• 대한의용생체공학회:의공학회지
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• 제33권2호
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• pp.98-103
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• 2012

The purpose of this study was to compare premotor time(PMT) and electro-mechanical delay(EMD) between sitting and standing posture. Twenty four healthy young subjects(12 women and 12 men) participated in this study. Subjects were instructed to perform maximal, voluntary, isometric contraction of ankle muscle(tibialis anterior and gastrocnemius muscles) in reaction to auditory stimulus. PMT and EMD, calculated from stimulus, EMG and torque profile were compared between sitting and standing postures. As statistical analysis, paired t-test was performed to assess difference between sitting and standing posture. In both tibialis anterior and gastrocnemius muscles, EMD was found to be significantly longer for standing than sitting. However, PMT in standing posture was longer than that in sitting posture only in gastrocnemius muscles. These result indicate that increased reaction time, particularly, increased EMD of ankle muscles in standing posture may be caused by co-contraction of ankle muscles for postural control in standing posture.

• 대한의용생체공학회:의공학회지
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• 제31권3호
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• pp.245-250
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• 2010

The purpose of this study is to investigate the effects of sex and age and their interactions in premotor-time (PMT) of ankle muscle. Forty-eight elderly subjects (aged 65-90 years) and thirty young subjects (aged 19-27 years) participated in this study. Subject were instructed to perform maximal, voluntary, isometric, bilateral contraction of ankle muscle in reaction to auditory stimulus to determine PMT. As analysis variables, PMT, intrasubject variability of PMT and asymmetry of PMT between dominant and nondominant legs were used. As statistical analysis, two-way ANOVA was performed to assess the main effects of age group and sex and also their interactions. All variables showed significant age effects (p<0.01). However, no sex effect and interaction existed in all variables in both dominant and nondomiant legs. Theses results suggest that the PMT of ankle muscle is related to the age-related deterioration in postural control, however, not related to the sex-difference of fall incidence in the elderly population.

• 한국운동역학회지
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• 제26권2호
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• pp.205-211
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• 2016

Purpose: The aim of this study was to analyze biomechanical factors and PMT (premotor time) of body muscles between elite college and amateur baseball players during the baseball batting motion. Method: Kinematic and electromyographic data were obtained for 10 elite college baseball players and 10 amateur baseball players who participated in this study. All motion capture data were collected at 200 Hz using 8 VICON cameras and the PMT of muscles was recorded using a Delsys Trigno wireless system. The peak mean bat speed and the peak mean angular velocities of trunk, pelvis, and bat with PMT of 16 body muscles were computed. These kinematic and PMT data of both groups were compared by independent t-tests (p < .05). Results: The pelvis, trunk, and bat showed a sequence of angular velocity value during baseball batting. The PMTs of right tibialis anterior, left gastrocnemius, external oblique, and erector spinae were significantly different between the two groups. Conclusion: The PMT of body muscles was related to the shifting of body and rotation of the pelvis and the trunk segment, and this action can be considered the coordinated muscle activity of the lower and upper body.

• 대한의용생체공학회:의공학회지
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• 제33권4호
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• pp.163-168
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• 2012

Elderly women are reported to have greater risk of falls. The purpose of this paper was to investigate the possible gender differences in the reaction performance of ankle joint muscles, which have dominant role in the control of sagittal plane balance. Twenty-six elderly men and women with comparable mean age participated in this study. Reaction times to the audible beeps were measured in the tibialis anterior muscle and gastrocnemius muscle. Reaction time variables included premotor time, electromechanical delay and total reaction time. Gender difference in each reaction time was investigated by independent t-test. In both muscles, premotor time was longer in men but the electromechanical delay was longer in women (p < 0.05). Resulting total reaction time was longer in men in tibialis anterior muscle (p < 0.01) and it tended to be longer in men also in gastrocnemius muscle (p = 0.25). The results demonstrates that the overall reaction performances of elderly women is better than or comparable to those of elderly men in ankle joint muscles. This suggests that the reaction performance of ankle muscles is hardly the cause of the greater risk of falls in elderly women.

