• The Korean Journal of Mycology
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• v.48 no.1
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• pp.69-74
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• 2020

In September 2017, a heavy damage by premature defoliation with the zonate leaf spots was observed in several shrubs of Lespedeza cyrtobotrya growing at Mt. Obongsan in Chuncheon, Korea. Numerous cone-shaped, white sporophores of a fungus were observed on lesions of the abaxial leaf surface. A similar fungus was isolated in September 2019 from the leaves of L. cyrtobotrya growing at Mt. Taegisan in Hoengseong, Korea. The morphological characteristics of the sporophores were consistent with those of Grovesinia moricola. The species identification was confirmed by sequencing the internal transcribed spacer (ITS) region of the ribosomal DNA from the two isolates (KACC48417 and KACC48934). The fungal pathogenicity was determined by an artificial inoculation in conditions of relative humidity and temperature of 100% and 15±2℃, respectively. This is the first report of association of G. moricola with L. cyrtobotrya in Korea.

• Journal of Electrical Engineering and Technology
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• v.9 no.1
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• pp.15-26
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• 2014

This paper proposes a Modified Particle Swarm Optimization with Time Varying Acceleration Coefficients (MPSO-TVAC) for solving economic load dispatch (ELD) problem. Due to prohibited operating zones (POZ) and ramp rate limits of the practical generators, the ELD problems become nonlinear and nonconvex optimization problem. Furthermore, the ELD problem may be more complicated if transmission losses are considered. Particle swarm optimization (PSO) is one of the famous heuristic methods for solving nonconvex problems. However, this method may suffer to trap at local minima especially for multimodal problem. To improve the solution quality and robustness of PSO algorithm, a new best neighbour particle called 'rbest' is proposed. The rbest provides extra information for each particle that is randomly selected from other best particles in order to diversify the movement of particle and avoid premature convergence. The effectiveness of MPSO-TVAC algorithm is tested on different power systems with POZ, ramp-rate limits and transmission loss constraints. To validate the performances of the proposed algorithm, comparative studies have been carried out in terms of convergence characteristic, solution quality, computation time and robustness. Simulation results found that the proposed MPSO-TVAC algorithm has good solution quality and more robust than other methods reported in previous work.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.17 no.3
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• pp.705-711
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• 2013

QRS detection of ECG is the most popular and easy way to detect cardiac-disease. But it is difficult to analyze the ECG signal because of various noise types. Also in the healthcare system that must continuously monitor people's situation, it is necessary to process ECG signal in realtime. In other words, the design of algorithm that exactly detects QRS wave using minimal computation and classifies PVC by analyzing the persons's physical condition and/or environment is needed. Thus, efficient QRS detection and PVC classification based on profiling method is presented in this paper. For this purpose, we detected QRS through the preprocessing method using morphological filter, adaptive threshold, and window. Also, we applied profiling method to classify each patient's normal cardiac behavior through hash function. The performance of R wave detection, normal beat and PVC classification is evaluated by using MIT-BIH arrhythmia database. The achieved scores indicate the average of 99.77% in R wave detection and the rate of 0.65% in normal beat classification error and 93.29% in PVC classification.

• Clinical and Experimental Pediatrics
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• v.53 no.4
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• pp.598-602
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• 2010

Transient hyperammonemia in a newborn is an overwhelming disease manifested by hyperammonemic coma. The majority of affected newborns are premature and have mild respiratory syndrome. The diagnosis may be difficult to determine. This metabolic disorder is primarily characterized by severe hyperammonemia in the postnatal period, coma, absence of abnormal organic aciduria and normal activity of the enzymes of the urea cycle. Hyperammonemic coma may develop within 2-3 days of life, although its etiology is unknown. Laboratory studies reveal marked hyperammonemia (>$4,000{\mu}mol/L$). The degree of neurologic impairment and developmental delay in this disorder depends on the duration of hyperammonemic coma. Moreover, the infant may succumb to the disease if treatment is not started immediately and continued vigorously. Hyperammonemic coma as a medical emergency requires dialysis therapy. Here, we report a case of severe transient hyperammonemia in a preterm infant (35 week of gestation) presented with respiratory distress, seizure, and deep coma within 48 hours and required ventilatory assistance and marked elevated plasma ammonia levels. He survived with aggressive therapy including peritoneal dialysis, and was followed 2 years later without sequelae.

