• Maxillofacial Plastic and Reconstructive Surgery
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• 제23권4호
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• pp.324-331
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• 2001

The present study was aimed to investigate the effects of latency period on alveolar ridge distraction using the intraoral distraction device. Nine adult mongrel dogs of either sex, weighing about 15kg, were used. They were divided into 3-day, 5-day, and 7-day groups according to the latency period. The left upper and lower premolars and first molars were extracted. Twelve weeks after the extraction, an osteotomy was performed and the distraction device was applied. After the latency period, the distraction was applied at a rate of 1.2mm for 8 days. The distraction device was left in place for 2 weeks to allow consolidation and was then removed. The animals were sacrified at 8 weeks after completion of distraction and were examined macroscopically, radiographically, and histologically. After completion of the distraction, the alveolar crest protruded prominently, showing the vertical augmentation of the alveolar bone. Soft tissues were broken down after the 6th day of distraction in 3-day latency group, and premature union occurred on the 7th day of distraction in the 7-day latency group. The average distance was $9.40{\pm}0.3mm$ in 3-day latency group, $9.35{\pm}0.1mm$ in 5-day latency group, and $8.85{\pm}0.1mm$ in 7-day latency group. In the radiograph taken at 8 weeks after distraction, there was slight bone resorption around the medial and distal edges of the alveolar bone segment, and a new bone deposition was observed in the neighboring alveolar crest area in all groups. Fibrous tissues were present in a part of the buccal cortical bone area of the distraction gap, and the woven and lamellar bones were observed in the distracted gap. There were bony bridges in the distraction gap in all animals examined. These results suggest that optimal time of latency period on alveolar ridge distraction using the intraoral distraction device is about 5 days in dogs, and about 7days in human beings.

• Journal of Oral Medicine and Pain
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• 제37권4호
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• pp.205-211
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• 2012

35세 여자환자가 갑작스런 개구장애와 함께 발생한 급성 교합변화를 주소로 내원하였다. 환자는 이전 수년 동안의 관절잡음의 병력을 가지고 있었으며 관절잡음의 소실과 동시에 개구제한이 발생하였음을 보고하였다. 환자는 개구제한과 함께 개구시 우측 악관절의 통증을 호소하였으며 구강내 교합 검사 시 전치부의 개교합과 함께 하악이 우측으로 전위된 양상이 관찰되었다. 또한 좌측으로의 측방운동량 또한 감소된 것으로 관찰되었다. 자기공명영상에서 우측 악관절에서 비정복성 관절 원판 전방 변위가 관찰되었으며 후방 관절강의 협착이 관찰되었다. 이 환자는 우측 악관절의 비정복성 관절원판 전방변위로 진단되었으며, 급성 교합변화는 변위된 관절원판에 의해 야기된 과두위치의 변화로 초래된 것으로 추정하였다. 처음 3개월간의 물리치료와 약물치료와 병행된 안정교합장치요법에서는 만족할 만한 치료결과를 얻지 못하였으나, 그 다음 약 8개월간 사용된 악간견인장치 치료를 통해서 통증 및 교합변화가 해소되었으며 정상적인 개구량으로 회복되었다. 술후 촬영된 자기공명영상에서 우측 과두가 재형성된 양상을 관찰할 수 있었다.

• 부모자녀건강학회지
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• 제5권2호
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• pp.129-144
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• 2002

This longitudinal quasi-experimental research was conducted to develop parent role education program and to evaluate the effect of this program for mother-infant interaction, childrearing environment and infant development. The subjects were the healthy infants weighing over 2,500gm at birth, whose gestational age was more than 37weeks, and their healthy mothers. The sample consisted of eighteen mother-infant dyads for intervention group and sixteen dyads for control group. Data were collected from March 15th in 1999 to Jun 20th in 2000. The intervention group received programmed education consisted of discharge education, telephone counselling, and home visiting care. But control group were collected data without programmed education. In this study, the Nursing Child Assessment Teaching Scale(NCATS) devised by Barnard was used to determine the mother-infant interaction, HOME was used to determine the childrearing environment, and Griffiths mental development scale was used to determine the infant development. The data were analyzed using SPSS Win using chi-square test, t-test, and repeated measure ANOVA. This study was focused on the results of twelve months time point. Summaries of the results were as follows: 1. There was no significant difference in mother-infant interaction(NCATS) between intervention group and control group. But both of two groups showed significantly higher in interaction score at twelve months than at six months in the subscales of social-emotional growth fostering, and responsiveness to caregiver. 2. There was no significant difference in childrearing environment(HOME) between two groups at twelve months. But when each subscale of HOME was examined, intervention group showed higher scores in the dimensions of maternal involvement with child(p=.001), and maternal emotional-verbal responsivity(p=.048). 3. There was no significant difference in GQ of the Griffiths mental development scale between two groups, although significant difference was found in performance subscale. 4. Infant development at twelve months showed significant correlation with mother-infant interaction and childrearing environment at six months, although mother-infant interaction and childrearing environment at twelve months did not show significant correlations with infant development at twelve months. 5. Developmental scores at six months showed significant correlations with variety in daily stimulation, and mother's emotional, verbal responsivity, whereas developmental scores at twelve months showed significant correlations with acceptance of child behavior at six months, and appropriate play material at twelve months. In conclusion, the maternal education program for primipara showed long term effect in some categories in organizing the childrearing environment, and fostering the infant development. We suggest further study and implications of parent role education program for high risk parents such as parents in low economic status or with premature babies.