• The Journal of Korean Physical Therapy
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• 제22권2호
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• pp.7-13
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• 2010

Purpose: This study was designed to determine the correlation between faster response time and functional activities of brain regions during cognitive time management. Methods: Twelve healthy subjects participated in this experiment. Subjects performed the serial reaction time task (SRTT), which was designed by the Superlab program, during fMRI scanning. When the 'asterisk' appeared in the 4 partition spaces on the monitor, the subject had to press the correct response button as soon as possible. Results: fMRI results showed activation of the left primary sensorimotor cortex, both premotor areas, the supplementary motor area, posterior parietal cortex and cerebellum. There were significant correlations, from moderate to strong, between faster reaction time and BOLD signal intensity in activated areas. Conclusion: These results suggest that motor skill learning to be needed cognitive time management is associated with greater activation of large scale sensorimotor networks.

• Investigative Magnetic Resonance Imaging
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• 제3권1호
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• pp.53-59
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• 1999

목적 : 언어기능의 지도화(language mapping) 및 우세반구 결정에 있어서 기능적 자기공명영상의 유용서을 알아보고자 하였다. 대상 및 방법 : 자원자 10명(남자 6명, 여자 4명, 오른손잡이 7명, 왼손잡이 3명)을 대상으로 단어생성 과제(명사만들기, 동사만들기)와 판단과제를 이용하여 언어영역의 활성화를 유도하였다. 1.5T 초진도 자기공명영상장치에서 EPI로 BOLD 기법을 이용하여 기능적 영상을 얻었으며, 여앙후처리는 SPM 분석 프로그램을 이용하였다. 기능적 영상은 2번의 활성기와 3번의 휴식기를 번갈아 시행하였고 스캔 시간은 각각30초였으며 총 영상획득시간은 162초였다. 유의수준 p<0.001을 기준ㅇ로 자극 과제에 따라 활성화된 뇌영역을 분석하였고 반구별로 활성화된 화소의 수를 측정하여 편재화지수(lateralization index)를 구하였다. 결과 : 왼손잡이 1명을 제외한 9명에서 성공적으로 기능적 영상을 얻었으며 양측 전운동영역(premotor area), 하전두회, 두정엽, 중측두회 등의 여러 영역에서 활성화 신호가 나타났다. 오른손잡이의 경우 편재화지수는 평균 0,64(0.16~1)로 모두 좌측으로 편재화 되었다. 과제별로는 동사만들기 과제가 명사만들기 및 판단 과제에 비해 언어 영역의 활성화가 많았고 편재화지수의 값도 높았다. 결론 : 기능적 자기공명영상은 언어영역의 뇌기능지도화 및 우세반구 결저에 있어서 유용한 검사 방법이 될 수 있으리라 생각된다.

• The Journal of Korean Physical Therapy
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• 제26권3호
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• pp.216-219
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• 2014

Purpose: We presented with a patient with traumatic brain injury who showed a transcallosal ipsilateral motor pathway from unaffected motor cortex to affected extremities, as evaluated by diffusion tensor tractography (DTT). Methods: One patient and six age-matched normal subjects were enrolled. A 42-year-old left hemiparetic male who suffered from brain injury by motor vehicle accident 9 years ago showed a leukomalactic lesion in the right corona radiata and parieto-temporal lobe. His left extremities were completely paralyzed initially, but recovered slowly over 2 years. At the time of the evaluation, he was able to grasp and release an object, and to walk with spastic gait pattern. DTT was performed using 1.5 T with a Synergy-L Sensitivity Encoding head coil. DTT was obtained with termination criteria of FA <0.2 and an angle change > $45^{\circ}c$. Results: The motor tracts of the unaffected (left) hemisphere of the patient and control subjects originated from the motor cortex and descended along the known corticospinal tract without any transcallosal tract. By contrast, the tract of the affected (right) hemisphere originated from the left premotor cortex, descended through the left corona radiata, and then crossed the mid-portion of the corpus callosum. The tract then descended through the known corticospinal tract pathway to the right medulla. Conclusion: We conclude that the transcallosal ipsilateral motor pathway from the unaffected hemisphere appeared to contribute to the motor recovery in this patient.

