chan Ok;Lee, Juyoung
    • Clinical and Experimental Pediatrics
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    • 제61권4호
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    • pp.114-120
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    • 2018
  • Purpose: Routine screening for toxoplasmosis, rubella, cytomegalovirus (CMV), and herpes simplex virus (TORCH) in intrauterine growth restriction (IUGR) and small for gestational age (SGA) neonates has become a common practice. However, the incidence of TORCH varies across countries, and the cost of TORCH testing may be disadvantageous compared to disease-specific screening. To evaluate the efficacy of TORCH screening, the medical charts of IUGR or SGA neonates born in a single institution in Bucheon, Korea from 2011 to 2015 were reviewed. Methods: The clinical data of the 126 IUGR or SGA neonates were gathered, including gestational age, Apgar scores, neonatal sonographic findings, chromosome study, morbidities, developmental follow-up, and growth catch-up. Maternal factors including underlying maternal disease and fetal sonography were collected, and placental findings were recorded when available. TORCH screening was done using serum IgM, CMV urine culture, quantification of CMV DNA with real-time polymerase chain reaction, and rapid plasma reagin qualitative test for syphilis. Tests were repeated only for those with positive results. Results: Of the 119 TORCH screenings, only one was positive for toxoplasmosis IgM. This result was deemed false positive due to negative IgM on repeated testing and the absence of clinical symptoms. Conclusion: Considering the incidence and risk of TORCH in Korea, the financial burden of TORCH screening, and the single positive TORCH finding in our study, we suggest disease-specific screening based on maternal history and the clinical symptoms of the neonate. Regarding CMV, which may present asymptomatically, universal screening may be appropriate upon cost-benefit analysis.

노화 관련 뇌인지 변화와 운동의 긍정적 영향: 인지신경과학적 연구 개관 (Age-related neurocognitive changes and exercise-induced benefits: A review of cognitive neuroscientific research)

  • 신은삼
    • 인지과학
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    • 제24권1호
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    • pp.1-24
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    • 2013
  • 한국 사회에서 고령 인구가 지속적으로 증가하고 있는 추세에 발맞추어 본 논문은 노화과정에서 일어나는 뇌의 구조, 기능적 변화 및 인지 기능의 저하를 살펴보고, 고령화 대처의 한 방안으로 제안되고 있는 운동의 효과에 관하여 인지신경과학적 연구를 중심으로 개관하였다. 정상 노화 과정에서 일어나는 뇌의 변화는 전전두엽과 측두엽(해마 포함)의 부피변화와 함께 인지 과제 수행 시 과잉활성화와 같은 현상들이다. 이러한 뇌의 변화와 함께 인지 기능의 저하도 관찰되는데 주로 억제 및 기억 기능의 저하가 노화를 특징짓는 인지기능의 변화로 알려져 왔다. 이와 같은 노화 관련 뇌인지의 퇴행적 변화에 대응할 수 있는 보호적 요인 중 하나가 운동이다. 실제 노인을 대상으로 장기간 운동 프로그램을 실시한 연구 결과들은 참가 노인들의 전두엽과 측두엽, 특히 해마의 위축이 개선되고 억제와 기억 기능 역시 향상되었음을 보고하였다. 이러한 결과는 뇌세포 단위에서의 변화로부터 시작하여 노화하는 뇌 역시 변화할 수 있고, 운동이 이러한 긍정적인 변화를 유도할 수 있음을 보여준다.

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한국재래산양 신생자축의 혈액학치 변화에 관한 연구 (Hematological values of Korean indigenous neonatal goats)

  • 조광현;박용수;김성국;어경연;곽동미;권오덕
    • 한국동물위생학회지
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    • 제40권1호
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    • pp.7-14
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    • 2017
  • The present study was undertaken to clarify the changes in hematological values of Korean indigenous goats according to age. Blood samples were collected from 16 goats (5 females and 11 males) from birth up to the age of 6 weeks and the levels of various hematological values were analyzed. The body weight was increased from 2.54 kg at birth to 6.41 kg at 6 weeks age. The erythrocytes (RBC) counts and hemoglobin (Hb) values of goats were decreased at 2 weeks after birth, and increased gradually from 4 weeks after birth. The hematocrit (Ht) values were decreased until 4 weeks after birth, and increased at 6 weeks after birth. The mean cell volume (MCV) and mean cell hemoglobin (MCH) were decreased until 6 weeks after birth. The mean cell hemoglobin concentration (MCHC) was increased slightly from 2 weeks after birth. The red cell distribution width (RDW) was increased significantly at 2 weeks after birth, and decreased from 4 weeks after birth. The platelet (PLT) counts were increased significantly from 2 weeks after birth. The mean platelet volume (MPV) was decreased at 2 weeks after birth, and increased gradually from 4 weeks after birth. The total white blood cell (WBC) counts and the mean absolute numbers of neutrophil, lymphocyte, monocyte and eosinophil were increased from 2 weeks after birth. In conclusion, the data obtained from this study may be valuable as a standard for interpreting results of hematological analyses in Korean indigenous goats.

청둥오리의 가슴샘 내분비세포에 대한 면역조직화학적 연구 (Immunohistochemical study on endocrine cells of the thymus of duck(Anas platyrhynchos platyrhyncos, Linne))

  • 김정미;이재현;구세광;이형식
    • 대한수의학회지
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    • 제38권2호
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    • pp.246-257
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    • 1998
  • Endocrine cells in the thymus of duck(Anas platyrhynchos platyrhyncos, Linne) were studied immunohistochemically from 23 days of incubation to 32 weeks of age. Somatostatin-, growth hormone(GH)-, gastrin/cholecystokinin(Gas/CCK)-, polypeptide YY(PYY)-, S-100 protein(S-100 P)-, dopamine-, serotonin(5-HT)-, and bovine chromogranin (BCG)-immunoreactive cells were detected in the duck thymus by the PAP techniques. These immunoreactive cells were observed in the medulla and in the juxtacortical medulla. No immunoreactivity of calcitonin and bovine pancreatic polypeptide(BPP) antiserum were observed. The argyrophil cells by Grimelius techniques were observed from 23 days of incubation to 32 weeks of age and peaked in 5 weeks of age. In the early develpmental stage, the argyrophil cells were distributed only in the medulla, while these cells were distributed mainly in the medulla and a few cells were distributed in the corticomedullary junction from 3 weeks of age. These immunoreactive cells were generally round, oval and elliptical and occasionally spindle, polygonal and polymorphous with the long cytopslasmic processes in shape. The present study suggests that the intrathymic endocrine cells may associate with the functional maturation of T-lymphocytes on the establishment of immunity. The further study will be needed to elucidate the function of these thymic endocrine cells.

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