• 대한장애인치과학회지
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• 제2권1호
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• pp.39-44
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• 2006

Cerebral palsy(CP) is one of the most common motor disease, due to brain injury during fetal and neonatal development which results in neuromotor paralysis and associated neuromuscular symptoms. Features of CP include motor disability due to the lack of muscle control, often accompanied by sensory disorders, mental retardation, speech disorders, hearing loss, epilepsy, behavior disorders, etc. There are increasing chances of treatment of dental patients with cerebral palsy, as the occurrence of CP is increasing with the decrease in infant mortality and an increase in immature birth and premature birth and also, there is a trend to pursue of higher quality of life. Reports on the relationship between CP and maxillofacial deformity are uncommon, but it is well known that the unbalance and discontrol of the facial muscles, lip, tongue and the jaws leads to malocclusion and temporomandibular joint disorders, and statistics show that class 2 relationship of the jaws and open bite is frequently reported. However, it is difficult to perform maxillofacial deformity treatment, which consists of orthodontic treatment, maxillofacial surgery and muscle adaptation training, due to difficulties in communication and problems of muscle adaptation caused by difficulties in motor control which leads to a high recurrence rate. This case report is to trearment of maxillofacial deformity in CP patient. A 26 year old female patient came to the department with the chief complaint of prognathism of the mandible and facial asymmetry. According to the past medical history, she was diagnosed as cerebral palsy 1 week after birth, classified as GMFC, classII accompanied with left side torticollis. The patient's intelligence was moderate, and there were no serious problems in communication. For two years time, the patient underwent lingual frenectomy, pre-operation orthodontic treatment and then bimaxillary orthognathic surgery to treat mandibular prognathism and facial asymmetry followed by rehabilitatory exercise of facial muscle. After 6 months of follow up, there was a good result. This is to report to the typical signs and symptoms of DFD in CP patient and the limitation of the usual method of the treatment of DFD in CP patient with literature review.

• 한국강구조학회 논문집
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• 제24권2호
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• pp.217-231
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• 2012

HSB 고강도 강재를 적용한 균일모멘트를 받는 세장 복부판을 갖는 강거더에 대하여 비탄성 횡비틂좌굴 거동을 상용 ABAQUS 프로그램을 이용하여 비선형 유한요소해석으로 분석하였다. 해석대상 강거더는 압축플랜지의 국부좌굴이 휨강도를 지배하지 않도록 플랜지는 조밀 또는 비조밀 요소에 해당하는 세장비를 갖도록 설계하였으며, 횡방향 비지지길이는 탄성 횡비틂좌굴 강도 이상의 휨강도를 갖도록 선정하였다. HSB600 및 HSB800 강재로 제작된 균질단면 강거더와 HSB800과 SM570-TMC 강재를 동시에 적용한 하이브리드 단면를 고려하였고, 일반강재와의 상대적인 비교를 위하여 SM490-TMC 균질단면 강거더에 대한 해석도 수행하였다. 비선형 유한요소해석 시에는 플랜지와 복부판을 쉘요소로, 강재는 탄소성-변형경화 재료로 모델링하였다. 초기변형과 단면의 잔류응력을 고려하였으며 이들이 비탄성 횡비틂좌굴 영역에서 휨거동에 미치는 영향을 분석하였다. 총 64개의 해석대상 강거더에 대하여 FE 해석과 설계식에 의한 휨저항강도를 비교한 결과, HSB 강재를 적용한 균질단면 및 하이브리드 단면 거더의 비탄성 횡비틂좌굴에 의한 휨강도는 현 AASHTO LRFD 압축플랜지 휨강도 탄성 설계규정을 적용하여 산정할 수 있는 것으로 분석되었다.