• 대한물리의학회지
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• 제5권3호
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• pp.395-404
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• 2010

Purpose : The object of this study was to examine the effect of motor learning on brain activation depending on the method of motor learning. Methods : The brain activation was measured in 9 men by fMRI. The subjects were divided into the following groups depending on the method of motor learning: actually practice (AP, n=3) group, action observation (AO, n=3) group and motor imagery (MI, n=3) group. In order to examine the effect of motor learning depending on the method of motor learning, the brain activation data were measured during learning. For the investigation of brain activation, fMRI was conducted. Results : The results of brain activation measured before and during learning were as follows; (1) During learning, the AP group showed the activation in the following areas: primary motor area located in precentral gyrus, somatosensory area located in postcentral gyrus, supplemental motor area and prefrontal association area located in precentral gyrus, middle frontal gyrus and superior frontal gyrus, speech area located in superior temporal gyrus and middle temporal gyrus, Broca's area located in inferior parietal lobe and somatosensory association area of precuneus; (2) During learning, the AD groups showed the activation in the following areas: primary motor area located in precentral gyrus, prefrontal association area located in middle frontal gyrus and superior frontal gyrus, speech area and supplemental motor area located in superior temporal gyrus and middle temporal gyrus, Broca's area located in inferior parietal lobe, somatosensory area and primary motor area located in precentral gyrus of right cerebrum and left cerebrum, and somatosensory association area located in precuneus; and (3) During learning, the MI group showed activation in the following areas: speech area located in superior temporal gyrus, supplemental area, and somatosensory association area located in precuneus. Conclusion : Given the results above, in this study, the action observation was suggested as an alternative to motor learning through actual practice in serial reaction time task of motor learning. It showed the similar results to the actual practice in brain activation which were obtained using activation of mirror neuron. This result suggests that the brain activation occurred by the activation of mirror neuron, which was observed during action observation. The mirror neurons are located in primary motor area, somatosensory area, premotor area, supplemental motor area and somatosensory association area. In sum, when we plan a training program through physiotherapy to increase the effect during reeducation of movement, the action observation as well as best resting is necessary in increasing the effect of motor learning with the patients who cannot be engaged in actual practice.

• 한국전문물리치료학회지
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• 제10권3호
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• pp.17-27
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• 2003

Repetitive transcranial magnetic stimulation (rTMS) modulates cortical excitability beyond the duration of the rTMS trains themselves. Depending on rTMS parameters, a lasting inhibition or facilitation of cortical excitability can be induced. Therefore, rTMS of high or low frequency over motor cortex may change certain aspects of motor learning performance and cortical activation. This study investigated the effect of high and low frequency subthreshold rTMS applied to the motor cortex on motor learning of sequential finger movements and brain activation using functional MRI (fMRI). Three healthy right-handed subjects (mean age 23.3) were enrolled. All subjects were trained with sequences of seven-digit rapid sequential finger movements, 30 minutes per day for 5 consecutive days using their left hand. 10 Hz (high frequency) and 1 Hz (low frequency) trains of rTMS with 80% of resting motor threshold and sham stimulation were applied for each subject during the period of motor learning. rTMS was delivered on the scalp over the right primary motor cortex using a figure-eight shaped coil and a Rapid(R) stimulator with two Booster Modules (Magstim Co. Ltd, UK). Functional MRI (fMRI) was performed on a 3T ISOL Forte scanner before and after training in all subjects (35 slices per one brain volume TR/TE = 3000/30 ms, Flip angle $60^{\circ}$, FOV 220 mm, $64{\times}64$ matrix, slice thickness 4 mm). Response time (RT) and target scores (TS) of sequential finger movements were monitored during the training period and fMRl scanning. All subjects showed decreased RT and increased TS which reflecting learning effects over the training session. The subject who received high frequency rTMS showed better performance in TS and RT than those of the subjects with low frequency or sham stimulation of rTMS. In fMRI, the subject who received high frequency rTMS showed increased activation of primary motor cortex, premotor, and medial cerebellar areas after the motor sequence learning after the training, but the subject with low frequency rTMS showed decreased activation in above areas. High frequency subthreshold rTMS on the motor cortex may facilitate the excitability of motor cortex and improve the performance of motor sequence learning in normal subject.