• The Korean Journal of Quaternary Research
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• v.15 no.2
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• pp.63-73
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• 2001

In total, 29 $^{14}C$ dates were obtained from Paleolithic sites in the Korean peninsula. If not the dates from the Sorori peat layers, the number will be less than 20. Low boundary of Upper Paleolithic could be estimated by some early of the dates from Blade stone industries. Couple of $^{14}C$ dates indicate that beginning of Upper Paleolithic industries could approach to 40 K BP, but it is premature to establish fine chronology of Upper Paleolithic. Some of the $^{14}C$ dates of microlithic industries probably represent too earlier age than generally thought. Tentatively, the beginning of microlithic industries may go back to an age of slightly older than 20 K BP, as indicated in Janghungri, Sokchangni, Noeundong etc. The obtained $^{14}C$ dates at present are very important for construction of Paleolithic chronology. but it is necessary to accumulate for more $^{14}C$ dates in future along with results from other dating techniques and to reconstruct site formation processes for obtaining objective age of stone industries.

• Journal of Crop Science and Biotechnology
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• v.10 no.3
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• pp.147-158
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• 2007

Xanthomonas axonopodis pv. glycines(Xag) is a pathogen that causes bacterial leaf pustule(BLP) disease in soybeans grown in Korea and the southern United States. Typical and early symptoms of the disease are small, yellow to brown lesions with raised pustules that develop into large necrotic lesions leading to a substantial loss in yield due to premature defoliation. After Xag infects PI 96188, only pustules without chlorotic haloes were observed, indicating the different response to Xag. To identify differentially expressed genes prior to and 24 hr after Xag inoculation to PI 96188 and BLP-resistant SS2-2, an oligonucleotide macroarray was constructed with 100 genes related to disease resistance and metabolism from soybean and Arabidopsis. After cDNAs from each genotype were applied on the oligonucleotide macroarrays with three replicates and dye swapping, 36 and 81 genes were expressed as significantly different between 0 hr and 24 hr in PI 96188 and SS2-2, respectively. Six UniGenes, such as the leucine-rich repeat protein precursor or 14-3-3-like protein, were selected because they down-regulated in PI 96188 and up-regulated in SS2-2 after Xag infection, simultaneously. Using tubulin and cDNA of Jangyeobkong(BLP-susceptible) as controls, the oligonucleotide macroarray data concurred with quantitative real-time RT-PCR(QRT RT-PCR) results in most cases, supporting the accuracy of the oligonucleotide macroarray experiments. Also, QRT RT-PCR data suggested six candidate genes that might be involved in a necrotic response to Xag in PI 96188.

• Journal of Veterinary Clinics
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• v.29 no.1
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• pp.33-37
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• 2012

This study was performed to evaluate the rate of twin pregnancy and parturition in dairy cows. Calving records of Holstein dairy cows from 1998 to 2009 comprising Goyang and Paju cities herd with 20,990 calving events representing 820 twin births were used to evaluate twinning rate, calf sex ratio, periods of pregnancy and complication after parturition in single and twin births. Overall, the reported twinning rate was 3.9% in Holstein dairy cows. Rate of bicornual pregnancy (75%) was larger than that of unicornual pregnancy (25%) among cows having twin. Regardless of parity, the greatest twinning rate was observed in fall season from September to November. Calf sex ratios (male, M; female, F) were 48.0% FM, 28.9% MM, 21.5% FF and 0.9% mummifications for twin calves. Parturition type among cows having twins included normal (4.7%), premature (66.9%), delayed (9.2%), abortion (18.4%) and mummification (0.8%). The period of pregnancy in twin pregnancy (mean 272.6 days) was shorter than single pregnancy (mean 278.1 days). The retained placenta after parturition was over fourth times such as twin parturition (34.8%) higher than single parturition (8.5%) and the abomasal displacement was over two times such as twin parturition (10.2%) higher than single parturition (4.9%). The distribution of twin pregnancy with parities was high rate during the 2~3 parities. The prevalence of complication such as retained placenta and abomasal displacement with twin parturition revealed higher than single parturition.