• 대한치과보철학회지
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• 제58권4호
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• pp.328-334
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• 2020

치과의사는 악간관계기록 오류로 인해 발생하는 교합오차를 줄이기 위해 진료실재부착을 시행한다. 진료실재부착으로 수정된 의치를 사용하면 일반적으로 통증이 감소하고 의치 사용이 편해지며 더 편하게 저작할 수 있다고 한다. 하지만 이러한 평가는 환자의 주관적인 평가이므로 본 연구에서는 실험적인 지표를 통해 진료실재부착의 효과를 확인하고자 하였다. 7명의 환자를 대상으로 전치부에서 1 - 2 mm의 공간이 있도록 중심위 악간관계를 채득하여 진료실재부착을 시행한 후 미끄러짐 유무를 확인하였으며, 압력감지센서로 교합력을 측정하였고 실리콘인기재로 교합면적을 측정하였다. 진료실재부착후 교합압의 변화는 없었으나 교합면적 증가와 함께 접촉 후 미끄러짐이 줄어드는 것을 확인할 수 있었다. 진료실재부착을 시행하면 조기접촉이 감소하고 교합면적이 증가하므로 시행하는 것이 필요하다.

• 대한소아치과학회지
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• 제41권1호
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• pp.47-53
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• 2014

상아질 이형성증은 매우 드물게 발생하는 상염색체 우성 유전 질환이다. 발생학적 원인에 대해서는 아직 명확하게 알려지지 않았으며 인구 100,000당 1명의 발병률을 나타낸다. 상아질 이형성증은 두 가지 형으로 분류가 되며, 치근부위 상아질 형성이상을 보이는 치근형의 제 1형과 치관부위 상아질 형성이상을 보이는 치관형인 제 2형으로 나눠진다. 제 1형 상아질 이형성증은 임상적으로 정상적인 치관형태을 보이고 있으나 동요도를 가지며 방사선학적으로 치수강과 치근관의 폐쇄, 짧은 원추형의 치근형태 및 자발적으로 형성된 치근단 병소가 특징적으로 관찰된다. 본 논문은 한 가족 내에서 아버지를 제외한 4명의 가족 구성원들에게 발생한 제 1형 상아질 이형성증을 관찰한 바, 이에 대해 이환된 가족 구성원들의 임상, 방사선학 및 조직병리학적 소견을 보고하고자 한다. 제 1형 상아질 이형성증은 방사선학적 검사를 시행하지 않고서는 임상적으로 인지하기 어려우며 조기 진단을 통해 정기적인 구강 위생 관리 및 예방치료를 시행할 경우 이환된 치아의 조기 탈락을 예방하거나 지연시킬 수 있을 것이다.

• 대한소아치과학회지
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• 제43권3호
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• pp.299-305
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• 2016

본 연구는 서울대학교 치과병원 소아치과에 내원한 부분 무치증 환자를 대상으로 질환의 원인이 될 수 있는 돌연변이를 규명하고, 그 역할에 대하여 고찰하고자 하였다. 다수의 영구치 결손을 주소로 서울대학교 치과 병원에 내원 한 7세 여아와 어머니를 대상으로 구강검진 및 파노라마 방사선 촬영을 진행하였다. 연구 동의서를 받고, 유전자 검사를 위한 채혈을 시행하였다. PAX9 유전자의 모든 exon에 대해 특이적인 primer를 이용하여 중합효소 연쇄반응을 시행하였으며, 해당 산물을 정제하고 염기서열분석을 진행하였다. 결과는 NCBI Gene Bank와 대조하여 해당 영역의 돌연변이를 조사하였다. 7세 환아는 총 11개의 영구치 결손이 관찰되었으며, 어머니는 총 19개의 영구치 결손이 관찰되었다. 치아 결손 외에 손톱, 모발, 피부, 땀샘과 연관 된 다른 결함은 관찰되지 않았다. 유전자 분석 결과, PAX9의 exon 2 영역에서 nonsense mutation(c.184G>T, $p.Glu62^*$)을 확인하였으며, 대상자 모두에서 이형접합 돌연변이로 관찰되었다. 해당 돌연변이의 결과로 exon 2 내에서 전사 종결이 일어나게 되며, 발현 된 단백질은 정상 단백질에 비하여 280개의 아미노산이 짧은 상태로 발현된다고 추측할 수 있다. 결손된 부분은 paired box domain 및 DNA binding site 등 해당 단백질의 기능에 있어서 필수적인 영역을 포함하고 있으므로, 부분 무치증을 유발했을 가능성이 높다. 또는 해당 돌연변이의 전사체가 nonsense-mediated decay system(NMD system)에 의하여 분해됨으로써 haploinsufficiency를 유발하여 부분 무치증의 원인으로 작용했을 것으로 사료된다.

