• 한국균학회지
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• 제48권1호
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• pp.69-74
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• 2020

2017년 9월 춘천의 오봉산에서 참싸리 잎에 겹둥근무늬가 생기고 조기낙엽이 일어나는 등 큰 피해가 발견되었다. 병든 잎의 뒷면에는 원뿔형의 흰색 포자과가 다수 발견되었다. 2019년 9월 횡성의 태기산에서도 참싸리 잎에서 유사한 증상이 발견되었다. 이러한 증상에서 발견된 포자과의 형태적 특징으로 보아 이 곰팡이는 Grovesinia moricola와 일치하였다. 확보된 두 균주(KACC48417 및 KACC48934)의 ITS rDNA 염기서열 분석을 통해 동정을 확인하였다. 이 곰팡이의 병원성은 상대습도 100%와 15±2℃의 조건에서 인공접종을 통하여 확인하였다. 이는 한국에서 참싸리와 G. moricola의 관계를 연구한 최초의 보고이다.

• Journal of Electrical Engineering and Technology
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• 제9권1호
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• pp.15-26
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• 2014

This paper proposes a Modified Particle Swarm Optimization with Time Varying Acceleration Coefficients (MPSO-TVAC) for solving economic load dispatch (ELD) problem. Due to prohibited operating zones (POZ) and ramp rate limits of the practical generators, the ELD problems become nonlinear and nonconvex optimization problem. Furthermore, the ELD problem may be more complicated if transmission losses are considered. Particle swarm optimization (PSO) is one of the famous heuristic methods for solving nonconvex problems. However, this method may suffer to trap at local minima especially for multimodal problem. To improve the solution quality and robustness of PSO algorithm, a new best neighbour particle called 'rbest' is proposed. The rbest provides extra information for each particle that is randomly selected from other best particles in order to diversify the movement of particle and avoid premature convergence. The effectiveness of MPSO-TVAC algorithm is tested on different power systems with POZ, ramp-rate limits and transmission loss constraints. To validate the performances of the proposed algorithm, comparative studies have been carried out in terms of convergence characteristic, solution quality, computation time and robustness. Simulation results found that the proposed MPSO-TVAC algorithm has good solution quality and more robust than other methods reported in previous work.

• 한국정보통신학회논문지
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• 제17권3호
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• pp.705-711
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• 2013

심전도 신호의 QRS 영역은 심장의 질환을 판단하는 중요한 자료로 쓰이는데, 여러 종류의 잡음으로 인해 이를 분석하는데 어려움을 준다. 또한 일반인들의 건강상태를 지속적으로 모니터링 하는 헬스케어 시스템에서는 신호의 실시간 처리가 필요하다. 그리고 생체신호의 특성상 개인 간의 차이가 있음에도 불구하고, 일반적인 ECG 신호의 판단 규칙에 따라 진단을 수행함으로써 성능하락이 나타날 수밖에 없다. 이러한 문제점을 해결하기 위해서는 최소한의 연산량으로 QRS를 검출하고 환자의 특성에 맞게 부정맥을 분류할 수 있는 알고리즘의 설계가 필요하다. 따라서 본 연구에서는 형태연산을 통한 효율적인 QRS 검출과 개인별 정상신호 분류를 위해 해쉬 함수를 적용하여 프로파일링 하였으며, 검출된 QRS 폭과 RR 간격을 이용하여 심실조기수축(PVC)을 분류하는 알고리즘을 개발하였다. 제안한 방법의 우수성을 입증하기 위해 MIT-BIH 부정맥 데이터베이스를 통해 기존 방법과 부정맥 분류 성능을 비교하였다. 성능평가 결과, R파는 평균 99.77%, 정상 신호 분류에 대한 에러율은 0.65%, PVC는 각각 93.29%로 기존 방법에 비해 약 5% 우수하게 나타났다.

• Clinical and Experimental Pediatrics
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• 제53권4호
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• pp.598-602
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• 2010

신생아 일과성 고암모니아혈증은 고암모니아혈증을 특징으로 하며 대부분 호흡곤란 치료를 받는 미숙아에서 발생한다. 발생원인은 정확히 알려져 있지 않으나 생후 2-3일에 호흡 곤란, 기면, 경련, 혼수 등의 임상 증상을 보이고, 생화학적 검사 상 혈중암모니아 농도가 현저히 증가하며 요소회로 효소 치는 정상을 보인다. 치료가 늦으면 사망에 이르는 응급을 요하는 질환이나 즉각적이고 적절한 치료 시 신경학적 손상을 남기지 않고 호전 가능하다. 저자들은 호흡곤란을 보여 호흡기 치료를 받던 35주 미숙아에서 48시간 내에 경련과 함께 혼수상태에 빠지고 검사상 고암모니아혈증을 보여 신투석 등의 치료 후 회복되었으며 2년 추적관찰에서 정상을 보인 환아를 보고하는 바이다.