• The Journal of Korean Society of Virology
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• v.29 no.2
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• pp.107-118
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• 1999

To characterize the molecular nature of human immunodeficiency virus (HIV)-1, we determined the full-length HIV-1 sequences from cultured peripheral blood mononuclear cells (PBMC) of a Korean long-term nonprogressor (LTNP). Without antiretroviral therapy, the individual has maintained CD4+ T counts over $500/{\mu}l$ from 1989 to 1999. Plasma viral RNA copy was 992 U/ml in 1998. Culture supernatant showed positive from culture days 9. A series of 9 overlapping PCR products were amplified from cultured PBMC and cloned About 9.2 kb from R of 5' LTR to R of 3' LTR was determined by automated sequencing. The G-to-A hypermutations were shown throughout the entire region. As a result of G to A hypermutations, premature stop codon was found in integrase coding region. Though there was no recombination between subtypes over all genomes, TATA box in both LTRs was TAAAA which is detected in subtype E instead of TATAA in subtype B. And, there were nucleotide GC insertion between $NF-{\kappa}B$ I and Sp1 III, and duplication of $TCF-1{\alpha}$ in LTR. We could not find any deletion of amino acid in Nef, Gag, Pol and Env gene. This study is the first report on molecular nature of full genomes of HIV-1 isolated in Korea.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• v.18 no.4
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• pp.238-245
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• 2015

Purpose: The aim of this study was to evaluate bolus transit during esophageal swallow (ES) and gastroesophageal reflux (GER) events and to investigate the relationship between the characteristics of ES and GER events in a population of term and preterm newborns with symptoms of gastroesophageal reflux disease (GERD). Methods: The study population consisted of term and preterm newborns referred to combined multichannel intraluminal impedance (MII) and pH monitoring for GERD symptoms. The frequency and characteristics of ES and GER events were assessed by two independent investigators. Statistical significance was set at p<0.05. Results: Fifty-four newborns (23 preterm) were included in the analyses. Median bolus head advancing time corrected for esophageal length (BHATc) was shorter during mealtime than during the postprandial period (median, interquartile range): 0.20 (0.15-0.29) s/cm vs. 0.47 (0.39-0.64) s/cm, p<0.001. Median bolus presence time (BPT) was prolonged during mealtime: 4.71(3.49-6.27) s vs. 2.66 (1.82-3.73) s, p<0.001. Higher BHATc (p=0.03) and prolonged BPT (p<0.001) were observed in preterm newborns during the postprandial period. A significant positive correlation between BHATc and bolus clearance time was also observed (${\rho}=0.33$, p=0.016). Conclusion: The analysis of ES and GER events at the same time by MII provides useful information to better understand the physiopathology of GERD. In particular, the analysis of BHATc during the postprandial period could help clinicians identify newborns with prolonged esophageal clearance time due to impaired esophageal motility, which could allow for more accurate recommendations regarding further tests and treatment.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• v.23 no.4
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• pp.377-387
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• 2020

Purpose: To compare between sodium acetate (SA) and sodium chloride (SC) in parenteral nutrition (PN) with associated metabolic acidosis and neonatal morbidities in preterm infants. Methods: Preterm infants below 33 weeks gestational age, and with a birth weight under 1,301 g were enrolled and further stratified into two groups: i) <1,000 g, or ii) ≥1,000 g in birth weight. The subjects were randomized to receive PN containing SA or SC within the first day of life. The results of routine blood investigations for the first 6 days of PN were collated, and the neonatal outcomes were recorded upon discharge or demise. Results: Fifty-two infants entered the study, with 26 in each group: 29 infants had extremely low birth weight (ELBW). There were no significant differences in birth weight, gestation, sex, exposure to chorioamnionitis and antenatal steroids, surfactant doses and duration of mechanical ventilation between groups. The SA group had significantly higher mean pH and base excess (BE) from days 4 to 6 than the SC (mean pH, 7.36 vs. 7.34; mean BE -1.6 vs. -3.5 [p<0.01]), with a two-fold increase in the mean BE among ELBW infants. Significantly fewer on SA required additional bicarbonate (n=4 vs. 13, p=0.01). The rate of bronchopulmonary dysplasia (BPD) was approximately four-fold lower in SA than SC (n=3 vs. 11, p<0.01). No significant differences were observed in necrotizing enterocolitis, patent ductus arteriosus, retinopathy of prematurity, cholestatic jaundice, and mortality between groups. Conclusion: The use of SA in PN was associated with reduced metabolic acidosis and fewer BPD.