• Tuberculosis and Respiratory Diseases
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• 제71권4호
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• pp.254-258
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• 2011

Background: Although the aging process and features of chronic obstructive pulmonary disease (COPD) have several similarities, the relationship between aging and COPD pathogenesis remains incompletely understood. The klotho gene was found to be related to premature aging and emphysematous changes in an animal model. We investigated whether klotho gene polymorphisms are related to COPD susceptibility and emphysema severity. Methods: A total of 219 COPD subjects from the Korean Obstructive Lung Disease Cohort and 305 control subjects were genotyped for two single nucleotide polymorphisms (SNPs) of the klotho gene associated with coronary artery disease. Logistic regression was performed to determine the association of these SNPs with COPD susceptibility and linear regression was performed to investigate their association with emphysema severity in COPD subjects. Results: The mean age of the COPD subjects was 66 years and their mean FEV1 was 1.46 L. There were no associations between either SNP or COPD susceptibility (p=0.6 and 0.2, respectively) and there were no associations with emphysema severity. Conclusion: Genetic polymorphisms of the klotho gene were not associated with COPD in a Korean population.

• 대한간호학회지
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• 제2권1호
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• pp.141-157
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• 1971

The peripheral infection is one of the major causes of maternal death, and although it is preventable through an effective prenatal as well as postnatal care its morbidity is increasing due to bacterial resistant to an effective antibiotics. The primary purpose of this study was to investigate the peripheral morbidity of 949 parturients who were admitted to the Obstetrics and Gynecologic department of Ewha Woman's University Hospital from January 1971 to September 1971. Among the 949 parturients, especially 40 normal parturients were selected (20, control soup was given complete aseptic care during labor and delivery and post delivery: 20, compare group was given the ordinary care practiced during labor and delivery and maternal ward of Ewha Woman's University Hospital) for bacteriologic test on vaginal flora twice, on admission and on complete cervical dilatation of each parturient. The results obtained from this study were as follows; 1. Majority of parturients age were 21 to 35 years old(90.83%), and educational level of 949 parturients was above high school. A large number of parturients socioeconomic level (according to their husbands' job) were moderate. 2, Among the 949 parturients, multipara (55.9%) were a little more than primipara (44. 1%) and 38.84% of parturients had experienced aborition. 3. In deliverty types, normal deliveries (804 cases) were more than cesarean section deliveries (145 cases) The peripheral morbidity after normal deliveries was 0.5%, and cesarean section deliveries, 23.45%. 4. Among 949 parturients incidence of hemorrhage eases (500cc or more bleeding) showed the higher peripheral morbidity (24.86%) than other cases (bleeding less than 500cc, 7.83%). 5. The majority of parturients (81.03%) had teen taking antenatal care, but most of them were taken irregular antenatal care. On the other hand, on admission, the parturients with complication were 30.32%, and their peripheral morbidity showed much higher (7.02%) than those with no complication (2.71%). 6. The incidence of peripheral morbidity in premature ruptured membrane was higher (10.91%) than normal parturienta (1.73%). 7. In the result of aseptic care during labor and delivery and post delivery, the number of cultured bacteria was legs in control group than Compare group (in control group, on admission 17, on complete cervical dilatation 12: in compare group, on admission 21 on complete cervical dilatation 21) . The most common bacteria were Staphylococcus (control group 14 on admission, compare group 16 on admission), and next Streptococcus, E- Coil, Bacillus Subtilis, in order. Also in control group the number. of colony were reduced (43%) more than in Compare group. Transient temperature elevation from 37℃ to 37.4℃ were noted in compare group (50%) than in control group (30%), and there was no one indicated above 38℃. In conclusion, the aseptic care is the test way of preventing peripheral infection as well as decreasing the puerperal morbidity. Therefore the most important nursing care is the aseptic care for each parturient during labor and delivery and peat delivery and also all the instruments must be cleaned and sterilized.