• 한국제4기학회지
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• 제15권2호
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• pp.63-73
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• 2001

현재까지 모두 29개의 탄소연대가 구석기유적과 관련하여 얻어졌다. 그런데 소로리 유적의 피트층의 연대를 제외한다면 그 수는 20개를 밑돌고 있다. 탄소연대측정치의 분포로 볼 때, 후기구석기시대의 시작은 4 만년 전의 연대에 접근할 수 있는 것으로 보이지만 아직도 연대측정치의 신뢰도의 확보가 중요하고 보다 많은 연대측정치가 누적되어야 할 것으로 생각된다. 세석인공작의 상한과 하한의 연대에 대해서도 현재까지 몇 건의 중요한 연대치로서 대체로 2 만년이 넘을 것으로 보인다. 그런데 후기구석기의 특성상 상당히 세밀한 연대치들이 필요할 것으로 판단되는데 아직도 연대치의 수효가 그리 많지 않아서 정확한 연대를 단언하기가 어렵다. 앞으로 석기공작들의 변화에 대한 분석과 함께 다른 방법의 연대측정치들과 비교하고 또한 많은 수의 탄소연대측정이 있어야 보다 정확한 편년을 기할 수 있을 것으로 판단된다. 한가지 특기할 것은 몇 유적에서 보이는 아이라화산재의 연대(약 24,000 BP)와 탄소연대와 정확하게 맞지 않는 경우들이 있는데 크게는 이해할 수 있는 범주에 들지만 앞으로 유적의 형성과정에 대한 세심한 배려가 결론의 신뢰도를 높일 것으로 생각된다.

• Journal of Crop Science and Biotechnology
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• 제10권3호
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• pp.147-158
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• 2007

Xanthomonas axonopodis pv. glycines(Xag) is a pathogen that causes bacterial leaf pustule(BLP) disease in soybeans grown in Korea and the southern United States. Typical and early symptoms of the disease are small, yellow to brown lesions with raised pustules that develop into large necrotic lesions leading to a substantial loss in yield due to premature defoliation. After Xag infects PI 96188, only pustules without chlorotic haloes were observed, indicating the different response to Xag. To identify differentially expressed genes prior to and 24 hr after Xag inoculation to PI 96188 and BLP-resistant SS2-2, an oligonucleotide macroarray was constructed with 100 genes related to disease resistance and metabolism from soybean and Arabidopsis. After cDNAs from each genotype were applied on the oligonucleotide macroarrays with three replicates and dye swapping, 36 and 81 genes were expressed as significantly different between 0 hr and 24 hr in PI 96188 and SS2-2, respectively. Six UniGenes, such as the leucine-rich repeat protein precursor or 14-3-3-like protein, were selected because they down-regulated in PI 96188 and up-regulated in SS2-2 after Xag infection, simultaneously. Using tubulin and cDNA of Jangyeobkong(BLP-susceptible) as controls, the oligonucleotide macroarray data concurred with quantitative real-time RT-PCR(QRT RT-PCR) results in most cases, supporting the accuracy of the oligonucleotide macroarray experiments. Also, QRT RT-PCR data suggested six candidate genes that might be involved in a necrotic response to Xag in PI 96188.

• 한국임상수의학회지
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• 제29권1호
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• pp.33-37
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• 2012

This study was performed to evaluate the rate of twin pregnancy and parturition in dairy cows. Calving records of Holstein dairy cows from 1998 to 2009 comprising Goyang and Paju cities herd with 20,990 calving events representing 820 twin births were used to evaluate twinning rate, calf sex ratio, periods of pregnancy and complication after parturition in single and twin births. Overall, the reported twinning rate was 3.9% in Holstein dairy cows. Rate of bicornual pregnancy (75%) was larger than that of unicornual pregnancy (25%) among cows having twin. Regardless of parity, the greatest twinning rate was observed in fall season from September to November. Calf sex ratios (male, M; female, F) were 48.0% FM, 28.9% MM, 21.5% FF and 0.9% mummifications for twin calves. Parturition type among cows having twins included normal (4.7%), premature (66.9%), delayed (9.2%), abortion (18.4%) and mummification (0.8%). The period of pregnancy in twin pregnancy (mean 272.6 days) was shorter than single pregnancy (mean 278.1 days). The retained placenta after parturition was over fourth times such as twin parturition (34.8%) higher than single parturition (8.5%) and the abomasal displacement was over two times such as twin parturition (10.2%) higher than single parturition (4.9%). The distribution of twin pregnancy with parities was high rate during the 2~3 parities. The prevalence of complication such as retained placenta and abomasal displacement with twin parturition revealed higher than single parturition.

• 대한바이러스학회지
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• 제29권2호
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• pp.107-118
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• 1999

To characterize the molecular nature of human immunodeficiency virus (HIV)-1, we determined the full-length HIV-1 sequences from cultured peripheral blood mononuclear cells (PBMC) of a Korean long-term nonprogressor (LTNP). Without antiretroviral therapy, the individual has maintained CD4+ T counts over $500/{\mu}l$ from 1989 to 1999. Plasma viral RNA copy was 992 U/ml in 1998. Culture supernatant showed positive from culture days 9. A series of 9 overlapping PCR products were amplified from cultured PBMC and cloned About 9.2 kb from R of 5' LTR to R of 3' LTR was determined by automated sequencing. The G-to-A hypermutations were shown throughout the entire region. As a result of G to A hypermutations, premature stop codon was found in integrase coding region. Though there was no recombination between subtypes over all genomes, TATA box in both LTRs was TAAAA which is detected in subtype E instead of TATAA in subtype B. And, there were nucleotide GC insertion between $NF-{\kappa}B$ I and Sp1 III, and duplication of $TCF-1{\alpha}$ in LTR. We could not find any deletion of amino acid in Nef, Gag, Pol and Env gene. This study is the first report on molecular nature of full genomes of HIV-1 isolated in Korea.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제18권4호
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• pp.238-245
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• 2015

Purpose: The aim of this study was to evaluate bolus transit during esophageal swallow (ES) and gastroesophageal reflux (GER) events and to investigate the relationship between the characteristics of ES and GER events in a population of term and preterm newborns with symptoms of gastroesophageal reflux disease (GERD). Methods: The study population consisted of term and preterm newborns referred to combined multichannel intraluminal impedance (MII) and pH monitoring for GERD symptoms. The frequency and characteristics of ES and GER events were assessed by two independent investigators. Statistical significance was set at p<0.05. Results: Fifty-four newborns (23 preterm) were included in the analyses. Median bolus head advancing time corrected for esophageal length (BHATc) was shorter during mealtime than during the postprandial period (median, interquartile range): 0.20 (0.15-0.29) s/cm vs. 0.47 (0.39-0.64) s/cm, p<0.001. Median bolus presence time (BPT) was prolonged during mealtime: 4.71(3.49-6.27) s vs. 2.66 (1.82-3.73) s, p<0.001. Higher BHATc (p=0.03) and prolonged BPT (p<0.001) were observed in preterm newborns during the postprandial period. A significant positive correlation between BHATc and bolus clearance time was also observed (${\rho}=0.33$, p=0.016). Conclusion: The analysis of ES and GER events at the same time by MII provides useful information to better understand the physiopathology of GERD. In particular, the analysis of BHATc during the postprandial period could help clinicians identify newborns with prolonged esophageal clearance time due to impaired esophageal motility, which could allow for more accurate recommendations regarding further tests and treatment.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제23권4호
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• pp.377-387
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• 2020

Purpose: To compare between sodium acetate (SA) and sodium chloride (SC) in parenteral nutrition (PN) with associated metabolic acidosis and neonatal morbidities in preterm infants. Methods: Preterm infants below 33 weeks gestational age, and with a birth weight under 1,301 g were enrolled and further stratified into two groups: i) <1,000 g, or ii) ≥1,000 g in birth weight. The subjects were randomized to receive PN containing SA or SC within the first day of life. The results of routine blood investigations for the first 6 days of PN were collated, and the neonatal outcomes were recorded upon discharge or demise. Results: Fifty-two infants entered the study, with 26 in each group: 29 infants had extremely low birth weight (ELBW). There were no significant differences in birth weight, gestation, sex, exposure to chorioamnionitis and antenatal steroids, surfactant doses and duration of mechanical ventilation between groups. The SA group had significantly higher mean pH and base excess (BE) from days 4 to 6 than the SC (mean pH, 7.36 vs. 7.34; mean BE -1.6 vs. -3.5 [p<0.01]), with a two-fold increase in the mean BE among ELBW infants. Significantly fewer on SA required additional bicarbonate (n=4 vs. 13, p=0.01). The rate of bronchopulmonary dysplasia (BPD) was approximately four-fold lower in SA than SC (n=3 vs. 11, p<0.01). No significant differences were observed in necrotizing enterocolitis, patent ductus arteriosus, retinopathy of prematurity, cholestatic jaundice, and mortality between groups. Conclusion: The use of SA in PN was associated with reduced metabolic acidosis and fewer BPD.